Journal of geriatric cardiology : JGC最新文献_第10页

Adverse reactions of Amiodarone 胺碘酮的不良反应

Journal of geriatric cardiology : JGC Pub Date : 2019-07-01 DOI: 10.11909/j.issn.1671-5411.2019.07.004

Ruben ML Colunga Biancatelli, Viviana Congedo, Leonardo Calvosa, M. Ciacciarelli, A. Polidoro, L. Iuliano

引用次数: 7

Thoracic aorta thickness and histological changes with aging: an experimental rat model 大鼠胸主动脉厚度及组织学随年龄变化的实验模型

Journal of geriatric cardiology : JGC Pub Date : 2019-07-01 DOI: 10.11909/j.issn.1671-5411.2019.07.001

Giulio Cesar Gequelim, Djanira Aparecida da Luz Veronez, Gustavo Lenci Marques, Camila Harumi Tabushi, Ronaldo da Rocha Loures Bueno

引用次数: 3

The value of serum metabolomics analysis in predicting the response to cardiac resynchronization therapy 血清代谢组学分析在预测心脏再同步化治疗反应中的价值

Journal of geriatric cardiology : JGC Pub Date : 2019-07-01 DOI: 10.11909/j.issn.1671-5411.2019.07.002

Mengruo Zhu, Zibire Fulati, Yang Liu, Wenshuo Wang, Qian Wu, Yangang Su, Hai-yan Chen, X. Shu

{"title":"The value of serum metabolomics analysis in predicting the response to cardiac resynchronization therapy","authors":"Mengruo Zhu, Zibire Fulati, Yang Liu, Wenshuo Wang, Qian Wu, Yangang Su, Hai-yan Chen, X. Shu","doi":"10.11909/j.issn.1671-5411.2019.07.002","DOIUrl":"https://doi.org/10.11909/j.issn.1671-5411.2019.07.002","url":null,"abstract":"Objective To construct a prediction model based on metabolic profiling for predicting the response to cardiac resynchronization therapy (CRT). Methods Peripheral venous (PV) and coronary sinus (CS) blood samples were collected from 25 patients with heart failure (HF) at the time of CRT implantation, and PV blood samples were obtained from ten healthy controls. The serum samples were analyzed by liquid chromatography-mass spectrometry (LC-MS). As per the clinical and echocardiographic assessment at the 6-month follow-up, the HF patients were categorized as CRT responders and non-responders. Results HF patients had altered serum metabolomic profiles that were significantly different from those of the healthy controls. Differential metabolites were also observed between CRT responders and non-responders. A prediction model for CRT response (CRT-Re) was constructed using the concentration levels of the differential metabolites, L-arginine and taurine. The optimal cutoff value of the CRT-Re model was found to be 0.343 by ROC analysis (sensitivity, 88.2%; specificity, 87.5%; Area under curve (AUC) = 0.897, P = 0.002). The concentration levels of the differential metabolites, L-arginine and lysyl-gamma-glutamate, in PV serum were significantly correlated with that in CS serum (r = 0.945 and 0.680, respectively, all P < 0.001). Conclusions Our results suggest that serum-based metabolic profiling may be a potential complementary screening tool for predicting the outcome of CRT.","PeriodicalId":285674,"journal":{"name":"Journal of geriatric cardiology : JGC","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133535238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A 99-year old patient with takotsubo cardiomyopathy recovering from cardiogenic shock 一位99岁的takotsubo型心肌病患者从心源性休克恢复

Journal of geriatric cardiology : JGC Pub Date : 2019-07-01 DOI: 10.11909/j.issn.1671-5411.2019.07.007

