发布求助
文献互助 智能选刊 最新文献

Cells & Development最新文献

筛选
英文 中文
The role of the node in maintaining axial progenitors.
IF 2.1 4区 生物学
Cells & Development Pub Date : 2025-02-13 DOI: 10.1016/j.cdev.2025.204004
Raffee Wright, Valerie Wilson
{"title":"The role of the node in maintaining axial progenitors.","authors":"Raffee Wright, Valerie Wilson","doi":"10.1016/j.cdev.2025.204004","DOIUrl":"10.1016/j.cdev.2025.204004","url":null,"abstract":"<p><p>The production of the vertebrate body axis involves the coordinating activity of the organizer, which coincides in amniotes with the node in the gastrulating embryo. This organizer orchestrates nearby axial progenitor populations that produce the spinal cord and musculoskeleton. Various findings, discussed further in this review, suggest that some of these axial progenitors exhibit stem cell-like properties as they display maintenance behaviour such as self-renewal and sustained contribution to derivative tissues. We consider how the node acts to maintain and regulate these progenitor populations by providing mechanical forces and a niche-like signalling environment.</p>","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":" ","pages":"204004"},"PeriodicalIF":2.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organizer formation, organizer maintenance and epithelial cell plasticity in Hydra: Role of the Wnt3/β-catenin/TCF/Sp5/Zic4 gene network.
IF 2.1 4区 生物学
Cells & Development Pub Date : 2025-02-08 DOI: 10.1016/j.cdev.2025.204002
Brigitte Galliot, Yvan Wenger
{"title":"Organizer formation, organizer maintenance and epithelial cell plasticity in Hydra: Role of the Wnt3/β-catenin/TCF/Sp5/Zic4 gene network.","authors":"Brigitte Galliot, Yvan Wenger","doi":"10.1016/j.cdev.2025.204002","DOIUrl":"10.1016/j.cdev.2025.204002","url":null,"abstract":"<p><p>The experimental and conceptual knowledge in 1909 led to the discovery of the Hydra head organizer through transplantation experiments between pigmented and non-pigmented animals; a discovery followed by numerous transplantations demonstrating cross-regulation between activating and inhibiting components distributed along the body axis. This experimental work inspired mathematicians, engineers, physicists and computer scientists to develop theoretical models predicting the principles of developmental mechanisms. Today, we know that the Wnt/β-catenin/Sp5/Zic4 gene regulatory network (GRN) links organizer activity, morphogenesis and cellular identity in Hydra, with variable conformations depending on the region or epithelial layer, and varied phenotypes depending on which GRN element is misregulated. In intact animals, Wnt/β-catenin signaling acts as the head activator at the tip of the hypostome, restricted by Sp5 in the other regions of the animal. Moreover, in the tentacle ring, Sp5 and Zic4 act epistatically to support tentacle differentiation and prevent basal disc differentiation. Along the body column, Sp5 is self-repressed in the epidermis and acts as a head inhibitor along the gastrodermis. Other players modulate these activities, such as TSP and Margin/RAX apically, Notch signaling in the tentacle zone, Dkk1/2/4 and HAS-7 in the body column. In the developmental context of regeneration, cells below the amputation zone switch from repressed to locally de novo activated head organizer status, a transition driven by immediate symmetrical and asymmetrical metabolic changes that lead to gene expression regulations involving components and modulators of Wnt/β-catenin signaling, early-pulse and early-late transient both often symmetrical, together with sustained ones, specific to head regeneration.</p>","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":" ","pages":"204002"},"PeriodicalIF":2.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organizer activity in the mouse embryo.
