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Cholestasis Linked to Bodybuilding Supplements: Exploring the Risks of Contamination. 胆汁淤积症与健美补充剂有关：探索污染的风险。
Case Reports in Hepatology Pub Date : 2024-05-24 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5112461
Mark Matusak, Jihad Aljabban, Mark Wirtz, Rashmi Agni, Erin Spengler
{"title":"Cholestasis Linked to Bodybuilding Supplements: Exploring the Risks of Contamination.","authors":"Mark Matusak, Jihad Aljabban, Mark Wirtz, Rashmi Agni, Erin Spengler","doi":"10.1155/2024/5112461","DOIUrl":"10.1155/2024/5112461","url":null,"abstract":"<p><p>Drug-induced liver injury resulting from herbal and dietary supplement use is increasingly common and underrecognized. We report a case of a 34-year-old male recreational bodybuilder who presented with muscle cramping, fatigue, and diffuse itching in the setting of bodybuilding supplement use. Labs showed cholestatic liver injury, and liver biopsy revealed bland cholestasis and sinusoidal dilation. He was diagnosed with anabolic-androgenic steroid-induced liver injury. He was symptomatically managed with plasmapheresis for debilitating pruritus. This case highlights drug-induced liver injury as a complication of bodybuilding supplement use containing unlabeled anabolic-androgenic steroids. Sports medicine providers should inquire on herbal and dietary supplement use and be aware of potential contaminants.</p>","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2024 ","pages":"5112461"},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11142851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Hepatic Neuroendocrine Tumor: A Case Report and Literature Review. 原发性肝脏神经内分泌肿瘤：病例报告与文献综述
Case Reports in Hepatology Pub Date : 2024-02-26 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9181560
Souad Ghattas, Jad Al Bitar, Georges Chahine, Francois Kamar, Marwan Haddad, Raja Wakim
{"title":"Primary Hepatic Neuroendocrine Tumor: A Case Report and Literature Review.","authors":"Souad Ghattas, Jad Al Bitar, Georges Chahine, Francois Kamar, Marwan Haddad, Raja Wakim","doi":"10.1155/2024/9181560","DOIUrl":"10.1155/2024/9181560","url":null,"abstract":"<p><p>Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare and account for about 0.3% of all neuroendocrine tumor cases. Resection is usually difficult because they are usually diagnosed in the late stages. We report the case of a patient diagnosed with PHNETs, initially classified as unresectable but then underwent a successful left hepatectomy. PHNETs are rare malignant tumors, and a high index of suspicion is warranted for the diagnosis after excluding the presence of a primary extrahepatic lesion. Radical hepatectomy can be curative when feasible along with a combination of multiple treatments that improve the prognosis.</p>","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2024 ","pages":"9181560"},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10911880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Unusual Case of Dietary-Induced Liver Injury during Pregnancy: A Case Report of Probable Liver Injury due to High-Dose Turmeric Intake and Literature Review. 妊娠期饮食诱发肝损伤的罕见病例：大剂量姜黄摄入可能导致肝损伤的病例报告和文献综述。
Case Reports in Hepatology Pub Date : 2024-02-06 eCollection Date: 2024-01-01 DOI: 10.1155/2024/6677960
Kareem Haloub, Elly McNamara, Rani Haj Yahya
