Jurnal Kesehatan Andalas最新文献_第2页

Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen PPAR-γ pada Tikus Alzheimer 间充质干细胞沃顿果冻对阿尔茨海默氏症小鼠 PPAR-γ 基因表达的影响

Jurnal Kesehatan Andalas Pub Date : 2023-10-24 DOI: 10.25077/jka.v12i2.2142

Nabila Priscilla Putri, Hirowati Ali, Tofrizal Tofrizal, Eryati Darwin, Restu Susanti, Hasmiwati Hasmiwati

{"title":"Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen PPAR-γ pada Tikus Alzheimer","authors":"Nabila Priscilla Putri, Hirowati Ali, Tofrizal Tofrizal, Eryati Darwin, Restu Susanti, Hasmiwati Hasmiwati","doi":"10.25077/jka.v12i2.2142","DOIUrl":"https://doi.org/10.25077/jka.v12i2.2142","url":null,"abstract":"The increased production of beta-amyloid marks Alzheimer's disease. PPAR-γ shows involvement in Alzheimer's disease. PPAR-γ Gene is suspected to reduce beta-amyloid plaques and reduce inflammation and oxidative stress in Alzheimer's disease. Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) is expected to increase the PPAR-γ Gene expression. Objective: To observed the PPAR-γ Gene expression in Alzheimer's Mice. Methods: The mice are induced using AlCl3 and were given MSC-WJ. This study was an experimental study with a post-test-only control group design on 18 samples of RNA from Alzheimer's mice that were divided into 3 groups. Negative control group (K-), positive control group (K+), and experimented group (P). The mean of PPAR-γ gene expression was obtained by comparing the PPAR-γ gene with the GAPDH gene. This study used semiquantitative methods using ImageJ. Data analysis was used with the Kruskal-Wallis test. It is significant if the value is <0,05. Results: The mean ratio of PPAR-γ gene expression that was obtained in K-, K+, and P were 0.12, 0.06, and 0.08, respectively. There were significant differences between each group, with a p-value of 0,023 (p<0,05). Conclusion: Giving MSC-WJ could increase the PPAR-γ gene expression. Further study using real-time PCR is highly needed to increase the MSC-WJ treatment in patients with Alzheimer's disease.Keywords: Alzheimer disease, MSC-WJ, PPAR- γ","PeriodicalId":30736,"journal":{"name":"Jurnal Kesehatan Andalas","volume":"54 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135323019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Karakteristik Analisis LCS Meningoensefalitis Anak di RSUD Abdoel Wahab Sjahranie Samarinda Tahun 2019-2022 2019-2022年阿布道尔-瓦哈卜-斯亚赫拉尼-萨马林达医院儿童脑膜脑炎的病例分析特点

Jurnal Kesehatan Andalas Pub Date : 2023-10-24 DOI: 10.25077/jka.v12i2.2287

Yunita Yunita, Yudanti Riastiti, Annisa Muhyi

{"title":"Karakteristik Analisis LCS Meningoensefalitis Anak di RSUD Abdoel Wahab Sjahranie Samarinda Tahun 2019-2022","authors":"Yunita Yunita, Yudanti Riastiti, Annisa Muhyi","doi":"10.25077/jka.v12i2.2287","DOIUrl":"https://doi.org/10.25077/jka.v12i2.2287","url":null,"abstract":"Meningoencephalitis is a pathological state characterized by concurrent inflammation of the meninges and the brain parenchyma. Liquor Cerebrospinal analysis (LCS) can help establish a diagnosis of diseases affecting the central nervous system, including meningoencephalitis. Objective: To identified the attributes of meningoencephalitis LCS analysis in pediatric patients at RSUD Abdoel Wahab Sjahranie Samarinda from 2019 until 2022. Methods: This study employs a descriptive research design to delineate the features of the LCS analysis. The data utilized in this study was acquired from the medical records of individuals who had experienced meningoencephalitis during their childhood and obtained as many as 39 patient data samples. Results: The findings revealed that most cases were observed in children aged 0-1 years (38.5%), with a higher incidence in males (59.0%). The LCS analysis parameters indicated that lymphocytic pleocytosis was the most common (76.9%), while clear LCS was observed in 82.1%. The leukocyte count was within the normal range of 56.4%, and the polymorphonuclear ratio was negative (79.5%). The protein levels increased by 56.4%, while the glucose levels were within the normal range (59.0%). Conclusion: There is an increase in LCS protein levels, which indicates inflammation.Keywords: LCS analysis, LCS parameters, meningoencephalitis","PeriodicalId":30736,"journal":{"name":"Jurnal Kesehatan Andalas","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135323001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pengaruh Walking Morning Exercise Terhadap Peningkatan Kualitas Tidur pada Lansia 早晨散步对老年人改善睡眠质量的影响

Jurnal Kesehatan Andalas Pub Date : 2023-10-24 DOI: 10.25077/jka.v12i2.2233

Anisah Oktaviatama, Dita Mirawati, Cahyo Setiawan

引用次数: 0

Can Purple Sweet Potato Water Extract (Ipomoea batatas L.) Induce Steatosis at Toxic Doses in Rat? 紫薯水提取物罐头(Ipomoea batatas L.)中毒剂量诱导大鼠脂肪变性?