IF 2.1 4区 生物学
Cells & Development Pub Date : 2025-02-05 DOI: 10.1016/j.cdev.2025.204001
Jenny Kretzschmar, Katharine Goodwin, Katie McDole
{"title":"Organizer activity in the mouse embryo.","authors":"Jenny Kretzschmar, Katharine Goodwin, Katie McDole","doi":"10.1016/j.cdev.2025.204001","DOIUrl":"10.1016/j.cdev.2025.204001","url":null,"abstract":"<p><p>The discovery of the embryonic organizer by Hilde Mangold and Hans Spemann in 1924 was one of the most ground-breaking achievements in the 1900 century for developmental biologists and beyond. Ever since the organizer was first described in newts, developmental biologists have been trying to uncover similar structures in other organisms. While the Spemann-Mangold organizer as an axis-inducing centre is evolutionary conserved in vertebrates, similar organizing centres have yet to be observed in mammals. In this review, we will provide a brief historical overview of the discovery of the mouse gastrula organizer and discuss its potential as an organizer throughout early post-implantation mouse development. We discuss cell migrations through the mouse organizer region and morphogenesis of organizer cells and tissues. Finally, we examine the evidence arguing for and against the existence of a head organizer in mice, and the role of the anterior visceral endoderm and the prechordal plate in organizing head structures.</p>","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":" ","pages":"204001"},"PeriodicalIF":2.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tempting fate: Neural crest induction along the body axis.
IF 2.1 4区 生物学
Cells & Development Pub Date : 2025-02-01 DOI: 10.1016/j.cdev.2025.204000
Jan Stundl, Marianne E Bronner
{"title":"Tempting fate: Neural crest induction along the body axis.","authors":"Jan Stundl, Marianne E Bronner","doi":"10.1016/j.cdev.2025.204000","DOIUrl":"10.1016/j.cdev.2025.204000","url":null,"abstract":"<p><p>Neural crest induction begins at the neural plate border and involves the intricate interplay of signaling and transcriptional events. In this review, we examine the literature on neural crest induction, focusing primarily on the chick model due to the extended time during which the induction process occurs. While it is well-established that induction initiates during mid-gastrulation, evidence from tissue recombination and transcriptomic analyses suggests that the process continues until neural tube closure. Along the body axis, distinct neural crest populations with varying developmental potentials emerge in a rostral to caudal progression. Testing axial level differences has revealed axial level specific subcircuits that influence region-specific neural crest cell fate decision, though what leads to axial level specification remains unknown.</p>","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":" ","pages":"204000"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional attributes of the anterior mesendoderm in patterning the anterior neural structures during head formation in the mouse.
IF 2.1 4区 生物学
Cells & Development Pub Date : 2025-01-28 DOI: 10.1016/j.cdev.2025.203999
Patrick P L Tam, Pragathi Masamsetti
{"title":"Functional attributes of the anterior mesendoderm in patterning the anterior neural structures during head formation in the mouse.","authors":"Patrick P L Tam, Pragathi Masamsetti","doi":"10.1016/j.cdev.2025.203999","DOIUrl":"https://doi.org/10.1016/j.cdev.2025.203999","url":null,"abstract":"<p><p>Induction of the neural ectoderm and the patterning of embryonic brain are the requisite organizing activity for head formation. Studies of loss-of-function mouse mutants that displayed a head truncation phenotype pointed to a key functional role of the anterior mesendoderm in anterior neural patterning. In this overview, we highlight the learning of the molecular attributes underpinning the formation of the anterior mesendoderm, the acquisition of ectoderm competence in the epiblast and the patterning of the embryonic brain during gastrulation and neurulation.</p>","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":" ","pages":"203999"},"PeriodicalIF":2.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A tale of two tissues: Patterning of the epidermis through morphogens and their role in establishing tracheal system organization.
