Koomesh journal最新文献

{"title":"Fractal dimension analysis and surface topography mapping to investigate the effects of low-level laser therapy on the physical behavior of osteosarcoma MG-63 cells","authors":"Amin Barati Shoorche, Alireza Mohammadkarim, M. Jadidi, M. Bahraminasab, H. Sameni","doi":"10.52547/koomesh.23.5.548","DOIUrl":"https://doi.org/10.52547/koomesh.23.5.548","url":null,"abstract":"Introduction : Previous studies indicated that the low-level laser therapy has an effective role in modulation behavior of human osteosarcoma cells, which leads to change of cell proliferation, differentiation and adhesion. The aim of this study was to evaluate the effects of low-level laser therapy on the biophysical behavior of osteosarcomas based on the surface topographic mapping and fractal dimension analysis. Materials and Methods : Human osteosarcoma MG-63 Cells were cultured in DMEM-F12 with 10% FBS and were exposed by laser beams after reaching to confluence of 80% in the fourth passage. The lasers with characteristics of 532nm with the power of 25mW, 650nm with powers of 3mW and 150mw and 780nm with the power of 70mW were implemented for irradiation within 8 minutes and cell proliferation was assessed 72h after exposure time. In the next step, cell size changes in three dimensions were evaluated by using surface topographic mapping with atomic force microscopy and confocal imaging and fractal dimension analysis was performed by using the processing of confocal images. Results: The laser irradiation causes significant changes in proliferation, height, perimeter and area of osteosarcomas. Moreover, except 3mW laser, all of them create significant changes in fractal dimension compared with the non-irradiated cells. Conclusion: Assessing the fractal dimension besides the evaluation of three-dimensional cell sizes can be considered as a reliable index for the prognosis of the osteosarcomas response to low-level laser therapy.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127160485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of fenofibrate on plasma level of BDNF and brain oxidative stress markers in pentylenetetrazole-induced kindling seizure in mice","authors":"N. Sarahian, M. Mohammadi, Shima Shahyad, M. Rezaei","doi":"10.52547/koomesh.23.5.636","DOIUrl":"https://doi.org/10.52547/koomesh.23.5.636","url":null,"abstract":"Introduction : The neuroprotective effect and pleiotropic functions of PPARα agonists (peroxisome proliferator activated receptor-alpha) such as fenofibrate and bezafibrate have been demonstrated by the previous studies. The current study evaluated the antiepileptic effects and neuroprotective functions of fenofibrate in pentylenetetrazole (PTZ)-induced kindling seizure in mice. Materials and Methods : Adult male NMRI mice were randomly assigned into three groups (n=8): Control, untreated kindled mice and fenofibrate-treated kindled animals. Repeated intraperitoneal injections of PTZ (45 mg/kg) once every 48 hours were used to develop the kindling seizure for 21 days. Treated mice were administered orally fenofibrate at doses of 30 mg/kg/day. Plasma level of brain-derived neurotrophic factor (BDNF), brain level of malondialdehyde (MDA) and histopathological changes were evaluated at termination of the study. Results: Fenofibrate administration considerably improved the seizure latency in treated kindled mice. Fenofibrate significantly ( P <0.05) decreased plasma BDNF level in treated kindled mice (12.06±0.08 ng/mL) compared to PTZ group (13.43±0.20 ng/mL). Treatment with fenofibrate significantly ( P <0.05) decreased MDA level of brain by 68% in treated kindled mice compared to PTZ group. In addition, fenofibrate improved the histopathological damages in treated kindled animals. Conclusion: Fenofibrate ameliorated the plasma level of BDNF and brain level of MDA accompanied with the brain histopathological damages in kindling seizure in mice that might be associated to improving the seizure behaviors.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"419 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124204718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of total body resistance exercise on sexual function and quality of life in female with multiple sclerosis","authors":"A. Moghadasi, G. Ghasemi, Maryam Abbsi","doi":"10.52547/koomesh.23.5.627","DOIUrl":"https://doi.org/10.52547/koomesh.23.5.627","url":null,"abstract":"Introduction (QOL) Recent emphasize on functional suspension training using body weight resistance against gravity. the purpose of this study was to determine the effect of total body resistance exercise (TRX) on sexual function and QOL in patients with MS. Materials and Methods : Among 93 female patients