{"title":"心得安、曲美他嗪和维拉帕米对豚鼠离体输精管收缩作用的比较","authors":"J. Sugimoto, H. Otani, S. Yuasa, Masayasu Suzuki","doi":"10.5361/JKMU1956.39.SUPPLEMENT_S13","DOIUrl":null,"url":null,"abstract":"1. The effects of propranolol, verapamil and trimetazidine were compared on calciuminduced and potassium-induced contractions of guinea-pig isolated vas deferens in a sucrose medium. The preparations were pretreated with tetrasodium edetate before eliciting calciuminduced contractions. 2. Propranolol (0. 1 mM) and verapamil (5 pM) depressed potassium-induced contractions, but did not depress calcium-induced contractions until the concentration of the antagonist was increased at least ten-fold. 3. Trimetazidine (3 pM) depressed calcium-induced contractions, but increased potassiuminduced contractions.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"122 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1987-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of Effects of Propranolol, Trimetazidine and Verapamil on the Contraction of Guinea-Pig Isolated Vas Deferens\",\"authors\":\"J. Sugimoto, H. Otani, S. Yuasa, Masayasu Suzuki\",\"doi\":\"10.5361/JKMU1956.39.SUPPLEMENT_S13\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"1. The effects of propranolol, verapamil and trimetazidine were compared on calciuminduced and potassium-induced contractions of guinea-pig isolated vas deferens in a sucrose medium. The preparations were pretreated with tetrasodium edetate before eliciting calciuminduced contractions. 2. Propranolol (0. 1 mM) and verapamil (5 pM) depressed potassium-induced contractions, but did not depress calcium-induced contractions until the concentration of the antagonist was increased at least ten-fold. 3. Trimetazidine (3 pM) depressed calcium-induced contractions, but increased potassiuminduced contractions.\",\"PeriodicalId\":281939,\"journal\":{\"name\":\"The journal of Kansai Medical University\",\"volume\":\"122 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-12-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The journal of Kansai Medical University\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5361/JKMU1956.39.SUPPLEMENT_S13\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The journal of Kansai Medical University","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5361/JKMU1956.39.SUPPLEMENT_S13","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparison of Effects of Propranolol, Trimetazidine and Verapamil on the Contraction of Guinea-Pig Isolated Vas Deferens
1. The effects of propranolol, verapamil and trimetazidine were compared on calciuminduced and potassium-induced contractions of guinea-pig isolated vas deferens in a sucrose medium. The preparations were pretreated with tetrasodium edetate before eliciting calciuminduced contractions. 2. Propranolol (0. 1 mM) and verapamil (5 pM) depressed potassium-induced contractions, but did not depress calcium-induced contractions until the concentration of the antagonist was increased at least ten-fold. 3. Trimetazidine (3 pM) depressed calcium-induced contractions, but increased potassiuminduced contractions.
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