International Journal of Pharmacognosy & Chinese Medicine最新文献

{"title":"Investigation of Antistress Activity of Operculina Terpethum Roots using Various Experimental Models","authors":"Varsha J. Galani","doi":"10.23880/ipcm-16000180","DOIUrl":"https://doi.org/10.23880/ipcm-16000180","url":null,"abstract":"The root part of Operculina terpethum has been widely used in Ayurveda to treat variety of common and stress related disorders. The antistress effect of a seven-days treatment (100 and 200 mg / kg, p.o.) of the 80% ethanolic extract of Operculina terpethum root (OTRE) was evaluated by using the swimming endurance test, anoxic tolerance test, and biochemical changes in the cold-restraint stress test. The immunomodulatory activity was also evaluated for the same doses, and treatment of OTRE using the hem agglutination test. Diazepam 1 mg/kg was used as reference standard for the comparison. Both the doses of OTRE showed anti stress activity in all the tested models. 7 days pretreatment of OTRE (100 and 200 mg / kg, p.o.) treated animals showed a decrease in immobility time and an increase in anoxic tolerance time in swimming endurance and the anoxic tolerance tests, respectively. Pretreatment with OTRE significantly ameliorated the cold restraint stress induced variation in biochemical level such as increase in plasma cholesterol, triglyceride, glucose, total protein, and cortisol. Further, OTRE treatment significantly inhibited cold restraint stress induced alteration in brain noradrenaline, dopamine and serotonin levels. In mice immunized with sheep red blood cells, the treatment groups subjected to restraint stress prevented the humoral immune response to the antigen. The immune stimulating activity of the OTRE was indicated by an increase in the antibody titer in mice pre-immunized with sheep red blood cells and subjected to restraint stress. The findings of the present investigations indicate that the OTRE has significant anti stress activity, which may be due to the immune stimulating property and increased resistance, nonspecifically, against all experimental stress conditions.","PeriodicalId":298121,"journal":{"name":"International Journal of Pharmacognosy & Chinese Medicine","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133616029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Phyto-Constituents in the Management of Hypertension","authors":"R. Bhatia","doi":"10.23880/ipcm-16000159","DOIUrl":"https://doi.org/10.23880/ipcm-16000159","url":null,"abstract":"Hypertension is one of the commonly prevailing ailments around the globe. It is evident that more than 7 million people are suffering from this disease every year. There is a wide variety of allopathic medicines available for the treatment of hypertension, but they are associated with drug dependence and fewer to larger number of adverse effects. Plants has been utilized as significant resources as therapeutic agents in the management of hypertension from the ancient time. There are so many categories of active constituents derived from plants which have excellent hypotensive properties. In this mini review, authors have summarized various phyto-constituents according to their classes which possess significant blood pressure lowering potential. The classes included are alkaloids, flavonoids, glycosides, coumarins and terpenoids.","PeriodicalId":298121,"journal":{"name":"International Journal of Pharmacognosy & Chinese Medicine","volume":"291 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133246713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asteraceae Plants used in Homoeopathic System of Medicine, Cultivated in the Center of Medicinal Plants Research in Homoeopathy (CMPRH), Emerald, the Nilgiris, Tamil Nadu","authors":"M. S","doi":"10.23880/ipcm-16000217","DOIUrl":"https://doi.org/10.23880/ipcm-16000217","url":null,"abstract":"The objective of the present study is to survey and document of homeopathic medicinal plants cultivated in the Center of Medicinal Plants Research in Homoeopathy (CMPRH), Emerald, Nilgiris District, Tamil Nadu, India. To prepare the documentation of homoeopathic Medicinal plants of Asteraceae in the Nilgiris District, the present study was conducted during the year 2019–2020. The plants collected were pressed, poisoned, mounted, and stitched on herbarium sheets and deposited at the Centre of Medicinal Plants Research in Homoeopathy herbarium (Acronym SMPRGH). The present study deals with the 29 species belonging to 26 genera of Asteraceae family viz. Achillea millefolium L., Anthemis nobilis L., Artemisia abrotanum L., Artemisia dracunculus L., Artemisia annua L., Bellis perennis L., Calendula officinalis L., Cichorium intybus L., Chrysanthemum parthenium L., Cynara scolymus L., Echinacea purpurea L., Eclipta prostrata (L.)L., Erigeron canadensis L., Galinsoga parviflora Cav., Gnaphalium polycepalum L., Helianthus annuus L., Lactuca sativa L., Leucanthemum vulgare (Vahill.) Lam., Matricaria chamomilla L., Parthenium hysterophorus L., Senecio cineraria DC., Sigesbeckia orientalis L., Silybum marianum (L) Gaertner., Solidago virgaurea L., Stevia rebaudiana (Bertoni) Bertoni., Taraxacum officinnale Wigg. Vernonia anthelmintica (L.)Willd., Xanthium indicum Koenig and Xanthium