Prospects in Pharmaceutical Sciences最新文献_第2页

COUNTERFEIT AND ILLEGAL MEDICINAL PRODUCTS AS AN EXAMPLE OF DRUGS THAT DO NOT MEET THE BASIC QUAITY REQUIREMENTS 假冒和非法药品是不符合基本质量要求的药品

Prospects in Pharmaceutical Sciences Pub Date : 2023-10-26 DOI: 10.56782/pps.164

Agnieszka Kalicka, Natalia Tarłowska

{"title":"COUNTERFEIT AND ILLEGAL MEDICINAL PRODUCTS AS AN EXAMPLE OF DRUGS THAT DO NOT MEET THE BASIC QUAITY REQUIREMENTS","authors":"Agnieszka Kalicka, Natalia Tarłowska","doi":"10.56782/pps.164","DOIUrl":"https://doi.org/10.56782/pps.164","url":null,"abstract":"Falsification or counterfeiting of medicinal products is a severe pharmaceutical crime. According to the World Health Organization, about 10% of medicinal products in developing countries are falsified. In the case of medicines sold over the Internet, the figure is as high as 50%, and this phenomenon's scale is increasing yearly. The illegally sourced preparations are not manufactured in accordance with Good Manufacturing Practice (GMP). Among the most frequently falsified medicinal products are preparations used for erectile dysfunction, weight loss aids, or anabolic-androgenic steroids. The presence of undeclared active ingredients and impurities, incorrect dosage due to different than declared contents, and the sourcing of over-the-counter medicines from unknown sources can lead to serious side effects that threaten patients' lives and health. In addition, inaccurate or incomplete descriptions of product formulation can additionally cause the risk of drug interactions, which can consequently lead to serious medical incidents. The purpose of this paper is to discuss the requirements for medicinal products and to present the problem of the quality of counterfeit and illegal medicinal products. This issue is discussed using phosphodiesterase type 5 inhibitors (applied to the treatment of erectile dysfunction) as an example. KEYWORDS: falsified medicinal products, quality of medicinal products, PDE-5 inhibitors","PeriodicalId":295830,"journal":{"name":"Prospects in Pharmaceutical Sciences","volume":"39 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134971590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Papaver species: usage areas, essential oil, nutrient and elements contents, biological activities 木瓜种类:使用地区、精油、营养元素含量、生物活性

Prospects in Pharmaceutical Sciences Pub Date : 2023-10-10 DOI: 10.56782/pps.142

Falah Saleh Mohammed, Imran Uysal, Hasan Hüseyin Yaz, Mustafa Sevindik

引用次数: 1

Efficacy of satralizumab therapy in the treatment of NMOSD satralizumab治疗NMOSD的疗效

Prospects in Pharmaceutical Sciences Pub Date : 2023-09-22 DOI: 10.56782/pps.166

Małgorzata Krzyżanowska, Katarzyna Kozon, Jakub Olszewski, Andrzej Patyra

引用次数: 0

ICH M10 guideline - a harmonized global approach to bioanalysis ICH M10指南-生物分析的统一全球方法

Prospects in Pharmaceutical Sciences Pub Date : 2023-09-22 DOI: 10.56782/pps.152

Elżbieta Gniazdowska, Edyta Gilant, Katarzyna Buś-Kwaśnik

引用次数: 0

Quercetin: derivatives, biosynthesis, biological activity, pharmacological and therapeutic effects 槲皮素:衍生物、生物合成、生物活性、药理和治疗作用

Prospects in Pharmaceutical Sciences Pub Date : 2023-09-08 DOI: 10.56782/pps.147

Falah Saleh Mohammed, Mustafa Sevindik, İmran Uysal, Ali Erdem Sabik

引用次数: 0

Autism: plants with neuro-psychopharmacotherapeutic potential 自闭症:具有神经精神药物治疗潜力的植物

Prospects in Pharmaceutical Sciences Pub Date : 2023-08-22 DOI: 10.56782/pps.143

M. Sevindik, F. Mohammed, I. Uysal

引用次数: 2

Twenty years of Prospects in Pharmaceutical Sciences: recent changes 制药科学二十年的展望:最近的变化