M. Yenerçağ, U. Arslan, Güney Erdoğan, Onur Seker, O. C. Yontar

{"title":"A 99-year old patient with takotsubo cardiomyopathy recovering from cardiogenic shock","authors":"M. Yenerçağ, U. Arslan, Güney Erdoğan, Onur Seker, O. C. Yontar","doi":"10.11909/j.issn.1671-5411.2019.07.007","DOIUrl":"https://doi.org/10.11909/j.issn.1671-5411.2019.07.007","url":null,"abstract":"Takotsubo syndrome (TTS) is a rare clinical entity commonly seen in post-menopausal women after an emotional or sometimes physical stress. This syndrome is thought to be caused by increased circulation catecholamine levels secondary to an adrenergic stimulus resulting in transient coronary spasm and microvascular dysfunction. TTS is characterized by acute and reversible left ventricular dysfunction with the typical ECG and clinical findings of an acute coronary syndrome but no significant coronary stenosis. Typically, in TTS, antero-apical ballooning is observed in ventriculography, and segmentary wall motion abnormalities are observed in magnetic resonance imaging and echocardiography. Acute heart failure, left ventricular outflow tract obstruction, mitral regurgitation and cardiogenic shock may complicate this syndrome. Herein, we present a case who is the oldest one in the literature with TTS and cardiogenic shock.  A 99-year old female patient known to have Alzheimer’s disease admitted to our emergency department with the complaints of acute severe chest pain and dyspnea. She had the signs of acute heart failure with a blood pressure of 70/50 mmHg. In her ECG, ST segment elevation in derivations V2-V6 and D2-D3-aVF, and ST segment depression in V1 and AVR were present (Figure 1). Troponin I level measured at admission was 13 μg/L. Coronary angiography was performed immediately revealing no significant coronary artery disease (Video 1). In the ventriculogram, apical and mid-ventricular ballooning with basal hyperkinesia, typically observed in TTS, was demonstrated (Figure 2, Video 2). In the echocardiography, depressed left ventricular ejection fraction (30%), akinesia and dilatation of the mid and apical portions of left ventricle were seen without an obstruction in the outflow tract (Video 3). Concerning with the diagnosis of TTS and cardiogenic shock, 0, 1","PeriodicalId":285674,"journal":{"name":"Journal of geriatric cardiology : JGC","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122760477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Predictors of non-response to cardiac resynchronization therapy implantation in patients with class I indications: the markedly dilated left ventricular end-diastolic dimension and the presence of fragmented QRS I类适应症患者心脏再同步化治疗植入无反应的预测因素:左室舒张末期尺寸明显扩大和QRS碎片化的存在

Journal of geriatric cardiology : JGC Pub Date : 2019-07-01 DOI: 10.11909/j.issn.1671-5411.2019.07.009

Yiran Hu, W. Hua, Shengwen Yang, M. Gu, Hongxia Niu, L. Ding, Jing Wang, Ran Jing, Xiaohan Fan, Shu Zhang

{"title":"Predictors of non-response to cardiac resynchronization therapy implantation in patients with class I indications: the markedly dilated left ventricular end-diastolic dimension and the presence of fragmented QRS","authors":"Yiran Hu, W. Hua, Shengwen Yang, M. Gu, Hongxia Niu, L. Ding, Jing Wang, Ran Jing, Xiaohan Fan, Shu Zhang","doi":"10.11909/j.issn.1671-5411.2019.07.009","DOIUrl":"https://doi.org/10.11909/j.issn.1671-5411.2019.07.009","url":null,"abstract":"Background Cardiac resynchronization therapy (CRT) is a highly effective treatment in patients with a class I recommendation. However, a small proportion of the strictly selected patients still fail to respond. This study was designed to identify predictors of non-response in patients with class I indications for CRT and determine the non-response probability of the patients. Methods A total of 296 consecutive patients with a class I recommendation received CRT from January 2009 to January 2017 were retrospectively analyzed. Multivariate logistic regression analysis was performed to identify predictors for non-response (defined as cardiac death, heart transplantation, or HF hospitalization during 1-year follow-up). Results Among 296 patients, 30 (10.1%) met non-response. Multivariate analysis demonstrated that non-response to CRT was associated with a fragmented QRS (odd ratio (OR) = 2.86, 95% CI: 1.14–7.12; P = 0.025) and left ventricular end-diastolic dimension (LVEDD) ≥ 77 mm (OR = 3.02, 95% CI: 1.17–7.82; P = 0.022). Patients with both of the predictors had a non-response probability of 46.2% (95% CI: 19.1%–73.3%). Conclusion In patients with left bundle branch block and wider QRS duration, the proportion of non-response to CRT is not low in real world. The presence of the dilated LVEDD or fragmented QRS is a strong predictor of non-response to CRT. The probability of non-response in the patients with the two predictors was 46.2%.","PeriodicalId":285674,"journal":{"name":"Journal of geriatric cardiology : JGC","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127707644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The relevance of serum albumin among elderly patients with acute decompensated heart failure 老年急性失代偿性心力衰竭患者血清白蛋白的相关性

Journal of geriatric cardiology : JGC Pub Date : 2019-07-01 DOI: 10.11909/j.issn.1671-5411.2019.07.005