Jurnal Kesehatan Andalas Pub Date : 2023-10-24 DOI: 10.25077/jka.v12i2.2172

Gemila Hikmatussalam, Yuktiana Kharisma, Nurul Romadhona

{"title":"Can Purple Sweet Potato Water Extract (Ipomoea batatas L.) Induce Steatosis at Toxic Doses in Rat?","authors":"Gemila Hikmatussalam, Yuktiana Kharisma, Nurul Romadhona","doi":"10.25077/jka.v12i2.2172","DOIUrl":"https://doi.org/10.25077/jka.v12i2.2172","url":null,"abstract":"Purple sweet potato (Ipomoea batatas L.) has a secondary metabolite that contains a lot of antioxidants. Some of the secondary metabolites in purple sweet potato have a hepatotoxic effect. Objective: To described the toxic effects of purple sweet potato water extract on steatosis in rats. Methods: This descriptive study was conducted on 29‒30 June 2019 in the Biomedical Laboratory of the Faculty of Medicine, Islamic Bandung University, with an in-vivo experimental design with random allocation techniques and using the proposed new method on 11 rats. One of the control rats was not given extract, and ten other rats were given a dose of purple sweet potato water extract 50, 200, 400, 800, 1000, 1500, 2000, 3000, 4000, and 5000 mg/KgBW/PO. The liver organ was harvested after 24 hours, and then slides were made at the Pathology Anatomy Laboratory of Padjajaran University. Results: The histopathological view did not find any steatosis either in macrovesicular or microvesicular, but other features were found in ballooning degeneration, sinusoidal dilation, and inflammation. Conclusion: Steatosis was not found because purple sweet potato contains anthocyanins and tannins.Keywords: purple sweet potato, steatosis, tannin","PeriodicalId":30736,"journal":{"name":"Jurnal Kesehatan Andalas","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135322199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rinosinusitis Kronis dengan Polip Nasal Inflamatori Bilateral serta Elongated Unsinatus 慢性鼻溶解伴双侧炎症性鼻息肉和细长的非鼻突

Jurnal Kesehatan Andalas Pub Date : 2023-07-22 DOI: 10.25077/jka.v12i1.2162

Bestari Jaka Budiman, Dolly Irfandy, Mohd Redza Qurniawan

引用次数: 0

Nilai Diagnostik Ultrasonografi Hepatobilier sebagai Prediktor Atresiabilier pada Kolestasis Bayi di RSUP Sanglah Denpasar Tahun 2017 - 2021 2017-2021年RSUP Sanglah Denpasar患者肝胆超声诊断价值对儿童Collestasis的预测价值

Jurnal Kesehatan Andalas Pub Date : 2023-07-22 DOI: 10.25077/jka.v12i1.2156

Kristina Agustina, Pande Putu, Yuli Anandasari, F. Sitanggang, W. Gede, Artawan Eka Putra, M. Asih, P. Patriawan, A. Penelitian

{"title":"Nilai Diagnostik Ultrasonografi Hepatobilier sebagai Prediktor Atresiabilier pada Kolestasis Bayi di RSUP Sanglah Denpasar Tahun 2017 - 2021","authors":"Kristina Agustina, Pande Putu, Yuli Anandasari, F. Sitanggang, W. Gede, Artawan Eka Putra, M. Asih, P. Patriawan, A. Penelitian","doi":"10.25077/jka.v12i1.2156","DOIUrl":"https://doi.org/10.25077/jka.v12i1.2156","url":null,"abstract":"Hepatobiliary ultrasound is the most common initial diagnostic modality in the early detection of biliary atresia. It is not the gold standard, but the hepatobiliary ultrasound examination can be used to determine the appropriate further management. Objective: To determined the diagnostic value of ultrasound examination as a predictor of biliary atresia in cholestasis of infants. Methods: This was an observational study with a diagnostic test to determine the validity of hepatobiliary ultrasound as a predictor of biliary atresia with cholangiography as the gold standard. The research subjects were 40 infants taken by total sampling from January 2017 until December 2021. Data were obtained from medical records, hepatobiliary ultrasound images were accessed from PACS, and cholangiography results from SIMARS. The hepatobiliary ultrasound images were scored by two observers using a scoring table. The variables assessed included: gallbladder morphology, absence of common bile duct, triangular cord sign, gallbladder contraction index and liver morphology. Data analysis consisted of interobserver reliability test, and relationship assessment analysis. Diagnostic tests to determine the optimal cut-off score, sensitivity, specificity, positive predictive value, negative predictive value and accuracy. Results: At cut-off≥ 5, the number of patients with radiologically impressive biliary atresia was 26 and not biliary atresia was 14. The validity analysis showed a sensitivity 87.5%, specificity 68.8%, positive predictive 80.8%, negative predictive 78.6%, and accuracy 80%. Conclusion: The diagnostic value of hepatobiliary ultrasound as a predictor of biliary atresia in cholestasis of infants is good.Keywords: biliary atresia, hepatobiliary ultrasound, neonatal cholestasis","PeriodicalId":30736,"journal":{"name":"Jurnal Kesehatan Andalas","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48289790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Korelasi Status Nutrisi dengan Tingkat Kadar Hemoglobin Darah pada Anak Usia Sekolah Dasar Markidam di Desa Cilame Kabupaten Bandung 万隆县次拉姆村小学马克达姆学生营养状况与血血红蛋白水平的相关性研究