{"title":"An Unusual Case of Dietary-Induced Liver Injury during Pregnancy: A Case Report of Probable Liver Injury due to High-Dose Turmeric Intake and Literature Review.","authors":"Kareem Haloub, Elly McNamara, Rani Haj Yahya","doi":"10.1155/2024/6677960","DOIUrl":"10.1155/2024/6677960","url":null,"abstract":"<p><p>Turmeric-induced liver injury is a controversial topic, and turmeric is safe to consume during pregnancy in small amounts; however, it might be an uncommon cause of liver injury if consumed in large amounts. We hereby report a case of a pregnant patient who demonstrated atypical signs and symptoms of dietary-induced liver injury during pregnancy. She presented with itching at 23 weeks 4 days of pregnancy and had deranged liver function tests and was diagnosed with dietary-induced liver injury. The patient was managed with a strict diet during the pregnancy which resulted in a significant improvement in the clinical and biochemical findings during the pregnancy.</p>","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2024 ","pages":"6677960"},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Idiosyncratic Drug-Induced Liver Injury in a Healthy Patient following PCSK9-Inhibitor Injection. 一名健康患者注射 PCSK9 抑制剂后出现的药物性肝损伤
Case Reports in Hepatology Pub Date : 2024-01-11 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5556907
B-O Stüben, D P Hoyer, S Radunz, F Saner, H Schmidt, H A Baba, J W Treckmann, L I Mazilescu
{"title":"Idiosyncratic Drug-Induced Liver Injury in a Healthy Patient following PCSK9-Inhibitor Injection.","authors":"B-O Stüben, D P Hoyer, S Radunz, F Saner, H Schmidt, H A Baba, J W Treckmann, L I Mazilescu","doi":"10.1155/2024/5556907","DOIUrl":"10.1155/2024/5556907","url":null,"abstract":"<p><strong>Background: </strong>Acute liver injury is a life-threatening condition with disparate aetiology. Swift and adequate interdisciplinary treatment is essential to assure the best possible outcomes in these patients. Investigations to identify the cause of the condition and the implementation of quick and appropriate treatment can be lifesaving. <i>Case Presentation</i>. In October 2022, an otherwise healthy 66-year-old male presented at the University Hospital Essen with acute liver injury following an inclisiran injection for hypercholesterinaemia. Four weeks following admission, the patient fully recovered after initially receiving short-term cortisol therapy and open albumin (OPAL) dialysis, and the indices of liver, kidney, and coagulation function were normal at discharge.</p><p><strong>Conclusion: </strong>This is to our knowledge the first reported acute liver injury due to an inclisiran injection. Cortisol in combination with OPAL dialysis is an effective method for the treatment of acute liver injury caused by inclisiran injury, and in this case, it led to a near-complete reversal of the acute liver injury at the time of discharge.</p>","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2024 ","pages":"5556907"},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemorrhagic Shock from a Duodenal Ulcer Eroding into an Ectopic Varix 十二指肠溃疡侵蚀到异位静脉曲张引发的失血性休克
Case Reports in Hepatology Pub Date : 2023-12-31 DOI: 10.1155/2023/7094924
Harjit Singh, Alexandra V. Kimchy, Camille Boustani, Mfoniso D. Umoren, Amol Rangnekar, Coleman Smith
{"title":"Hemorrhagic Shock from a Duodenal Ulcer Eroding into an Ectopic Varix","authors":"Harjit Singh, Alexandra V. Kimchy, Camille Boustani, Mfoniso D. Umoren, Amol Rangnekar, Coleman Smith","doi":"10.1155/2023/7094924","DOIUrl":"https://doi.org/10.1155/2023/7094924","url":null,"abstract":"Ectopic varices are an infrequent yet fatal complication resulting from the progression of liver cirrhosis. Duodenal varices pose a significant challenge to clinicians as they are not easily visualized on endoscopy due to their submucosal location and lack of red color signs. Identification of duodenal varices is important given the risk of massive and life-threatening bleeding that is difficult to control. Patients may present in hemorrhagic shock requiring immediate resuscitation; however, confirmation of the bleeding source as variceal or non-variceal is critical in determining the optimal therapeutic intervention. Here, we report an unusual case of a duodenal ulcer that eroded into an ectopic varix resulting in hemorrhagic shock.","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":" 1172","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139136174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidental Vascular Lesion in Explanted Liver: A Rare Case Report and Review of the Literature. 外植肝偶发血管病变1例报告及文献复习。
