Bangladesh Journal of Medical Biochemistry最新文献

{"title":"The Correlation Between Lipid Profile and Proteinuria In Adult Nephrotic Syndrome Patients in Bangladeshi Population","authors":"T. Rahman, N. Sultana, P. Mazumder, S. Chowdhury, A. Akter, KF Raihan","doi":"10.3329/bjmb.v11i2.68495","DOIUrl":"https://doi.org/10.3329/bjmb.v11i2.68495","url":null,"abstract":"The nephrotic syndrome is a constellation of abnormalities that includes massive proteinuria, hypoalbuminemia and edema. Dyslipidemia is an important secondary biochemical abnormalities in nephrotic syndrome due to proteinuria and hypoalbuminemia. Dyslipidemia in nephrotic syndrome involved in the cardiovascular risk and also accelerates the progression of glomerular dysfunction. This study was conducted to evaluate the relationship between dyslipidemia and proteinuria in adult nephrotic syndrome patients. A total of 50 (fifty) diagnosed adult nephrotic syndrome patients from the Dept of Nephrology, Dhaka Medical College, Dhaka with age range from 20-50 years of both sexes were enrolled as study subjects. To evaluate the correlation between serum TC, TAG, HDL-C and LDL-C with 24 hour urinary total protein. This case control study was carried out in the Department of Biochemistry, Dhaka Medical College, Dhaka, during the period of July 2013 to June 2014. With baseline information, lipid profile and 24 hour urinary total protein of study subjects were estimated. Mean values of the variables were determined. Correlation between variables were determined by Pearson's correlation test by using SPSS for windows version 20.0. For all the statistical analysis p<0.05 was considered as significant. Mean(±SD) values of serum total cholesterol (Tchol), TAG, HDL-C and LDL-C in adult nephrotic syndrome patients were 288.23±35.67 mg/dl, 174.53±18.86 mg/dl, 23.71±4.58 mg/dl and 231.16±34.28 mg/dl respectively. Mean value of 24 hour urinary total protein in study subjects was 5.65±0.54 gm/d. Positive correlation was found between 24 hour urinary total protein and Tchol (r=0.476, p<0.05), TAG (r=0.354, p<0.05), LDL-C (r=0.444, p<0.05) and positive correlation was found between 24 hour urinary total protein and HDL-C (r=0.028 p>0.05). Dyslipidemia in adult nephrotic syndrome possesses a significant relationship with proteinuria which could predispose them to develop coronary artery disease. \u0000Bangladesh J Med Biochem 2018; 11(2): 24-33","PeriodicalId":283881,"journal":{"name":"Bangladesh Journal of Medical Biochemistry","volume":"148 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123464165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preanalytic Error - Still a Challenge to Overcome","authors":"D. Saha, Lubna Nazneen","doi":"10.3329/bjmb.v11i2.68489","DOIUrl":"https://doi.org/10.3329/bjmb.v11i2.68489","url":null,"abstract":"Abstract not available \u0000Bangladesh J Med Biochem 2018; 11(2): i-ii","PeriodicalId":283881,"journal":{"name":"Bangladesh Journal of Medical Biochemistry","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117042195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Uric Acid and Atherogenic Index Of Plasma in Diabetes Mellitus","authors":"R. Ahmed, S. Khanduker, F. Khondker, S. Biswas, S. Sultana, F. Kabir, S. Islam, MM Jamaluddin","doi":"10.3329/bjmb.v11i2.68490","DOIUrl":"https://doi.org/10.3329/bjmb.v11i2.68490","url":null,"abstract":"Diabetes mellitus (DM) is a chronic disease characterized by insulin deficiency or peripheral resistance resulting in hyperglycemia. Diabetic patients have increased rates of coronary heart disease, cerebrovascular disease and peripheral vascular disease, and are two to three times more likely to develop cardiovascular disease (CVD). Serum uric acid (SUA) has been known to be associated with cardiovascular diseases. \"Atherogenic index of plasma\" (AIP) is considered to be a very sensitive predictor of future cardiovascular events. The study was done to evaluate the association of serum uric acid and atherogenic index of plasma in diabetic patients. A total of 315 diabetic patients were selected as study subjects based on predefined enrollment criteria. The patients were separated into groups according to their serum uric acid levels. Serum uric acid levels under 6 mg/dL were considered as normal. AIP was calculated as the logarithmically