Bioengineering eJournal最新文献

{"title":"Injectable Hydrogel Mediated Delivery of Gene-Engineered Adipose-Derived Stem Cells for Enhanced Osteoarthritis Treatment","authors":"Wei Yu, Bin Hu, Kofi Oti Boakye-Yiadom, William Ho, Qijing Chen, Xiaoyang Xu, Xue-Qing Zhang","doi":"10.2139/ssrn.3855729","DOIUrl":"https://doi.org/10.2139/ssrn.3855729","url":null,"abstract":"Osteoarthritis (OA), a chronic and degenerative joint disease, remains a challenge in treatment due to the lack of disease-modifying therapies. As a promising therapeutic agent, adipose-derived stem cells (ADSCs) have an effective anti-inflammatory and chondroprotective paracrine effect that can be enhanced by genetic modification. Unfortunately, direct cell delivery without matrix support often results in poor viability of therapeutic cells. Herein, a hydrogel implant approach that enabled intra-articular delivery of gene-engineered ADSCs was developed for improved therapeutic outcomes in a surgically induced rat OA model. An injectable extracellular matrix (ECM)-mimicking hydrogel was prepared as the carrier for cell delivery, providing a favorable microenvironment for ADSC spreading and proliferation. The ECM-mimicking hydrogel could reduce cell death during and post injection. Additionally, ADSCs were genetically modified to overexpress transforming growth factor-β1 (TGF-β1), one of the paracrine factors that exert an anti-inflammatory and pro-anabolic effect. The gene-engineered ADSCs overexpressing TGF-β1 (T-ADSCs) had an enhanced paracrine effect on OA-like chondrocytes, which effectively decreased the expression of tumor necrosis factor-alpha and increased the expression of collagen II and aggrecan. In a surgically induced rat OA model, intra-articular injection of the T-ADSC-loaded hydrogel markedly reduced cartilage degeneration, joint inflammation, and the loss of the subchondral bone. Taken together, this study provides a potential biomaterial strategy for enhanced OA treatment by delivering the gene-engineered ADSCs within an ECM-mimicking hydrogel.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116260719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical Justification of Selecting a Method for Cultivation of Mammal Cells as a Basis for Designing Membrane Bioreactors in Accordance with the Requirements of Good Manufacturing Practice","authors":"S. Semeniuk, V. Povodzinskiy, V.Yu. Shybetskiy","doi":"10.15587/2706-5448.2021.229666","DOIUrl":"https://doi.org/10.15587/2706-5448.2021.229666","url":null,"abstract":"The object of research is technological cultivation systems, the central element of which are bioreactors, which ensure efficient metabolism of mammalian cells (Metazoa). Fundamental differences in the phenotypic characteristics of mammalian cells from microorganisms and the special phase-hydrodynamic state of the cultivation system form special requirements for the design and operation of bioreactors. One of the most problematic areas in the process of using cell cultures to obtain medicinal products of biological origin is to ensure the correct cultivation conditions in order to obtain the maximum amount of the target product. The quality assurance system for drug production is based on good manufacturing practice, which puts forward a number of general requirements for the organization of production of drugs of specified quality, efficacy and safety.\u0000The study analyzed the phenotypic characteristics of mammalian cells. The analysis of industrial cultivation systems is carried out and a new classification is proposed, which takes into account the phase-hydrodynamic state of the culture and the specifics of the hydrodynamics of the bioreactor. The analysis made it possible to determine membrane cultivation systems as the most promising. The choice of this cultivation system has a number of features, in particular, the provision of favorable conditions during a long process of cultivation of support-dependent cells. This system guarantees a constant and efficient supply of nutrients, including dissolved oxygen, and the removal of waste products. A wide range of materials for the manufacture of membranes allows to use an individual approach to different types of cell lines. Due to this, it is ensured that high cultivation rates are obtained - the density of cells on the growth surface, the provision of the necessary substances during the entire cultivation process without negative mechanical effects on the cells. The modular design of the membrane elements allows for scalability of the cultivation process from laboratory development to industrial cultivation. The results obtained in this work can be the initial data in the study of hydrodynamic and mass transfer characteristics and in the development or construction of new bioreactors, which will reduce the stage of laboratory development and accelerate the introduction of innovative drugs.