spinosum L. The present article gives the scientific name, common name, homeopathic drug name, original author citation, English name, phenology, distribution, short description, and part of plant used for preparing homoeopathic medicine. Details such as indigenous or exotic and uses are also given. Reported 29 homoeopathic medicinal plants are used in homoeopathic medicinal system to treat various diseases. Present study also reveals the importance of conservation and sustainable utilization. The documented information is useful for Homeopathic practitioners, scientists, drug developers, medicinal plant enterprises and other scientific bodies which deal with isolation of active ingredients for effective treatment.","PeriodicalId":298121,"journal":{"name":"International Journal of Pharmacognosy & Chinese Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132980760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Biological Activity of 6-Substituted Pyrimidine-2,4- Dionesderivatives","authors":"M. Gupta","doi":"10.23880/ipcm-16000211","DOIUrl":"https://doi.org/10.23880/ipcm-16000211","url":null,"abstract":"Cancer is a terrible disease and second leading cause of death, behind cardio-vascular disease in the world. At present, there are three main methods of cancer treatment: surgery, radiation therapy and chemotherapy. Pyrimidineis a six-membered heterocyclic aromatic organic compound containing two nitrogen atoms at positions 1 and 3. Pyrimidine derivatives occupy a distinct and unique place in chemotherapy. The chemotherapeutic efficacy of pyrimidine derivatives is related to their ability to inhibit vital enzymes responsible for DNA biosynthesis as dihydrofolatereductase (DHFR), thymidylatesynthetase (TSase), thymidine phosphorylase (TPase) and reverse transcriptase (RTase). In the present study involves synthesis of 6-Substituted pyrimidine 2,4-diones derivatives. The synthesized compounds were subjected to antimicrobial activity against Gram negative E. coli (MTCC 40) and S. aureus (MTCC 87). The synthesized compounds possessed good to moderate antibacterial activity. Compounds 1, 2, 3a possessed good antibacterial activity when compared with standard however the compounds 2a, 2b, 2d, 1b, 1d, 1e possessed moderate activity. 1c, 1d, 1a, 2e, 2c were observed to be totally inactive compounds. The derivatives with electron withdrawing substituent on the phenyl ring at para position had poor activity in comparison to derivatives possessing no or electron donating substituents. The structures of the synthesized compounds were established by IR and NMR spectral studies.","PeriodicalId":298121,"journal":{"name":"International Journal of Pharmacognosy & Chinese Medicine","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133904062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Depression and Balance Affection in Postmenopausal Women-A Cross-Sectional Study","authors":"Ankur Khant","doi":"10.23880/ipcm-16000223","DOIUrl":"https://doi.org/10.23880/ipcm-16000223","url":null,"abstract":"Background: Menopause is an essential and normal developmental process in a women’s life that may result in a wide variety of symptoms hence creating different problems. Psychological disorders particularly depression and balance affection are the most frequently observed public health problems of postmenopausal women requiring attention and even physiotherapy intervention. Hence, this study aimed to evaluate the prevalence of depression and balance affection in post-menopausal women. Materials and Methods: This study was conducted on 210 post-menopausal women aged between 45-60 years fulfilling the inclusion criteria. The subjects were selected by convenient sampling with prior consent and general assessment was taken. Gujarati version of Patient Health Questionnaire-9 (PHQ-9) and Berg Balance Scale (BBS) were used as outcome measures and data analysis was conducted for descriptive and analytical statistics. Results and Discussion: The mean value of age was 53.22 + 4.5 years. The mean score of depression for the subjects was 8.58 ± 3.59, which indicated mild depression. The results showed that 17.14% of women had minimal depression, 41.43% had mild depression, 32.86 had moderate depression and 8.57% had moderately severe depression. For balance affection mean value was 48.64±3.59, which indicated low fall risk. In balance affection, results showed that 97.63% had low fall risk, 2.38% had medium fall risk and 0% had high fall risk. Conclusion: A significant percentage of women in their menopause experienced depression and balance affection. This study showed that the majority of women included in the study had experienced mild depression and low fall risk for balance affection.","PeriodicalId":298121,"journal":{"name":"International Journal of Pharmacognosy & Chinese Medicine","volume":"49 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113956477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Supplements, Medicinal Plants and Beverages in Treating Obesity: A Mini Review of Clinical Evidence","authors":"A. Kabir","doi":"10.23880/ipcm-16000176","DOIUrl":"https://doi.org/10.23880/ipcm-16000176","url":null,"abstract":"Once considered a problem of developed countries, obesity and