T. Mene-Afejuku, Ela-Anamaria Moisa, Adedoyin Akinlonu, Carissa Dumancas, Shushan Veranyan, Jose A Perez, Peggy Salazar, S. Chaudhari, Gerald Pekler, Savi Mushiyev, F. Visco

{"title":"The relevance of serum albumin among elderly patients with acute decompensated heart failure","authors":"T. Mene-Afejuku, Ela-Anamaria Moisa, Adedoyin Akinlonu, Carissa Dumancas, Shushan Veranyan, Jose A Perez, Peggy Salazar, S. Chaudhari, Gerald Pekler, Savi Mushiyev, F. Visco","doi":"10.11909/j.issn.1671-5411.2019.07.005","DOIUrl":"https://doi.org/10.11909/j.issn.1671-5411.2019.07.005","url":null,"abstract":"Objective To assess the prognostic utility of serum albumin among elderly patients admitted for acute decompensated heart failure (ADHF) in terms of all-cause mortality and also to identify the predictors of hypoalbuminemia. Methods Retrospective cohort study of 119 elderly patients admitted for ADHF. Elderly patients were defined as patients over the age of 65 years. The patients were followed up for approximately 11 years. Patients with advanced renal failure, liver disease not due to HF, cancer and other causes of low life expectancy were excluded. Hypoalbuminemia was defined as serum albumin ≤ 2.9 g/dL. Results The study was made up of 65 females and 54 males with age ranging from 65 to 96 years. Of the 119 elderly patients with ADHF, there were 26 deaths. A significantly higher proportion of patients in the mortality group had an admission serum albumin level of ≤ 2.9 g/dL than those surviving (P = 0.011). After Cox's logistic regression, low albumin (P = 0.016), elevated direct bilirubin (P = 0.03), age greater than 85 (P = 0.008), lack of use of beta blockers (P = 0.0001) and left ventricular ejection fraction less than 35% (P = 0.005) increased the risk of death. Elevated serum creatinine (P = 0.0357) was the only predictor of hypoalbuminemia following multiple linear regression. Conclusions Hypoalbuminemia may be an unrecognized marker of death in elderly patients with ADHF.","PeriodicalId":285674,"journal":{"name":"Journal of geriatric cardiology : JGC","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134289556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

In elderly population prophylactic anticoagulation favors early detection of digestive track cancers: an observational study in eastern Poland 在老年人群中，预防性抗凝有利于早期发现消化道癌症:波兰东部的一项观察性研究

Journal of geriatric cardiology : JGC Pub Date : 2019-06-01 DOI: 10.11909/j.issn.1671-5411.2019.06.008

Małgorzata Szlendak, W. Myśliński, J. Mosiewicz, W. Barud

{"title":"In elderly population prophylactic anticoagulation favors early detection of digestive track cancers: an observational study in eastern Poland","authors":"Małgorzata Szlendak, W. Myśliński, J. Mosiewicz, W. Barud","doi":"10.11909/j.issn.1671-5411.2019.06.008","DOIUrl":"https://doi.org/10.11909/j.issn.1671-5411.2019.06.008","url":null,"abstract":"The launch of non-VKA oral anticoagulants (NOACs) caused revolution in thrombosis prevention, which was mainly due to their safety and simplicity in treatment when compared to vitamin K antagonists (VKA). Clinical observations indicate that despite the benefits of NOACs, many patients still use VKA even if they cannot cope with dose modifications and often do not control INR.  In the Department of Internal Diseases of Medical University of Lublin (Poland) the large group of hospitalised patients are the elderly with atrial fibrillation on the prophylactic antithrombotic therapy. Some of them have coexisting anemia and undergo extended diagnostics, which in the past had repeatedly resulted in the detection of gastrointestinal (GI) tumors at a very early stage that enabled an effective surgical treatment. The objectives of the presented study were: (1) compare the frequency of GI tumors detection among the elderly patients (defined as ≥ 75 years of age) treated with oral anticoagulants and their peers in entire population of the Lublin region (western Poland); and (2) determine if in the examined group of elderly patients there was a difference in the predisposition to bleeding depending on the used therapyVKA, NOAC and low molecular weight heparin (LMWH). Data presented in the study were collected prospectively for twelve months, from May 2017 to April 2018. The qualification conditions were an admission to the clinic due to anemia of the unknown reason and ongoing prophylactic antithrombotic therapy, mostly due to atrial fibrillation. The drugs used for this reason included: VKA-acenocoumarol and warfarin, NOAC-rivaroxaban, apixaban and dabigatran and LMWH in the form of enoxaparin. The therapy of some of the patients was modified during hospital stay, but the analysis included treatment applied before the admission to the clinic.","PeriodicalId":285674,"journal":{"name":"Journal of geriatric cardiology : JGC","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130503486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful opening in-stent chronic total occlusion lesion of coronary artery by excimer laser coronary angioplasty 准分子激光冠脉成形术成功切开支架内慢性冠脉全闭塞病变