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115864616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilayered, Peptide Biofunctionalized Hydrogels for in Vivo Osteochondral Tissue Repair","authors":"Jason L. Guo, Yu Seon Kim, Gerry L. Koons, Johnny Lam, A. Navara, Sergio Barrios, V. Y. Xie, Emma Watson, Brandon T. Smith, Hannah A. Pearce, Elysse A. Orchard, J. J. van den Beucken, J. Jansen, M. Wong, A. Mikos","doi":"10.2139/ssrn.3762205","DOIUrl":"https://doi.org/10.2139/ssrn.3762205","url":null,"abstract":"Osteochondral defects present a unique clinical challenge due to their combination of phenotypically distinct cartilage and bone, which require specific, stratified biochemical cues for tissue regeneration. Furthermore, the articular cartilage exhibits significantly worse regeneration than bone due to its largely acellular and avascular nature, prompting significant demand for regenerative therapies. To address these clinical challenges, we have developed a bilayered, modular hydrogel system that enables the click functionalization of cartilage- and bone-specific biochemical cues to each layer. In this system, the crosslinker poly(glycolic acid)-poly(ethylene glycol)-poly(glycolic acid)-di(but-2-yne-1,4-dithiol) (PdBT) was click conjugated with either a cartilage- or bone-specific peptide sequence of interest, and then mixed with a suspension of thermoresponsive polymer and mesenchymal stem cells (MSCs) to generate tissue-specific, cell-encapsulated hydrogel layers targeting the cartilage or bone. We implanted bilayered hydrogels in rabbit femoral condyle defects and investigated the effects of tissue-specific peptide presentation and cell encapsulation on osteochondral tissue repair. After 12 weeks implantation, hydrogels with a chondrogenic peptide sequence produced higher histological measures of overall defect filling, cartilage surface regularity, glycosaminoglycan (GAG)/cell content of neocartilage and adjacent cartilage, and bone filling and bonding compared to non-chondrogenic hydrogels. Furthermore, MSC encapsulation promoted greater histological measures of overall defect filling, cartilage thickness, GAG/cell content of neocartilage, and bone filling. Our results establish the utility of this click functionalized hydrogel system for in vivo repair of the osteochondral unit. STATEMENT OF SIGNIFICANCE: : Osteochondral repair requires mimicry of both cartilage- and bone-specific biochemical cues, which are highly distinct. While traditional constructs for osteochondral repair have mimicked gross compositional differences between the cartilage and bone in mineral content, mechanical properties, proteins, or cell types, few constructs have recapitulated the specific biochemical cues responsible for the differential development of cartilage and bone. In this study, click biofunctionalized, bilayered hydrogels produced stratified presentation of developmentally inspired peptide sequences for chondrogenesis and osteogenesis. This work represents, to the authors' knowledge, the first application of bioconjugation chemistry for the simultaneous repair of bone and cartilage tissue. The conjugation of tissue-specific peptide sequences successfully promoted development of both cartilage and bone tissues in vivo.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117242111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Situ Stable Injectable Collagen-Based Hydrogels for Cell and Growth Factor Delivery","authors":"Seyedsina Moeinzadeh, YoungBum Park, Sien Lin, Y. Yang","doi":"10.2139/ssrn.3693557","DOIUrl":"https://doi.org/10.2139/ssrn.3693557","url":null,"abstract":"Here we report development of in-situ stable injectable hydrogels for delivery of cells and growth factors based on two precursors, alginate, and collagen/calcium sulfate (CaSO4). The alg/col hydrogels were shear-thinning, injectable through commercially available needles and stable right after injection. Rheological measurements revealed that pre-crosslinked alg/col hydrogels fully crosslinked at 37°C and that the storage modulus of alg/col hydrogels increased with increasing the collagen content or the concentration of CaSO4. The viscoelastic characteristics and injectability of the alg/col hydrogels were not significantly impacted by the storage of precursor solutions for 28 days. An osteoinductive bone morphogenic protein-2 (BMP-2) loaded into alg/col hydrogels was released in 14 days. Human mesenchymal stem cells (hMSCs) encapsulated in alg/col hydrogels had over 90% viability over 7 days after injection. The DNA content of hMSC-laden alg/col hydrogels increased by 6-37 folds for 28 days, depending on the initial cell density. In addition, hMSCs encapsulated in alg/col hydrogels and incubated in osteogenic medium were osteogenically differentiated and formed a mineralized matrix. Finally, a BMP-2 loaded alg/col hydrogel was used to heal a critical size calvarial bone defect in rats after 8 weeks of injection. The alg/col hydrogel holds great promise in tissue engineering and bioprinting applications.