referred to Isfahan Multiple Sclerosis Society (IMSS) 34 females in the age range of 20 to 50 years with expanded disability status scale of 1-4 were selected as a statistical sample. The participants were intentionally selected into two of control (n=15) and experimental (n=19) groups. The experimental group received the TRX program for 8 weeks and the control group received their usual care. Results: The results showed that there was a significant improvement in physical function ( P =0.001), role limitations due to physical problems ( P =0.001) and emotional ( P =0.015), physical health ( P =0.018), sexual function ( P =0.018) and sexual satisfaction ( P =0.040) of the experimental group compared to the control group. However, no significant differences were found n relation to pain ( P =0.485), emotional well-being ( P =0.468), energy ( P =0.459), health perceptions ( P =0.600), social function ( P =0.116), cognitive function ( P =0.896), concern about their health distress ( P =0.118) and mental health ( P =0.091), between the two groups. Conclusion: TRX has the necessary components to improve the physical dimensions of quality of life and sexual function of patients with MS.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128576679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Yoga practice and immersion in cold water on blood lactic acid levels during recovery phase after Cunningham treadmill test in football players","authors":"S. M. Khatami, M. Rashidi, Mohammad Reza Heidarian","doi":"10.52547/koomesh.23.5.607","DOIUrl":"https://doi.org/10.52547/koomesh.23.5.607","url":null,"abstract":"Introduction : Fatigue occurs during strenuous exercise in response to the accumulation of lactic acid in active muscles and blood. The aim of this study was to compare two training methods (immersion in cold-water pond and yoga technique) on blood lactate during the return phase to the original state after a grueling exercise. Materials and Methods : 45 male soccer players were randomly divided into 3 equal groups and performed 15 minutes of recovery in cold-water immersion at 10 ° C and performing yoga techniques and passive rest (control) immediately after Cunningham intensive execise test. Blood lactate levels before, immediately, 5 minutes and 15 minutes after test in three the group was measured. Results: A significant increase in blood lactate levels immediately after exercise compared to baseline levels was observed in all groups ( P <0.05). Significant differences were observed in blood lactate levels at 5 and 15 minutes of recovery compared to baseline levels in the two groups than control group ( P <0.05). A significant decrease in blood lactate after 5 minutes in the immersed group and 15 minutes in the yoga group was more than the other groups. Conclusion: Both methods are able to return the levels of blood lactate to the original state. However, the highest reduction in blood lactate was found at 5 min after immersing in pond of cold water, and at 15 min after the yoga practice.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126418186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of topical rosemary ointment on the phlebitis and peripheral vascular catheter infection in children","authors":"Jamal Bahramsari, M. Kazemi, Azade Nasrollah nezahad, T. Sadeghi","doi":"10.52547/koomesh.23.5.665","DOIUrl":"https://doi.org/10.52547/koomesh.23.5.665","url":null,"abstract":"Introduction of peripheral vascular is phlebitis. According to the anti-inflammatory role of Rosemary, this study aimed to determine the effect of rosemary ointment on the phlebitis and infections caused by peripheral vascular catheter in children admitted to the pediatric ward. Materials and Methods : This double-blind clinical trial study was conducted on 96 children admitted at pediatric ward of Ganjavian Hospital in Dezful, Iran in 2017. Children were randomly divided into intervention and control groups using permuted block randomization. In the intervention group, 0.5 cc of rosemary ointment was used and in the control group Eucerin ointment was used in the distal IV cannula site. IV cannula site was monitored for every 12 hours for up to 72 hours for control phlebitis and every 24 hours was cleaned and re-ointment was used. If the phlebitis was detected, the IV cannula was isolated sterilized and sent to the laboratory for culture. Results: Catheter survival time in the intervention group was 9.98 hours higher than the control group ( P =0.027) and the incidence of phlebitis in the control group (37.5%) was higher than the intervention group (18.8%) ( P =0.034). There was no significant difference in the catheter cannulation in the culture medium between the two groups ( P =0.213). Conclusion: Local application of rosemary ointment can reduce the incidence of phlebitis due to intravenous catheter in children, therefore, it is recommended as a substitute for reducing phlebitis.