IF 2.1 4区 生物学
Cells & Development Pub Date : 2025-01-28 DOI: 10.1016/j.cdev.2025.203998
L E Sánchez-Cisneros, M F Frutis-Osorio, L D Ríos-Barrera
{"title":"A tale of two tissues: Patterning of the epidermis through morphogens and their role in establishing tracheal system organization.","authors":"L E Sánchez-Cisneros, M F Frutis-Osorio, L D Ríos-Barrera","doi":"10.1016/j.cdev.2025.203998","DOIUrl":"10.1016/j.cdev.2025.203998","url":null,"abstract":"<p><p>Throughout embryonic development, cells respond to a diverse set of signals and forces, making individual or collective decisions that drive the formation of specialized tissues. The development of these structures is tightly regulated in space and time. In recent years, the possibility that neighboring tissues influence one another's morphogenesis has been explored, as some of them develop simultaneously. We study this issue by reviewing the interactions between Drosophila epidermal and tracheal tissues in early and late stages of embryogenesis. Early in development, the epidermis emerges from the ectodermal layer. During its differentiation, epidermal cells produce morphogen gradients that influence the fundamental organization of the embryo. In this work, we analyze how molecules produced by the epidermis guide tracheal system development. Since both tissues emerge from the same germ layer and lie in close proximity all along their development, they are an excellent model for studying induction processes and tissue interactions.</p>","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":" ","pages":"203998"},"PeriodicalIF":2.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-organization from organs to embryoids by activin in early amphibian development.
IF 2.1 4区 生物学
Cells & Development Pub Date : 2025-01-23 DOI: 10.1016/j.cdev.2025.203996
Makoto Asashima, Yumeko Satou-Kobayashi, Yoshikazu Haramoto, Takashi Ariizumi
{"title":"Self-organization from organs to embryoids by activin in early amphibian development.","authors":"Makoto Asashima, Yumeko Satou-Kobayashi, Yoshikazu Haramoto, Takashi Ariizumi","doi":"10.1016/j.cdev.2025.203996","DOIUrl":"10.1016/j.cdev.2025.203996","url":null,"abstract":"<p><p>Embryonic development is a complex self-organizing process orchestrated by a series of regulatory events at the molecular and cellular levels, resulting in the formation of a fully functional organism. This review focuses on activin protein as a mesoderm-inducing factor and the self-organizing properties it confers. Activin has been detected in both unfertilized eggs and embryos, suggesting its involvement in early developmental processes. To explore its effects, animal cap cells-pluripotent cells from the animal pole of amphibian blastula-stage embryos-were treated with varying concentrations of activin. The results showed that activin induced mesodermal tissues, including blood, muscle, and notochord, in a dose-dependent manner. Co-treatment with activin and retinoic acid further promoted the development of kidney and pancreatic tissues, while activin alone stimulated the formation of beating cardiac tissue. In subsequent experiments, high concentrations of activin conferred an organizer-like activity on animal cap cells. The pretreatment duration affected outcomes: longer exposure induced anterior structures, such as eyes, while shorter exposure resulted in posterior structures, like tails. These findings reflect moderate self-assembly, where cells become increasingly organized. In another experiment, activin was used to create an artificial gradient. Explants cultured on this gradient developed into embryoids with well-defined anteroposterior, dorsoventral, and left-right axes, exemplifying higher-order self-organization. These results demonstrate that controlled activin gradients can drive the formation of nearly complete tadpole-like larvae, effectively recapitulating the processes of early embryogenesis. This system offers valuable insights into the mechanisms underlying axis formation and organogenesis, providing a promising platform for future research in developmental biology.</p>","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":" ","pages":"203996"},"PeriodicalIF":2.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic behavior of cell-cell adhesion factors in collective cell migration.
