Koomesh journal最新文献

{"title":"Effects of forced exercise on object location memory and anxiety behaviour in morphine dependent ovariectomized rats","authors":"Abbas Ali Vafaei, Farinaz Haghayegh Khorasani, Z. Seraj, H. Miladi-Gorji, A. Rashidy-Pour","doi":"10.29252/KOOMESH.22.4.704","DOIUrl":"https://doi.org/10.29252/KOOMESH.22.4.704","url":null,"abstract":"Introduction : Previous findings from our laboratory indicated that exercise alleviates the deficits in cognitive and anxiety disorders in healthy female rats. But the effect of exercise on cognitive and anxiety disorders induced by chronic morphine in experimental monopose of rats (ovariectomized) not known. Aim of this study was to investigate the effects of mild and modorate forced exercise on anxiety-like behaviors, and object location memory in ovariectomized of morphine-dependent rats during spontaneous withdrawal period. Materials and Methods : Sham or ovariectomized rats were injected with bi-daily doses (10 mg/kg, at 12 h intervals) of morphine or saline over a period of 10 days. Then the rats were trained under mild and moderate exercises for 30 minute in a session of five days per week for four weeks. Then object location memory, and anxiety profile in elevated plus maze (EPM) were examined. Results: Chronic morphine induced the anxiogenic-like behaviours (reductions in time spent, and entry into the EPM open arm) in intact, but not ovariectomized rats, which alleviated by both mild and moderate treadmill exercise. Also, both mild and moderate exercise produced anxiolytic behaviours in the non-morphine depedent intact and ovariectomized rats. Chronic morphine did not change object location memory in the intact and ovariectomized rats. Meanwhile, moderate exercise enhaced spatial location memory in non-morphine dependent, but not morphine dependent intact and ovarietomized rats. Conclusion: In general, our findings demostrate that sex ovarian hormones modulate the effects of chronic morphine on congnitive function and anxiety behaviour. It seems the nature of this interaction is complex and needs further investigation.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"17 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113937319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of home visit on perceived social support of mothers and the continuation of exclusive breastfeeding: A randomized clinical trial study","authors":"Z. Bayati, M. Jamshidimanesh, M. Hasani, B. Afshar","doi":"10.29252/KOOMESH.22.4.581","DOIUrl":"https://doi.org/10.29252/KOOMESH.22.4.581","url":null,"abstract":"Introduction : Exclusive breastfeeding does not continue until six months in many places. It is seem, many factors are involved. The interventions for increase mothers’ social support during breastfeeding could be effective. The aim of this study was to examine effect of home visit on social support and the continuity exclusive breastfeeding in Bokan city from kurdestan province. Materials and Methods : In this research, 108 mothers which have 3-5 day’s old neonates that were referred to 8 health care centers of Bokan (Iran). They were entered into the study by random allocation using randomized block design and were divided into intervention and control groups. The intervention consisted of six home-based training programs of about 30 minutes. The instruments used included demographic questionnaire and midwifery history, perceived social support tool of Zimet, and a researcher-made questionnaire on exclusive breastfeeding. Results: Most mothers in the intervention group continued exclusive breastfeeding until the fourth month, and the majority in the control group continued exclusive breastfeeding until the first and second months. In general, the mean number of breastfeeding months in the intervention group was 3.15±1.01 months and in the control group 1.71±0.906 months. Also, most people in the intervention group (76%) had more than 8 times breastfeeding per day, while most mothers in the control group (88%) had less than 8 times breastfeeding. Mothers’ perception social support score were not significant difference in two groups. Conclusion: Home visit and follow-ups have led to a long-term exclusive breastfeeding and more often overnight, so it's possible to set up such plans to enhance breastfeeding status. Home visit did not effect on mothers’ perceive social support and fathers’ attitude. It is seem to need future further interventions in this field with long time follow up and qualitative study with influence in deep layer in culture people in Bokan city.