Case Reports in Hepatology最新文献

Sarcomatoid Carcinoma Arising in the Gallbladder of a 58-Year-Old Female: Case Report. 58岁女性胆囊肉瘤样癌一例报告。

Case Reports in Hepatology Pub Date : 2025-06-26 eCollection Date: 2025-01-01 DOI: 10.1155/crhe/5172834

Ahmed A Ahmed, Yan Gao, Rossana Kazemimood

{"title":"Sarcomatoid Carcinoma Arising in the Gallbladder of a 58-Year-Old Female: Case Report.","authors":"Ahmed A Ahmed, Yan Gao, Rossana Kazemimood","doi":"10.1155/crhe/5172834","DOIUrl":"10.1155/crhe/5172834","url":null,"abstract":"Sarcomatoid carcinoma of the gallbladder is a rare malignancy with no specific clinical manifestation. It is characterized by the presence of malignant epithelial and mesenchymal components intermingled with each other. This disease usually presents at an advanced stage, and its final diagnosis needs to be confirmed by histopathological and immunohistochemical examination. Sarcomatoid carcinoma is characterized by early metastasis through lymphatics, rapid progression, a high recurrence rate, and a worse prognosis than usual gallbladder adenocarcinoma. Herein, we report the case of a 58-year-old female patient, who underwent laparoscopic cholecystectomy, with sarcomatoid carcinoma of the gallbladder. Histologically, the epithelial component of the tumor was composed of adenocarcinoma, and the mesenchymal component was composed of spindle cell sarcoma and chondrosarcoma. The tumor was identified as invading the perimuscular connective tissue on the hepatic side without involvement of the liver. The prognosis of sarcomatoid carcinoma of the gallbladder remains poor despite surgical resection of the gallbladder. The patient passed away in less than 1 year after the procedure despite chemotherapy due to cancer progression.","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2025 ","pages":"5172834"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Partial Splenic Artery Embolization for the Treatment of Painful Splenomegaly Secondary to Noncirrhotic Portal Hypertension. 病例报告：部分脾动脉栓塞治疗继发于非肝硬化门脉高压的疼痛性脾大。

Case Reports in Hepatology Pub Date : 2025-06-06 eCollection Date: 2025-01-01 DOI: 10.1155/crhe/9303407

Logan Kratzer, Maddison Waters, Simon Parkes, Nicholas Cheung, Nicholas Shackel

引用次数: 0

Recurrent Ascites Beyond the Usual Suspects: Uncovering an Overlooked Culprit. 反复腹水超出通常的怀疑：发现一个被忽视的罪魁祸首。

Case Reports in Hepatology Pub Date : 2025-05-24 eCollection Date: 2025-01-01 DOI: 10.1155/crhe/9961539

Binoy Desai, Harjit Singh, Alessandra Martorella, Bryce Kunkle, Amol S Rangnekar

引用次数: 0

Hemophagocytic Lymphohistiocytosis Complicating a Case of Drug-Induced Liver Injury Precipitated by Cephalexin: A Rare Consequence of Commonly Prescribed Medications. 吞噬性淋巴组织细胞增多症合并头孢氨苄引起的药物性肝损伤一例：常用处方药的罕见后果。

Case Reports in Hepatology Pub Date : 2025-05-19 eCollection Date: 2025-01-01 DOI: 10.1155/crhe/4600879

Matthew T Newman, Thu Anne Mai, Joe McClanaghan, Nicholas Burley, Tamira Robinson, Yang Jiang, Amandeep Sahota

引用次数: 0

Budd-Chiari Syndrome Treated With IVC Stenting With Subsequent Right Hepatic Vein to IVC Retrograde Sharp Recanalization. 右肝静脉下腔静脉支架置入术治疗Budd-Chiari综合征。

Case Reports in Hepatology Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI: 10.1155/crhe/2216461

