Recent Advances in Inflammation & Allergy Drug Discovery最新文献

{"title":"Vanillin: A Review on the Therapeutic Potential as an Anti-inflammatory Agent.","authors":"Sonia Singh, Bhupesh Chander Semwal, Bhoopendra Singh, Aditya Pratap Singh, Siva Prasad Panda","doi":"10.2174/0127722708368753250713180110","DOIUrl":"https://doi.org/10.2174/0127722708368753250713180110","url":null,"abstract":"<p><p>Vanillin is a naturally occurring compound found in numerous plant species and is commonly utilized in food, beverages, cosmetics, and pharmaceuticals. It is the main ingredient in vanilla pods, and numerous studies have indicated that it has a variety of pharmacological properties, including anti-inflammatory, antioxidant, and anticancer properties. Vanillin is extensively utilized in modern drug research for the treatment of many diseases, including cancer, due to its anti-inflammatory properties. Besides its application in food and flavoring, vanillin acts as a precursor in the production of other valuable petroleum-derived chemicals. This review provides a thorough explanation of the impact of this phytochemical on many signalling pathways, which are interconnected with the root cause of disease. This review also discusses its pharmacokinetic characteristics and clinical trial studies.</p>","PeriodicalId":29815,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Hibiscus Sabdariffa</i> Linn: Phytochemical Impact on the Mechanism of Neuroprotective and Anti-inflammatory Pathways.","authors":"Renuka Ekka, Bharti Ahirwar","doi":"10.2174/0127722708302750240916064255","DOIUrl":"https://doi.org/10.2174/0127722708302750240916064255","url":null,"abstract":"<p><p>The <i>Hibiscus sabdariffa</i> plant is an herbaceous member of the Malvaceae family. It is a widely recognized herb with medicinal properties. It is utilized extensively in many traditional medical practices along with delicious food items, like jams, puddings, and cakes. The purpose of this review was to investigate and compile all of the available data and evidence about the calyxes of <i>Hibiscus sabdariffa</i> with a particular focus on their nutritional composition, bioactive components, and therapeutic benefits. This article provides a comprehensive overview of the plant's traditional usage, pharmacognostic characterization, nutritional and phytochemical composition, and pharmacological properties. This paper elucidates the mechanisms by which <i>Hibiscus sabdariffa</i> exerts neuroprotective and anti-inflammatory effects in managing neurological disorders. Additionally, <i>Hibiscus sabdariffa</i> has been shown to prevent memory impairment, which may be attributed to its effects on neuroinflammation and amyloidogenesis. <i>Hibiscus sabdariffa</i> has been reported to have anti-inflammatory effects due to the presence of polyphenol compounds that possess anti- inflammatory properties. Flavonoids are also commonly found in it, which inhibit the transcription factor nuclear factor kappa B. This plant has a variety of health benefits, including antioxidant, antidepressant, diuretic, antihyperlipidemic, anti-obesity, hepatoprotective, anti-inflammatory, anti-cancer, antimicrobial, and neuroprotective activities. Based on the literature, this review provides a thorough analysis of the pharmacological and phytochemical characteristics of Hibiscus sabdariffa.</p>","PeriodicalId":29815,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":"19 2","pages":"173-188"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking Toll-Like Receptors: Targeting Therapeutics for Respiratory Tract Infections and Inflammatory Disorders.","authors":"Vishal Pandey, Debasis Sen, Sunny Rathee, Sakshi Soni, Shashank Mishra, Sanjay K Jain, Umesh K Patil","doi":"10.2174/0127722708329138240926073013","DOIUrl":"https://doi.org/10.2174/0127722708329138240926073013","url":null,"abstract":"<p><p>The Toll-like Receptors (TLRs) family has significantly enhanced the understanding of innate immune responses by identifying and responding to various microbes or host-derived organisms. TLRs contribute to these responses by increasing the levels of cytokines, interleukins, and other inflammatory mediators through multiple pathways. Located both intracellularly and on the surface of various cells and tissues, including vascular smooth muscles (VSMs) and myocardium cells, TLRs play distinct roles in innate immune activation, such as recognizing pathogen-associated molecular patterns (PAMPs) and activating downstream signaling pathways. In the context of COVID-19, TLRs are critically involved in the pathophysiology by mediating excessive inflammatory responses that exacerbate disease severity, influencing both the acute phase and long-term outcomes. It has been observed that inflammatory diseases such as atherosclerosis, viral myocarditis, and other comorbidities associated with the spread of COVID-19 have increased, although the exact mechanisms remain not fully understood. Nonetheless, there is evidence of TLR-mediated increased pro-inflammatory signaling by different mechanisms in these diseases. This review explains the role of TLRs in various inflammatory diseases related to COVID-19, including viral myocarditis, acute lung infections, and atherosclerosis. Furthermore, the review discusses various herbal drugs, such as <i>Platycodon grandiflorum, Acanthopanax senticosus, Scutellaria baicalensis Georgi</i>, and <i>Engelhardia roxburghiana</i>, and their mechanisms of action on TLRs, including NF-κB, MyD88-dependent, MyD88-independent pathways, and Plasmacytoid DCs. Enhanced clarity on TLRs' specific contributions to COVID-19 pathophysiology and stronger evidence supporting herbal interventions targeting TLRs could improve the impact and applicability of these findings in clinical settings.