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"96 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132226517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of resistance training on general health, happiness and its correlation with glycemic control in diabetic men with peripheral neuropathy","authors":"F. Miri, F. Gholami, Mansore Mokaberian","doi":"10.52547/koomesh.23.4.433","DOIUrl":"https://doi.org/10.52547/koomesh.23.4.433","url":null,"abstract":"Introduction : Painful diabetic neuropathy may have psychological consequences and lower quality of life and happiness in this population. The aim of the present study was to investigate the effect of circuit resistance training on general health, happiness and its correlation with glucose control in diabetic men with peripheral neuropathy. Materials and Methods : In the present clinical trial study, 30 diabetic men with peripheral neuropathy were randomly divided into experimental (n=15) and control (n=15) groups based on the level of neuropathy. The experimental group performed a circuit resistance-training program (50%-60% of 1RM, 3 sessions a week) over 12 weeks. Before and 48 hours after the experimental period, body composition was measured and blood samples were collected in a fasting state. Furthermore, General Health Questionnaire (GHQ-28) and Oxford Happiness Inventory (OHI) assessed general health and happiness, respectively. Results: HbA1c level significantly decreased in the experimental group compared with the control group ( P =0.04). In addition, general health and happiness significantly improved in the experimental group compared with the control group ( P =0.0001 and P =0.001, respectively). Importantly, Pearson’s correlation also indicated a significant correlation between happiness with HbA1c (r=-0.4 and P =0.02) and general health with HbA1c (r=0.36 and P =0.04). Conclusion: Based on the results, diabetic patients with peripheral neuropathy may benefit from glucose-lowering effect of resistance training, which was coupled with improved general health score and happiness.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122683678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associacion between blood sugar control on unstimulated saliva and Xerostomia","authors":"M. Jalili Sadrabad, Seyed Habibollah Hashemian, R. Ghorbani, Shabnam Sohanian","doi":"10.52547/koomesh.23.4.489","DOIUrl":"https://doi.org/10.52547/koomesh.23.4.489","url":null,"abstract":"","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125587604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the prevalence of musculoskeletal disorders and postural status and ergonomic risk factors in the workplace","authors":"A. Salehi Sahl Abadi, Hamideh Bidel, H. Rabiei, Seyed Hojjat Moosavi_Kordmiri, F. Ábbasi Balochkhaneh","doi":"10.52547/koomesh.23.4.494","DOIUrl":"https://doi.org/10.52547/koomesh.23.4.494","url":null,"abstract":"Introduction : Musculoskeletal disorders are one of the most common causes of occupational injuries and known as the most common cause of absenteeism. The aim of this study was to investigate the prevalence of musculoskeletal disorders and ergonomic risk factors in one of the faculty of Shahid Beheshti University of medical sciences. Materials and Methods : This cross-sectional descriptive study was done between 108 administrative staff (n=57) and professors (n=51 people) in one faculty of Shahid Beheshti University of Medical Sciences in 2020. Nordic standard questionnaire, comprehensive ergonomic checklist for office work environments and rapid assessment of administrative stress (ROSA) were used. Results: The results of the study showed that the highest prevalence of pain or discomfort in a recent year was in the shoulder (50%) and leg (50%). The evaluation by ROSA method showed that 34% of the subjects were in the area of need for ergonomic intervention. Remarkebly, there was also a significant relationship between the final score of ROSA and the three main parts of the ergonomic checklist ( P <0.05). Conclusion: Given the association between prevalence of musculoskeletal disorders and workplace ergonomic risk factors, control measures should be taken to improve risk factors.