Bioelectricity最新文献_第4页

Connexin Connections: A Special Issue on Gap Junctions 连接:间隙连接的特刊

Bioelectricity Pub Date : 2023-09-01 DOI: 10.1089/bioe.2023.0036

Jennifer S. Fang, Jose F. Ek-Vitorin

引用次数: 0

Gap Junction Currents and Countercurrents 间隙结电流和逆流

Bioelectricity Pub Date : 2023-09-01 DOI: 10.1089/bioe.2023.0035

David C. Spray

引用次数: 0

Special Issue “The Xenopus Oocyte: A Tool for Membrane Biology,” Mattei and Limon (eds.) Membranes (Vol. 1; ISSN 2077-0375) 特刊“爪蟾卵母细胞:膜生物学的工具，”Mattei和Limon(编)。膜(卷1;ISSN 2077 - 0375)

Bioelectricity Pub Date : 2023-09-01 DOI: 10.1089/bioe.2023.0030

Scott P. Fraser

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Retinoic Acid Influences connexin43 Expression During Joint Formation in the Regenerating Zebrafish Fin. 维甲酸对再生斑马鱼鳍关节形成过程中连接蛋白43表达的影响。

IF 1.6

Bioelectricity Pub Date : 2023-09-01 Epub Date: 2023-09-12 DOI: 10.1089/bioe.2023.0018

Alexander W Seaver, Noah S Weaver, M Kathryn Iovine

{"title":"Retinoic Acid Influences connexin43 Expression During Joint Formation in the Regenerating Zebrafish Fin.","authors":"Alexander W Seaver, Noah S Weaver, M Kathryn Iovine","doi":"10.1089/bioe.2023.0018","DOIUrl":"10.1089/bioe.2023.0018","url":null,"abstract":"Background: The regenerating zebrafish fin skeleton is comprised of multiple bony fin rays, each made of alternating bony segments and fin ray joints. This pattern is regulated by the gap junction protein Connexin43 (Cx43), which provides instructional cues to skeletal precursor cells (SPCs). Elevated Cx43 favors osteoblast differentiation and disfavors joint forming cell differentiation. The goal of this article is to test if retinoic acid (RA) contributes to the regulation of cx43 expression.Materials and methods: Functional studies inhibiting the RA-synthesizing enzyme Adh1a2 were evaluated using in situ hybridization to monitor gene expression and with measurements of the length of fin ray segments to monitor impacts on SPC differentiation and joint formation.Results: Aldh1a2-knockdown leads to reduced expression of cx43 and increased expression of evx1, a gene required for joint formation. Additionally, inhibition of Aldh1a2 function leads to short fin ray segments. We also find evidence for synergy between aldh1a2 and cx43, suggesting that these genes function in a common molecular pathway to regulate joint formation.Conclusions: The role of RA is to promote cx43 expression in the regenerating fin to regulate joint formation and the length of bony fin ray segments. We suggest that RA signaling must coordinate with additional pathways that also regulate cx43 transcription.","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"5 3","pages":"173-180"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41142128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Cx43 on the Bone Cell Generation, Function, and Survival. Cx43在骨细胞生成、功能和存活中的作用。

IF 1.6

Bioelectricity Pub Date : 2023-09-01 Epub Date: 2023-09-12 DOI: 10.1089/bioe.2023.0028

Lilian I Plotkin, Iqra Asad, Alex E Kritikos, Natasha Sanz

{"title":"Role of Cx43 on the Bone Cell Generation, Function, and Survival.","authors":"Lilian I Plotkin, Iqra Asad, Alex E Kritikos, Natasha Sanz","doi":"10.1089/bioe.2023.0028","DOIUrl":"10.1089/bioe.2023.0028","url":null,"abstract":"The presence of gap junction intercellular communication structures in bone cells has been known since the early 1970s, further confirmed by Doty and Marotti at the structural level in the 1980-1990s. Work by Civitelli, Donahue, and others showed the expression of Cx43 at the mRNA and protein levels in all bone cell types: osteoclasts (bone resorbing cells), osteoblasts (bone forming cells), and osteocytes (mature osteoblasts embedded in the bone matrix that regulate the function of both osteoclasts and osteoblasts). While Cx45, Cx46, and Cx37 were also shown to be expressed in bone cells, most studies have focused on Cx43, the most abundant member of the connexin (Cx) family of proteins expressed in bone. The role of Cx43 has been shown to be related to the formation of gap junction intercellular channels, to unopposed hemichannels, and to channel independent functions of the molecule. Cx43 participates in the response of bone cells to pharmacological, hormonal, and mechanical stimuli, and it is involved in the skeletal phenotype with old age. Human and murine studies have shown that mutations of Cx43 lead to oculodentodigital dysplasia and craniometaphyseal dysplasia, both conditions associated with abnormalities in the skeleton. However, whereas substantial advances have been made on the skeletal role of Cx43, further research is needed to understand the basis for the effects of mutated Cx43 and potential ways to prevent the effects of these mutations on bone.","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"5 3","pages":"188-195"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connexins: A Brief Overview 连接:简要概述

Bioelectricity Pub Date : 2023-09-01 DOI: 10.1089/bioe.2023.0033

Jennifer S. Fang, Jose F. Ek-Vitorin

引用次数: 0

The Role of Gap Junctions Dysfunction in the Development of Cataracts: From Loss of Cell-to-Cell Transfer to Blurred Vision-Review. 间隙连接功能障碍在白内障发展中的作用：从细胞间转移的丧失到视力模糊综述。

IF 1.6

Bioelectricity Pub Date : 2023-09-01 Epub Date: 2023-09-12 DOI: 10.1089/bioe.2023.0025

Jose F Ek-Vitorin, Jean X Jiang

引用次数: 0

An Interview with Sally Adee, the Author of the Book “We Are Electric” 专访《我们是电的》一书的作者莎莉·阿迪

IF 2.3