Case Reports in Hepatology Pub Date : 2023-11-06 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8864977
Rossana Kazemimood, Shohreh Eliaszadeh, Kenneth Wind
{"title":"Incidental Vascular Lesion in Explanted Liver: A Rare Case Report and Review of the Literature.","authors":"Rossana Kazemimood, Shohreh Eliaszadeh, Kenneth Wind","doi":"10.1155/2023/8864977","DOIUrl":"10.1155/2023/8864977","url":null,"abstract":"<p><p>Hepatic small vessel neoplasm (HSVN) is a rare vascular hepatic lesion that is usually an asymptomatic incidental finding. Here we present a case of a 66-year-old male with HSVN who was discovered to have a lesion presenting as a small nodule in an explanted liver. HSVN is a recently described hepatic vascular lesion that has been previously underdiagnosed. It has an uncertain long-term malignant potential, so close follow-up is recommended.</p>","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2023 ","pages":"8864977"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasmapheresis for Fulminant Wilson's Disease Improves Mental Status and Coagulopathy. 血浆置换治疗暴发性威尔逊病可改善精神状态和凝血功能。
Case Reports in Hepatology Pub Date : 2023-01-01 DOI: 10.1155/2023/3985823
Quarshie Glover, William Nicholas Rose
{"title":"Plasmapheresis for Fulminant Wilson's Disease Improves Mental Status and Coagulopathy.","authors":"Quarshie Glover,&nbsp;William Nicholas Rose","doi":"10.1155/2023/3985823","DOIUrl":"https://doi.org/10.1155/2023/3985823","url":null,"abstract":"<p><p>Wilson's disease is a rare genetic condition that affects copper metabolism, resulting in tissue copper accumulation and resultant organ damage. We report a case of a young woman who presents with Wilson's disease complicated by hemolysis, impaired hepatic function, coagulopathy, and acute kidney injury. She was treated with plasmapheresis as a bridge to a liver transplant. Her mental state, renal function, and bilirubin level improved after starting plasmapheresis. She successfully underwent a liver transplant and remained stable post-liver transplant. We share our experience on the use of plasmapheresis in treating Wilson's disease.</p>","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2023 ","pages":"3985823"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9717588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CALFAN (Low γ-Glutamyl Transpeptidase (GGT) Cholestasis, Acute Liver Failure, and Neurodegeneration) Syndrome: A Case Report with 3-Year Follow-Up after Liver Transplantation in Early Adulthood. 低γ-谷氨酰转肽酶(GGT)淤积、急性肝衰竭和神经退行性变综合征:1例成年早期肝移植术后3年随访报告
Case Reports in Hepatology Pub Date : 2023-01-01 DOI: 10.1155/2023/3010131
Mariam Youssef, Katherine L Mascia, Brendan McGuire, Chirag R Patel, Sameer Al Diffalha, Deepti Dhall, Goo Lee
{"title":"CALFAN (Low <i>γ</i>-Glutamyl Transpeptidase (GGT) Cholestasis, Acute Liver Failure, and Neurodegeneration) Syndrome: A Case Report with 3-Year Follow-Up after Liver Transplantation in Early Adulthood.","authors":"Mariam Youssef,&nbsp;Katherine L Mascia,&nbsp;Brendan McGuire,&nbsp;Chirag R Patel,&nbsp;Sameer Al Diffalha,&nbsp;Deepti Dhall,&nbsp;Goo Lee","doi":"10.1155/2023/3010131","DOIUrl":"https://doi.org/10.1155/2023/3010131","url":null,"abstract":"<p><p>CALFAN syndrome is an extremely rare disease consisting of recurrent pediatric acute liver failure (PALF), neurodegenerative diseases, and skeletal abnormalities associated with <i>SCYL1</i> gene mutation. To date, three of 18 patients reported underwent liver transplantation in infancy and early childhood (7-23 months). Here, we report a case of CALFAN syndrome with infantile onset, recurrent jaundice/PALF requiring liver transplantation in early adulthood. At the most recent follow-up, 3 years after transplantation, the patient is doing well.</p>","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2023 ","pages":"3010131"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9956239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ciliated Hepatic Foregut Cyst: Definitive Diagnosis Is Critical to the Optimal Treatment Pathway. 纤毛肝前肠囊肿:明确诊断对最佳治疗途径至关重要。
