{"title":"2.1.3 Gold/Organocatalyst Dual Catalysis","authors":"X. Shi, J. Wang","doi":"10.1055/sos-sd-232-00041","DOIUrl":"https://doi.org/10.1055/sos-sd-232-00041","url":null,"abstract":"Since the beginning of the 21st century, gold catalysis and organocatalysis have become two important branches in modern synthetic methodology thanks to the tremendous efforts the synthetic chemistry community have devoted to these two fields. While gold catalysis demonstrates superior capability in the activation of C-C multiple bonds, organocatalysis has been a remarkable tool for the activation and functionalization of carbonyl compounds, such as aldehydes and ketones, in a stereoselective fashion. Combining these two powerful, yet complementary, catalytic modes in a dual-catalytic manner will lead to even more-efficient and sophisticated catalytic systems and, thus, dual gold/organocatalysis has become a hot topic in the past decade. In this chapter, a summary of reported examples of dual gold/organocatalysis are discussed, including gold/aminocatalysis, gold/Brønsted acid catalysis, and gold/hydrogen-bonding catalysis.","PeriodicalId":287506,"journal":{"name":"Dual Catalysis in Organic Synthesis 2","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114752282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2.1.1 General Principles of Metal/Organocatalyst Dual Catalysis","authors":"Z. Shao, Y.-H. Deng","doi":"10.1055/sos-sd-232-00001","DOIUrl":"https://doi.org/10.1055/sos-sd-232-00001","url":null,"abstract":"Metal/organocatalyst dual catalysis is a privileged catalytic strategy which involves both a metal-based catalyst and an organocatalyst to catalyze the organic transformation. Based on the type of activation of substrates with both catalysts, there are seven kinds of dual catalysis; namely cooperative catalysis, cascade catalysis, sequential catalysis, double activation catalysis, restorative catalysis, bifunctional catalysis, and multiple relay catalysis. The generic activation of the metal-based catalyst and the organocatalyst applied in the dual-catalytic system is summarized. In these dual-catalytic approaches, the advantages of both metal catalysis and organocatalysis are converged to achieve many transformations that were previously inaccessible or challenging by any single-catalyst paradigm, to develop new reactions, to discover unique reaction mechanisms, and even to allow for stereodivergent synthesis.","PeriodicalId":287506,"journal":{"name":"Dual Catalysis in Organic Synthesis 2","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124829710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2.1.2 Palladium/Organocatalyst Dual Catalysis","authors":"M. Vitale","doi":"10.1055/sos-sd-232-00019","DOIUrl":"https://doi.org/10.1055/sos-sd-232-00019","url":null,"abstract":"This chapter describes the recent development of original asymmetric transformations based on the synergistic merger of palladium catalysis with organocatalysis. Thanks to this association, the orthogonal and complementary activation of different reaction partners has proven to be key to the discovery of efficient enantioselective catalytic processes that would not otherwise be possible. To illustrate this, several selected examples are discussed. The combination of πallylpalladium catalysis with organocatalysis allows a considerable widening of the scope of enantioselective allylic alkylation reactions of carbonyl-containing compounds. Moreover, innovative asymmetric arylation of aldehydes, ketones, and alkenes has also been developed. Finally, palladium/organocatalyst dual catalysis constitutes a unique opportunity for the discovery of new cycloaddition processes.","PeriodicalId":287506,"journal":{"name":"Dual Catalysis in Organic Synthesis 2","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128506463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2.2 Metal/Biocatalyst Dual Catalysis","authors":"M. Diéguez, J. Bäckvall, O. Pàmies","doi":"10.1055/sos-sd-232-00083","DOIUrl":"https://doi.org/10.1055/sos-sd-232-00083","url":null,"abstract":"Chemoenzymatic dynamic kinetic resolution (DKR) and dynamic kinetic asymmetric transformation (DYKAT) processes have become some of the most appealing transformations for the preparation of chiral molecules. In this review, we present the huge advances made in the combination of a metal racemization catalyst and a biocatalyst for the synthesis of enantiopure alcohols, amines, and other relevant compounds.","PeriodicalId":287506,"journal":{"name":"Dual Catalysis in Organic Synthesis 2","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133129904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Parmeggiani, J. Galman, S. L. Montgomery, N. Turner
