N. Simurova, I. Popova, O. Mayboroda, O. O. Karmachov
{"title":"A CONVENIENT METHOD FOR THE PREPARATION OF 2-ARYL(HETERYL)-5-CHLOROMETHYL-1,3,4-OXADIASOLES","authors":"N. Simurova, I. Popova, O. Mayboroda, O. O. Karmachov","doi":"10.32838/2663-5941/2020.1-2/15","DOIUrl":"https://doi.org/10.32838/2663-5941/2020.1-2/15","url":null,"abstract":"The 1,3,4-oxadiazole molecule is of considerable interest due to a wide range of biological and pharmacological activities and has been generally recognized as a privileged structure in drug chemistry. The development of convenient methods for the production of substituted 1,3,4-oxadiazoles is an important area of research. Particularly interesting are derivatives of 1,3,4-oxadiazoles containing of the reactive chloromethyl group, which allows their further chemical modification. This paper is devoted to the development of a convenient preparative method of obtaining 2-aryl/heteryl-5-chloromethyl-1,3,4-oxadiazoles. A scheme is proposed in which aromatic and heterocyclic carboxylic acids are commercially available starting materials. The method is based on the preparation of carboxylic acid hydrazides, their subsequent acylation and cyclization of synthesized intermediates under the action of phosphorus trichloroxide (V). The advantages of the method are the high yields of the targeted 1,3,4-oxadiazoles and the absence of the need to purify the intermediate compounds, which greatly simplifies the procedure, shortens the required time, saves the necessary reagents. The method is suitable for the preparation of both a wide range of 5-aryl-2-chloromethyl-1,3,4-oxadiazoles and some derivatives with heterocyclic substituents, in particular 5-thienyl (furyl)-2-chloromethyl-1,3,4- oxadiazoles. The structure of all the compounds obtained was confirmed by 1H NMR spectra and their composition by elemental analysis. The results of these studies can be applied in synthetic practice, and the obtained compounds containing the reactive chloromethyl group are promising building blocks for their further chemical modification in order to obtain biologically active derivatives, which may find use as drugs, insecticides","PeriodicalId":308855,"journal":{"name":"Scientific notes of Taurida National V.I. Vernadsky University. Series: Technical Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125673313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Kravchenko, M. O. Demchenko, O.V. Voloshko, M. Filippova
{"title":"ANALYSIS OF THE EFFICIENCY OF USING RESOURCES IN THE COMPANY USING DIGITAL TWIN","authors":"O. Kravchenko, M. O. Demchenko, O.V. Voloshko, M. Filippova","doi":"10.32782/2663-5941/2023.2.1/26","DOIUrl":"https://doi.org/10.32782/2663-5941/2023.2.1/26","url":null,"abstract":"","PeriodicalId":308855,"journal":{"name":"Scientific notes of Taurida National V.I. Vernadsky University. Series: Technical Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125996403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Artuhov, O. Brytov, V.S. Hiorhizova-Hai, B. Kyriusha, V. Stikanov
{"title":"CALCULATION AND SIMULATION OF NON-RECURSIVE DIGITAL FILTERS IN ANALOG-DIGITAL CIRCUIT SIMULATOR","authors":"V. Artuhov, O. Brytov, V.S. Hiorhizova-Hai, B. Kyriusha, V. Stikanov","doi":"10.32838/2663-5941/2022.2/05","DOIUrl":"https://doi.org/10.32838/2663-5941/2022.2/05","url":null,"abstract":"","PeriodicalId":308855,"journal":{"name":"Scientific notes of Taurida National V.I. Vernadsky University. Series: Technical Sciences","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127916101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"VEHICLE WHEELS OF CONTROL SELF VIBRATION MODEL IMPROVEMENT","authors":"V. Redchits, E. Holovina, S. V. Redchits","doi":"10.32838/2663-5941/2019.3-2/29","DOIUrl":"https://doi.org/10.32838/2663-5941/2019.3-2/29","url":null,"abstract":"","PeriodicalId":308855,"journal":{"name":"Scientific notes of Taurida National V.I. Vernadsky University. Series: Technical Sciences","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127940590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"NON-LINEAR REGRESSION MODEL FOR ESTIMATING THE EFFORT OF WORKS IN SHIPBUILDING PROJECTS BASED ON THE JONSON BIVARIATE NORMALIZING TRANSFORMATION","authors":"N. Prykhodko, L. Makarova, O. O. Kudin","doi":"10.32838/2663-5941/2019.3-1/27","DOIUrl":"https://doi.org/10.32838/2663-5941/2019.3-1/27","url":null,"abstract":"","PeriodicalId":308855,"journal":{"name":"Scientific notes of Taurida National V.I. Vernadsky University. Series: Technical Sciences","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115795336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RESTORING PARAMETERS OF INFORMATION OBJECTS IN A UNIFIED INFORMATION SPACE AT FULLY CONNECTED TOPOLOGY","authors":"V. Zavgorodnii","doi":"10.32838/2663-5941/2021.3/15","DOIUrl":"https://doi.org/10.32838/2663-5941/2021.3/15","url":null,"abstract":"","PeriodicalId":308855,"journal":{"name":"Scientific notes of Taurida National V.I. Vernadsky University. Series: Technical Sciences","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132081430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Belyanovskaya, К. Sukhyy, R. Lytovchenko, I. Sukha, Y. Serhiienko
{"title":"THERMAL MASSES OF ADSORPTIVE HEAT STORAGE DEVICES BASED ON COMPOSITES “SILICA GEL – SODIUM SULPHATE” AND “SILICA GEL – SODIUM ACETATE”","authors":"E. Belyanovskaya, К. Sukhyy, R. Lytovchenko, I. Sukha, Y. Serhiienko","doi":"10.32838/2663-5941/2021.2-2/07","DOIUrl":"https://doi.org/10.32838/2663-5941/2021.2-2/07","url":null,"abstract":"","PeriodicalId":308855,"journal":{"name":"Scientific notes of Taurida National V.I. Vernadsky University. Series: Technical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132244484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V.V. Dadyverin, K. Potapova, I.O. Feshchenko, O.V. Tarasenko-Kliatchenko, D. Ivasenko
{"title":"FACE RECOGNITION SYSTEM USING COMBINATION OF HAAR TA SVM METHODS","authors":"V.V. Dadyverin, K. Potapova, I.O. Feshchenko, O.V. Tarasenko-Kliatchenko, D. Ivasenko","doi":"10.32782/2663-5941/2022.6/15","DOIUrl":"https://doi.org/10.32782/2663-5941/2022.6/15","url":null,"abstract":"","PeriodicalId":308855,"journal":{"name":"Scientific notes of Taurida National V.I. Vernadsky University. Series: Technical Sciences","volume":"278 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132352883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DIRECTIONS FOR IMPROVING THE SYSTEM OF PORT DUES FORMATION","authors":"A. Muradian, O.V. Demydiukov","doi":"10.32782/2663-5941/2023.2.2/28","DOIUrl":"https://doi.org/10.32782/2663-5941/2023.2.2/28","url":null,"abstract":"","PeriodicalId":308855,"journal":{"name":"Scientific notes of Taurida National V.I. Vernadsky University. Series: Technical Sciences","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134061971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}