Jurnal Kesehatan Andalas Pub Date : 2023-07-22 DOI: 10.25077/jka.v12i1.2154

Lenny Oktorina, Fadhli Dharmansyach Hakim, J. Buntoro, A. Berbudi, Bayu Ewangga

{"title":"Korelasi Status Nutrisi dengan Tingkat Kadar Hemoglobin Darah pada Anak Usia Sekolah Dasar Markidam di Desa Cilame Kabupaten Bandung","authors":"Lenny Oktorina, Fadhli Dharmansyach Hakim, J. Buntoro, A. Berbudi, Bayu Ewangga","doi":"10.25077/jka.v12i1.2154","DOIUrl":"https://doi.org/10.25077/jka.v12i1.2154","url":null,"abstract":"Malnutrition has many adverse effects, including a decrease in hemoglobin levels, or known as anemia. Malnutrition caused by nutritional deficiencies can affect the decrease in hemoglobin levels or anemia. Objective: To determined the correlation between nutritional status and hemoglobin levels in Markidam elementary school-age children in Cilame Village Methods: This cross-sectional study uses primary data from research subjects who have agreed. The number of subject research that has been taken was 143 respondents. Anthropometric examinations using weight scales and microtoise were then carried out in a plotting process to determine the nutritional status of respondents. The hemoglobin level was used as a rapid diagnostic test tool with the Easytouch brand type GCHB. Spearman test to find out the results of this research hypothesis. Results: Hemoglobin levels did not have a significant correlation with nutritional status. This could be seen from the significance value (p-value) of 0,172, where this value is greater than 0,05. Conclusion: There is no correlation between nutritional status and hemoglobin level at the age of elementary school children.Keywords: anemia, hemoglobin, nutritional status","PeriodicalId":30736,"journal":{"name":"Jurnal Kesehatan Andalas","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46340054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hubungan Konsumsi Herbal dengan Kepatuhan Minum Obat Standar pada Pasien Hipertensi di Wilayah Kerja Puskesmas Lempake Samarinda Samarinda劳教中心高血压患者草药消费与标准药物成瘾的关系

Jurnal Kesehatan Andalas Pub Date : 2023-07-22 DOI: 10.25077/jka.v12i1.2167

Wenda Safitri, Sjarif Ismail, Ronny Isnuwardana

{"title":"Hubungan Konsumsi Herbal dengan Kepatuhan Minum Obat Standar pada Pasien Hipertensi di Wilayah Kerja Puskesmas Lempake Samarinda","authors":"Wenda Safitri, Sjarif Ismail, Ronny Isnuwardana","doi":"10.25077/jka.v12i1.2167","DOIUrl":"https://doi.org/10.25077/jka.v12i1.2167","url":null,"abstract":"It is crucial for patients with hypertension to always control their blood pressure by consuming medicines for hypertension, the morbidity and mortality rates will be hopefully reduced. Medication adherence is necessary in order to reach the target of controlling blood pressure. There are a lot of causes affecting medication adherence, one of which is the consumption of herbal remedies. Objective: To investigated the correlation between the consumption of herbal remedies and medication adherence among patients with hypertension at Lempake Public Health Centre in Samarinda. Methods: The research design was analytical observational with a cross-sectional approach. The statistical analysis used Chi-Square test. The data were collected through interviews with 94 respondents. They were selected using convenience sampling and also asked to fulfill the identity form and MMAS-8 questionnaire. Results: Most respondents at Lempake Public Health Centre in Samarinda consumed herbal remedies (42.6%), but their medication adherence was low (82.9%). The significant p-value was 0.008 based on the statistical analysis. Conclusion: There is a significant correlation between the consumption of herbal remedies and medication adherence among patients with hypertension at Lempake Public Health Centre in Samarinda.Keywords: herbal, hypertension, medication adherence, MMAS-8","PeriodicalId":30736,"journal":{"name":"Jurnal Kesehatan Andalas","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44945433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hubungan antara Kadar HbA1c dan Derajat Retinopati Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Mata Cicendo Bandung Cicendo眼科医院2型糖尿病患者HbA1c与视网膜病变程度的关系