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133325375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of health communicators program in promoting of community knowledge, attitude and practice in Iran through educational interventions: A systematic review","authors":"F. Gharibi, Sayed Saeed Kassaeian, M. Kahouei, Ali Vailnezhadi","doi":"10.29252/koomesh.22.4.563","DOIUrl":"https://doi.org/10.29252/koomesh.22.4.563","url":null,"abstract":"Introduction : Community participation in health programs is essential for their success, and community health volunteers (CHVs) program is a favored form of participation. Given that three decades have passed since the launch of the Health Communicator Program (as a form of health volunteers) in Iran and the importance of evaluating its achievements, the purpose of this study was to evaluate the effectiveness of health communicators program in promoting knowledge, attitude and practice of community health thorough educational interventions. Materials and Methods : This is a systematic review and its literature review was conducted in February of 2020. The search of resources was conducted using ‘community health communicator’, ‘community health volunteer’, and ‘Iran’ in PubMed, Scopus, Web of Sciences and their Persian equivalent in SID, Magiran and Elmnet database/ search engine. The number of 13558 was obtained from this search, which finally the number of 15 articles was included in study and their quality were appraised. In continue, the related contents of included articles were reported as extraction and comparative tables, and final conclusion was done based on them. Results: The health communicators program in Iran had good positive effect health knowledge and attitude of community in different health areas but this program has not been successful in improving community health performance/behavior. Assessing the targeted areas to improve in community health performance through provided educational interventions by CHVs in the final included articles showed that from 34 targeted health areas, CHVs have succeeded in promoting six areas, only. Conclusion: The health communicators' program needs to be promoted or replaced with a more effective one in community participation due to its low impact on community health behavior.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"75 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129353658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bremsstrahlung imaging from the liver using the Monte Carlo simulation","authors":"H. Rajabi, H. T. Ahangari","doi":"10.29252/koomesh.22.3.497","DOIUrl":"https://doi.org/10.29252/koomesh.22.3.497","url":null,"abstract":"Introduction to localize the radionuclide within of the lesion. Secondary scattering of gamma rays of higher energy and bremsstrahlung causes contamination in the energy window and reducing the contrast and resolution of the images and the quantization validation of the images cannot be performed. Therefore, the accuracy of scatter correction methods is of great importance. The method involves the use of energy window, empirically selected broad bremsstrahlung energy to enhance the signal to noise ratio and a wiener restoration filter to compensate for system blur. Materials and Methods : To simulate and validate the system, a water bottle containing Phosphorus-32 (P32) radio was taken. GATE package was used to determine the spectrum of bremsstrahlung radiation from P32 inside the liver and Zubal phantom was used to model a liver. Importantly, simulations were performed in the presence of a collimator without collimator and the collimator function was calculated. Zubal Phantom was also used to model liver imaging. The Wiener filter was used as a resolution adjuster. Results: Despite the small number of electrons reaching the collimator, a considerable spectrum is produced. Collimator function and simulated liver image were calculated. No significant change in resolution was observed after using the Weiner filter. Conclusion: The energy spectrum of the beams was altered after collimation to the collimator. Also, the shape of the energy spectrum was influenced by the type of tissue and size of the patient. The results had shown that planar gamma camera imaging and quantitation of P32 can be done. There is no compelling reason to suggest that the Wiener filter is useful in planning a Plane. Nuclear Medicine, Bremsstrahlung, Monte Carlo, Liver, Phosphorus-32.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116859647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-cancer and anti-bacterial effects of crude venom of Pseudocerastes persicus snake","authors":"J. Zargan, Majid Mirzaei nodushan, H. Sobati, H. Goodarzi, A. H. Mohammadi, F. Ebrahimi","doi":"10.29252/koomesh.22.3.518","DOIUrl":"https://doi.org/10.29252/koomesh.22.3.518","url":null,"abstract":"كچ ي هد :فده رتکاب تمواقم ي اه ي ب ي رام ي تنآ هب از ي ب ي تو ي ک ناونع هب اه ي ک ي مومع تشادهب مهم تلاکشم زا ي هدش شرازگ ناهج رد قحت .