Clinical and Experimental Hypertension (New York, N.y. : 1993)最新文献_第4页

Aldehyde dehydrogenase 2 partly mediates hypotensive effect of nitrite on L-NAME-induced hypertension in normoxic rat. 乙醛脱氢酶2部分介导亚硝酸盐对l - name致高血压大鼠的降压作用。

IF 12.3

Clinical and Experimental Hypertension (New York, N.y. : 1993) Pub Date : 2014-01-01 Epub Date: 2013-10-28 DOI: 10.3109/10641963.2013.846355

Kunihiro Sonoda, Kazuo Ohtake, Yoshinori Kubo, Hiroyuki Uchida, Masaki Uchida, Hideshi Natsume, Miya Kobayashi, Jun Kobayashi

{"title":"Aldehyde dehydrogenase 2 partly mediates hypotensive effect of nitrite on L-NAME-induced hypertension in normoxic rat.","authors":"Kunihiro Sonoda, Kazuo Ohtake, Yoshinori Kubo, Hiroyuki Uchida, Masaki Uchida, Hideshi Natsume, Miya Kobayashi, Jun Kobayashi","doi":"10.3109/10641963.2013.846355","DOIUrl":"https://doi.org/10.3109/10641963.2013.846355","url":null,"abstract":"Nitrite has become a topic of interest in the field of medical research because of its potential therapeutic role as an alternative source of nitric oxide (NO). While the bioconversion of nitrite to NO occurs via either nonenzymatic or enzymatic reduction under acidic or hypoxic conditions, little is known about its conversion to NO under normoxic conditions. Because of a recent report of aldehyde dehydrogenase 2 (ALDH2)-catalyzed glyceryl trinitrate (GTN) vasorelaxation by denitration of GTN to 1,2-glyceryl dinitrate (1,2-GDN) and nitrite, we therefore investigated a catalytic activity of ALDH2 for nitrite reduction and subsequent effect on N(ω)-nitro-l-arginine methyl ester (l-NAME)-induced hypertension in normoxic rat. Male Sprague-Dawley rats treated with l-NAME in drinking water for 3 weeks developed hypertension with significantly reduced plasma levels of nitrite and nitrate. The intravenous injection of sodium nitrite lowered the arterial pressure in a dose-dependent manner (17, 50 and 150 μmol/kg). Pretreatment with ALDH2 inhibitors (cyanamide and chloral hydrate) partially inhibited the hypotensive responses to sodium nitrite. In addition, cyanamide significantly delayed the nitrite clearance from plasma and most of the organs examined during the experimental period. These results suggest that ALDH2 may be at least in part involved in nitrite-mediated hypotensive effects and nitrite catalysis in many organs of normoxic rats.","PeriodicalId":286988,"journal":{"name":"Clinical and Experimental Hypertension (New York, N.y. : 1993)","volume":" ","pages":"410-8"},"PeriodicalIF":12.3,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641963.2013.846355","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40270871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Associations between visit-to-visit variability in blood pressure measured in the office and antihypertensive drugs: the J-HOME-Morning study. J-HOME-Morning研究:办公室测得的每次来访血压变异性与抗高血压药物之间的关系

IF 12.3

Clinical and Experimental Hypertension (New York, N.y. : 1993) Pub Date : 2013-01-01 Epub Date: 2013-04-04 DOI: 10.3109/10641963.2013.780070

Taku Obara, Masahiro Kikuya, Yuka Kobayashi, Kazuki Ishikura, Urara Ikeda, Mami Ishikuro, Hirohito Metoki, Nariyasu Mano, Shinichi Kuriyama, Takayoshi Ohkubo, Yutaka Imai

引用次数: 6

The effect of non-dipper and dipper blood pressure patterns on aortic elasticity in patients with metabolic syndrome. 代谢综合征患者血压变化对主动脉弹性的影响。

IF 12.3

Clinical and Experimental Hypertension (New York, N.y. : 1993) Pub Date : 2013-01-01 Epub Date: 2013-04-03 DOI: 10.3109/10641963.2013.776572