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129992881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibody titers of PEG-PLA block copolymer nanosphere containing chimeric recombinant protein of protective antigen and lethal factor of Bacillus anthracis","authors":"H. Honari, M. Minaei, H. Mirhaj, Seyyed Masih Etemad- Ayoubi","doi":"10.52547/koomesh.23.4.441","DOIUrl":"https://doi.org/10.52547/koomesh.23.4.441","url":null,"abstract":"chimeric containing domain 1 lethal factor domain 4 protective of Bacillus anthracis in copolymer nanocapsules to the problems caused by existing vaccines and to the efficiency of the proposed Materials and Methods : In this experimental study, dual solvent evaporation method was used to produce nanocapsules containing chimeric recombinant protein of protective antigen and lethal factor of Bacillus anthracis. Zeta potential of nanoparticles, nanoparticle loading efficiency, recombinant protein release pattern, potential effect of poly (lactic acid)- poly (ethylene glycol) nanoparticle (PLA-PEG) production on the viability of recombinant proteins were investigated. Mice were used as test and control samples for antibody production and immune response evaluation. Results: The mean antibody titer produced against chimeric proteins loading was significantly different from that of free antigens. Correspondingly, the difference in antibody titer was significant between the groups of one and two times’ injection of loading and free antigens and the most antibody titer was related to two times injections of loading antigens. In addition, there was a significant difference between one times injection of loading and the free antigens. This suggests that the loading chimeric antigen on PLA-PEG nanoparticles and one time injection (instead of four times injections) could produce more antibodies. Conclusion: The results of this study showed that the domain 4 protective antigens and the domain 1 lethal factor of Bacillus anthracis could chimeric with each other and produced the active antigen. This chimeric antigen (LFD1-PA4) is active and able to inducing the animal's immune system. In addition, nanocarriers containing controlled release antigens can induce the immune system of the animal.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116627889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of anxiety symptoms in preschoolers with and without autism spectrum disorder","authors":"S. Behzadpoor, H. Pouretemad, Saeed Akbari-Zardkhaneh, Soheil Sardari","doi":"10.52547/koomesh.23.4.425","DOIUrl":"https://doi.org/10.52547/koomesh.23.4.425","url":null,"abstract":"Introduction : Anxiety symptoms have been reported in children with autism. However, most studies have focused on school-aged children and early anxiety symptoms in preschoolers with autism and their comparison in groups of children with different symptom severity and normal children have been less addressed. So, this study sought to compare total anxiety and anxiety symptoms in children with mild, moderate and severe autism symptom severity and typically developing children. Materials and Methods : The research design is descriptive ex post facto and takes up the form of a cross-sectional study. In this study, four sample groups including 25 children with mild autism symptoms, 25 children with moderate autism symptoms, 21 children with severe autism symptoms and 25 typically developing children participated in the study. Data were collected using the Gilliam Autism Rating Scale-Second Edition (GARS-2) and Preschool Children Anxiety Scale. Results: The results of univariate and multivariate analysis of variance showed that there was a significant difference between four groups in total anxiety and symptoms of generalized anxiety disorder, social anxiety and separation anxiety ( P <0.001). The group of children with moderate and severe autism were not significantly different in total anxiety and anxiety symptoms ( P =0.99). There was no significant difference between four groups in specific phobias ( P <0.05). Also, the results of Scheffe post hoc test showed that the group of children with mild autism experienced higher levels of total anxiety, social anxiety and generalized anxiety than the group of children with severe and moderate autism and children with typically developing children ( P <0.001). Separation anxiety was higher in children with mild autism and children with typically developing children than the other two groups ( P <0.001). Conclusion: Our findings indicates that as the severity of autism symptoms increases, their cognitive abilities decrease in these children and their anxiety levels decreases. Accordingly, it seems that the experience of anxiety requires some cognitive skills and levels of cognitive development that are deficient in children with moderate and severe autism.","PeriodicalId":291099,"journal":{"name":"Koomesh journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125708513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}