IF 2.1 4区 生物学
Cells & Development Pub Date : 2025-01-23 DOI: 10.1016/j.cdev.2025.203995
Sayuki Hirano, Kazuhiro Aoki, Naoto Ueno
{"title":"Dynamic behavior of cell-cell adhesion factors in collective cell migration.","authors":"Sayuki Hirano, Kazuhiro Aoki, Naoto Ueno","doi":"10.1016/j.cdev.2025.203995","DOIUrl":"10.1016/j.cdev.2025.203995","url":null,"abstract":"<p><p>Collective cell migration is a fundamental process underlying various biological phenomena, including embryonic development and cancer cell invasion. The cohesive yet flexible movement of cell collectives largely depends on the coordinated regulation of cell-cell and cell-substrate adhesions. In this review, we summarize the regulation of key cell-cell junction components, such as cadherins and zonula occludens proteins during collective cell migration, with a particular focus on the recently discovered multifaceted roles of ZO-1 in both cell-cell and cell-substrate interactions.</p>","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":" ","pages":"203995"},"PeriodicalIF":2.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Butterfly pupal wing tissue with an eyespot organizer. 带眼斑组织的蝴蝶蛹翅膀组织。
IF 2.1 4区 生物学
Cells & Development Pub Date : 2025-01-02 DOI: 10.1016/j.cdev.2024.203992
Joji M Otaki, Atsuko Tanaka, Euichi Hirose
{"title":"Butterfly pupal wing tissue with an eyespot organizer.","authors":"Joji M Otaki, Atsuko Tanaka, Euichi Hirose","doi":"10.1016/j.cdev.2024.203992","DOIUrl":"https://doi.org/10.1016/j.cdev.2024.203992","url":null,"abstract":"<p><p>Butterfly wing eyespots are developmentally determined at the early pupal stage, when prospective eyespot focal cells underneath the pupal cuticle focal spot function as eyespot organizers in the pupal wing tissue. Here, we performed light microscopy and transmission electron microscopy (TEM) to describe cellular structures of pupal wing tissue with an eyespot organizer immediately after pupation using the Blue Pansy butterfly Junonia orithya. The pupal forewing dorsal epidermis was a pseudostratified monolayer of vertically elongated epidermal cells. The apical portion of the cells adhered laterally to one another, but their medial and basal portions were thinner than the apical portion and were tilted to enclose cells at the center, forming a cellular cluster. The cellular cluster at the organizer was relatively large laterally and vertically. The apical portion of the cells and its corresponding cuticle at the organizer were thicker than those in the surroundings. The innermost cuticle layer was being synthesized, indicating high cuticle synthesis and secretion activity of the cells. At the medial and basal portions of the dorsal epidermis, there were many intracellular and extracellular vacuole-like globules, most likely containing extracellular matrix molecules. Some of the basal processes from epidermal cells extended to form protrusions of the basement membrane, which was often attended by hemocytes. These results suggest that the butterfly eyespot organizer is composed of a single or a few cellular clusters that secrete more cuticle than surrounding clusters, supporting the pupal cuticle hypothesis that cuticle formation is critical for eyespot color pattern determination in butterflies.</p>","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":" ","pages":"203992"},"PeriodicalIF":2.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comments on the Hox timer and related issues. 关于Hox定时器和相关问题的评论。
IF 2.1 4区 生物学
Cells & Development Pub Date : 2024-12-27 DOI: 10.1016/j.cdev.2024.203991
Denis Duboule, Hocine Rekaik
{"title":"Comments on the Hox timer and related issues.","authors":"Denis Duboule, Hocine Rekaik","doi":"10.1016/j.cdev.2024.203991","DOIUrl":"10.1016/j.cdev.2024.203991","url":null,"abstract":"<p><p>2024 not only marked the 100th anniversary of the discovery of the organizer by Hilde Pröscholdt-Mangold and Hans Spemann, but also the 40th anniversary of the discovery of the homeobox, a DNA region encoding a DNA binding peptide present in several transcription factors of critical importance for the gastrulating embryo. In particular, this sequence is found in the 39 members of the amniote Hox gene family, a series of genes activated in mid-gastrulation and involved in organizing morphologies along the extending anterior to posterior (AP) body axis. Over the past 30 years, the study of their coordinated regulation in various contexts has progressively revealed their surprising regulatory strategies, based on mechanisms acting in-cis, which can translate a linear distribution of series of genes along the chromatin fiber into the proper sequences of morphologies observed along our various body axes. The first regulatory layer is controlled by the Hox timer, a mechanism implementing a time-sequenced activation of these genes following their chromosomal order. Here, we discuss various aspects of this mechanism, emphasizing some of its singularities.</p>","PeriodicalId":29860,"journal":{"name":"Cells & Development","volume":" ","pages":"203991"},"PeriodicalIF":2.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信