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124918853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viscoelastic Characterization of Human Descending Thoracic Aortas Under Cyclic Load","authors":"Giulio Franchini, I. Breslavsky, G. Holzapfel, M. Amabili","doi":"10.2139/ssrn.3793934","DOIUrl":"https://doi.org/10.2139/ssrn.3793934","url":null,"abstract":"Experiments were carried out on 15 human descending thoracic aortas from heart-beating healthy donors who donated organs for transplant. The aortas were kept refrigerated in organ preservation solution and tested were completed within 48 hours from explant. Donors' age was comprised between 25 and 70 years, with an average of 51.7 ± 12.8 years. Quasi-static and dynamic uniaxial tensile test were carried out in thermally controlled physiological saline solution in order to characterize the viscoelastic behavior. Strips were tested under harmonic deformation of different frequency, between 1 and 11 Hz, at three initial pre-stretches. Cyclic deformations of two different amplitudes were used: a physiological one and a small one, the latter one for comparison purposes to understand the accuracy limits of viscoelastic models. Aortic strips in circumferential and longitudinal directions were cut from each aorta. Some strips were dissected to separate the three layers: intima, media and adventitia. They were tested individually in order to obtain layer-specific data. However, strips of the intact wall were also tested. Therefore, 8 strips per donors were tested. Viscoelastic parameters are accurately evaluated from the hysteresis loops. Results show that small-amplitude cyclic strain over-estimate the storage modulus and under-estimate the loss-factor. Therefore, cyclic deformation of physiological amplitude is necessary to obtain correct viscoelastic data of aortic tissue. The value of the applied pre-stretch is significant on the dynamic stiffness ratio (storage modulus divided by the corresponding quasi-static stiffness), while it is less significant for the loss factor. The median of the dynamic stiffness ratios, in physiological conditions, varies between 1.14 and 1.33 for the different layers and the intact wall; the corresponding median of the loss factors varies between 0.050 and 0.066. The lowest dynamic stiffness ratios and loss factors were obtained from donors of the youngest age group. STATEMENT OF SIGNIFICANCE: : There is an increasing interest in replacing traditional Dacron grafts used to repair thoracic aortas after acute dissection and aneurysm, with grafts in innovative biomaterials that mimic the mechanical properties and the dynamic behavior of the aorta. The human aorta is a complex laminated structure with hyperelastic and viscoelastic material properties and residual stresses. This study aims to characterize the nonlinear viscoelastic properties of ex-vivo human descending thoracic aortas by measuring hysteresis loops of physiological amplitude under harmonic strain. Results show the necessity to characterize the viscoelastic material properties of the aorta under physiological conditions, as well as the necessity to introduce improved models that take better into account the influence of the initial pre-stretch and amplitude of the cyclic load.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131796787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Nanocomposite Based on Montmorillonite, Fe Oxides, and Hydrothermal Carbon: Synthesis, Characterization and Pollutants Adsorption Tests","authors":"M.E. Zelaya Soulé, F. Barraqué, C. F. Morantes, F. M. Flores, M. Fernández, R. Sánchez, M. L. Montes","doi":"10.2139/ssrn.3678817","DOIUrl":"https://doi.org/10.2139/ssrn.3678817","url":null,"abstract":"Abstract This work presents the synthesis and characterization of montmorillonite-Fe oxides (Mt-Mag) and Mt-Fe oxides-carbon (Mt-Mag-C) systems as adsorbent materials, prepared by efficient and low-cost procedures. Fe oxides were synthesized by alkaline oxidation in the presence of nitrates while carbonization was