Andrew C Gordon, Kush R Desai, Justin R Boike, Bartley G Thornburg

引用次数: 0

An Uncommon Association: Eltrombopag and Autoimmune Hepatitis. 一种罕见的关联：依曲巴格和自身免疫性肝炎。

Case Reports in Hepatology Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI: 10.1155/crhe/6637055

Fady Salama, Hassnain Syed, Nimish Thakral

引用次数: 0

Unmasking Hepatitis A: A Case Study of Atypical Presentation in a Returning Traveler From Egypt. 揭露甲型肝炎：一个从埃及返回的旅行者的非典型表现的个案研究。

Case Reports in Hepatology Pub Date : 2025-03-06 eCollection Date: 2025-01-01 DOI: 10.1155/crhe/8150734

Emmanuel Edwar Siddig, Claude M Muvunyi, Ayman Ahmed

{"title":"Unmasking Hepatitis A: A Case Study of Atypical Presentation in a Returning Traveler From Egypt.","authors":"Emmanuel Edwar Siddig, Claude M Muvunyi, Ayman Ahmed","doi":"10.1155/crhe/8150734","DOIUrl":"https://doi.org/10.1155/crhe/8150734","url":null,"abstract":"Hepatitis, characterized by inflammation of the liver, arises from various infectious and noninfectious causes, with viral hepatitis being caused by a diverse group of viruses including hepatitis A, B, C, D, and E. Infection with the Hepatitis A virus (HAV) can result in liver inflammation and damage, primarily spread through fecal-oral contamination. Clinical symptoms often overlap with other infections, complicating diagnosis in returning travelers from endemic regions. This case study focuses on a 46-year-old Sudanese housewife who presented with symptoms of fever, chills, headache, and muscle aches, along with a high temperature of 103.5°F, following a recent visit to Egypt. The initial assessment showed hemodynamic stability and abnormal liver function tests. This raise suspicion about the potential involvement of several infections including malaria, hepatitis, arboviral diseases such as Chikungunya, Yellow, and dengue fevers. Further investigations revealed acute hepatitis A infection confirmed through positive serology. Notably, the patient displayed atypical features such as atypical lymphocytosis, splenomegaly, and mild anemia. This case emphasizes the significance of essentially considering a wide range of diseases among travelers including hepatitis A among people coming from highly endemic areas such as Egypt, even when the patient is not manifested with the typical clinical presentation of specific disease. Particular attention is needed for epidemic-prone infections like hepatitis A.","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2025 ","pages":"8150734"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report on Management of Liver Cirrhosis Using Ayurveda and Integrative Approach of Treatment. 阿育吠陀综合疗法治疗肝硬化1例报告。

Case Reports in Hepatology Pub Date : 2024-11-27 eCollection Date: 2024-01-01 DOI: 10.1155/crhe/1176751

Prasan Shankar, Bhavya Vijay, Bhargavi, Mahima Rahman, Kimi Anand, Vasudevan Nampoothiri, Prashanth

