2.1.2 Palladium/Organocatalyst Dual Catalysis

Abstract

This chapter describes the recent development of original asymmetric transformations based on the synergistic merger of palladium catalysis with organocatalysis. Thanks to this association, the orthogonal and complementary activation of different reaction partners has proven to be key to the discovery of efficient enantioselective catalytic processes that would not otherwise be possible. To illustrate this, several selected examples are discussed. The combination of πallylpalladium catalysis with organocatalysis allows a considerable widening of the scope of enantioselective allylic alkylation reactions of carbonyl-containing compounds. Moreover, innovative asymmetric arylation of aldehydes, ketones, and alkenes has also been developed. Finally, palladium/organocatalyst dual catalysis constitutes a unique opportunity for the discovery of new cycloaddition processes.