transformed ratio of triglyceride to high density lipoprotein cholesterol. The study found that AIP levels were significantly high in high SUA group compared to normal SUA group. The study showed a positive significant correlation between AIP and SUA (r=0.347, P<0.001) in diabetes patients. Additionally, in binary logistic regression analysis, AIP was found to be independently associated with high UA levels. Present study reveals that SUA and AIP are closely related. \u0000Bangladesh J Med Biochem 2018; 11(2): 6-10","PeriodicalId":283881,"journal":{"name":"Bangladesh Journal of Medical Biochemistry","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122948644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Mutation of BRCA1 Gene at Chromosome 17q21 in Bangladeshi Women With Familial Breast Cancer","authors":"A. Siddiqua, N. Martuza, J. Tasnim, M. Rahman, Ij Akhi, A. Shahanaj, M. Rahman, N. Sultana, TJ Shoha","doi":"10.3329/bjmb.v11i2.68494","DOIUrl":"https://doi.org/10.3329/bjmb.v11i2.68494","url":null,"abstract":"Breast cancer is the most common cancer among women in Bangladesh. About 69% cancer death of women is due to breast cancer. In Bangladesh the incidence rate of breast cancer is about 22.5 per 100000 female. Female who carries mutation in the BRCA1 gene have an 80% chance of developing breast cancer during their lifetime. Due to its high prevalence, genetic testing for BRCA1 mutation has become an integral part of clinical practice. This study was aimed to characterize the mutation at chromosome 17q21 by targeting BRCA1 gene among Bangladeshi women with familial breast cancer. This descriptive case series study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka, from July 2017 to June 2018. In this study, thirty diagnosed breast cancer patients with family history breast cancer were selected according to the selection criteria from the Department of Surgery and Department of Radiotherapy, Dhaka Medical College, Dhaka. Mutations were detected by Next Generation Sequencing method. Characterization and clinical significance were verified from NCBI genome database. The study parameters were presence of mutation, types of mutation, clinical significance, frequency (%) of mutation. In this study, sixteen distinct mutations were found. Three pathogenic mutations (10%) were found among the patients which were nonsense mutations. Pathogenic mutations were c.5251C>T, c.2158G>T and c.1059G>A. Three mutations of uncertain significance with missense variant, five benign mutations of missense variant and five benign mutations of silent variant were also found among thirty patients. In this study we found that, Bangladeshi women with familial breast cancer had 10% pathogenic mutations. Early screening for BRCA1 gene mutations might provide better information for health to those who have family history of breast cancer. \u0000Bangladesh J Med Biochem 2018; 11(2): 17-23","PeriodicalId":283881,"journal":{"name":"Bangladesh Journal of Medical Biochemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130617419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Serum Uric Acid in Type 2 Male Diabetes Mellitus Patient In a Tertiary Care Hospital","authors":"R. Yeasmin, M. Muttalib, N. Sultana, Mjh Karami, NH Bhuiyan, A. Nesa","doi":"10.3329/bjmb.v11i2.68493","DOIUrl":"https://doi.org/10.3329/bjmb.v11i2.68493","url":null,"abstract":"Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance. The prevalence of diabetes is rapidly rising all over the globe at an alarming rate. Hyperuricemia is probably associated with glucose intolerance due to various mechanisms, however, the most important is the association between insulin and renal resistance to absorption of urates. 