2009 International Association of Computer Science and Information Technology - Spring Conference最新文献_第10页

Computational Analysis of CpG Island Distribution in Human EEF1A2 Gene Encoding a Putative Oncoprotein Implicated in Ovarian and Breast Cancer 编码卵巢癌和乳腺癌推定癌蛋白的人EEF1A2基因CpG岛分布的计算分析

2009 International Association of Computer Science and Information Technology - Spring Conference Pub Date : 2009-04-17 DOI: 10.1109/IACSIT-SC.2009.16

P. Dharmasaroja

{"title":"Computational Analysis of CpG Island Distribution in Human EEF1A2 Gene Encoding a Putative Oncoprotein Implicated in Ovarian and Breast Cancer","authors":"P. Dharmasaroja","doi":"10.1109/IACSIT-SC.2009.16","DOIUrl":"https://doi.org/10.1109/IACSIT-SC.2009.16","url":null,"abstract":"The tissue-specific translation elongation factor eEF1A2 was recently shown to be a potential oncoprotein that is over expressed in human ovarian and breast cancer. eEF1A2 encoded on chromosome 20 shares similar features to the near-ubiquitously expressed eEF1A1, a closely-related isoform encoded on chromosome 6. It is still unknown why the tissue-specific eEF1A2 should have oncogenic properties in tissues in which eEF1A1 is already present at high levels. Abnormal methylation of CpG islands can lead to changes in expression of genes resulting in cancer growth and metastasis. In the present study, recently-developed and more stringent criteria for CpG islands, as being a DNA sequence longer than 500 bp with a G + C content equal to or greater than 55% and observed CpG/expected CpG of 0.65, were used to analyze CpG islands distribution in EEF1A1 and EEF1A2. Under these criteria, two CpG islands were identified in EEF1A1: one with an Alu repeat located in the promoter region and one without Alus, which spanned exon 1 and exon 2 and overlapped the transcription start site. In contrast, three out of four CpG islands in EEF1A2 were located in the exonic regions (exons 3, 4, 7 and 8), and none of them overlapped the transcription start site. Differences in the number and distribution of CpG islands, including the presence or absence of Alu repeats, in EEF1A1 and EEF1A2 may explain their differential expressions in certain cancer cells.","PeriodicalId":286158,"journal":{"name":"2009 International Association of Computer Science and Information Technology - Spring Conference","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129291347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An in silico Approach to Detect Efficient Malaria Drug Targets to Combat the Malaria Resistance Problem 一种检测有效疟疾药物靶点以对抗疟疾耐药性问题的计算机方法

2009 International Association of Computer Science and Information Technology - Spring Conference Pub Date : 2009-04-17 DOI: 10.1109/IACSIT-SC.2009.128

S. Fatumo, E. Adebiyi, G. Schramm, R. Eils, R. Konig

{"title":"An in silico Approach to Detect Efficient Malaria Drug Targets to Combat the Malaria Resistance Problem","authors":"S. Fatumo, E. Adebiyi, G. Schramm, R. Eils, R. Konig","doi":"10.1109/IACSIT-SC.2009.128","DOIUrl":"https://doi.org/10.1109/IACSIT-SC.2009.128","url":null,"abstract":"Resistance to malaria drugs is a major challenging problem in most parts of the world especially in the African continent where about ninety per cent of malaria cases occur. As a response to this alarming problem, the World Health Organisation (W.H.O) recommends that all countries experiencing resistance to conventional monotherapies, such as chloroquine, amodiaquine or sulfadoxine–pyrimethamine, should use combination therapies [1]. Therefore there is a need to discover new drug targets that are able to target the malarial parasite at distinct pathways for an efficient malaria drug. In this paper, we presented a machine-learning tool which is able to identify novel drug targets from the metabolic network of Plasmodium falciparum. With our tool we identified among others 19 drug targets confirmed from literature which we analyzed further with a sophisticated gene expression analysis tool. Our data was clustered using common distance similarity measurements and hierarchical clustering to propose a profound combination of drug targets. Our result suggests that two or more enzymatic reactions from the list of our drug targets which span across about ten pathways (Table 2) could be combined to target at distinct time points in the parasite's intraerythrocytic developmental cycle to detect efficient malaria drug target combinations.","PeriodicalId":286158,"journal":{"name":"2009 International Association of Computer Science and Information Technology - Spring Conference","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127256008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Customer Orientation Behaviors of Frontline Employees: Moderating Roles of Emotional Intelligence 一线员工顾客导向行为:情绪智力的调节作用

2009 International Association of Computer Science and Information Technology - Spring Conference Pub Date : 2009-04-17 DOI: 10.1109/IACSIT-SC.2009.102

W. Chih, Tsung-Ju Yang, Ling-Chu Huang, Che-Hao Hsu

引用次数: 4

Development of an Instrumented and Passive Exoskeleton for the Lower Limb Rehabilitation 用于下肢康复的仪器化被动外骨骼的研制

2009 International Association of Computer Science and Information Technology - Spring Conference Pub Date : 2009-04-17 DOI: 10.1109/IACSIT-SC.2009.78

Qiuhao Zhang, Kechao Tian, Hongche Guo

引用次数: 6

The Diagnosis of Hepatitis Diseases by Support Vector Machines and Artificial Neural Networks 支持向量机与人工神经网络在肝炎疾病诊断中的应用

2009 International Association of Computer Science and Information Technology - Spring Conference Pub Date : 2009-04-17 DOI: 10.1109/IACSIT-SC.2009.25

M. Rouhani, M. M. Haghighi

引用次数: 17

Model for Decision-Making in Business Strategy 商业战略决策模型

2009 International Association of Computer Science and Information Technology - Spring Conference Pub Date : 2009-04-17 DOI: 10.1109/IACSIT-SC.2009.136

Popa Ion, Dobrin Cosmin, C. Sebastian, Ciolac Camelia Elena, C. Eduard

引用次数: 0

The Value of Contract Flexibility on Supply Chain Coordination with Alternative Criteria 契约柔性在可选准则下供应链协调中的价值

2009 International Association of Computer Science and Information Technology - Spring Conference Pub Date : 2009-04-17 DOI: 10.1109/IACSIT-SC.2009.77

Yu Tian, Shao-chao Sun, Yanxue Gong

引用次数: 0

High Level Net Model for Analyzing Agent Base Distributed Decision Support System 基于Agent的分布式决策支持系统高层网络模型分析

2009 International Association of Computer Science and Information Technology - Spring Conference Pub Date : 2009-04-17 DOI: 10.1109/IACSIT-SC.2009.131

B. Sarkar, N. Chaki

引用次数: 4

Cardiac Motion Evaluation for Disease Diagnosis Using ICA Basis Neural Network 基于ICA神经网络的心脏运动评价疾病诊断

2009 International Association of Computer Science and Information Technology - Spring Conference Pub Date : 2009-04-17 DOI: 10.1109/IACSIT-SC.2009.117

M. Mansoory, M. Ashtiyani, H. N.

引用次数: 8

Work in Progress: Developing Arabic Plagiarism Detection Tool for E-Learning Systems 正在进行的工作:为电子学习系统开发阿拉伯语剽窃检测工具

2009 International Association of Computer Science and Information Technology - Spring Conference Pub Date : 2009-04-17 DOI: 10.1109/IACSIT-SC.2009.22

Salha M. Alzahrani, N. Salim, Mohammed M. Alsofyani

引用次数: 8