G C Miescher, V Taylor, L Kappos, J M Matthieu, P Honegger
{"title":"Protein kinases expressed in aggregating brain cell cultures during myelination.","authors":"G C Miescher, V Taylor, L Kappos, J M Matthieu, P Honegger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Serum-free aggregating rat brain cell cultures provide sufficient cell surface and paracrine interactions between neurons and glial cells for compact myelination. We are interested in the part played in these signalling pathways by protein kinases and have used a PCR cDNA cloning approach to catalogue the protein kinase genes expressed by these cultures. 8 transmembrane protein kinases were identified: IGF1-R, trk B, bFGF-R, c-met, Tyro2, Tyro1, Tyro4 and a novel eck-related gene. The first 4 are receptors for ligands with known trophic functions. Tyro2 is a novel gene related to the EGF-R. The latter 3 belong to the eck gene family of more than 8 highly related putative receptors for, as yet, unknown ligands. 8 cDNAs for intracellular protein kinases were also isolated including 3 novel genes. Ongoing studies are investigating whether these proteins contribute to myelination and/or could be used as therapeutic targets in demyelinating diseases.</p>","PeriodicalId":30134,"journal":{"name":"Swiss Archives of Neurology and Psychiatry","volume":"144 3","pages":"217-21"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18690376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Psychiatry and psychotherapy].","authors":"W Pöldinger","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30134,"journal":{"name":"Swiss Archives of Neurology and Psychiatry","volume":"144 4","pages":"371-7"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18695631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D Burger, A J Steck, C C Bernard, N Kerlero De Rosbo
{"title":"Human myelin/oligodendrocyte glycoprotein: a new member of the L2/HNK-1 family.","authors":"D Burger, A J Steck, C C Bernard, N Kerlero De Rosbo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30134,"journal":{"name":"Swiss Archives of Neurology and Psychiatry","volume":"144 3","pages":"227-8"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18691991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improvement of culture conditions for aggregating brain cells to study remyelination.","authors":"M G Zurich, J M Matthieu, P Honegger","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30134,"journal":{"name":"Swiss Archives of Neurology and Psychiatry","volume":"144 3","pages":"228-32"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18691992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"8th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). Barcelona, Spain, October 23-24, 1992. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30134,"journal":{"name":"Swiss Archives of Neurology and Psychiatry","volume":"144 4","pages":"293-368"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18695629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E Ruzicka, V Tesar, E Jelinkova, M Mmerta, S Nevsimalova, O Kucerova
{"title":"Event-related potentials in evaluation of metabolic encephalopathies.","authors":"E Ruzicka, V Tesar, E Jelinkova, M Mmerta, S Nevsimalova, O Kucerova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Auditory event-related potentials (ERPs) were studied in 28 patients with chronic liver cirrhosis and in 34 patients on regular hemodialysis treatment for chronic renal failure. Prolongation of P3 wave latency was the earliest and most evident sign of brain cognitive dysfunction in both groups. The changes of ERPs well corresponded to the stage of metabolic affliction when, in addition, N1 and N2 wave latencies were delayed in patients with more advanced liver cirrhosis. In the group of hemodialyzed patients, ERPs reflected the effects of an individual treatment procedure as well.</p>","PeriodicalId":30134,"journal":{"name":"Swiss Archives of Neurology and Psychiatry","volume":"144 4","pages":"378-84"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18695632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Revalidation of the Saul and Sheppard \"Dream Hostility Counts\" in a time series of 24 dreams, of which 7 ended in a migraine at awakening].","authors":"F Beyme","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our Series of 24 dreams can be used for validating hostility scales. Nocturnal migraine represents an ideal archimedian point (C. G. Jung) from which psychology can reach certainties comparable to those of physics. By Pearsons Phi coefficient psychological findings can be solidly moored to the \"non-psychical\", the somatic sphere. Revalidation of the Dream-Hostility-Count lead us to a higher degree of significance (p < 0.005 instead of p < 0.01) than that reached by Saul and Sheppard who used hypertensives for a critical group.</p>","PeriodicalId":30134,"journal":{"name":"Swiss Archives of Neurology and Psychiatry","volume":"144 6","pages":"561-73"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18517971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The family and Alzheimer's disease: making choices].","authors":"O Diener","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30134,"journal":{"name":"Swiss Archives of Neurology and Psychiatry","volume":"144 5","pages":"402-11"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18511903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Endocarditis, brain lesions and anticoagulants (anatomic clinical and statistical study of 229 cases)].","authors":"P Liard, R Lang, E Wildi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study of brain autopsy findings in 229 cases of endocarditis (67 anticoagulated, 162 non-anticoagulated) shows that treatment with anticoagulation does not increase the incidence of cerebral hemorrhage, neither from the conversion of ischaemic necroses into hemorrhagic ones nor from an increase in other circulatory or vascular lesions. The analysis was based on the pathogenesis and detailed descriptions of the lesions, paying particular attention to hemorrhagic infarctions of the cerebral cortex. Using chi-square analysis, there was no significant difference between the frequency of lesions in anticoagulated versus non-anticoagulated patients.</p>","PeriodicalId":30134,"journal":{"name":"Swiss Archives of Neurology and Psychiatry","volume":"144 1","pages":"39-61"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18686419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F Wiederkehr, M R Büeler, R Fried, D J Vonderschmitt
{"title":"Immune complexes in sera of MS patients: a new strategy of the analysis of their antigen portion.","authors":"F Wiederkehr, M R Büeler, R Fried, D J Vonderschmitt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30134,"journal":{"name":"Swiss Archives of Neurology and Psychiatry","volume":"144 3","pages":"210-2"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18690373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}