{"title":"Polymeric micromachines driven by laser-induced negative dielectrophoresis","authors":"S. Maruo, N. Yoshimura","doi":"10.1109/MHS.2011.6102203","DOIUrl":"https://doi.org/10.1109/MHS.2011.6102203","url":null,"abstract":"Optoelectronic micromachines driven by laser-induced dielectrophoretic force were developed by two-photon microfabrication. The optoelectronic driving system consists of the lower photoconductive layer of amorphous silicon on an indium tin oxide (ITO)-coated glass substrate and the upper transparent, conductive ITO-coated glass substrate. Micromachines are fabricated on the upper ITO-coated substrate by two-photon microfabrication. To estimate the driving condition, we examined the displacement of a microparticle by focusing a laser beam. Micromachines such as manipulators and microgears were also driven at proper driving condition. Furthermore a prototype of microfluidic components was developed. The optoelectronic micromachines will be powerful tools applicable to high-performance, low-cost lab-on-a-chip devices.","PeriodicalId":286457,"journal":{"name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132848883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eijiro Maeda, A. Sugawara, J. Cooper-White, T. Ohashi
{"title":"Micropillar-integrated device for monitoring dynamic regulation of traction forces during cell migration","authors":"Eijiro Maeda, A. Sugawara, J. Cooper-White, T. Ohashi","doi":"10.1109/MHS.2011.6102149","DOIUrl":"https://doi.org/10.1109/MHS.2011.6102149","url":null,"abstract":"Cell migration plays an important role in many physiological and pathological processes such as morphogenesis, wound healing, and tumor metastasis. Although the majority of such events occur with cells moving as a group, called collective cell migration, mechanics of collective cell migrations has not been understood well compared to a single cell migration. Mechanical interactions between cells and their surroundings have been demonstrated to regulate cell migration. One of such interactions is the induction of traction forces by acto-myosin dynamics within cells to their local environment, as it has been reported that cells alter the magnitude of traction forces depending on the stiffness of attaching substrates. In connection with cell migration, it has also been demonstrated the importance of substrate stiffness during cell migration using microfabricated substrates consisting of arrays of micropillars. To understand the mechanics of collective cell migration, it is important to know how cells within a moving cell collectivity generate forces to move the collectivity forward at single cell level. Accordingly, the present study was performed to clarify the mechanics of collective cell migration by measuring traction forces exerted by mouse NIH 3T3 fibroblasts using a newly developed migration assay device.","PeriodicalId":286457,"journal":{"name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133881308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Hagiwara, T. Kawahara, Toru Iijima, T. Masuda, Y. Yamanishi, F. Arai
{"title":"On-chip high speed microrobot made of Ni-Si composite structure with three-dimensionally patterned surface","authors":"M. Hagiwara, T. Kawahara, Toru Iijima, T. Masuda, Y. Yamanishi, F. Arai","doi":"10.1109/MHS.2011.6102169","DOIUrl":"https://doi.org/10.1109/MHS.2011.6102169","url":null,"abstract":"This paper presents the high speed microrobot actuation driven by permanent magnet in a microfluidic chip. The comprehensive analysis of fluid force, the optimum design and its fabrication was conducted to reduce the fluid force on the magnetically driven microrobot by attaching riblet shape on the microrobot. The Ni and Si composite fabrication was employed to form the optimum riblet shape on the Ni based microrobot by anisotropic Si wet etching and deep reactive ion etching. The evaluation experiments show the microrobot can actuate up to 100 Hz, which is 10 times higher than the original microrobot. In addition, since the microrobot was covered by Si, which is bio-compatible, it can be applied to cell manipulation without harm.","PeriodicalId":286457,"journal":{"name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116474752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Noncontact nanometric positioning of probe tip for continuous stiffness measurement system","authors":"S. Sakuma, F. Arai","doi":"10.1109/MHS.2011.6102159","DOIUrl":"https://doi.org/10.1109/MHS.2011.6102159","url":null,"abstract":"This paper presents noncontact nanometric positioning of on-chip probe. In order to obtain nanometric order resolution, we proposed the reduction mechanism. We succeeded in nanometric order non-contact actuation of on-chip probe by using reduction mechanism. This mechanism utilizes magnetic force and the difference of stiffness of the beam and center structure. The on-chip probe features are 1.possible to operate in a flow environment in a biochip, 2.accurate positioning with high resolution, 3.parallel plate mechanisms for stable operation and 4.reduction rate depends on only the rate of stiffness. In this paper we developed on-chip nanometric probe with reduction mechanism. The performance of the probe was examined. We succeeded in nanometric order non-contact actuation of on-chip probe.","PeriodicalId":286457,"journal":{"name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124545221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simulation and experimental verification of bacteria-driven micromotors","authors":"T. Sawada, Y. Hiratsuka, S. Maruo","doi":"10.1109/MHS.2011.6102153","DOIUrl":"https://doi.org/10.1109/MHS.2011.6102153","url":null,"abstract":"We report a flower-shaped micromotor driven by gliding bacteria named Mycoplasma mobile (M. mobile). This micromotor is autonomously rotated by the collisions of M. mobiles gliding randomly on a substrate. The flower-shaped rotor is derived from the unique motility of M. mobile. We examined the motility characteristics of M. mobile using walls with different corner angles. As a result, we found that M. mobile kept going at cusps. Owing to this property, the microrotor can be continuously rotated by random collisions of M. mobiles. In addition, we simulated the rotation of some kinds of microrotors with different number of blades. It was demonstrated that a microrotor with four blades could be stably rotated in experiments. The bacteria-driven micromotor will be applied to self-powered microsystems.","PeriodicalId":286457,"journal":{"name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125121183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multi-scale intelligent information processing for multi-robot system based on human-friendly