Mustafa Kuzeytemiz, Kemal Karaagac, Fahriye Vatansever, Ozlem Arican Ozluk, Mustafa Yilmaz, Burhan Arslan, Tezcan Peker

{"title":"The effect of non-dipper and dipper blood pressure patterns on aortic elasticity in patients with metabolic syndrome.","authors":"Mustafa Kuzeytemiz, Kemal Karaagac, Fahriye Vatansever, Ozlem Arican Ozluk, Mustafa Yilmaz, Burhan Arslan, Tezcan Peker","doi":"10.3109/10641963.2013.776572","DOIUrl":"https://doi.org/10.3109/10641963.2013.776572","url":null,"abstract":"The purpose of this study was to evaluate the effect of blood pressure (BP) rhythm on aortic functions in patients with metabolic syndrome. Seventy patients with newly diagnosed hypertension who fulfilled the metabolic syndrome criteria according to the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP/ATP-III) were evaluated with 24-hour BP holter monitoring. According to BP rhythm, 35 patients with dipper BP pattern and 35 patients with non-dipper BP pattern were enrolled as two groups in our study. Systolic and diastolic diameters of the ascending aorta were measured by M-mode echocardiography and aortic functions (aortic strain, distensibility, and stiffness index) were calculated. The nocturnal systolic and diastolic BPs were significantly higher in non-dipper patients than the dipper group. According to clinical parameters including age, gender, height, weight, body mass index, waist circumference, clinical systolic, and diastolic BPs, we did not find significantly difference between the two groups. Aortic strain was significantly higher (6.63 ± 3.37 vs. 1.81 ± 0.92; P < .0001) and aortic distensibility was lower (2.38 ± 1.18 cm(-2)/dyn/10(-6) and 6.66 ± 3.67 cm(-2)/dyn/10(-6); P < .001) in non-dipper group. These findings suggest that aortic functions were prominently deteriorated in non-dipper hypertensive patients than dippers with metabolic syndrome.","PeriodicalId":286988,"journal":{"name":"Clinical and Experimental Hypertension (New York, N.y. : 1993)","volume":" ","pages":"632-6"},"PeriodicalIF":12.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641963.2013.776572","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40195129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Patients with non-insulin depending diabetes mellitus and metabolic syndrome are suboptimal treated in Swiss primary care. 非胰岛素依赖型糖尿病和代谢综合征患者在瑞士初级保健中治疗效果不佳。

IF 12.3

Clinical and Experimental Hypertension (New York, N.y. : 1993) Pub Date : 2013-01-01 Epub Date: 2013-01-09 DOI: 10.3109/10641963.2012.758275

Hans Hendrik Schäfer, Jacob Daniel de Villiers, Ulrich Lotze, Elena Sivukhina, Michel Burnier, Georg Noll, Gian-Reto Theus, Thomas Dieterle

