The journal of Kansai Medical University最新文献

{"title":"The Rate of Gastric Emptying in Patients with Gastric Ulcer","authors":"S. Kude","doi":"10.5361/JKMU1956.41.SUPPLEMENT_S87","DOIUrl":"https://doi.org/10.5361/JKMU1956.41.SUPPLEMENT_S87","url":null,"abstract":"The rate of gastric emptying was studied using the acetaminophen method in 35 normal subjects and 85 gastric ulcer patients. The gastric emptying rate was significantly lower in gastric ulcer patients than in normal subjects (p<0. 05) . Among the patients with gastric ulcer, those with a smoking habit had a markedly low gastric emptying rate (p<0. 05). Such a tendency was also observed in normal subjects. The smoking load on normal subjects with a smoking habit caused a marked decrease in the gastric emptying rate (p<0. 05) . Administration of domperidone to gastric ulcer patients significantly increased the gastric emptying rate.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127132184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Dislocation of the Extensor Tendons in Both Hands","authors":"K. Kasai","doi":"10.5361/JKMU1956.41.SUPPLEMENT_S27","DOIUrl":"https://doi.org/10.5361/JKMU1956.41.SUPPLEMENT_S27","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125833992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ラット実験潰瘍とPAF(platelet-activating factor,血小板活性化因子)","authors":"和代 藤村","doi":"10.5361/JKMU1956.41.3-4_268","DOIUrl":"https://doi.org/10.5361/JKMU1956.41.3-4_268","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130351331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrastructural Observations of Colchicine-Effect on Ethionine-Induced Fat Accumulation in Rat Hepatocytes","authors":"K. Naito, T. Nishimura, S. Morii","doi":"10.5361/JKMU1956.40.SUPPLEMENT_S6","DOIUrl":"https://doi.org/10.5361/JKMU1956.40.SUPPLEMENT_S6","url":null,"abstract":"Adult female Sprague-Dawley rats weighing 260-300g were starved overnight and injected i. p. with ethionine, 1 g/Kg, at the 11th hr of fasting, and a half of them was also injected i. p. with colchicine, 2.5 mg/Kg, twice at 3 and 6 hr after the single administration of ethionine. For the control fasting animals, the vehiclds (saline) were injected at the indicated times, respectively. All rats were sacrificed after having fasted a total of 20 hr, and the hepatocytes in periportal areas were examined with electron microscopy. The accumulation of larger biomembrane-bound lipid particles (diameter ; 0.2-0.4 prn) were greater in these hepatocytes of the rats injected doubly with ethionine and colchicine than the rats injected only with ethionine. Such hepatocytes of the former group had fewer intracytoplasmic lipid inclusions than the latter group, although the livers of both groups were harvested 9 hr after the ethionine injection. The control fasting rats treated with or without colchicine showed no distinct fatty livers. These observations indicate that colchicine inhibits the development of intracytoplasmic lipid inclusions within ethionine-injured livers of fasting female rats, and that this inhibition is accompained by a significant increase of larger biomembrane-bound lipid particles,","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1988-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123454345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silent perforation of Duodenum due to Swallowed Needles","authors":"S. Uetsuji, M. Yamamura, Yasunobu Asao, K. Hioki, M. Yamamoto","doi":"10.5361/JKMU1956.40.SUPPLEMENT_S52","DOIUrl":"https://doi.org/10.5361/JKMU1956.40.SUPPLEMENT_S52","url":null,"abstract":"The case of a patient who ingested two large needles and two razors is presented. The two razors were removed from the stomach by endoscopy while one needle caused a perforation of the duodenum and the other remained in the ileocecal area. The diagnosis was made by finding the needle in the same position after repeated plain abdominal roentgenograms, thus indicating that the tip of the needle protruded outside the gastrointestinal tract. Immediately after this diagnosis was made, the patient was operated on and one needle was extirpated from retroperitoneal area of the upper abdomen.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"175 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1988-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134153053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subacute cutaneous lupus erythematosus-like eruption from Tegafur","authors":"Michiaki Ueda, J. Komura, T. Higashida, S. Futamura, Y. Asada","doi":"10.5361/JKMU1956.40.SUPPLEMENT_S57","DOIUrl":"https://doi.org/10.5361/JKMU1956.40.SUPPLEMENT_S57","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1988-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131184138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Platelet Aggregation and the Condition of GPIIb-IIIa Complex in Unstimulated Platelets","authors":"S. Nomura, H. Nagata, M. Yanabu, Masahiko Suzuki, T. Soga, S. Ohga, K. Kondo, N. Sone, C. Kitada, H. Kitajima, T. Kokawa, K. Yasunaga","doi":"10.5361/JKMU1956.40.SUPPLEMENT_S33","DOIUrl":"https://doi.org/10.5361/JKMU1956.40.SUPPLEMENT_S33","url":null,"abstract":"We used a monoclonal antibody against GP II bIIIa complex (NNKY1-32) to study the relationship between platelet aggregation and the condition of GP II bIII a complex in unstimulated platelets. The quantities of GP II bIII a complex in Glanzmann's thrombasthenia (Type I, Type II), Heterozygote, EDTA-treated and cation-treated platelets were classified into three groups according to the binding of anti-GP I I bIII a complex antibody. Despite the similarity in binding of monoclonal anti-GP II bIII a complex antibody within each groups, however, differences were found in platelet aggregability between samples. (a2+ and Mg2+ promoted the reassociation of dissociated GP II b and GP III a in intact cells, and restored aggregabilities of platelets. In particular, mixed materials (Ca2+ Mg2+ + auto-plasma) significantly restored ADP-induced aggregabilities of platelets. These results suggest the following. The conformational change of GP II b/ III a after platelet activation also depends on the conditions of complex formation by GP II b and GP III a and the microenvironment around GP II b/ III a in resting platelets. Complex formation alone is insufficient for ADP-induced aggregation, and the presence of Ca2+, Mg2+ and some factors in plsma appears to be necessary condition.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1988-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129611883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiation and Cell Kinetics of Mammary Gland in Pubescent Virgin Rats Treated with Bromocriptine","authors":"T. Sakaki","doi":"10.5361/JKMU1956.40.SUPPLEMENT_S15","DOIUrl":"https://doi.org/10.5361/JKMU1956.40.SUPPLEMENT_S15","url":null,"abstract":"Sprague-Dawley female rats were orally administered 10 mg/kg of Bromocriptine (CB) daily between 31 to 51 days of age. In metaand di-estrus rats with regular sex cycles, serum prolactin (PRL) was elevated for 3 days and peaked at 2 days (96. 6 ± 9. 82 ng/ml) after the termination of subchronic treatment, compared with those (2. 1 ± 0. 29 ng/ml) at the termination. Untreated, ovariectomized, and ovariectomized and CB-treated rats were used as controls, and mammary gland development was observed in relation to the serum PRL fluctuation in such regularly sex-cycling metaand di-estrus rats. