The journal of Kansai Medical University最新文献_第9页

DMBA-induced Mammary Carcinogenesis, in Relaton to Rebound Increase of Serum Prolactin after Suppression with Bromocryptine in Pubescent Virgin Rats dmba诱导的乳腺癌发生与溴隐碱抑制后血清泌乳素反弹升高有关

The journal of Kansai Medical University Pub Date : 1987-12-20 DOI: 10.5361/JKMU1956.39.SUPPLEMENT_S37

F. Hara

{"title":"DMBA-induced Mammary Carcinogenesis, in Relaton to Rebound Increase of Serum Prolactin after Suppression with Bromocryptine in Pubescent Virgin Rats","authors":"F. Hara","doi":"10.5361/JKMU1956.39.SUPPLEMENT_S37","DOIUrl":"https://doi.org/10.5361/JKMU1956.39.SUPPLEMENT_S37","url":null,"abstract":"Twenty six, 31 and 53 young female Sprague-Dawley rats in Groups A, C and E, respectively, were administered 10 mg/Kg Bromocryptine daily by intubation for 3 weeks from 31 to 51 days of age. Twenty five rats each in Groups B and D served as the controls. Tail blood was collected for radioimmunoassay of prolactin from only metaand di-estrus rats in Groups A, B and E around 10 am at the age of 51-58 days, and the sampling was not repeated in any animal. A rebound increase of serum prolactin level occurred within 3 days after the termination of Bromocryptine treatment. A single dose of 5mg/rat DMBA in Groups A and B and 2.5mg/rat in Groups C and D was given orally around 11 am at the age of 52 days, and the carcinogenesis with DMBA was evaluated 22 weeks after the single administration of carcinogen. Mammary adenocarcinoma developed in some animals, but no other tumors could be found. When a single weaker dose of DMBA was administered orally on the day after the cessation of the 3 week treatment with Bromocryptine, the chemical induction of mammary carcinogenesis was enhanced distinctly.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"259 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1987-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131406406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Effects of Propranolol, Trimetazidine and Verapamil on the Contraction of Guinea-Pig Isolated Vas Deferens 心得安、曲美他嗪和维拉帕米对豚鼠离体输精管收缩作用的比较

The journal of Kansai Medical University Pub Date : 1987-12-20 DOI: 10.5361/JKMU1956.39.SUPPLEMENT_S13

J. Sugimoto, H. Otani, S. Yuasa, Masayasu Suzuki

引用次数: 0

Methylguanidine(MG)の中枢神経系および末梢神経系に及ぼす影響に関する電気生理学的研究 Methylguanidine(MG)对中枢神经系统和末梢神经系统影响的电生理学研究

The journal of Kansai Medical University Pub Date : 1986-12-20 DOI: 10.5361/JKMU1956.38.4_432

昌久澤田

引用次数: 0

An Application of Immuno Peroxidase Staining Technique for the Titration of Dengue Virus in vitro 免疫过氧化物酶染色技术在登革病毒体外测定中的应用

The journal of Kansai Medical University Pub Date : 1986-12-20 DOI: 10.5361/JKMU1956.38.SUPPLEMENT_S27

Tomiyoshi Ito, E. Tanimura, Yukio Ohsugi, Kohei Maeda, F. Hirata, A. Ohyama

引用次数: 1

Pseudomonas aeruginosaのマクロファージに対する動態,並びにその形態学的観察 Pseudomonas aeruginosa对巨噬细胞的动态及其形态学观察

The journal of Kansai Medical University Pub Date : 1986-12-20 DOI: 10.5361/JKMU1956.38.4_393

英紀谷村

引用次数: 0

Pathogenicity and Pathophysiology of Dengue Virus type 2 Strains in Mice 登革病毒2型株在小鼠体内的致病性和病理生理

The journal of Kansai Medical University Pub Date : 1986-12-20 DOI: 10.5361/JKMU1956.38.SUPPLEMENT_S65

Yukio Ohsugi

引用次数: 0

Morphological Analysis of Adherent Platelets: Influence of Platelet Inhibitors or Antineoplastic Agents on Platelet Adhesion 粘附血小板的形态学分析:血小板抑制剂或抗肿瘤药物对血小板粘附的影响

The journal of Kansai Medical University Pub Date : 1986-12-20 DOI: 10.5361/JKMU1956.38.SUPPLEMENT_S1

S. Takayama

引用次数: 0

Immunohistological Studies on Ovarian Epithelial Cystic Tumors with Monoclonal Antibodies against CEA, CA 19-9, and MAM-6 CEA、ca19 -9和MAM-6单克隆抗体对卵巢上皮性囊性肿瘤的免疫组织学研究