تسا ي تاق خا ي ر خرب رهز هک تسا هداد ناشن ي زا اهرام ي مس ي اراد ي لاعف ي ت م دض ي بورک ي روموت دض و ي م ي دشاب زا فده . ا ي ن سررب هعلاطم ي لاعف ي ت رتکاب دض ي ا يي رهز رام ا رادخاش ي نار ي لع رب ي ه Escherichia coli ، Bacillus subtilis و Staphylococcus","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125257559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of the attitude of patients participating in narcotics anonymous program and undergoing methadone maintenance therapy towards substance abuse","authors":"N. Sotodehasl, Saeed Mahigir, Fatemeh Paknazar, M. Mirmohammadkhani","doi":"10.29252/koomesh.22.3.550","DOIUrl":"https://doi.org/10.29252/koomesh.22.3.550","url":null,"abstract":"Introduction : Narcotics Anonymous (NA) program includes some meetings to extend the continuity of giving up addiction in patients after detoxification. The purpose of this study was to evaluate the attitudes of patients undergoing methadone maintenance therapy in comparison with narcotics anonymous towards drug abuse. Materials and Methods : In this comparative-analytical cross-sectional study which was accomplished in Semnan, Iran, 90 single males 20 to 40 years old participated in the study as three balanced groups including Methadone Maintenance Therapy (MMT), NA and a group without past-history of drug use as controls were studied. To measure attitude, the questionnaire \"Drug Attitude Questionnaire\" was used. Results: Findings showed that the difference between the three groups was significant in terms of attitude score in general and subscales of effects, risks and consumption, so that in the MMT group it was more and in the NA group it was less unfavorable than the other two groups ( P <0.001). Conclusion: Comparing to MMT, participation in the NA meetings may promote or improve the attitude of the patents towards drug abuse more.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124036108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of endurance training in \u00006-hydroxydopamine rat model of Parkinson’s disease","authors":"Z. Rezaee, S. M. Marandi, H. Alaei, F. Esfarjani","doi":"10.29252/koomesh.22.3.556","DOIUrl":"https://doi.org/10.29252/koomesh.22.3.556","url":null,"abstract":"Introduction : Parkinson’s disease (PD) is characterized by progressive dopamine depletion in the striatum, and leads to mitochondrial and motor disorders. The present study investigated the effect of moderate endurance training on motor disorder and mRNA expression of PPAR-γ, PGC-1α and BDNF in 6-hydroxydopamine (6-OHDA) rat model of PD Materials and Methods : Thirty two male Wistar rats were divided into 4 eqaul groups: 1. Vehicle (Sham), 2. Vehicle + endurance training, 3. 6-OHDA and 4. 6-OHDA + endurance training. The PD model obtained by unilateral injection of 6-OHDA (8µg/2µl) into the medial forebrain bundle, and the sham group recevied vehicle alone. Two weeks after the surgery, endurance training groups ran on a treadmill 30 min per day for 30 days. Six weeks after the surgery, the rat’s rotations due to apomorphine injection and hippocampal mRNA expression of PPAR-γ, PGC-1α and BDNF were analyzed using Real Time-PCR. Results: 6-OHDA lesioned rats showed increased rotations ( P ≤0.001), decreased expression of PPAR-γ and BDNF mRNA and compensatory increased in PGC-1α mRNA. Edurance training improved both behavioural and molecular changes. Conclusion: It seems that endurance training can reduce motor disorder and defects in expression of the mitochondrial factors in Parkinson’s disease.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114696293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of mindfulness based cognitive therapy on disability, thickness of the lumbar multifidus muscle, fear avoidance beliefs and metacognitive beliefs in the subjects with non-specific low back pain","authors":"Z. S. Farokhi, A. A. far, A. Ziari, Mahboubeh Rahmati, Sajad Khorasani","doi":"10.29252/koomesh.22.3.483","DOIUrl":"https://doi.org/10.29252/koomesh.22.3.483","url":null,"abstract":"Introduction : Non-specific chronic low back pain is a large and costly musculoskeletal problem. It is affected by biological and psychological factors. There is preliminary evidence that mindfulness based cognitive therapy might be beneficial in chronic low back pain. The purpose of this study was to investigate the effect of Mindfulness based cognitive therapy in combination with stability exercise on thickness of the lumbar multifidus muscle, disability, fear avoidance beliefs and metacognitive beliefs in patients with non-specific chronic low back pain. Materials