Journal of geriatric cardiology : JGC Pub Date : 2019-06-01 DOI: 10.11909/j.issn.1671-5411.2019.06.006

Jing Bai, Hai-Xia Wang, Jiang Wang, Jing Zhao, Liang Peng, Xuedong Yang, Zhe Tang, Shaheena Nazneen, Gaokun Wang, Yu Wang

引用次数: 2

Intracoronary arterial retrograde thrombolysis with percutaneous coronary intervention: a novel use of thrombolytic to treat acute ST-segment elevation myocardial infarction 冠状动脉逆行溶栓与经皮冠状动脉介入治疗:溶栓治疗急性st段抬高型心肌梗死的新应用

Journal of geriatric cardiology : JGC Pub Date : 2019-06-01 DOI: 10.11909/j.issn.1671-5411.2019.06.004

Jinwen Tian, Mei Zhu, Feng-Qi Wang, Ke Li, Chao-Fei Zhou, Bo Li, Min Wang, Jue-lin Deng, B. Jiang, Jing Bai, Yi Guo, Rongjie Jin, Zhao Zhang, Ying-min Lin, Jihui Wang, Shitong Zhao, M. Shen

{"title":"Intracoronary arterial retrograde thrombolysis with percutaneous coronary intervention: a novel use of thrombolytic to treat acute ST-segment elevation myocardial infarction","authors":"Jinwen Tian, Mei Zhu, Feng-Qi Wang, Ke Li, Chao-Fei Zhou, Bo Li, Min Wang, Jue-lin Deng, B. Jiang, Jing Bai, Yi Guo, Rongjie Jin, Zhao Zhang, Ying-min Lin, Jihui Wang, Shitong Zhao, M. Shen","doi":"10.11909/j.issn.1671-5411.2019.06.004","DOIUrl":"https://doi.org/10.11909/j.issn.1671-5411.2019.06.004","url":null,"abstract":"Background Clearance of coronary arterial thrombosis is necessary in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing urgent percutaneous coronary intervention (PCI). There is currently no highly-recommended method of thrombus removal during interventional procedures. We describe a new method for opening culprit vessels to treat STEMI: intracoronary arterial retrograde thrombolysis (ICART) with PCI. Methods & Results Eight patients underwent ICART. The guidewire was advanced to the distal coronary artery through the occlusion lesion. Then, we inserted a microcatheter into the distal end of the occluded coronary artery over the guidewire. Urokinase (5–10 wu) mixed with contrast agents was slowly injected into the occluded section of the coronary artery through the microcatheter. The intracoronary thrombus gradually dissolved in 3–17 min, and the effect of thrombolysis was visible in real time. Stents were then implanted according to the characteristics of the recanalized culprit lesion to achieve full revascularization. One patient experienced premature ventricular contraction during vascular revascularization, and no malignant arrhythmias were seen in any patient. No reflow or slow flow was not observed post PCI. Thrombolysis in myocardial infarction flow grade and myocardial blush grade post-primary PCI was 3 in all eight patients. No patients experienced bleeding or stroke. Conclusions ICART was accurate and effective for treating intracoronary thrombi in patients with STEMI in this preliminary study. ICART was an effective, feasible, and simple approach to the management of STEMI, and no intraprocedural complications occurred in any of the patients. ICART may be a breakthrough in the treatment of acute STEMI.","PeriodicalId":285674,"journal":{"name":"Journal of geriatric cardiology : JGC","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114820211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Approach to a patient with pulmonary hypertension 一例肺动脉高压患者的治疗方法

Journal of geriatric cardiology : JGC Pub Date : 2019-06-01 DOI: 10.11909/j.issn.1671-5411.2019.06.007

C. Inampudi, A. Hemnes, A. Briasoulis

引用次数: 5