Case Reports in Hepatology Pub Date : 2023-01-01 DOI: 10.1155/2023/6637890
Tatsuhiro Kato, Christine M G Schammel, Hubert Fenton, Steven D Trocha, A Michael Devane
{"title":"Ciliated Hepatic Foregut Cyst: Definitive Diagnosis Is Critical to the Optimal Treatment Pathway.","authors":"Tatsuhiro Kato,&nbsp;Christine M G Schammel,&nbsp;Hubert Fenton,&nbsp;Steven D Trocha,&nbsp;A Michael Devane","doi":"10.1155/2023/6637890","DOIUrl":"https://doi.org/10.1155/2023/6637890","url":null,"abstract":"<p><p><i>Background</i>. Ciliated hepatic foregut cyst (CHFC) is a rare, benign cyst of the liver, derived from the embryonic foregut epithelium. Although CHFCs are typically asymptomatic, some present with nonspecific abdominal symptoms. Imaging modalities alone are insufficient for diagnosis, with intrahepatic cholangiocarcinoma included in the differential due to nonspecific imaging features; definitive diagnosis relies on histologic confirmation. These lesions are often benign; however, larger lesions can have malignant transformation into squamous cell carcinoma (SCC), which carries a poor prognosis, thus making a definitive diagnosis, no matter what size, essential. Here, we present a case of CHFC as well as a comprehensive literature review. Given these data, we propose an algorithm for definitive diagnosis.</p>","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2023 ","pages":"6637890"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9878488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fulminant Neonatal Liver Failure in MPV 17-Related Mitochondrial DNA Depletion Syndrome. 暴发性新生儿肝衰竭与MPV 17相关的线粒体DNA缺失综合征。
Case Reports in Hepatology Pub Date : 2023-01-01 DOI: 10.1155/2023/4514552
Razan Abduljalil, Hadhami Ben Turkia, Aysha Fakhroo, Cristina Skrypnyk
{"title":"Fulminant Neonatal Liver Failure in MPV 17-Related Mitochondrial DNA Depletion Syndrome.","authors":"Razan Abduljalil,&nbsp;Hadhami Ben Turkia,&nbsp;Aysha Fakhroo,&nbsp;Cristina Skrypnyk","doi":"10.1155/2023/4514552","DOIUrl":"https://doi.org/10.1155/2023/4514552","url":null,"abstract":"<p><p>Mitochondrial depletion syndromes are well established causes of liver failure in infants. Hepatocerebral variant related to MPV17 gene defect is characterized by infantile onset of progressive liver failure, developmental delay, neurological manifestations, lactic acidosis, hypoglycemia, and mtDNA depletion in liver tissue. We report a hepatocerebral variant of mitochondrial DNA depletion syndrome in a neonate who presented with septic shock picture, hypoglycemia, jaundice, hypotonia, and rotatory nystagmus. Family history was significant for consanguinity and a brother who died at the age of 4 months. Investigations showed mild liver function derangement contrasting with severe coagulopathy, hyperlactatemia, and generalized aminoaciduria. The brain MRI was normal. Next generation sequencing (NGS) panel identified a MPV17 gene missense homozygous pathogenic variant. The infant expired at the age of 2 weeks with refractory ascites. This case illustrates a challenging diagnosis causing liver failure and death in neonatal period. Genetic testing of mitochondrial DNA depletion syndromes should be a part of liver failure workup in addition to other treatable disorders presenting with encephalo-hepatopathy in infancy.</p>","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2023 ","pages":"4514552"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10113461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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