</p>","PeriodicalId":29815,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":"19 3","pages":"303-315"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring Tacrolimus and Cyclosporine Blood Trough Levels and the Capacity of Anti-oxidant after Kidney Transplantation: A Patent Perspective.","authors":"Zahra Tolou-Ghamari","doi":"10.2174/0127722708319486241202113259","DOIUrl":"https://doi.org/10.2174/0127722708319486241202113259","url":null,"abstract":"<p><strong>Background: </strong>It is well known that acute or chronic kidney injury could be due to free radicals and pro-oxidants. This investigation aimed to monitor tacrolimus or cyclosporine blood trough levels and anti-oxidant capacity after kidney transplantation.</p><p><strong>Methods: </strong>There was no intervention in the routine management of transplant recipients. The sample size (n=70) included healthy individuals and kidney-transplanted recipients (n=25 on tacrolimus and n=10 on cyclosporine). The study population was matched for age. The attained information was examined by using the Statistical Package (SPSS Inc, Chicago, IL, USA). The significance level was considered as P ≤ 0.05.</p><p><strong>Results: </strong>In healthy individuals, the mean ± SD for the capacity of antioxidants was 91.9 ± 16.6 (u/ml), which was significantly higher when compared to the mean value of 28.5 ± 22.6 (u/ml) versus 24.7 ± 25.5 (u/ml), kidney recipients with tacrolimus versus cyclosporine (P ≤ 0.04) as immunosuppressive drugs. The mean value of tacrolimus levels was 14.6 ± 6.4 (ng/ml). The correlation between tacrolimus and cyclosporine trough levels and anti-oxidant capacity was 0.19 (P ≤ 0.14). There were no significant differences regarding age in cases and controls (P ≤ 0.42).</p><p><strong>Conclusion: </strong>This study showed that the capacity of anti-oxidants in kidney transplant recipients, those on tacrolimus or cyclosporine, might be lower than in healthy individuals. Subsequent investigations are recommended to delve into the therapeutic consequences of the influence of antioxidant therapies on the clinical outcomes of transplanted recipients.</p>","PeriodicalId":29815,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":"19 3","pages":"374-379"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential Anti-psoriatic Effects of Andrographolide: A Comparative Study to Topical Corticosteroids.","authors":"Indira Dharmasamitha, Luh Made Mas Rusyati, Dyah Kanya Wati, I Made Agus Gelgel Wirasuta","doi":"10.2174/0127722708296983240424102212","DOIUrl":"10.2174/0127722708296983240424102212","url":null,"abstract":"<p><strong>Background: </strong>Andrographolide (AP), a bioactive anti-inflammatory compound of Sambiloto, inhibits NF-κB, TNF-α, and interleukin IL-6. Nowadays, molecular docking simulation between AP and dexamethasone against NF-κB receptor presented the energy AP higher than dexamethasone. This becomes a potential treatment for psoriasis.</p><p><strong>Objective: </strong>This manuscript reported the effectiveness of AP from Sambiloto in treating psoriasis compared to topical steroids.</p><p><strong>Methods: </strong>This study conducted TLC analysis of AP content and its metabolite impurities, emulgel formulation, molecular docking, <i>in-silico</i> skin toxicity study, and <i>in-vivo</i> anti-psoriatic activity. This was a combination study of an <i>in-silico</i> study and an <i>in-vivo</i> study. This <i>in-silico</i> study was analyzed through multivariate statistical analysis (PCA) to elucidate the data constellation relationship of andrographolide derivatives with several target proteins. The intervention was performed in seven days. The PASI score, molecular parameters (IL-6, IL-17, VEGF, and TNF-a levels), and histopathological findings were assessed.</p><p><strong>Results: </strong>Molecular docking results revealed andrographolide to exhibit a relatively high binding affinity towards IL-6, NF-kB, and TNF-α which is comparable to the corticosteroids, andrographolide also shares similar residue interaction profile with each of the respective protein's native ligand. In the <i>in-vivo</i> study, we found several parameters statistically significantly different regarding the intervention, including final PASI score (p = 0.017), redness (p = 0.017), scale (p = 0.040), thickness (p = 0.023), total histopathology of psoriasis score (p = 0.037), keratin layer score (p = 0.018).</p><p><strong>Conclusion: </strong>Emulgel AP 0.1% could lower the anti-inflammatory agent, which is vital to psoriasis progression.