1/2, The aim of the study is to examine the serum uric acid level in Type 2 male Diabetic patients and to assess the association of serum uric acid level with fasting blood sugar (FBS), blood sugar two hours after breakfast (2HAB), glycated hemoglobin (HbA1C), duration of diabetes, and exercise time. This case-control study was conducted in Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorders (BIRDEM), out-patient department (OPD) during the period of June 2016 to January 2017. It included 110 Subjects of type 2 male diabetic patients as cases. In addition 100 age and sex matched non-diabetic male subjects were randomly selected as control Results: The mean serum uric acid of all cases of Type 2 DM was 8.39±2.61mg/dl which was significantly higher than controls (5.14±84 mg/dl). The study found that there were significant differences in mean age, duration of diabetes, exercise time, waist-hip ratio, systolic blood pressure (SBP), and diastolic blood pressure (DBP) within cases and controls but no significant differences of mean BMI was found. This study also found that significant differences in mean of FBS, ABF and HbA1C between case and controls but there was no significant differences of mean TG, Cholesterol, HDL and LDL. The serum uric acid was not significantly correlated with FBS, 2HAB and HbA1C but significantly correlated with exercise time where r =.340. Chi square test was carried out to measure the association between HbA1C and Uric acid category. But had no significant association Conclusion: Our study findings conclude that serum uric acid is not significantly correlated with FBS, 2HAB and HbA1C, but significantly correlated with age, duration of DM, and exercise time. \u0000Bangladesh J Med Biochem 2018; 11(2): 11-16","PeriodicalId":283881,"journal":{"name":"Bangladesh Journal of Medical Biochemistry","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115422683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Phenotyping Using Metabolic Syndrome Criteria and Cardiometabolic Disabilities Criteria in Bangladeshi Adult Population","authors":"S. Naher, Ss Sejooti, Mozammel Hoque, Zaman, H. Imam, T. Ahmed, R. Tabassum, Md. Shafiul Ferdous","doi":"10.3329/BJMB.V11I1.39762","DOIUrl":"https://doi.org/10.3329/BJMB.V11I1.39762","url":null,"abstract":"Obesity has become a global epidemic and has been found to be associated with numerous comorbidities. Body mass index (BMI) based classification of obesity is simple but co-morbidities do not affect all obese and overweight people. The present study was aimed to find out the frequency of metabolic phenotypes in different BMI groups using metabolic syndrome (MetS) criteria and cardiometabolic disabilities (CA) criteria and also to find out an appropriate method for defining metabolic health among adult population attending out patient department of Bangabandhu Sheikh Mujib Medical University (BSMMU). This cross-sectional analytical study was carried out in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU) from March 2016 to February 2017. By non probability sampling, a total of 1023 study subjects were selected from apparently healthy adult individuals attending outpatient department of BSMMU. The study subjects were grouped into three body mass index classes and also further categorized into six groups according to metabolically unhealthy or healthy phenotypes by presence or absence of metabolic syndrome (MetS) criteria as well as cardiometabolic disabilities (CA) criteria respectively. Then agreement among different metabolic phenotypes based on these two criteria were observed. Frequency of different metabolic phenotypes i,e metabolically healthy normal weight (MHNW), metabolically obese normal weight (MONW), metabolically healthy over weight (MHOW), metabolically obese over weight (MOOW), metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) were 12.3%, 6.9%, 21.4%, 27.7%, 7.7%, 23.9% by MetS criteria and 7.7%, 11.5%, 11.6%, 37.4%, 6.1%, 25.6% by CA criteria respectively. MOOW followed by MUO were found to be predominant among all phenotypes. Fare agreement was found between two criteria in case of normal weight and overweight groups and good agreement was found in case of obese groups. From this study, it may be concluded that, attention should be given to the metabolically obese phenotypes in different BMI classes to reduce co-morbidities. \u0000Bangladesh J Med Biochem 2018; 11(1): 1-8","PeriodicalId":283881,"journal":{"name":"Bangladesh Journal of Medical Biochemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130104036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incretin Hormones, Thyroid Stimulating Hormone and Human Growth Hormone Responses During Ogtt in Newly Diagnosed T2DM Patients","authors":"K. A. Jhuma, A. Giasuddin, Hossain, A. Haq","doi":"10.3329/BJMB.V11I1.39761","DOIUrl":"https://doi.org/10.3329/BJMB.V11I1.39761","url":null,"abstract":"Several