D. Bļizņuks, E. Cibulska, A. Bondarenko, Y. Chizhov, I. Lihacova
{"title":"Deep learning model deploying on embedded skin cancer diagnostic device","authors":"D. Bļizņuks, E. Cibulska, A. Bondarenko, Y. Chizhov, I. Lihacova","doi":"10.1117/12.2582108","DOIUrl":"https://doi.org/10.1117/12.2582108","url":null,"abstract":"The number of research papers, where neural networks are applied in medical image analysis is growing. There is a proof that Convolutional Neural Networks (CNN) are able to differentiate skin cancer from nevi with greater accuracy than experienced specialists on average (sensitivity 82% and 73% accordingly).1 Team's latest research2 allows achieving even greater accuracy, by using specific narrow-band illumination. Nevertheless, the overall probability of early skin cancer detection depends on the availability of diagnostic tools. If screening tools will be available to a high number of general practices, the chance of disease detection will increase. The previous research3 shows that scalable cloud service is able to process a high number of users. After a certain number of users, the overall cost of the system, including cloud processing expenses and cost of high computational power portable device, might be higher if compared to an on-premises solution, where each device is capable of diagnosing without Internet access. It might be cheaper to equip devices with additional neural processing unit (NPU) and exclude cloud processing. Another option is to make screening available by using the newest smartphones that are equipped with NPU.4 The problem of using the NPU is that they are limited in storage space, accuracy, and features. Therefore, a full-size CNN model should be adapted and minimized to fit in a limited NPU. Research reviews existing CNN optimization methods and proposes the most accurate for skin cancer diagnostics. The paper evaluates CNN prediction losses when the model's elements’ precision is reduced from 32 bits to 8 and rounded to integer values.","PeriodicalId":283327,"journal":{"name":"Biophotonics-Riga","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131571015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopes for internal organs cancer diagnostics based on television and multispectral methods of image processing","authors":"K. Zaichenko, B. Gurevich","doi":"10.1117/12.2581738","DOIUrl":"https://doi.org/10.1117/12.2581738","url":null,"abstract":"Endoscopes are applied widely for diagnostics of different diseases of internal organs. However, simultaneous transmission of spectral and spatial information by means of even the most perfect endoscopes meets significant obstacles. A new kind of endoscope has been proposed in this paper, in which the image of internal organ is transmitted not only by video camera but also some certain fragments of the image are transmitted by the image transmitter based on fiber optics. This composition provides elimination of the information losses which are connected with three-colored principle of television image transmission. Additional spectral information increases the reliability of diagnoses made on the base of data presented by endoscope. The structural circuit of the proposed endoscope has been considered and discussed. The most common area of practical application of this endoscope is internal organs oncology diagnostics. In order to perform such diagnostics, some preliminary investigations are required because the reflection spectra of human tissues defeated by the cancer cells, are not yet known. Such hybrid endoscope can be used in gastroscopy, bronchoscopy, colonoscopy, laparoscopy, and all other similar areas. The principle of multispectral processing which is used in fiber-optics-based sensors provides obtaining of maximum possible spectral information in addition to high spatial resolution provided by RGB camera.","PeriodicalId":283327,"journal":{"name":"Biophotonics-Riga","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131170247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Lihacova, E. Cibulska, A. Lihachev, M. Lange, E. V. Plorina, D. Bļizņuks, A. Derjabo, N. Kiss
{"title":"Challenges of automatic processing of large amount of skin lesion multispectral data","authors":"I. Lihacova, E. Cibulska, A. Lihachev, M. Lange, E. V. Plorina, D. Bļizņuks, A. Derjabo, N. Kiss","doi":"10.1117/12.2582049","DOIUrl":"https://doi.org/10.1117/12.2582049","url":null,"abstract":"This work will describe the challenges involved in setting up automatic processing for a large differentiated data set. In this study, a multispectral (skin diffuse reflection images using 526nm (green), 663nm (red), and 964nm (infrared) illumination and autofluorescence (AF) image using 405 nm excitation) data set with 756 lesions (3024 images) was processed. Previously, using MATLAB software, finding markers, correctly segmenting images with dark edges and image alignment were the main causes of the problems in automatic data processing. To improve automatic processing and eliminate the use of licensed software, the latter was substituted with the open source Python environment. For more precise segmentation of skin markers and skin lesions, as well for image alignment, the processing of artificial neural networks was utilized. The resulting processing method solves most of the issues of the MATLAB script. However, for even