and Methods : This clinical trial study was performed on 40 non-specific chronic low back pain participants aged between 18-45 years. The participants were randomly assigned in two intervention and control groups. The scores of fear of pain, fear of movement, disability and metacognitive beliefs questionnaires were recorded. Correspondingly, the thickness of the lumbar multifidus muscle at the level of the L5 vertebra was measured by ultrasonography. The control group performed 8 sessions of stability exercises within 8 weeks (3 repetitions per week). The intervention group received stability exercises as mentioned above and mindfulness based cognitive therapy for 8 weeks (2 repetitions per week). At the end of the 8 weeks intervention, the variables immediately were assessed in both groups. Results: The results showed that there was no significant between-group difference on effect lumbar multifidus muscle thickness ( P =0.76); but there were significant reduction in the avoidance of fear (fear of pain and fear of movement), disability, and meta-cognitive beliefs in the intervention group compared to the control group. ( P = 0.000) Conclusion: Psychological factors associated with pain is one of the factors of low back pain continuation. The combination of mindfulness based cognitive therapy and stability exercises can help to further improvement of low back pain.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132068466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a relationship between body mass index and postural deviations in overweight and obese powerlifting athletes?","authors":"Cyrus Taghizadeh Delkhoush, Hadi Fahrvandi, R. Ghorbani","doi":"10.29252/koomesh.22.3.461","DOIUrl":"https://doi.org/10.29252/koomesh.22.3.461","url":null,"abstract":"to one of two groups based on their body mass index, 25 athletes for obese group (BMI: ≥ 30) and 50 athletes for overweight group (BMI: 25-29.9). The Sagittal and Frontal planes were photographed using a plumb line and a symmetrograph®, and then deviations of the postural key points were investigated on the images. Results: Athletes in both groups only had normal posture in the head, cervical and lumbar vertebral levels in the frontal plane, and also the deviations in obese athletes in the sagittal plane at the level of the thoracic vertebral ( P =0.008), and in the frontal plane at the level of the leg ( P =0.019) and the scapula ( P =0.029) were significantly lower than those of overweight athletes. the obese athletes may be protected against the injurious forces due to the greater muscle mass.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114967069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of fibromodulin protein expression on NFkB and TGFβ signaling pathways in liver cancer cells","authors":"S. Khatami, F. Tavakoli, H. Bagheri, Reza Salarinia, Amirreza Hesari, F. Ghasemi","doi":"10.29252/koomesh.22.3.529","DOIUrl":"https://doi.org/10.29252/koomesh.22.3.529","url":null,"abstract":"Introduction: The incidence rate of liver cancer is continuously increasing. Currently, gene therapy is applied to improve various medical issues such as cancer treatment approaches. Correspondingly, fibromodulin involves in many biological and physiological processes through interaction with growth factors and signaling pathway receptors. The aim of this study was to investigate the effects of fibromodulin gene expression on NF-kB and TGF-β signaling pathways in liver cancer cells in order to investigate the molecular pathway genes involved in this cancer. \u0000Materials and Methods: Huh-7 human liver cancer cells were cultured and the effect of fibromodulin on cell growth and proliferation was assessed using MTT assay. Then, fibromodulin gene was transfected into cells using lipofectamine and the expression of SMAD2 / 3 and TGF-β genes were investigated by Real-Time PCR method. \u0000Results: The effect of fibromodulin on TGF-β and SMAD 2/3 expression genes was evaluated in liver cancer cell line. Fibromodulin down-regulated the TGF-β and NF-kB pathways in transfected cells, compared to the control. Also, MTT results demonstrated that treatment with fibromodulin increased growth and proliferation of Huh-7 cell line in a dose-dependent manner. \u0000Conclusion: According to the results of the study, fibromodulin significantly decreased the expression levels of TGF/β and NF/kB pathway genes in liver cancer cell line. Furthermore, growth and proliferation of liver cancer cells were increased after treatment with fibromodulin. It seems that fibromodulin gene has anticancer effects on liver cancer cells.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123743244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}