Bioengineering eJournal最新文献_第5页

Ergonomics in Medical Equipment Development and System Design 医疗设备开发和系统设计中的人体工程学

Bioengineering eJournal Pub Date : 2017-01-31 DOI: 10.21276/IJIRCST.2017.5.1.1

Sukwon Kim

引用次数: 0

Mechanical Characterization of Banana/Sisal Fibre Reinforced PLA Hybrid Composites for Structural Application 香蕉/剑麻纤维增强PLA杂化复合材料的力学性能

Bioengineering eJournal Pub Date : 2013-06-30 DOI: 10.18034/EI.V1I1.216

R. Ranjan, P. Bajpai, R. Tyagi

{"title":"Mechanical Characterization of Banana/Sisal Fibre Reinforced PLA Hybrid Composites for Structural Application","authors":"R. Ranjan, P. Bajpai, R. Tyagi","doi":"10.18034/EI.V1I1.216","DOIUrl":"https://doi.org/10.18034/EI.V1I1.216","url":null,"abstract":"Advanced technology emergence in the field of petrochemical-based polymers has brought many benefits to mankind. It is validating that the ecosystem is considerably disturbed and damaged as a result of the non-degradable plastic materials used for disposable items. This paper relates the use of hybrid bio-composites, which is eco-friendly and easily degradable. Previous literature related to hybrid bio-composites proves its eco-friendly and excellent degradable properties. In this paper, banana and sisal fibers were selected to execute the hybrid bio-composite preparation with poly lactic as its matrix. Specimens were made with and without fibre treatment and their mechanical properties like tensile, flexural and impact were evaluated as per the standard test procedures. The test results obtained evident that the treated fibers having the best mechanical properties than pure PLA and untreated fibre bio-composites. The chemical treatment also improved fiber matrix interaction by removal of lignin and hemicellulose, which led to the better incorporation of fiber with the matrix. The SEM micrographs of untreated banana/sisal fibre reinforced PLA bio-composites and treated banana/sisal fibre reinforced PLA bio-composites clearly indicated the extent of the fiber-matrix interface adhesion.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"09 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127313224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Financial Engineering Versus Cancer 金融工程与癌症

Bioengineering eJournal Pub Date : 1900-01-01 DOI: 10.20955/ES.2015.18

Christopher J. Neely

引用次数: 1

Ultra-Small Size Gelatin Nanogel as a Blood Brain Barrier Impermeable Contrast Agent for Magnetic Resonance Imaging 超小尺寸明胶纳米凝胶作为磁共振成像的血脑屏障不渗透造影剂

Bioengineering eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3687915

Atsushi Kimura, J. Jo, Fumiya Yoshida, Zhang Hong, Y. Tabata, M. Taguchi, I. Aoki

{"title":"Ultra-Small Size Gelatin Nanogel as a Blood Brain Barrier Impermeable Contrast Agent for Magnetic Resonance Imaging","authors":"Atsushi Kimura, J. Jo, Fumiya Yoshida, Zhang Hong, Y. Tabata, M. Taguchi, I. Aoki","doi":"10.2139/ssrn.3687915","DOIUrl":"https://doi.org/10.2139/ssrn.3687915","url":null,"abstract":"Magnetic Resonance Imaging (MRI) contrast agents with rapid renal excretion that do not penetrate the blood brain barrier (BBB) and blood cerebrospinal fluid barrier (BCFB) are preferred for safer and low-risk diagnosis. Gadolinium (Gd)-conjugated nanoparticles have been proposed for use as such contrast agents; however, the particle size must range between 1 to 7 nm to ensure rapid renal excretion. In this study, three types of gelatin, dissolved in water at varying concentrations of 0.1–2 wt.%, were irradiated with 5 kGy γ-rays at 25 °C under aerated conditions to produce ultra-small gelatin nanogels having an average particle size ranging between 5.5 ± 1.9 to 21 ± 3.7 nm. Ultra-small Gd-coordinated gelatin nanogels (GdGN) suitable for use as MRI contrast agents were produced using 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid mono- N -hydroxysuccinimide ester (DOTA-NHS) and DOTA-butylamine as Gd ligand derivatives. Non-cytotoxicity and effective relaxivity of GdGN as a positive MRI contrast agent were verified using in vivo experiments. Rapid renal excretion of GdGN was observed in mice within 1 h with no accumulation in the liver. GdGN did not migrate across the BCFB in normal mice, thus emphasizing its safety as an MRI contrast agent.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121411847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of PGS/PCL Scaffold in Promoting Differentiation of Human Embryonic Stem Cells Into Retinal Ganglion Cells PGS/PCL支架促进人胚胎干细胞向视网膜神经节细胞分化的作用