obesity-related complications are rapidly spreading around the globe. Increased body mass index and obesity are strongly associated with metabolic dysfunction. The purpose of this study was to review and explain the role of different dietary supplements, medicinal plants, and beverages in reducing obesity. The drug used in treating obesity has so many adverse effects, including drug abuse and drug resistance. This evidence based review article suggested that several dietary supplements including Chitosan, Prolibra, Phosphorus supplementation, Vitamin D3 supplementation and beverages like Yerba Mate, Green coffee bean extract, Green tea extract may be more effective for treating obese individuals.","PeriodicalId":298121,"journal":{"name":"International Journal of Pharmacognosy & Chinese Medicine","volume":"2020 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121239562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Phenolic Content, Flavonoids Content, Antioxidant and Antimicrobial Activities of the Leaves, Peels and Fruits of Locally Available Citrus Plants Collected from Kavre District of Nepal","authors":"B. Pandey","doi":"10.23880/ipcm-16000181","DOIUrl":"https://doi.org/10.23880/ipcm-16000181","url":null,"abstract":"Aim of this study was to evaluate the total phenolic content (TPC), total flavonoids content (TFC), antioxidant and antibacterial activities of fruits, leaves and peels of locally available citrus species. Result revealed that TPC and TFC of the fruit, leaves and peels range from 6.1 to 34.22 mg GAE/ g DW and 1.71 to 28.96 mg QUE/g DW, respectively. Highest TPC and TFC were Citrus medica leaves. Furthermore, range of antioxidant activities of the fruits, leaves and peels range were analyzed using DPPH scavenging as well as reducing power assays. Both analysis revealed that Citrus maxima leaves, Citrus aurantum Peels and Citrus medica leaves have the highest antioxidant activities with IC50 values 54.86 ± 0.09, 56.69 ± 0.08 and 66.81 ± 0.03 µg/ml, respectively. Furthermore, analyzed plant extract revealed the range of antibacterial activities in both grams positive and gram negative bacteria. Our results revealed that not only fruits, and leaves but also peels showed significant biological activities.","PeriodicalId":298121,"journal":{"name":"International Journal of Pharmacognosy & Chinese Medicine","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129203243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Application of Different Formulations (Kalpana) of Guduchi (Tinospora Cordifolia)","authors":"Anamika Gupta","doi":"10.23880/ipcm-16000206","DOIUrl":"https://doi.org/10.23880/ipcm-16000206","url":null,"abstract":"In Ayurveda, rasashastra and bhaishajya Kalpana plays a very important role in therapeutics. The main basic dosage forms are five i.e. panchvidha Kashaya Kalpana (five formulations), swarasa (liquid), kalka (paste), kwatha (decoction), hima (cold infusion) and phanta (hot infusion). These Kashaya kalpanas are mainly designed to obtain different mode of actions, different powers from same dravya. In this paper, the main stress is on guduchi (Tinospora cordifolia) formulations and its therapeutic applications, that how a single drug being used in different formulations in different therapeutic indications. The findings were presented in a tabular form and discussed to suggest any generalized remark.","PeriodicalId":298121,"journal":{"name":"International Journal of Pharmacognosy & Chinese Medicine","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125369577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Clusters from Plants to Microbes: Their Role in Specialized Metabolism and Drug Development","authors":"P. Chakraborty","doi":"10.23880/ipcm-16000149","DOIUrl":"https://doi.org/10.23880/ipcm-16000149","url":null,"abstract":"Most of the drugs we use as anticancer agents, antiinfective agents, heart protective and antidiabetic are secondary metabolites of plants or microbes or derived from natural products.","PeriodicalId":298121,"journal":{"name":"International Journal of Pharmacognosy & Chinese Medicine","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121963623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substituting Drugs in Ayurveda with Special Reference to Botany","authors":"Mallikarjuna Rao","doi":"10.23880/ipcm-16000189","DOIUrl":"https://doi.org/10.23880/ipcm-16000189","url":null,"abstract":"Substitute drugs utilize for the drugs which are not available. It mainly deals with rational substitution intentionally selected of crude drugs required for medicinal purpose. This concept is referred from one of the Laghutrayi, Bhavapraksha written in 16th century A.D. As the list of substitute is first of its kind and this Nighantu is considered. With proper revalidation of existing documented examples, there is always a scope to find out new substitutes for Abhava dravyas of today’s time, keeping in mind, it is selected for discussion and bringing awareness about is the main concern for present research topic.","PeriodicalId":298121,"journal":{"name":"International Journal of Pharmacognosy & Chinese Medicine","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132516129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}