more accurate results, it is necessary to provide more accurate ground-truth segmentation masks and generate more input data to increase the training image database by using data augmentation.","PeriodicalId":283327,"journal":{"name":"Biophotonics-Riga","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116797566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimization of information presentation process by multispectral processing systems of biological objects images","authors":"K. Zaichenko, B. Gurevich","doi":"10.1117/12.2581743","DOIUrl":"https://doi.org/10.1117/12.2581743","url":null,"abstract":"The method of multispectral images processing foresees the simultaneous processing of several kinds of information, preferably spatial , spectral, and gradational kinds. The reliable recording of these kinds of information causes in many cases the time information losses which is often look undesirable. However if the selective element operation rate is enough high, as it takes place in the case of acousto-optic tunable filters application, so it is possible to minimize the losses of time information. The mutual dependencies of amounts of different information kinds have been considered during their transmission while the images multispectral processing procedures. The special attention have been paid to the definition of spatial and spectral information relationships optimums as well as the same for spatial and gradational information. The areas of medical diagnostics have been discussed for which the multispectral processing method application can increase the probability of the correct diagnostic solutions accepting significantly.","PeriodicalId":283327,"journal":{"name":"Biophotonics-Riga","volume":"143 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120845446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Objective noninvasive monitoring of laser tattoo removal in a human volunteer: a proof of principle study","authors":"N. Verdel, B. Majaron","doi":"10.1117/12.2582137","DOIUrl":"https://doi.org/10.1117/12.2582137","url":null,"abstract":"We explore the potential for noninvasive monitoring of laser tattoo removal treatment by adapting a recently introduced methodology for quantitative assessment of structure and composition of human skin in vivo.1 The approach combines diffuse reflectance spectroscopy in visible part of the spectrum with pulsed photothermal radiometry, involving timeresolved measurements of mid-infrared emission after irradiation with a millisecond laser pulse. The experimental data are fitted simultaneously with the respective predictions of a dedicated numerical model of light and heat transport in tattooed skin. For this purpose we apply a three-layer optical model of skin, consisting of epidermis, upper dermis, and lower dermis which includes the tattoo ink. This proof of principle study involved one healthy volunteer undergoing tattoo removal treatment. One half of the tattoo was treated with 5 ns pulses from a commercial Nd:YAG laser (StarWalker® MaQX, Fotona) at radiant exposure of 3 J/cm2, and the other half with much shorter, \"picosecond\" pulses at the same wavelength and 1.3 J/cm2. Measurements were performed before and 8 weeks after the first treatment session, as well as 20 weeks after the second treatment. The results show a significant reduction of the ink content and an increase of the subsurface depth of the tattoo layer over the course of treatment with both lasers, in agreement with gradual fading of the tattoo.","PeriodicalId":283327,"journal":{"name":"Biophotonics-Riga","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130435647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study of As and Tl high-frequency electrodeless lamps for Zeeman absorption spectroscopy","authors":"N. Zorina, A. Skudra, G. Revalde, A. Abola","doi":"10.1117/12.2580856","DOIUrl":"https://doi.org/10.1117/12.2580856","url":null,"abstract":"High-frequency electrodeless light sources are known as bright radiators with the line spectrum, characterized by high intensities and narrow line shapes. The lamp balloons are mostly made of quartz and filled with a metal and buffer gas. These light sources must be optimized for each application in accordance with the specific requirements of radiation quality, lifetime, and stability. This work is devoted to the diagnostic of high-frequency electrodeless light sources for their use in high precision atomic absorption analyzers and other applications like disinfection. The spectral line intensities and profiles were studied in discharges with arsenic and thallium fillings. Special attention is devoted to the UV lines of 193.7 nm and 197.2 nm of As and 377.6 nm of Tl spectral lines. The intensities and profiles were measured by means of a Fourier transform spectrometer. The deconvolution procedure was implemented to obtain the real form of emitted profiles for further analysis. The integrated areas, values of self-absorption, and other parameters were obtained and compared for both fillings as a function of working regimes.","PeriodicalId":283327,"journal":{"name":"Biophotonics-Riga","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123790691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photoplethysmographic waves and their detailed pulse interval distribution analysis on Poincare plots before and after