{"title":"Patients with non-insulin depending diabetes mellitus and metabolic syndrome are suboptimal treated in Swiss primary care.","authors":"Hans Hendrik Schäfer, Jacob Daniel de Villiers, Ulrich Lotze, Elena Sivukhina, Michel Burnier, Georg Noll, Gian-Reto Theus, Thomas Dieterle","doi":"10.3109/10641963.2012.758275","DOIUrl":"https://doi.org/10.3109/10641963.2012.758275","url":null,"abstract":"The prevalence of complicated hypertension is increasing in America and Europe. This survey was undertaken to assess the status quo of primary care management of hypertension in patients with the high-risk comorbid diseases metabolic syndrome (MetS) and/or type 2 diabetes mellitus (non-insulin depending diabetes mellitus (NIDDM)). Data of anti-hypertensive treatment of 4594 Swiss patients were collected over 1 week. We identified patients with exclusively NIDDM (N = 95), MetS (N = 168), and both (N = 768). Target blood pressure (TBP) attainment, frequency of prescribed substance-classes, and correlations to comorbidities/end-organ damages were assessed. In addition, we analyzed the prescription of unfavorable beta-blockers (BB) and high-dose diuretics (Ds). In NIDDM, Ds (61%), angiotensin receptor blockers (ARBs) (40%), and angiotensin converting enzyme inhibitors (ACEIs) (31%) were mostly prescribed, while in MetS, drugs prevalence was Ds (68%), ARBs (48%), and BB (41%). Polypharmacy in patients with MetS correlated with body mass index; older patients (>65 years) were more likely to receive dual-free combinations. TBP was attained in 25.2% of NIDDM and in 28.7% of MetS patients. In general, low-dose Ds use was more prevalent in NIDDM and MetS, however, overall, Ds were used excessively (NIDDM: 61%, MetS: 68%), especially in single-pill combination. Patients with MetS were more likely to receive ARBs, ACEIs, CCBs, and low-dose Ds than BBs and/or high-dose Ds. Physicians recognize DM and MetS as high-risk patients, but select inappropriate drugs. Because the majority of patients may have both, MetS and NIDDM, there is an unmet need to define TBP for this specific population considering the increased risk in comparison to patients with MetS or NIDDM alone. ","PeriodicalId":286988,"journal":{"name":"Clinical and Experimental Hypertension (New York, N.y. : 1993)","volume":" ","pages":"496-505"},"PeriodicalIF":12.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641963.2012.758275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40223359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Various approaches for vascular health in elderly women. 老年妇女血管健康的各种方法。

IF 12.3

Clinical and Experimental Hypertension (New York, N.y. : 1993) Pub Date : 2013-01-01 Epub Date: 2013-03-29 DOI: 10.3109/10641963.2013.780068

Hiromichi Suzuki, Manami Dogi, Tsuneo Takenaka

{"title":"Various approaches for vascular health in elderly women.","authors":"Hiromichi Suzuki, Manami Dogi, Tsuneo Takenaka","doi":"10.3109/10641963.2013.780068","DOIUrl":"https://doi.org/10.3109/10641963.2013.780068","url":null,"abstract":"Cardiovascular disease is one of the leading causes of morbidity and mortality in elderly women. Several previous studies evaluated various cardiovascular risk factors, such as brachial blood pressure (BP), systolic blood pressure (SBP), pulse pressure (PP), pulse wave velocity (PWV), central aortic pressure (CAP), and so on. More recently, measurement of ambulatory blood pressure (AMBP) was shown to be superior to clinic measurements in predicting cardiovascular mortality. However, the data are limited concerning the relationship among these variables in elderly women. In the present study, the data for clinic BP including PP, PWV, CAP, and AMSBP and AMCAP obtained using BPro were evaluated in 24 elderly hypertensive women. Although there was a significant correlation between AMSBP and AMCAP, no correlations were found between repeated measured values and values measured in the clinic on one occasion. In conclusion, measuring PWV and CAP in the clinic in patients with white coat hypertension or masked hypertension may not be an accurate way to measure these parameters.","PeriodicalId":286988,"journal":{"name":"Clinical and Experimental Hypertension (New York, N.y. : 1993)","volume":" ","pages":"295-9"},"PeriodicalIF":12.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641963.2013.780068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40233735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Investigation of cardiac autonomic and peripheral sensory neuropathy in diabetic and nondiabetic patients with hypertension. 糖尿病和非糖尿病高血压患者心脏自主神经和周围感觉神经病变的研究。

IF 12.3

Clinical and Experimental Hypertension (New York, N.y. : 1993) Pub Date : 2013-01-01 Epub Date: 2013-01-09 DOI: 10.3109/10641963.2012.758272

Peter Legrady, Dora Bajcsi, Csaba Lengyel, Tamas T Varkonyi, Imola Fejes, Peter Kempler, Gyorgy Abraham

引用次数: 11

The genetic control of blood pressure and body composition in rats with stress-sensitive hypertension. 应激敏感性高血压大鼠血压和体成分的遗传控制。

IF 12.3

Clinical and Experimental Hypertension (New York, N.y. : 1993) Pub Date : 2013-01-01 Epub Date: 2013-01-09 DOI: 10.3109/10641963.2012.758274