research groups have reported variable results about incretin effects of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1(GLP-1), altered thyroid stimulating hormone (TSH) status, human growth hormone (hGH) deficiency and perturbed cytokines balances in type 2 diabetes mellitus (T2DM).The present case-control prospective interventional study was conducted investigating responses of incretin hormones (GIP, GLP-1), TSH and hGH to oral glucose tolerance test (OGTT) in newly diagnosed Bangladeshi T2DM patient. Blood samples were collected from 36 OGTT positive newly diagnosed T2DM patients as cases and 30 normal adults as controls at '0' minute (fasting) and at 2 hours after OGTT. Laboratory investigations were done and special parameters in serum, i.e. hGH, TSH, Insulin, GIP and GLP-1 were analyzed using enzyme immunoassay (EIA) kits. Statistical analyses were made by Student's 't' test using SPSS programm. T2DM patients (cases) had FBG and BG2Hr levels much higher than controls (p<0.001). No significant differences were observed between controls and cases for F-TSH (p=0.927), TSH2HrA (p=0.413), F-hGH (p=0.532) and hGH2HrA (p=0.773) levels. It was observed that F-GIP (p=0.309) and F-GLP-1 (p=0.984) levels were similar between cases and controls. Interestingly, control subjects responded to OGTT by increasing GIP2HA and GLP-1, 2HR levels about 3 times compared to F-GIP and F-GLP-1 (p<0.001). In cases, F-GIP and F-GLP-1 levels were also raised responding to OGTT but by about 1.5 times only compared to F-GIP and F-GLP-1 (p<0.025). Although no significant differences were observed for F-TSH, TSH2HrA, F-hGH and hGH2HrA between cases and controls, F-GIP and F-GLP-1 levels were raised responding to OGTT in cases by about 1.5 times only compared to about 3.0 times in controls subjects. But responses of GIP and GLP-1 to glucose load were lower leading to reduced insulin levels in these T2DM patients reported earlier. Further studies with a larger sample size including cytokines are warranted. \u0000Bangladesh J Med Biochem 2018; 11(1): 9-16","PeriodicalId":283881,"journal":{"name":"Bangladesh Journal of Medical Biochemistry","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127012540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of Dhaka City Retailers on User Choice of Self-Monitoring Blood Glucose Devices","authors":"J. Nayeem, S. Kamaluddin, H. Chowdhury, L. Ali","doi":"10.3329/BJMB.V11I1.39763","DOIUrl":"https://doi.org/10.3329/BJMB.V11I1.39763","url":null,"abstract":"Self-Monitoring Blood Glucose (SMBG) Devices are now thought to be an integral component in the prevention and management of diabetes mellitus which is increasingly becoming a major health and economic burden particularly in developing countries. The marketing of these Devices, however, are still not well regulated in most of the countries and this, in turn, may lead to more harm than good to the patients who are using these devices. Retailers are the most important contact points who create the interface among the Manufacturers, Professionals and Consumers for popularization of health related devices. In this study, the Users' Choice of SMBG Devices and its determinants, as reflected in the views of the Sales Persons (in a retail shop) in Dhaka City of Bangladesh, have been explored. Twenty Sales Persons from 20 Retail Shops, purposively selected from among major Dhaka City markets where these devices are commonly sold, were individually interviewed using a pretested Interviewer administered Questionnaire. The instrument consisted of six questions covering the Users' preference regarding quality vs cost and also regarding the guidance and motives for purchasing specific items. The results were analyzed by descriptive statistics. It was found that 90% of the consumers are dependent on the suggestions of the Sales Persons regarding the choice of devices. In 80% of the subjects the cost of the System was found to be the determining factor regarding the choice of a meter. Only among 20% subjects, quality played any role in the choice. In conclusion, the choice of specific SMBG devices in Dhaka City is overwhelmingly influenced by Retailers (who, in most cases are not even qualified Pharmacists or Pharmacy Assistants) and, except in few cases; Users are not concerned with