Bioengineering eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3729640

S. Behtaj, F. Karamali, Samaneh Najafian, E. Masaeli, M. N. Nasr Esfahani, M. Rybachuk

{"title":"Roles of PGS/PCL Scaffold in Promoting Differentiation of Human Embryonic Stem Cells Into Retinal Ganglion Cells","authors":"S. Behtaj, F. Karamali, Samaneh Najafian, E. Masaeli, M. N. Nasr Esfahani, M. Rybachuk","doi":"10.2139/ssrn.3729640","DOIUrl":"https://doi.org/10.2139/ssrn.3729640","url":null,"abstract":"Stem cell-based therapeutic approaches have opened promising avenues to restoring vision in progressive optic neuropathies, including glaucomatous, and as such, the stem cell-based retinal ganglion cells (RGCs) replacement therapy offers a potential to replace degenerated RGCs and promote RGC axon regeneration. However, challenges associated with the successful generation of clinically safe and functional RGCs, which can appropriately integrate into the hosts’ retinas still remain unresolved. The use of polymeric tissue-supporting scaffolds is a known and tested solution to enhance the efficiency of cell delivery and differentiation process due to providing an appropriate physical environment and structural support, however, for RGC generation their application has been far from conclusive. Our study aims, firstly, to reveal a process that enables generation of RGCs from human embryonic stem cells (hESCs) that is simple, straightforward and repeatable and, secondly, to show the influence of the aligned poly(glycerol sebacate) (PGS)/poly(ε-caprolactone) (PCL) scaffold on this differentiation process. Our findings demonstrate that PGS/PCL scaffold promotes differentiation of hESCs into RGCs, possibly, by simulating cells active environmental signalling, as well as, by supporting the growth of RGCs neurites along their lengths.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130355084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active Origin of Ordered Mesoporous Ir-Based Electrocatalysts for Acidic Water Oxidation 有序介孔ir基酸性水氧化电催化剂的活性来源

Bioengineering eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3900206

Lianhai Zu, Xingyue Qian, Shenlong Zhao, Qinghua Liang, Yu Chen, Bing-Jian Su, Kuang‐Hsu Wu, Long Qu, Linlin Duan, Min Liu, Hualin Zhan, Junye Zhang, Cang Li, Wei Li, J. Juang, Junwu Zhu, Dan Li, A. Yu, Dongyuan Zhao

{"title":"Active Origin of Ordered Mesoporous Ir-Based Electrocatalysts for Acidic Water Oxidation","authors":"Lianhai Zu, Xingyue Qian, Shenlong Zhao, Qinghua Liang, Yu Chen, Bing-Jian Su, Kuang‐Hsu Wu, Long Qu, Linlin Duan, Min Liu, Hualin Zhan, Junye Zhang, Cang Li, Wei Li, J. Juang, Junwu Zhu, Dan Li, A. Yu, Dongyuan Zhao","doi":"10.2139/ssrn.3900206","DOIUrl":"https://doi.org/10.2139/ssrn.3900206","url":null,"abstract":"Iridium (Ir)-based electrocatalysts are widely explored as benchmarks for acidic oxygen evolution reaction (OER), but further enhancing their catalytic activity has been retarded by the unidentified active species and unfavorable architectures. In this work, we first report two-dimensional (2D), ordered mesoporous Ir-IrOx/C catalysts with mixed valent species (Ir0, IrIV, and IrV) through a nanoconfined self-assembly strategy. The mesoporous Ir-IrOx/C catalyst has highly ordered layered nanochannels (~20 nm) and uniformly dispersed Ir-IrOx nanoparticles (~2 nm). Benefits from the mixed valence states and favorable mesostructured architecture, the resultant catalyst displays the lowest overpotential (η) of 198 mV at 10 mA cm-2geo for Ir-based OER electrocatalysts in an acid medium. Both experimental and computational results reveal that the IrV moiety of 2D mesoporous Ir-IrOx/C catalysts with a shortened Ir-O(II-δ)- bond (1.91 Å) is the key active species for the enhancement of OER by balancing the adsorption free energy of oxygen-containing intermediates. This study provides a model for an in-depth understanding of the active origin of the ordered mesoporous Ir-based electrocatalysts and role of V species in OER, as well as opens an avenue for designing high-efficient 2D ordered mesoporous electrocatalysts for water oxidation.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125236064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomaterial-Guided Organoid Engineering for Modeling Development and Diseases 生物材料引导的类器官工程建模发展和疾病