tele-operation","authors":"N. Kubota, Y. Toda, Shintaro Suzuki","doi":"10.1109/MHS.2011.6102177","DOIUrl":"https://doi.org/10.1109/MHS.2011.6102177","url":null,"abstract":"Recently, tele-operation using multi-robot system has been discussed from various viewpoints of shared autonomy, intelligent control, formation behaviors, and information visualization. Furthermore, tele-operation systems have been applied to the remote monitoring of dangerous areas for people such as deep seas, nuclear power plants, and disaster-stricken areas. In this paper, we focus on the structured intelligence based on interconnected intelligent functions of map building, localization of mobile robots, 3D reconstruction and visualization, and human-friendly interface for tele-operation.","PeriodicalId":286457,"journal":{"name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128675293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of the medical systems using mechatronics for improvement of accuracy and quantitative reliability of medical treatments","authors":"J. Okamoto","doi":"10.1109/MHS.2011.6102245","DOIUrl":"https://doi.org/10.1109/MHS.2011.6102245","url":null,"abstract":"In many medical fields, the result of operation or diagnosis depends on a doctor's empirical value. As you know, doctor's medical experiences vary appreciably from person to person and it causes health disparities. To eliminate health disparities from our society, the author has been developing some medical devices using mechatronics to improvement the accuracy and quantitative reliability of medical treatments like operation or diagnosis. In this paper, the author introduced two medical devices. The first device is arm-holding manipulator “EXPERT” which aims to reduce the surgeon fatigue and realize intuitive operation support in microscopic neurosurgery. The developed system was successfully used in 9 clinical cases at Shinshu University School of Medicine, STA-MCA anastomosis, meningioma removals, and aneurysmal clipping treatments. The second device is orthopaedic physical examination assisting system that aims to improve accuracy and reproducibility of knee laxity diagnosis. The examination result of posterior drawer test with the developed system showed that the examination accuracy was significantly improved in all evaluation parameters.","PeriodicalId":286457,"journal":{"name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115048400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yajing Shen, M. Nakajima, Z. Najdovski, Zhan Yang, M. Kojima, S. Kojima, M. Homma, T. Fukuda
{"title":"Method to study the single cell's time-variation adhesion strength during the manipulation inside ESEM","authors":"Yajing Shen, M. Nakajima, Z. Najdovski, Zhan Yang, M. Kojima, S. Kojima, M. Homma, T. Fukuda","doi":"10.1109/MHS.2011.6102180","DOIUrl":"https://doi.org/10.1109/MHS.2011.6102180","url":null,"abstract":"The cell adhesion force to the substrate is important for the cell manipulation. In our previous work, the maximum cell adhesion force during the manipulation has been studied. However, the relation ship of the force virus time was still not clear. In this paper, a method to measure the time-variation adhesion force during the manipulation was proposed. A hybrid laser sensor and nanorobotic manipulation system was build inside an environment scanning electron microscope (ESEM). A micro putter was fabricated from an atomic force microscope (AFM) cantilever through focused ion beam (FIB) etching technique. The laser head and the micro putter were assembled and fixed to the nano manipulator inside ESEM chamber. The displacement between the micro putter and the laser head can be measured by the laser sensor system. The relationship of the deflection of the micro putter and the applied force was calibrated by nanorobotic manipulation approach. The single cell's time-variation adhesion force to substrate surface was measured based on this hybrid system. The result indicates that both the dynamic data and precise observation can be achieved owing to the combination of the advantages of AFM and ESEM nano robotic manipulation system.","PeriodicalId":286457,"journal":{"name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128313630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fabrication and evaluation of Pt and Au hybrid and geometric Pt nano vehicle","authors":"Jingjing Bao, M. Nakajima, Zhan Yang, T. Fukuda","doi":"10.1109/MHS.2011.6102182","DOIUrl":"https://doi.org/10.1109/MHS.2011.6102182","url":null,"abstract":"In order to realize functional nanomachine and nanorobot, we introduce one novel method of producing bimetallic nanowire motor, which is making use of focus ion beam (FIB) and gold sputtering to fabricate nanowire prototype. And the method is proved valid by Energy Dispersive Spectroscopy (EDS) analysis. And also we design a fine process to manipulate the nanowire prototype successfully. Moreover, we use FIB to fabricate geometric Platinum nanowire with T letter shape, which can swim in hydrogen peroxide with rotary orbit. This novel design of catalytic nanomotor can help us have an advanced understanding of catalytic nanomotor.","PeriodicalId":286457,"journal":{"name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134105923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of interpolation for DBIM reconstruction of ultrasound tomography","authors":"Duc-Tan Tran, Anh Nguyen-Tien","doi":"10.1109/MHS.2011.6102185","DOIUrl":"https://doi.org/10.1109/MHS.2011.6102185","url":null,"abstract":"Ultrasonic tomography technique has a great potential value in many applications such as medicine, underwater acoustics, non-destructive testing, etc. However, one of the most disadvantages of this technique is time consumption in reconstruction process. The distorted Born iterative method (DBIM) has been utilized to reconstruct the ultrasound tomography. It can take several iterations depend on the quantity of measured signals. This paper has proposed a solution of fast reconstruction by combining interpolation technique and DBIM. The tomography of scatters' sound contrast is first reconstructed with a raw meshed integration area. We can easily obtain the convergent even after one or two iterations using DBIM. After that, the interpolation is applied to the signal to obtain a dense image. A method like nearest neighbor is chosen because it doesn't generate any new data values. Finally, the dense image is brought back to DBIM to continue the reconstruction process. The simulation show that we can save up to 50% of reconstructed time.","PeriodicalId":286457,"journal":{"name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127610588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}