新诊断T2DM患者Ogtt期间肠促胰岛素、促甲状腺激素和生长激素的反应

K. A. Jhuma, A. Giasuddin, Hossain, A. Haq
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引用次数: 0

摘要

几个研究小组已经报道了关于2型糖尿病(T2DM)中葡萄糖依赖性胰岛素性多肽(GIP)和胰高血糖素样肽-1(GLP-1)的肠促胰岛素效应、促甲状腺激素(TSH)状态改变、人类生长激素(hGH)缺乏和细胞因子平衡紊乱的不同结果。本研究采用病例对照前瞻性介入研究,探讨孟加拉新诊断T2DM患者肠促胰岛素激素(GIP、GLP-1)、TSH和hGH对口服糖耐量试验(OGTT)的反应。在OGTT后0分钟(空腹)和2小时采集36例OGTT阳性新诊断T2DM患者和30例正常成人的血液样本作为对照。采用酶免疫分析法(EIA)检测血清中hGH、TSH、胰岛素、GIP和GLP-1等特殊参数。统计学分析采用SPSS软件进行Student's t检验。T2DM患者(例)FBG和BG2Hr水平明显高于对照组(p<0.001)。对照组与病例间F-TSH (p=0.927)、TSH2HrA (p=0.413)、F-hGH (p=0.532)和hGH2HrA (p=0.773)水平无显著差异。观察到F-GIP (p=0.309)和F-GLP-1 (p=0.984)水平在病例和对照组之间相似。有趣的是,与F-GIP和F-GLP-1相比,对照受试者对OGTT的反应是GIP2HA和glp - 1,2hr水平升高约3倍(p<0.001)。在某些情况下,F-GIP和F-GLP-1水平也因OGTT而升高,但仅为F-GIP和F-GLP-1的1.5倍左右(p<0.025)。虽然F-TSH、TSH2HrA、F-hGH和hGH2HrA在病例和对照组之间没有显著差异,但F-GIP和F-GLP-1水平在OGTT作用下仅升高了约1.5倍,而对照组约为3.0倍。但在这些T2DM患者中,GIP和GLP-1对葡萄糖负荷的反应较低,导致胰岛素水平降低。进一步的研究需要更大的样本量,包括细胞因子。孟加拉国J Med Biochem 2018;11(1): 9到16
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Incretin Hormones, Thyroid Stimulating Hormone and Human Growth Hormone Responses During Ogtt in Newly Diagnosed T2DM Patients
Several research groups have reported variable results about incretin effects of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1(GLP-1), altered thyroid stimulating hormone (TSH) status, human growth hormone (hGH) deficiency and perturbed cytokines balances in type 2 diabetes mellitus (T2DM).The present case-control prospective interventional study was conducted investigating responses of incretin hormones (GIP, GLP-1), TSH and hGH to oral glucose tolerance test (OGTT) in newly diagnosed Bangladeshi T2DM patient. Blood samples were collected from 36 OGTT positive newly diagnosed T2DM patients as cases and 30 normal adults as controls at '0' minute (fasting) and at 2 hours after OGTT. Laboratory investigations were done and special parameters in serum, i.e. hGH, TSH, Insulin, GIP and GLP-1 were analyzed using enzyme immunoassay (EIA) kits. Statistical analyses were made by Student's 't' test using SPSS programm. T2DM patients (cases) had FBG and BG2Hr levels much higher than controls (p<0.001). No significant differences were observed between controls and cases for F-TSH (p=0.927), TSH2HrA (p=0.413), F-hGH (p=0.532) and hGH2HrA (p=0.773) levels. It was observed that F-GIP (p=0.309) and F-GLP-1 (p=0.984) levels were similar between cases and controls. Interestingly, control subjects responded to OGTT by increasing GIP2HA and GLP-1, 2HR levels about 3 times compared to F-GIP and F-GLP-1 (p<0.001). In cases, F-GIP and F-GLP-1 levels were also raised responding to OGTT but by about 1.5 times only compared to F-GIP and F-GLP-1 (p<0.025). Although no significant differences were observed for F-TSH, TSH2HrA, F-hGH and hGH2HrA between cases and controls, F-GIP and F-GLP-1 levels were raised responding to OGTT in cases by about 1.5 times only compared to about 3.0 times in controls subjects. But responses of GIP and GLP-1 to glucose load were lower leading to reduced insulin levels in these T2DM patients reported earlier. Further studies with a larger sample size including cytokines are warranted. Bangladesh J Med Biochem 2018; 11(1): 9-16
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