</p>","PeriodicalId":29815,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":" ","pages":"46-70"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unseen Dangers: The Effects of Micro- and Nanoplastics on Human Reproductive Health - A Narrative Review.","authors":"Naina Kumar","doi":"10.2174/0127722708359509250331150754","DOIUrl":"10.2174/0127722708359509250331150754","url":null,"abstract":"<p><p>Micro(nano)plastics (MNPs) have become pervasive environmental pollutants due to widespread use and inadequate waste management practices. These tiny particles infiltrate various ecosystems, including the human body, raising significant concerns about their potential health effects. Of particular concern is their impact on human reproductive health, with emerging research indicating MNPs' ability to breach biological barriers, accumulate in reproductive organs, and potentially reach the placenta. A comprehensive literature search spanning from July 2015 to July 2024 was conducted across prominent electronic databases, including Pub- Med, Scopus, Web of Science, and Google Scholar. Key search terms such as \"micro and nanoplastics,\" \"microplastics and male reproductive health,\" \"microplastics and female reproductive health,\" \"transgenerational spread of microplastics,\" and \"microplastics and fetal health\" were used to identify relevant studies published in peer-reviewed journals, books, and reputable conference proceedings. Selection criteria favoured review articles, original research papers, metaanalyses, and authoritative texts published in English. Synthesized findings from these studies were critically analysed to underscore their potential impacts on reproductive health. The accumulating evidence emphasizes the urgent need for further research to fully grasp the risks posed by MNPs to human reproductive health. Effective mitigation strategies are essential to minimize exposure and mitigate potential long-term consequences. Policy interventions aimed at enhancing waste management practices and regulating plastic usage are crucial to curb the environmental spread of MNPs and safeguard human reproductive health effectively.</p>","PeriodicalId":29815,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":" ","pages":"127-138"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Oral and Gut Microbiota Composition in Children with Dental Caries by NGS Approaches.","authors":"Stefano Cianetti, Silvia Marchianò, Dhanushka Frank Wijeratne, Adriana Carino, Michele Biagioli, Martina Bordoni, Rosalinda Roselli, Cristina Di Giorgio, Rachele Bellini, Chiara Valenti, Maddalena Coniglio, Giuseppe Lomurno, Anna Palma Lomurno, Stefano Pagano","doi":"10.2174/0127722708335159241117062704","DOIUrl":"https://doi.org/10.2174/0127722708335159241117062704","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to characterize oral and gut microbiota of children with high dmft index and caries-free children at phylum, family and species levels as well as to evaluate the effect of <i>Streptococcus salivarius</i> M18 DSM 14685 (Carioblis) administration on microbiota composition of caries active children.</p><p><strong>Materials and methods: </strong>Ten children with active caries and nine caries-free children have been recruited. Four samples from different oral niches and stools were collected from each patient for the NGS sequencing of 16s Microbiota rDNA by S5 Ion Torrent.</p><p><strong>Results: </strong>Our results revealed modifications in the microbiota composition of teeth, saliva and vestibular regions of the oral cavity and faecal samples in the presence of dental caries. These changes were evident at the family and species levels, with no significant differences found at the phylum composition level. In particular, Streptococcaceae were positively correlated to the high degree of caries in all niches, and the analysis at the species level led to the identification of 39 bacterial species significantly modulated in the analyzed groups. The use of probiotic seemed to exert beneficial effects on oral but not on faeces dysbiosis. The intestinal tract was confirmed to have a different microbiota composition compared to the oral cavity.</p><p><strong>Conclusion: </strong>Dental caries mainly lead to modifications in the oral microbiota composition. <i>Streptococcus salivarius</i> M18 DSM 14685 administration determines a shift in the oral microbiota composition towards a healthier state. Concerning the gastrointestinal tract, our study found for the first time that caries cause the increase of two bacterial species, related to other disorders: Bifidobacterium adolescentis and Ruminococcus torques.</p>","PeriodicalId":29815,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":"19 3","pages":"413-427"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Inflammatory Bowel Disease Activity by Non-invasive Biomarkers: Still a Long Way Ahead.","authors":"Stefano Fiorucci, Ginevra Urbani","doi":"10.2174/0127722708402763250424092507","DOIUrl":"10.2174/0127722708402763250424092507","url":null,"abstract":"","PeriodicalId":29815,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":" ","pages":"275-278"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Inflammatory and Hemostatic Markers in the Prediction of Severe Acute Pancreatitis: An Observational Cohort Study.","authors":"Liudmila Orbelian, Nikita Trembach, Vladimir Durleshter","doi":"10.2174/0127722708356543241209060544","DOIUrl":"10.2174/0127722708356543241209060544","url":null,"abstract":"<p><strong>Introduction: </strong>Acute pancreatitis (AP) is a serious inflammatory disease of the pancreas that can lead to significant morbidity and increased mortality. The special role of inflammation and disruption of the hemostatic system in the development of severe forms of the disease is known, however, the relationship between inflammatory and anti-inflammatory cytokines and thromboelastogram parameters has not been sufficiently studied.