Olga E Redina, Svetlana E Smolenskaya, Larissa N Maslova, Arcady L Markel

引用次数: 14

Investigation of the aortic pulse wave velocity in patients with Gilbert's syndrome. 吉尔伯特综合征患者主动脉脉波速度的研究。

IF 12.3

Clinical and Experimental Hypertension (New York, N.y. : 1993) Pub Date : 2013-01-01 Epub Date: 2013-01-03 DOI: 10.3109/10641963.2012.758277

Erol Arslan, Mustafa Çakar, Hakan Şarlak, Ali Kılınç, Seref Demirbaş, Seyit Ahmet Ay, Murat Karaman, Fatih Bulucu, Kenan Sağlam

{"title":"Investigation of the aortic pulse wave velocity in patients with Gilbert's syndrome.","authors":"Erol Arslan, Mustafa Çakar, Hakan Şarlak, Ali Kılınç, Seref Demirbaş, Seyit Ahmet Ay, Murat Karaman, Fatih Bulucu, Kenan Sağlam","doi":"10.3109/10641963.2012.758277","DOIUrl":"https://doi.org/10.3109/10641963.2012.758277","url":null,"abstract":"Arterial stiffness is currently the \"gold standard\" measure of aortic (carotid-femoral) pulse wave velocity (PWV), which is an important independent predictor of risk of developing a cardiovascular event. Gilbert's syndrome is a congenital disorder characterized by intermittent and non-hemolytic elevation of indirect bilirubin levels due to the deficiency of the enzyme UDP-glucuronyl transferase in the liver and many prospective studies found an inverse relationship between bilirubin levels and cardiovascular events in these patients. We aimed to investigate serum bilirubin levels and arterial stiffness parameters in patients with Gilbert's syndrome in this study. A total of 53 cases, consisting of 26 patients with a diagnosis of Gilbert's syndrome and 27 healthy control subjects, were included in the study. Serum bilirubin levels, other routine blood chemistry, and arterial stiffness measurements were recorded. The mean ages of Gilbert's syndrome and the control group were 31.5 ± 9.7 and 36.8 ± 11.1 years, respectively. PWV measurements were significantly lower in Gilbert syndrome patients (6.68 and 7.3 m/s in patients and controls; respectively) (P < .05). In correlation analysis in Gilbert's syndrome patients, PWV had a significant correlation with total and indirect bilirubin levels (r = -0.370, P = .009/r = -0.495, P = .003, respectively). Gilbert's syndrome patients have lower PWV measurements compared to healthy subjects, and the total and indirect bilirubin levels are also associated with PWV measurements. These findings may indicate the decreased atherosclerotic disease incidence in Gilbert's syndrome patients. ","PeriodicalId":286988,"journal":{"name":"Clinical and Experimental Hypertension (New York, N.y. : 1993)","volume":" ","pages":"512-5"},"PeriodicalIF":12.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641963.2012.758277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40209531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The comparative effects of valsartan and amlodipine on vWf levels and N/L ratio in patients with newly diagnosed hypertension. 缬沙坦与氨氯地平对新诊断高血压患者vWf水平及N/L比值的影响比较

IF 12.3

Clinical and Experimental Hypertension (New York, N.y. : 1993) Pub Date : 2013-01-01 Epub Date: 2013-01-04 DOI: 10.3109/10641963.2012.758734

Murat Karaman, Sevket Balta, A Y Seyit Ahmet, Mustafa Cakar, Ilkin Naharci, Sait Demirkol, Turgay Celik, Zekeriya Arslan, Omer Kurt, Necmettin Kocak, Hakan Sarlak, Seref Demirbas, Fatih Bulucu, Ergun Bozoglu

