Cells & Development最新文献

Of criminals and cancer: The importance of social bonds and innate morality on cellular societies. 罪犯与癌症社会纽带和先天道德对细胞社会的重要性。

IF 2.1 4区生物学

Cells & Development Pub Date : 2024-08-14 DOI: 10.1016/j.cdev.2024.203964

Anuraag Bukkuri, Frederick R Adler

引用次数: 0

'Three signals - three body axes' as patterning principle in bilaterians. 三信号-三体轴 "是两栖动物的模式化原则。

IF 2.1 4区生物学

Cells & Development Pub Date : 2024-08-08 DOI: 10.1016/j.cdev.2024.203944

Christof Niehrs, Ettore Zapparoli, Hyeyoon Lee

引用次数: 0

Podoplanin and its multifaceted roles in mammalian developmental program. Podoplanin 及其在哺乳动物发育过程中的多方面作用

IF 2.1 4区生物学

Cells & Development Pub Date : 2024-08-05 DOI: 10.1016/j.cdev.2024.203943

Yi Ying Cheok, Grace Min Yi Tan, Yee Teng Chan, Suhailah Abdullah, Chung Yeng Looi, Won Fen Wong

引用次数: 0

Self-organization underlies developmental robustness in plants. 自组织是植物发育稳健性的基础。

IF 2.1 4区生物学

Cells & Development Pub Date : 2024-07-01 DOI: 10.1016/j.cdev.2024.203936

Shuyao Kong, Mingyuan Zhu, Adrienne H K Roeder

引用次数: 0

Head organizer: Cerberus and IGF cooperate in brain induction in Xenopus embryos. Head organizer：Cerberus和IGF在爪蟾胚胎大脑诱导过程中的合作

IF 3.9 4区生物学

Cells & Development Pub Date : 2023-12-16 DOI: 10.1016/j.cdev.2023.203897

Yagmur Azbazdar, Edgar M Pera, Edward M De Robertis

{"title":"Head organizer: Cerberus and IGF cooperate in brain induction in Xenopus embryos.","authors":"Yagmur Azbazdar, Edgar M Pera, Edward M De Robertis","doi":"10.1016/j.cdev.2023.203897","DOIUrl":"10.1016/j.cdev.2023.203897","url":null,"abstract":"<p><p>Neural induction by cell-cell signaling was discovered a century ago by the organizer transplantations of Spemann and Mangold in amphibians. Spemann later found that early dorsal blastopore lips induced heads and late organizers trunk-tail structures. Identifying region-specific organizer signals has been a driving force in the progress of animal biology. Head induction in the absence of trunk is designated archencephalic differentiation. Two specific head inducers, Cerberus and Insulin-like growth factors (IGFs), that induce archencephalic brain but not trunk-tail structures have been described previously. However, whether these two signals interact with each other had not been studied to date and was the purpose of the present investigation. It was found that Cerberus, a multivalent growth factor antagonist that inhibits Nodal, BMP and Wnt signals, strongly cooperated with IGF2, a growth factor that provides a positive signal through tyrosine kinase IGF receptors that activate MAPK and other pathways. The ectopic archencephalic structures induced by the combination of Cerberus and IGF2 are of higher frequency and larger than either one alone. They contain brain, a cyclopic eye and multiple olfactory placodes, without trace of trunk structures such as notochord or somites. A dominant-negative secreted IGF receptor 1 blocked Cerberus activity, indicating that endogenous IGF signals are required for ectopic brain formation. In a sensitized embryonic system, in which embryos were depleted of β-catenin, IGF2 did not by itself induce neural tissue while in combination with Cerberus it greatly enhanced formation of circular brain structures expressing the anterior markers Otx2 and Rx2a, but not spinal cord or notochord markers. The main conclusion of this work is that IGF provides a positive signal initially uniformly expressed throughout the embryo that potentiates the effect of an organizer-specific negative signal mediated by Cerberus. The results are discussed in the context of the history of neural induction.</p>","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation and oxidative stress impair preimplantation embryonic morphogenesis in allergic asthma model. 炎症和氧化应激对过敏性哮喘模型着床前胚胎形态发生的影响。