The journal of Kansai Medical University Pub Date : 1986-12-20 DOI: 10.5361/JKMU1956.38.SUPPLEMENT_S40

T. Toyoda, A. Tsubura, K. Naito, S. Ueda, H. Izumi, S. Morii

{"title":"Immunohistological Studies on Ovarian Epithelial Cystic Tumors with Monoclonal Antibodies against CEA, CA 19-9, and MAM-6","authors":"T. Toyoda, A. Tsubura, K. Naito, S. Ueda, H. Izumi, S. Morii","doi":"10.5361/JKMU1956.38.SUPPLEMENT_S40","DOIUrl":"https://doi.org/10.5361/JKMU1956.38.SUPPLEMENT_S40","url":null,"abstract":"Ovarian epithelial cystic tumors, 132 samples of which were classified to 69 mucinous and 63 serous tumors, were observed immunohistologically with 3 monoclonal antibodies ; CEA 010, anti-CA 19-9 antibody, and MAM 115D8, respectively, in addition to 20 non-neoplastic ovarian tissues with fallopian tubes. The antigen expression with CEA 010 in the mucinous tumors were observed in 7% of benign, 33% of borderline and 65% of malignant ones, respectively. On the contrary, this expression was never detected in the serous tumors as well as non-neoplastic ovarian tissues. Therefore, the application of CEA 010 may be one of the choice for differential diagnosis of the mucinous cystadenocarcinoma from the serous one and for the estimation of malignancy of the mucinous tumors. Anti-CA 19-9 antibody revealed a higher positivity (36% in benign, 67% in borderline and 94% in malignant) in the mucinous tumors, but it showed also positive findings (13% in benign, 24% in borderline and 32% in malignant) in the serous tumors. MAM 115D8 expressed MAM antigen in most cases of the examined tumors, as well as surface epithelia, lining cells of inclusion cysts and fallopian tubal cells in nonneoplastic ovarian tissues. In general, staining patterns of the expression were apically cytoplasmic and homologous in normal and benignly tumorous tissues, but they were diffusely intracytoplasmic and heterologous in the malignant one.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"259 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1986-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115808884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Unexpected Antibody Found in Pregnant Women, and Haemolytic Diseases in Newborn:Trial of Blood Transfusion into Rh (E)-Negative Women 孕妇中发现意外抗体和新生儿溶血疾病:Rh (E)阴性妇女输血试验

The journal of Kansai Medical University Pub Date : 1986-12-20 DOI: 10.5361/JKMU1956.38.SUPPLEMENT_S50

S. Okubo, S. Ohnishi, T. Ishida, K. Yasunaga, I. Sawaragi

{"title":"Unexpected Antibody Found in Pregnant Women, and Haemolytic Diseases in Newborn:Trial of Blood Transfusion into Rh (E)-Negative Women","authors":"S. Okubo, S. Ohnishi, T. Ishida, K. Yasunaga, I. Sawaragi","doi":"10.5361/JKMU1956.38.SUPPLEMENT_S50","DOIUrl":"https://doi.org/10.5361/JKMU1956.38.SUPPLEMENT_S50","url":null,"abstract":"Since January, 1979, we examined all pregnant women visiting our hospital on antierythrocyte unexpected antibodies in order to detect haemolytic disorder in the newborn (HDN) as early as possible. Among the 4, 748 pregnant women examined, antibodies could be found in 147 cases (3. 1%) . Anti-Le antibodies were found to be the most frequent, and anti-E formed the majority of anti-Rh antibodies detected. Blood transfusion seemed to play a great role in the production of anti-E in our examined women. Among the seven Rh (E) incompatible pregnant cases at our hospital, two were so severe as to need exchange transfusion therapy. Therefore, trials were made ; i. e. Rh (E) -negative red blood cell preparations were transfused into the same-blood-type women under forty years of age requiring blood transfusion. We had to prepare 6. 9 units of Rh (E) -negative red blood cell preparations per day. The amount was within the capacity of our transfusion unit. Therefore, Rh (E) -negative red blood cell preparations should be used for blood transfusion into Rh (E) -negative women under forty years of age who may experience future pregnancy. Moreover, not only antiRh (D) immunoglobulin preparations, but anti-Rh (E) preparations should be developed, particularly in Japan.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"16 Suppl 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1986-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116851001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Systemic Lupus Erythematosus Accompanied by Unexpected Eclampsia of Pregnancy 系统性红斑狼疮伴意外妊娠子痫

The journal of Kansai Medical University Pub Date : 1986-12-20 DOI: 10.5361/JKMU1956.38.SUPPLEMENT_S59

S. Okubo, K. Yasunaga, R. Kondoh, K. Sugano, I. Sawaragi

引用次数: 0