{"title":"The comparative effects of valsartan and amlodipine on vWf levels and N/L ratio in patients with newly diagnosed hypertension.","authors":"Murat Karaman, Sevket Balta, A Y Seyit Ahmet, Mustafa Cakar, Ilkin Naharci, Sait Demirkol, Turgay Celik, Zekeriya Arslan, Omer Kurt, Necmettin Kocak, Hakan Sarlak, Seref Demirbas, Fatih Bulucu, Ergun Bozoglu","doi":"10.3109/10641963.2012.758734","DOIUrl":"https://doi.org/10.3109/10641963.2012.758734","url":null,"abstract":"High levels of circulating Von Willebrand factor (vWf) and increased neutrophil to lymphocyte (N/L) ratio may reflect vascular inflammation in hypertensive patients. In present study, we aimed to investigate the effects of valsartan as an angiotensin II receptor antagonist and amlodipine as a calcium channel blocker on the vWf levels and N/L ratio in patients with essential hypertension. Patients were randomized to one of the following intervention protocols: calcium channel blocker (amlodipine, 5-10 mg/day) as group A (n = 20 mean age = 51.85 ± 11.32 y) and angiotensine II receptor blocker (valsartan, 80-320 mg/day) as group B (n = 26 mean age = 49.12 ± 14.12 y). Endothelial dysfunction and vascular inflammation were evaluated with vWf levels and N/L ratio in hypertensive patients before treatment and after treatment in the 12th week. No statistically significant differences were found among the groups in terms of age, sex, and body mass index (BMI). There was a significant decrease in vWf levels (P < .001) and N/L ratio after treatment (P = .04, P < .001, respectively) in both the groups. Von Willebrand factor levels and N/L ratio are very important markers having a role in vascular inflammation and antihypertensive treatment with amlodipine and valsartan may improve cardiovascular outcomes by decreasing these biomarkers. ","PeriodicalId":286988,"journal":{"name":"Clinical and Experimental Hypertension (New York, N.y. : 1993)","volume":" ","pages":"516-22"},"PeriodicalIF":12.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641963.2012.758734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40212346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 88

Serum urotensin II levels in patients with non-dipper hypertension. 非杓型高血压患者血清尿紧张素II水平。

IF 12.3

Clinical and Experimental Hypertension (New York, N.y. : 1993) Pub Date : 2013-01-01 Epub Date: 2013-01-09 DOI: 10.3109/10641963.2012.758276

Ali Riza Erbay, Murat Meric, Hasan Alacam, Halit Zengin, Filiz Akin, Ali Okuyucu, Serkan Yuksel, Korhan Soylu, Omer Gedikli

{"title":"Serum urotensin II levels in patients with non-dipper hypertension.","authors":"Ali Riza Erbay, Murat Meric, Hasan Alacam, Halit Zengin, Filiz Akin, Ali Okuyucu, Serkan Yuksel, Korhan Soylu, Omer Gedikli","doi":"10.3109/10641963.2012.758276","DOIUrl":"https://doi.org/10.3109/10641963.2012.758276","url":null,"abstract":"Hypertension terms “dipper” and “non-dipper” are propounded by the change that occurs during ambulatory blood pressure (BP) monitoring. The purpose of this study is to present whether the serum urotensin II levels are different in patients with dipper and non-dipper hypertension and to put forward the effects causing this difference, if there are any. Patients recently diagnosed with hypertension were included in the study. With ambulatory BP monitoring, 81 patients with high BP were divided into two groups, dipper (n = 40) and non-dipper (n = 41). Serum urotensin II levels were analyzed by ELISA method. Serum urotensin II levels were higher in patients with non-dipper hypertension than in patients with dipper hypertension (204 [106–533] vs. 140 [96–309], P = .004). There was a positive correlation between total systolic BP and serum urotensin II levels (r = 0.408 and P = .009), but the relation in the non-dipper hypertension group was not significant (r = 0.194 and P = .2). In conclusion, serum urotensin II levels were higher in non-dipper HT patients than dipper HT patients. This higher urotensin II level might be responsible for poor prognoses.","PeriodicalId":286988,"journal":{"name":"Clinical and Experimental Hypertension (New York, N.y. : 1993)","volume":" ","pages":"506-11"},"PeriodicalIF":12.3,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641963.2012.758276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40220405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3