the sauna exposures","authors":"M. Huotari, Kari Määttä, J. Röning","doi":"10.1117/12.2582204","DOIUrl":"https://doi.org/10.1117/12.2582204","url":null,"abstract":"Photoplethysmography (PPG) has proved to be valuable signal carrier information from many biomedical sources. Especially, sauna studies have shown that heart pulse inter beat intervals, heart rate variability (HRV), shape and morphology of PPG can provide much interesting information about arterial elasticity during and after a sauna exposure. These parameters are pulse amplitude, pulse width, and pulse to pulse beat intervals changes caused by the sauna exposure. In our preliminary study there is searched on heart pulse variability information and other hemodynamic parameters. However, there is not yet standard detailed calculation algorithms for these parameters. Merged Poincaré plots, or so called return maps, could give valuable information which is here at the first time noticed.","PeriodicalId":283327,"journal":{"name":"Biophotonics-Riga","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123427357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improved biomedical imaging over a wide spectral range from UV to THz towards multimodality","authors":"L. M. Oliveira, K. Zaytsev, V. Tuchin","doi":"10.1117/12.2584999","DOIUrl":"https://doi.org/10.1117/12.2584999","url":null,"abstract":"The concept of ‘tissue optical windows’ and method of optical clearing (OC) based on controllable and reversible modification of tissue optical properties by their soaking with a biocompatible optical clearing agent (OCA) are prsented. Fundamentals and major mechanisms of OC allowing one to enhance optical imaging facilities and laser treatment efficiency of living tissues are described. Perspectives of immersion optical clearing/contrasting technique aiming to enhance optical imaging of living tissues by using different imaging modalities working in the ultra-broad wavelength range from deep UV to terahertz waves are discussed. It demonstrated that immersion OC method can be applied to evaluate the characteristic diffusion properties of water and OCA in various tissues and even discriminate between the mobile water content in normal and pathological tissues.","PeriodicalId":283327,"journal":{"name":"Biophotonics-Riga","volume":"12 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124913343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Selection of erythema index and image sampling method for the objective erythema estimation in dogs with atopic dermatitis","authors":"B. Cugmas, Daira Viskere, E. Struc, J. Spigulis","doi":"10.1117/12.2581997","DOIUrl":"https://doi.org/10.1117/12.2581997","url":null,"abstract":"Canine atopic dermatitis (CAD) is a common inflammatory and pruritic skin disease associated with allergy to exogenous allergens. The regular monitoring of skin lesions is essential to execute the anti-allergic therapy successfully. Erythema is one of the most important CAD-related lesions since it represents acute skin inflammation. Previously, we studied two optical systems (i.e., multispectral and dermatoscopic devices), which could objectively estimate erythema severity. However, we did not investigate, which image sampling method for selecting erythema-representing pixels and erythema index (EI) are correlated with the visual erythema assessment the most. In this paper, we tested three image sampling methods and four EIs for erythema severity estimation in 43 dogs. We discovered that all studied sampling methods and EIs were strongly correlated (r> 0.58) with the visual CADESI-4-based erythema severity assessment. However, the highest average Spearman’s correlations coefficient r of 0.77 was achieved when the average pixel value from the two small squared image sections without the hair and pigment was considered. On the other hand, EI, which was calculated from all three RGB values, achieved the highest r of 0.78. In this study, we identified a reliable image sampling method and erythema index (EI), which are well correlated with the visual erythema estimation.","PeriodicalId":283327,"journal":{"name":"Biophotonics-Riga","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128508363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Remote photoplethysmography device with adaptive illumination for skin microcirculation assessment","authors":"E. Kviesis-Kipge, U. Rubins","doi":"10.1117/12.2581933","DOIUrl":"https://doi.org/10.1117/12.2581933","url":null,"abstract":"Measuring blood perfusion is important in medical care. However, currently available devices to measure blood perfusion are bulky, expensive and not easy-to-use. In this work a compact and portable low-cost prototype device for remote monitoring of palm skin microcirculation has been developed. Presented device consists of precisely controlled near-infrared illuminators (760nm peak wavelength) and video camera. The device with the custom designed software provides stable uniform illumination of curved skin surfaces, using feedback algorithm. Verification tests of this device showed improvements in the quality of skin blood perfusion maps in the case when the feedback system was used.","PeriodicalId":283327,"journal":{"name":"Biophotonics-Riga","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127957064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}