Bioengineering eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3708575

Plansky Hoang, Zhen Ma

引用次数: 0

Anatomical Variation of Human Bone Bioapatite Crystallography and Comparison to Hydroxyapatite 人骨生物磷灰石晶体学的解剖变异及与羟基磷灰石的比较

Bioengineering eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3600187

Foley Brittany, Greiner Martina, McGlynn George, W. Schmahl

{"title":"Anatomical Variation of Human Bone Bioapatite Crystallography and Comparison to Hydroxyapatite","authors":"Foley Brittany, Greiner Martina, McGlynn George, W. Schmahl","doi":"10.2139/ssrn.3600187","DOIUrl":"https://doi.org/10.2139/ssrn.3600187","url":null,"abstract":"This systematic investigation of bioapatite, the mineral component of human bone, aims to characterize its crystallographic state, including lattice parameters and average crystallite size, and correlate these values with respect to anatomical position (bone function), physicality, and age. In bone sample sets from three different human adults, anatomical variation of crystallographic lattice parameters and average crystallite size were observed.In general, the observed bioapatite lattice parameters among all analyzed human bones in this study are larger compared to those of stoichiometric hydroxyapatite (HAP) lattice parameters. Across all analyzed samples, the relative standard deviation of the mean a(=b) cell lattice parameter (unit cell edge-length) varies more (0.032%) than it does for the c lattice parameter (0.018%). Average crystallite size (average coherent diffracting domain size) in the c-direction was equal to approximately 25 nm, ranging among the analyzed 18 bone samples from about 20-32 nm, varying more than crystallite size in the a,b-direction (~8-10 nm). Neither lattice parameters nor average bioapatite crystallite sizes appeared to be correlated with bone function and the associated mechanical stresses but may be correlated to age. The results of this study prompt the need for large-scale systematic study of human bone mineral structure with consideration of different influencing bone traits, including but not limited to anatomical position, individual physical constitution, and age.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127867698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rat Calvarial Bone Regeneration by 3D-Printed Beta-Tricalcium Phosphate Incorporating MicroRNA-200c 含MicroRNA-200c的3d打印β -磷酸三钙再生大鼠颅骨骨

Bioengineering eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3708590

Matthew T Remy, Adil Akkouch, Li He, S. Eliason, M. Sweat, Tadkamol Krongbaramee, F. Qian, B. Amendt, Xuan Song, L. Hong

{"title":"Rat Calvarial Bone Regeneration by 3D-Printed Beta-Tricalcium Phosphate Incorporating MicroRNA-200c","authors":"Matthew T Remy, Adil Akkouch, Li He, S. Eliason, M. Sweat, Tadkamol Krongbaramee, F. Qian, B. Amendt, Xuan Song, L. Hong","doi":"10.2139/ssrn.3708590","DOIUrl":"https://doi.org/10.2139/ssrn.3708590","url":null,"abstract":"Advanced fabrication methods of bone grafts designed to match defect sites that combine biodegradable, osteoconductive materials with potent, osteoinductive biologics would significantly impact the clinical treatment of large bone defects. In this study, we engineered synthetic bone grafts using a hybrid material approach that combined 3D-printed biodegradable, osteoconductive β-tricalcium phosphate (β-TCP) with osteoinductive microRNA(miR)-200c. 3D-printed β-TCP scaffolds were fabricated utilizing suspension-enclosing projection-stereolithography (SEPS) process to produce constructs with reproducible microarchitectures that enhanced the osteoconductive properties of β-TCP. 3D-printed β-TCP scaffolds coated with miR-200c incorporated collagen increased the transfection efficiency of miR-200c and osteogenic differentiation of hBMSCs in vitro. Furthermore, these hybrid material, miR-incorporated scaffolds significantly enhanced bone regeneration in critical-sized rat calvarial defects. These results strongly indicate that through use of SEPS 3D-printing technology, hybrid scaffolds combined by osteoconductive biomaterials and osteoinductive biologics can be used as superior bone substitutes for the clinical treatment of large bone defects.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129965029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0