quality. Price, particularly the price of the strip, is the dominant factor on Users' choice of SMBG Devices. \u0000Bangladesh J Med Biochem 2018; 11(1): 17-21","PeriodicalId":283881,"journal":{"name":"Bangladesh Journal of Medical Biochemistry","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130155765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raised Serum Homocysteine Level is Associated with Hypertension","authors":"S. Biswas, R. Haque, N. Uddin, A. Saha, K. Sultan, F. Khondker, P. Saha, L. Siddique","doi":"10.3329/BJMB.V11I1.39764","DOIUrl":"https://doi.org/10.3329/BJMB.V11I1.39764","url":null,"abstract":"An elevated serum homocysteine concentration is associated with an increased risk of coronary, cerebral, and peripheral vascular disease. The objective of the study was to evaluate the association of serum homocysteine level with hypertension (HTN). This cross sectional analytical study was conducted at Sir Salimullah Medical College & Mitford Hospital and National Health Care Network Dhaka, Bangladesh over a duration of 21 months from July 2012 to May 2014. Fifty HTN patients were included as study subjects and age and sex matched fifty non-HTN healtlhy controls were included. All the clinical measurements were taken and serum Hcy was measured for all study subjects. In this study, females were predominant in both groups, mean age of the HTN patients was 41.0±5.6 years and non-HTN healthy subjects was 38.2±5.2 years. BMI and FBG were found higher in HTN group than that of non-HTN group but the differences were not statistically significant. Systolic and diastolic BP were found significantly higher in HTN group than that of non-HTN group. Serum Hcy level was significantly higher in HTN group (19.93±4.12 μmol/L) than that of non-HTN group (13.20±1.88 μmol/L). This study depicted that serum Hcy had significant correlation with SBP and DBP in HTN. In conclusion, it was seen that elevated serum Hcy level is associated with hytpertension. \u0000Bangladesh J Med Biochem 2018; 11(1): 22-25","PeriodicalId":283881,"journal":{"name":"Bangladesh Journal of Medical Biochemistry","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127757204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Some Predictors of Metabolic Syndrome in an Important Group of Health Care Providers of Bangladesh","authors":"Sk Baul, D. Parvin, S. Hossain, M. Hadiuzzaman, F. Mollah, M. Hoque","doi":"10.3329/BJMB.V11I1.39765","DOIUrl":"https://doi.org/10.3329/BJMB.V11I1.39765","url":null,"abstract":"Metabolic syndrome (MS), a global epidemic, is a cluster of risk factors for CHD, T2DM, stroke and other various medical problems, which affects specially those who lead sedentary and stressful life. Among the health service providers of Bangladesh, doctors are very important group who leads sedentary and mentally stressful life with low physical exercise. The aim was to evaluate WHR (waist-hip ratio), WHtR (waist-height ratio) and TG, HDL-C for their predictive value of MS. In this cross-sectional study, by convenient and purposive sampling technique, 25-55 years aged 500 Bangladeshi doctors (male 334, female 166) were enrolled. The study was carried out in the Department of Biochemistry, BSMMU, Shahbag, Dhaka, Bangladesh. MS was diagnosed by modified NCEP ATP III criteria. Prevalence of MS was measured at 95% CI. Statistical significance was set at p<0.05. Prevalence of MS was found 38.8% in total study subjects; that in male and female was 24.6% and 14.2% respectively. Performance tests of predictors were done. WHR was the most sensitive (99.19% male & 98.59% female), TG was the most specific (94.79% male & 62.11% female) & accurate (78.1% male & 68.1% female) predictor. ROC curves of predictors were produced and all were found good (AUC>0.6) for their predictive value of MS; WHtR was revealed better than WHR as an index for MS (AUC 0.667 vs. 0.652 in male; 0.706 vs. 0.681 in female). It can be concluded, the prevalence of MS is very high among the doctors of Bangladesh; WHtR can be used as a good and relevant index for MS. \u0000Bangladesh J Med Biochem 2018; 11(1): 26-35","PeriodicalId":283881,"journal":{"name":"Bangladesh Journal of Medical Biochemistry","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122220154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}