</p><p><strong>Aim: </strong>The aim of this study is to assess the prognostic significance of thromboelastogram parameters, interleukin-6, and interleukin-22 levels in assessing the risk for developing severe forms of acute pancreatitis.</p><p><strong>Materials and methods: </strong>Data from 149 patients with acute pancreatitis were included in the analysis. The classification of AP was performed according to the 2012 Revision of the Atlanta Classification. Data including gender, age, lab tests, radiological information, and prognosis were included. The following scales were used to assess severity: SOFA scale and BISAP scale. IL-6 and IL-22 were analyzed at 24 h and 48 h after the onset of symptoms. The collected TEG parameters included K-time, R-value, and Maximum amplitude value at admission. All patients were divided into three groups: mild, moderate-severe, and severe pancreatitis.</p><p><strong>Results: </strong>Statistically significant differences were found between the groups in the IL-6 level at the first measurement and on day 2 of the study. IL-22 values were also higher in the group with severe pancreatitis, however, on day 2, its level became lower compared to the group of patients with moderate and mild pancreatitis. Statistically significant differences were found in the level of K-time, R-value, Maximum amplitude, fibrinogen concentration, and platelets count, demonstrating a hypercoagulation state in severe pancreatitis at admission. The conducted logistic regression showed that the factors associated with the development of severe forms are the number of points on the BISAP scale, the level of interleukin-6 in the first 24 hours of the disease, delta IL-22, and K-time. (AUC = 0.948).</p><p><strong>Conclusion: </strong>The study highlights that both IL-6 and IL-22 play crucial roles in the inflammatory cascade of severe acute pancreatitis. Their levels, along with specific hemostasis parameters like K-time and BISAP score, serve as reliable early predictors of disease severity.</p>","PeriodicalId":29815,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":" ","pages":"428-440"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12678983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of Dexamethasone and Methylprednisolone in COVID-19 Patients: Clinical Outcomes and Inflammatory Markers.","authors":"Alireza Ziaei Moghaddam, Mostafa Soleimani, Behnam Imani, Sepideh Hejazi, Mohammadhossein Taherynejad, Mona Kabiri, Maryam Emadzadeh, Sahar Ravanshad","doi":"10.2174/0127722708310247240718100251","DOIUrl":"https://doi.org/10.2174/0127722708310247240718100251","url":null,"abstract":"<p><strong>Background: </strong>The Coronavirus disease 2019 (COVID-19) pandemic, prompted by SARS-CoV-2, has created complicated health crises. An excessive inflammatory response and cytokine storm characterize severe COVID-19. Corticosteroids like dexamethasone and methylprednisolone are used for their anti-inflammatory effects, but comparisons of their efficacy are lacking.</p><p><strong>Objective: </strong>This study seeks to rigorously assess and contrast the effectiveness of dexamethasone and methylprednisolone in combating COVID-19 infections.</p><p><strong>Methods: </strong>This retrospective clinical study evaluates the effects of these two corticosteroids by reviewing the files of 500 hospitalized COVID-19 patients. The baseline characteristics of the patients, chest CT severity score, type of steroid prescription, duration of hospitalization and steroid prescription, dosage of corticosteroid therapy, their recovery status, hospital mortality, and specific disease severity-associated markers, such as lactate dehydrogenase (LDH), complete blood count (CBC), C-reactive protein (CRP), and Erythrocyte sedimentation rate (ESR) were collected and compared.</p><p><strong>Results: </strong>The study found no significant difference in most disease severity-associated markers between the two corticosteroid groups. However, lower mortality rates and shortened hospital stays were significantly associated with dexamethasone, especially in critical patient groups. A detailed analysis of inflammatory markers suggested minimal differences based on the type of corticosteroid used.</p><p><strong>Conclusion: </strong>The study indicates that dexamethasone may have some advantages in specific clinical outcomes. Further research needs to explore the mechanisms involved despite similar anti-inflammatory profiles.</p>","PeriodicalId":29815,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":"19 2","pages":"259-268"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}