Jurnal Kesehatan Andalas Pub Date : 2023-07-22 DOI: 10.25077/jka.v12i1.2157

F. Farhani, Zulfachmi Wahab, Yanuarita Tursinawati

{"title":"Hubungan antara Kadar HbA1c dan Derajat Retinopati Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Mata Cicendo Bandung","authors":"F. Farhani, Zulfachmi Wahab, Yanuarita Tursinawati","doi":"10.25077/jka.v12i1.2157","DOIUrl":"https://doi.org/10.25077/jka.v12i1.2157","url":null,"abstract":"Diabetic retinopathy is the common complication of T2DM, which leads to vision loss. The severity of retinopathy can be affected by HbA1c levels. Controlling the glycemic such as HbA1c, may prevent the severity of diabetic retinopathy. Objective: To identified the association between HbA1c levels and severity of retinopathy in Type 2 DM patients at Cicendo Eye Hospital, Bandung. Methods: This research was an analytic observational study and cross-sectional approach. Samples were taken using purposive sampling and consisted of 70 people. The secondary data were from the outpatient's medical records at the Cicendo Eye Hospital in Bandung for the period September-October 2022. The Chi-square test was used for data analysis. Results: According to HbA1c levels, the uncontrolled HbA1C levels were found in 52 patients (74,3%) and the controlled were found in 18 patients (25,7%). Most of them were diagnosed with PDR were found 62% and the rest of it were diagnosed with NPDR. A significant association is found between HbA1c levels and the degree of diabetic retinopathy with p-value = 0.018 (p <0.05). Conclusion: HbA1c levels in Type 2 Diabetes Mellitus patients have a significant association with the severity of diabetic retinopathy, which can be used as a parameter for controlling diabetes complications, particularly retinopathy.Keywords: diabetic retinopathy, T2DM, HbA1c, glycemic control","PeriodicalId":30736,"journal":{"name":"Jurnal Kesehatan Andalas","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43355556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pengaruh Pemberian Mesenchymal Stem Cells Wharton's Jelly terhadap Ekspresi Gen Sirtuin 1 pada Tikus Model Alzheimer 针对阿尔茨海默病模型小鼠Sirtuin 1基因表达的Wharton’s Jelly间充质干细胞资助编辑器

Jurnal Kesehatan Andalas Pub Date : 2023-07-22 DOI: 10.25077/jka.v12i1.2140

Havina Nurul Aizah, Amel Yanis, Hirowati Ali, Tofrizal Tofrizal, Cimi Ilmiawati, Dessy Arisanty

{"title":"Pengaruh Pemberian Mesenchymal Stem Cells Wharton's Jelly terhadap Ekspresi Gen Sirtuin 1 pada Tikus Model Alzheimer","authors":"Havina Nurul Aizah, Amel Yanis, Hirowati Ali, Tofrizal Tofrizal, Cimi Ilmiawati, Dessy Arisanty","doi":"10.25077/jka.v12i1.2140","DOIUrl":"https://doi.org/10.25077/jka.v12i1.2140","url":null,"abstract":"Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) has become a new hope for Alzheimer's disease due to its capability to suppress Amyloid-beta (Aβ) plaques formation. It is found that people with Alzheimer's disease have a lower expression of Sirtuin-1 because of the oxidative stress that was produced by Aβ plaques. Objective: To observe the Sirtuin-1 gene in Alzheimer's disease rat models that AlCl3 was inducing after being given MSC-WJ. Methods: This was an experimental study with a post-test-only control group design, including three groups with a total sample of 18 samples of Alzheimer RNA rat models. Group-1without AlCl3 and MSC-WJ; Group-2 with AlCl3; Group-3 AlCl3 and MSC-WJ. Mean value of the Sirtuin-1 gene was obtained by the Image-J application using a semiquantitative method which was then tested using the One Way ANOVA test. The study was significant if the p-value < 0,05. Results: This study found that the mean ± standard error value of the Sirtuin-1 gene in three groups were 0.18±0.04; 0.16±0.03; and 0.36±0.06 respectively. The statistical test showed a significant difference between the three groups (p = 0.014). Conclusion: There was an increased Sirtuin 1 gene expression in Alzheimer’s rat Model after being given Mesenchymal Stem Cells Wharton’s Jelly.Keywords: Alzheimer, MSC-WJ, Sirtuin-1","PeriodicalId":30736,"journal":{"name":"Jurnal Kesehatan Andalas","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42166783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0