hydrothermally synthesized. The adsorption capacity of the synthesized materials was tested against different pollutants (norfloxacin, thiabendazole, thiophanate-methyl, oxytetracycline, P4R and Cr(VI)). Fe particles and carbon were not homogeneously distributed while Mt-Mag-C sample presented a lower specific surface area and porosity than Mt-Mag, related to carbon presence, while magnetic nanoparticles seem not to block Mt external pores. Both materials revealed negative surface charge, indicating that is dominated by montmorillonite. Besides, Mt structure seems to be modified by both Fe oxides and carbon synthesis. The magnetic response was higher in Mt-Mag-C than in Mt-Mag, indicating Fe phases modifications during carbonization. The principal identified Fe oxide was magnetite, with minor contributions of paramagnetic Fe3+, goethite, and paramagnetic relaxation, with a significantly increased of the spectral area of the latter in Mt-Mag-C. Fe concentration determined by Mossbauer spectroscopy resulted higher on Mt-Mag-C than Mt-Mag, indicating that Fe atoms located at the interlayer space of montmorillonite, that give not Mossbauer signal, are exposed by sonication and carbon synthesis, and new magnetite particles are formed through the reduction of Fe3+ atoms in dextrose aqueous solution. The paramagnetic relaxation increase is related to new magnetite particles, that, because of carbon presence, cannot be magnetically coupled. A significant sorption capacity was found for cationic and zwitterionic compounds, revealing the relevance of electrostatic interaction. The magnetic response of Mt-Mag-C and the results of sorption tests for cationic and zwitterionic compounds, claims Mt-Mag-C as a promising sorbent material.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121910363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The AML Microenvironment Catalyzes a Step-Wise Evolution to Gilteritinib Resistance","authors":"S. Joshi, T. Nechiporuk, D. Bottomly, P. Piehowski, J. Reisz, Janét Pittsenbarger, A. Kaempf, Sara J. C. Gosline, Yi-Ting Wang, J. Hansen, M. Gritsenko, Chelsea M. Hutchinson, K. Weitz, J. Moon, T. Fillmore, Chia-Feng Tsai, A. Schepmoes, Tujin Shi, O. A. Arshad, J. Mcdermott, O. Babur, Kevin Watanabe-Smith, E. Demir, A. D’Alessandro, Tao Liu, C. Tognon, J. Tyner, S. McWeeney, K. Rodland, B. Druker, E. Traer","doi":"10.2139/ssrn.3771433","DOIUrl":"https://doi.org/10.2139/ssrn.3771433","url":null,"abstract":"Our study details the stepwise evolution of gilteritinib resistance in FLT3-mutated acute myeloid leukemia (AML). Early resistance is mediated by the bone marrow microenvironment, which protects residual leukemia cells. Removing these supportive extrinsic ligands drives evolution of late, intrinsic resistance. Whole exome sequencing, CRISPR/Cas, metabolomics, proteomics, and pharmacologic approaches were used to mechanistically define both early and late resistance. Early resistant cells undergo metabolic reprogramming, grow more slowly, and are dependent upon Aurora kinase B (AURKB). Late resistant cells are characterized byexpansion of pre-existing NRAS mutant subclones and continued metabolic reprogramming. Our model closely mirrors the timing and mutations of AML patients treated with gilteritinib.Pharmacological inhibition of AURKB resensitized both early resistant cell cultures and primary leukemia cells from gilteritinib-treated AML patients. These findings support a combinatorial strategy to target early resistant AML cells with AURKB inhibitors and gilteritinib before the expansion of pre-existing resistance mutations occurs.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129576099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Distinctive Nanocomposite Hydrogel Integrated Platform for the Healing of Wound after the Resection of Melanoma","authors":"Qizhen Xu, Yingying Wang, Taijun Chen, Cheng-ying Lao, Hongkun Gao, Ran Wei, B. Feng, Wei Zhi, J. Weng, Jianxin Wang","doi":"10.2139/ssrn.3693554","DOIUrl":"https://doi.org/10.2139/ssrn.3693554","url":null,"abstract":"Abstract During the surgical removal of melanoma, that the incompletely eradicated cancer cells enter the circulatory system with blood flow will lead to the risk of distant metastasis and then the recurrence of postoperative residual tumor, which will greatly reduce the cure rate. Additionally, microbial resistance makes the problem of infection more serious during the process of defect repair. Considering these problems, we developed a nanocomposite hydrogel (Gel/PF127) with excellent mechanical properties, hemostasis and broad-spectrum antibacterial activity. It was used for the dual release system