{"title":"2.6 Dual Catalysis with Two or More Biocatalysts","authors":"F. Parmeggiani, J. Galman, S. L. Montgomery, N. Turner","doi":"10.1055/sos-sd-232-00169","DOIUrl":"https://doi.org/10.1055/sos-sd-232-00169","url":null,"abstract":"The remarkable activity, selectivity, and stability of many commercially available or easily prepared biocatalysts, along with their simple operative conditions and the intrinsic “greenness” of biocatalytic processes, have all contributed to a rapidly accelerating expansion of the research area dedicated to the design and development of one-pot multistep synthetic approaches involving two or more enzymes and/or microbial cells. A brief survey of the literature is presented, focusing mainly on efficient protocols that are generally applicable to a broad range of substrates and relevant to the synthesis of small, often chiral, organic molecules as synthons for the pharmaceutical and fine-chemical industries.","PeriodicalId":287506,"journal":{"name":"Dual Catalysis in Organic Synthesis 2","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128936885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2.1.4 Rhodium/Organocatalyst Dual Catalysis","authors":"F. Cruz, V. Dong","doi":"10.1055/sos-sd-232-00061","DOIUrl":"https://doi.org/10.1055/sos-sd-232-00061","url":null,"abstract":"This chapter reviews the combined use of rhodium and organocatalysis. The combination of two catalysts enables new reactivity and selectivity.","PeriodicalId":287506,"journal":{"name":"Dual Catalysis in Organic Synthesis 2","volume":"149 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133863499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2.4 Organocatalyst/Photocatalyst Dual Catalysis","authors":"K. Zeitler","doi":"10.1055/sos-sd-232-00119","DOIUrl":"https://doi.org/10.1055/sos-sd-232-00119","url":null,"abstract":"Recent advances in dual-catalytic methods combining organocatalysis with (visible-light) photocatalysis are detailed within this chapter. It summarizes general aspects together with selected state-of-the-art procedures, highlighting both pioneering examples and current developments.The merger of organocatalysis with photocatalysis has proven to be enormously powerful, not only because it provides a synthetic platform to readily access radical intermediates within an organocatalytic manifold and its potential to alter the reactivity of typical organocatalytic intermediates, but also due to the new opportunities in asymmetric synthesis. The synergistic dual combination with organocatalysis enables photocatalytic reactions to be conducted in an enantioselective fashion and thereby has had a profound influence on several fields of current chemical research, including radical chemistry.","PeriodicalId":287506,"journal":{"name":"Dual Catalysis in Organic Synthesis 2","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127232393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2.3 Dual Catalysis with Two Organocatalysts","authors":"H. Wang, G. Zhao","doi":"10.1055/sos-sd-232-00208","DOIUrl":"https://doi.org/10.1055/sos-sd-232-00208","url":null,"abstract":"The field of asymmetric organocatalysis has attracted the attention of chemists due to the environmentally benign conditions, particularly for the synthesis of chiral molecules, bioactive compounds, natural products, and drugs. Besides the conventional approaches using a single organocatalyst in asymmetric reactions, dual catalysis with two organocatalysts has emerged as an important strategy for resolving existing challenging problems, including the synthesis of complex molecules, improvement of enantioselectivities, and the development of new catalytic mechanisms. In this review, selected recent examples of the combination of two organocatalysts are covered in detail. Moreover, future perspectives are also described.","PeriodicalId":287506,"journal":{"name":"Dual Catalysis in Organic Synthesis 2","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117215583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2.5 Organocatalyst/Biocatalyst Dual Catalysis","authors":"Y. Yamashita, H. Gröger","doi":"10.1055/sos-sd-232-00103","DOIUrl":"https://doi.org/10.1055/sos-sd-232-00103","url":null,"abstract":"The combination of catalysts from the fields of organocatalysis and biocatalysis toward chemoenzymatic one-pot syntheses is an attractive concept for enabling efficient enantioselective synthetic processes for chiral building blocks without the need for isolation of intermediates, thus avoiding time-consuming as well as waste-producing work-up steps.","PeriodicalId":287506,"journal":{"name":"Dual Catalysis in Organic Synthesis 2","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133568396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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