Comparison of Effects of Propranolol, Trimetazidine and Verapamil on the Contraction of Guinea-Pig Isolated Vas Deferens

Abstract

1. The effects of propranolol, verapamil and trimetazidine were compared on calciuminduced and potassium-induced contractions of guinea-pig isolated vas deferens in a sucrose medium. The preparations were pretreated with tetrasodium edetate before eliciting calciuminduced contractions. 2. Propranolol (0. 1 mM) and verapamil (5 pM) depressed potassium-induced contractions, but did not depress calcium-induced contractions until the concentration of the antagonist was increased at least ten-fold. 3. Trimetazidine (3 pM) depressed calcium-induced contractions, but increased potassiuminduced contractions.