{"title":"A Case Report on Management of Liver Cirrhosis Using Ayurveda and Integrative Approach of Treatment.","authors":"Prasan Shankar, Bhavya Vijay, Bhargavi, Mahima Rahman, Kimi Anand, Vasudevan Nampoothiri, Prashanth","doi":"10.1155/crhe/1176751","DOIUrl":"10.1155/crhe/1176751","url":null,"abstract":"Background: Liver cirrhosis is an advanced stage of abnormal fibrogenesis of tissues that causes liver injuries. Though cirrhosis can be managed by etiological parameters, its long-term reversal is still a question. Ayurveda system of medicine diagnoses liver disease under \"Kamala\" and \"Udara\" with promising outcomes of treatment. This case series discusses three cases of liver cirrhosis where internal Ayurvedic medications and external therapies including \"Panchakarma\" (a treatment approach of detoxifying and rejuvenating) resulted in effective management of the disease. Case Presentation: Three cases of decompensated liver cirrhosis were treated at an Ayurveda hospital. Relevant examinations and investigations were done, and patients were monitored at regular intervals. Patients were treated with Ayurvedic therapies and were monitored for changes using standardized tools of assessment. Conclusion: In all three patients, there was an improvement in quality of life and a reduction in symptoms such as abdominal pain, transpyloric diameter, pedal oedema, and fatigue, as well as a significant reduction in liver function test parameters. Decompensated liver cirrhosis can be managed with an Ayurvedic treatment regimen that includes Ayurvedic medications, Panchakarma, along with a proper diet regimen with salt and fluid restrictions. This case series concludes that while cirrhosis is not completely reversible, fibrosis could be reversed. The support of modern medicine for monitoring and emergency care remains paramount. Furthermore, proper documentation of all the observations can help in assessing the outcomes of Ayurveda therapies and aid in developing integrative protocols for the management of liver cirrhosis in the future.","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2024 ","pages":"1176751"},"PeriodicalIF":0.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11617052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Onset of Wilson's Disease and Possible Role of Disease-Modifying Genes: A Case Report and Literature Review. 肝豆状核变性的早期发病及疾病修饰基因的可能作用：1例报告及文献复习。

Case Reports in Hepatology Pub Date : 2024-11-25 eCollection Date: 2024-01-01 DOI: 10.1155/crhe/3815089

Alessandro La Rosa, Angela Elvira Covone, Domenico Coviello, Serena Arrigo, Jacopo Ferro, Paolo Gandullia, Annalisa Madeo

{"title":"Early Onset of Wilson's Disease and Possible Role of Disease-Modifying Genes: A Case Report and Literature Review.","authors":"Alessandro La Rosa, Angela Elvira Covone, Domenico Coviello, Serena Arrigo, Jacopo Ferro, Paolo Gandullia, Annalisa Madeo","doi":"10.1155/crhe/3815089","DOIUrl":"10.1155/crhe/3815089","url":null,"abstract":"Wilson's disease (WD) is a rare autosomal recessive disorder caused by mutations in the ATP7B gene, resulting in copper accumulation. Symptoms rarely appear before the age of 5, almost never before 3. The phenotypic variability of WD suggests the presence of modifying factors, making early diagnosis challenging. We present a case of symptomatic WD in a toddler, emphasizing the importance of considering WD in differential diagnoses and exploring genetic modifiers influencing disease onset. Clinical and laboratory assessments, including liver biopsy, were performed on a 4.2-year-old boy presenting with hypertransaminasemia and mild hepatomegaly. Histological evaluation revealed chronic hepatitis with fibrosis and severe steatosis, indicating long-standing active disease. Genetic analysis identified a missense variant and a 15-nucleotide deletion in the 5' UTR promoter region of the ATP7B gene, confirming the WD diagnosis. Additionally, homozygosity for the HFE H63D variant was detected, with transferrin saturations at the upper limit of normal. The patient's clinical management included a trial of D-penicillamine, discontinued due to side effects, followed by successful zinc acetate therapy. This case underscores the consideration of WD in the differential diagnosis of toddlers. The Ferenci-Leipzig score remains a valid diagnostic tool for WD even in the presence of a single ATP7B variant, although extended genetic analysis should still be considered. Normal ceruloplasmin levels do not rule out WD. Environmental, epigenetic, and genetic factors appear to influence the WD phenotype; HFE variants may act as modifiers given the link between iron and copper homeostasis, possibly explaining the early symptomatic onset in our patient.","PeriodicalId":30295,"journal":{"name":"Case Reports in Hepatology","volume":"2024 ","pages":"3815089"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Pseudomonas aeruginosa-Associated Diarrhea in a Cirrhotic Patient. 肝硬化患者铜绿假单胞菌相关性腹泻的罕见病例

Case Reports in Hepatology Pub Date : 2024-08-16 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8238951

Malcolm Chapman, Atul Lodh, Joven Tristeza, Alexander Yang

引用次数: 0