based on micelles and hydrogel used for maintaining long-term release of paclitaxel (PTX) at the wound site after melanoma surgery, thereby killing residual tumor cells and repairing tissue defects better. The results showed that PF127 nano micelles could effectively load PTX and release it in tumor environment. Moreover, the quaternary ammonium gel network showed excellent growth inhibition for E. coli and S. aureus (inhibition rate up to 98%). The introduction of Ca2+ endowed the gel with the excellent hemostatic effect. The combination of reversible chemical bonds and electrostatic interaction made Gel/PF127 have good mechanical stability, excellent tissue adhesion and self-healing properties. The experimental results showed that such nanocomposite hydrogel could stop bleeding quickly and avoid wound infection, induce apoptosis of tumor cells and inhibit their recurrence very effectively, thus suggesting that the construction of in situ chemotherapy platform which integrates trauma repair and tumor inhibition will greatly promote the recurrence inhibition and trauma repair of melanoma. At the same time, it provides a simple and efficient strategy for other cancer postoperative wound healing.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115250537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dependence of Tendon Multiscale Mechanics on Sample Gauge Length is Consistent with Discontinuous Collagen Fibrils","authors":"Benjamin E. Peterson, Spencer E. Szczesny","doi":"10.2139/ssrn.3627993","DOIUrl":"https://doi.org/10.2139/ssrn.3627993","url":null,"abstract":"While collagen fibrils are understood to be the primary load-bearing elements in tendon, controversy still exists on how fibrils functionally transmit load from muscle to bone. Specifically, it's unclear whether fibrils are structurally continuous along the tendon length and bear load independently, or if they are discontinuous and transfer load through interfibrillar shear forces. To address this question, we investigated whether the multiscale mechanics of rat tail tendon fascicles is dependent on sample gauge length. We hypothesized that as the grip-to-grip length is reduced and approaches the length of the collagen fibrils, tendon fascicles will adopt a multiscale mechanical response consistent with structurally continuous fibrils. Our findings show that, for gauge lengths of 20 mm or greater, the local fibril strains are less than the bulk tissue strains, which can be explained by relative sliding between discontinuous collagen fibrils. In contrast, at a 5 mm gauge length, the fibril strains are equivalent to the applied tissue strains, suggesting that the collagen fibrils are structurally continuous between the grips. Additionally, the macroscale tissue modulus is increased at gauge lengths of 5 and 10 mm. Together, these data support the hypothesis that collagen fibrils in rat tail tendon fascicles are discontinuous and also suggest that their length is between 5 and 10 mm. This fundamental information regarding tendon structure-function relationships underscores the importance of the tissue components that transmit load between fibrils and is critical for understanding tendon pathology as well as establishing structural benchmarks for suitable tissue engineered replacements.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121383874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solving the Optimal Trading Trajectory Problem Using Simulated Bifurcation","authors":"Kyle Steinhauer, Takahisa Fukadai, S. Yoshida","doi":"10.2139/ssrn.3656242","DOIUrl":"https://doi.org/10.2139/ssrn.3656242","url":null,"abstract":"We use an optimization procedure based on simulated bifurcation (SB) to solve the integer portfolio and trading trajectory problem with an unprecedented computational speed. The underlying algorithm is based on a classical description of quantum adiabatic evolutions of a network of non-linearly interacting oscillators. This formulation has already proven to beat state of the art computation times for other NP-hard problems and is expected to show similar performance for certain portfolio optimization problems. Inspired by such we apply the SB approach to the portfolio integer optimization problem with quantity constraints and trading activities. We show first numerical results for portfolios of up to 1000 assets, which already confirm the power of the SB algorithm for its novel use-case as a portfolio and trading trajectory optimizer.","PeriodicalId":283911,"journal":{"name":"Bioengineering eJournal","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123547787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}