Prospects in Pharmaceutical Sciences Pub Date : 2023-08-04 DOI: 10.56782/pps.162

Andrzej Patyra

引用次数: 0

Functıonal food Momordıca charantıa: bıologıcal actıvıtıes

Prospects in Pharmaceutical Sciences Pub Date : 2023-08-03 DOI: 10.56782/pps.138

Falah Saleh Mohammed, Imran Uysal, Mustafa Sevindik

{"title":"Functıonal food Momordıca charantıa: bıologıcal actıvıtıes","authors":"Falah Saleh Mohammed, Imran Uysal, Mustafa Sevindik","doi":"10.56782/pps.138","DOIUrl":"https://doi.org/10.56782/pps.138","url":null,"abstract":"Complementary medicine history includes a lot of knowledge based on human history. In this context, different plant species are used in the treatment and prevention of diseases. Plants are important natural productsthat attract attention with their nutritive and non-nutritive compounds. They contain many bioactive compounds that are not particularly nutritious but very important from a medical point of view. In our study, the biological activities of Momordica charantia reported in the literature were compiled. In addition, mineral, nutrient and chemical contents reported in the literature were compiled. The fruits of M. charantia are known as bitter gourd. In different parts of the world, it is used for many purposes as salad, direct food product, dried and spiced. It is used locally for different purposes in different countries. It is used as a supplement or sweetener in many foods, especially in East Asian countries. In our study, in addition to the nutritional properties of the plant, its medicinal properties were emphasized. As a result of the research, it was determined that the plant has many biological activities such as antioxidant, antimicrobial, antiinflammatory, antihyperglycemic, antiulcer, DNA protective, cytotoxic, anthelmintic, antiepimastigote, antiviral, immunomodulative, radioprotective, hepatoprotective, antidiabetes, antitumor, antiproliferative, antistress, hypoglycaemic, antimutagenic, or antiaging. In addition, it stands out with its nutritional properties. It is thought that it may be a natural source for the compounds reported in the literature data. Based on these studies, it is thought that Momordica charantia may be an important natural agent.","PeriodicalId":295830,"journal":{"name":"Prospects in Pharmaceutical Sciences","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124338018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Overview of cyclodextrins and medicinal products containing cyclodextrins currently registered in Poland 目前在波兰注册的环糊精和含有环糊精的药品概述

Prospects in Pharmaceutical Sciences Pub Date : 2023-08-03 DOI: 10.56782/pps.161

Ewa Napiórkowska

{"title":"Overview of cyclodextrins and medicinal products containing cyclodextrins currently registered in Poland","authors":"Ewa Napiórkowska","doi":"10.56782/pps.161","DOIUrl":"https://doi.org/10.56782/pps.161","url":null,"abstract":"Cyklodekstryny należą do cyklicznych oligosacharydów o unikalnych zdolnościach do tworzenia niekowalencyjnych kompleksów inkluzyjnych typu gospodarz-gość z wieloma cząsteczkami o właściwościach hydrofobowych, w tym także lekami. W efekcie mogą poprawiać rozpuszczalność wiązanych cząsteczek, a także zwiększać ich stabilność. Liczne zastosowania cyklodekstryn, m.in. w produkcji żywności, przemyśle kosmetycznym oraz naukach farmaceutycznych, świadczą o ich uniwersalności. Przeanalizowanie potencjału cyklodekstryn w naukach farmaceutycznych stwarza nowe możliwości poprawy właściwości fizykochemicznych leków, tworzenia nowych formulacji, projektowania systemów dostarczania leków, a także rozwoju innowacyjnych metod leczenia. Celem pracy było zebranie najważniejszych aspektów dotyczących cyklodekstryn, w tym ich budowy, sposobu tworzenia kompleksów inkluzyjnych, zastosowania w przemyśle farmaceutycznym, a także bezpieczeństwa stosowania cyklodekstryn. Artykuł obejmuje także przegląd dostępnych produktów leczniczych zarejestrowanych w Polsce zawierających w swoim składzie cyklodekstryny, wraz ze wskazaniami do ich stosowania oraz podaniem postaci farmaceutycznych. Różnorodność dostępnych produktów leczniczych podkreśla potencjał wykorzystania cyklodekstryn w projektowaniu nowych leków.","PeriodicalId":295830,"journal":{"name":"Prospects in Pharmaceutical Sciences","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127249863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Thiamine: overview of history of discovery, mechanism of action, role and deficiency 硫胺素:发现的历史，作用机制，作用和缺乏的概述

Prospects in Pharmaceutical Sciences Pub Date : 2023-07-27 DOI: 10.56782/pps.159

E. Napiórkowska

{"title":"Thiamine: overview of history of discovery, mechanism of action, role and deficiency","authors":"E. Napiórkowska","doi":"10.56782/pps.159","DOIUrl":"https://doi.org/10.56782/pps.159","url":null,"abstract":"Thiamine is the first water-soluble vitamin to be discovered that acts as a cofactor of several important enzymes. Vitamin B1 plays an essential role in obtaining energy in carbohydrates metabolism and substrates production which are further used as neurotransmitters, nucleic acids, and coenzymes. The aim of this work was to give a summary of various aspects related to thiamine including a rich history of the discovery, synthesis, role in human organism, mechanism of action and also the consequences of its insufficient intake leading to beriberi disease. The study takes into consideration pharmaceutical aspects like main sources of vitamin B1, its absorption, nutrient recommendations, interaction with drugs and the variety of formulations available in treating its deficiency. Understanding the role of vitamin B1 in cellular metabolism shows its significance in maintaining health and emphasizes the importance of ensuring adequate dietary intake to maintain the proper functioning of the nervous and cardiovascular systems. Although thiamine deficiency is less common in developed countries, it can be still observed due to poor diet intake, alcoholism, and certain medical conditions which reduce absorption, e.g. celiac disease. Overall, all mentioned aspects make the problem of its deficiency still present and important. Performing an overview of various aspects related to thiamine deficiency can help to properly diagnose or even to prevent an insufficient intake of vitamin B1 among patients with specific medical conditions.","PeriodicalId":295830,"journal":{"name":"Prospects in Pharmaceutical Sciences","volume":"226 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116603459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0