IF 3.9 4区生物学

Cells & Development Pub Date : 2023-06-13 DOI: 10.2139/ssrn.4367239

Che Ismail Wafriy, Y. S. Kamsani, M. Nor-Ashikin

{"title":"Inflammation and oxidative stress impair preimplantation embryonic morphogenesis in allergic asthma model.","authors":"Che Ismail Wafriy, Y. S. Kamsani, M. Nor-Ashikin","doi":"10.2139/ssrn.4367239","DOIUrl":"https://doi.org/10.2139/ssrn.4367239","url":null,"abstract":"The incidence of allergic asthma has been increasing worldwide in recent decades. Also, an increasing number of women are suffering from poor pregnancy outcome. However, the causal relationship between allergic asthma and embryonic growth in terms of cell morphogenesis has not been well elucidated. Here, we investigated the impact of allergic asthma on the morphogenesis of preimplantation embryos. Twenty-four female BALB/c were randomly divided into control (PBS), 50-μg (OVA1), 100-μg (OVA2) and 150-μg (OVA3). On Days-0 and -14, mice were induced intraperitoneally (i.p) with ovalbumin (OVA). On Days-21 until -23, mice were challenged with OVA via intranasal instillation (i.n). Control animals were sensitized and challenged with PBS. At the end of treatment (Day-25), 2-cell embryos were retrieved and cultured in vitro until the blastocysts hatched. Results showed reduced number of preimplantation embryos at all developing stages in all treated groups (p ≤ 0.0001). Uneven blastomere size, partial compaction- and cavitation-activity, low formation of trophectoderm (TE), as well as cell fragmentation were noted in all the treated groups. Maternal serum interleukin (IL)-4, immunoglobulin (Ig)-E and 8-hydroxydeoxyguanosine (8-OHdG) were notably high (p ≤ 0.0001, p ≤ 0.01) in contrast with low total antioxidant capacity (TAOC) (p ≤ 0.0001). Our findings indicated that OVA-induced allergic asthma had compromised cell morphogenesis through reduced blastomere cleavage division, partial compaction and cavitation-activity, impairment of TE production, and cell fragmentation leading to embryonic cell death via OS mechanism.","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91204783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Disrupted neurogenesis, gliogenesis, and ependymogenesis in the Ccdc85c knockout rat for hydrocephalus model. 脑积水模型中Ccdc85c基因敲除大鼠神经发生、胶质瘤发生和室管膜形成被破坏。

IF 3.9 4区生物学

Cells & Development Pub Date : 2023-06-01 DOI: 10.2139/ssrn.4367238

Mehedi Hasan, Shizuka Konishi, Miyuu Tanaka, T. Izawa, J. Yamate, M. Kuwamura

{"title":"Disrupted neurogenesis, gliogenesis, and ependymogenesis in the Ccdc85c knockout rat for hydrocephalus model.","authors":"Mehedi Hasan, Shizuka Konishi, Miyuu Tanaka, T. Izawa, J. Yamate, M. Kuwamura","doi":"10.2139/ssrn.4367238","DOIUrl":"https://doi.org/10.2139/ssrn.4367238","url":null,"abstract":"Coil-coiled domain containing 85c (Ccdc85c) is a causative gene for congenital hydrocephalus and subcortical heterotopia with frequent brain hemorrhage. We established Ccdc85c knockout (KO) rats and investigated the roles of CCDC85C and intermediate filament protein expression, including nestin, vimentin, GFAP, and cytokeratin AE1/AE3 during the lateral ventricle development in KO rats to evaluate the role of this gene. We found altered and ectopic expression of nestin and vimentin positive cells in the wall of the dorso-lateral ventricle in the KO rats during development from the age of postnatal day (P) 6, whereas both protein expression became faint in the wild-type rats. In the KO rats, there was a loss of cytokeratin expression on the surface of the dorso-lateral ventricle with ectopic expression and maldevelopment of ependymal cells. Our data also revealed disturbed GFAP expression at postnatal ages. These findings indicate that lack of CCDC85C disrupts the proper expression of intermediate filament proteins (nestin, vimentin, GFAP, and cytokeratin), and CCDC85C is necessary for normal neurogenesis, gliogenesis, and ependymogenesis.","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79305322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1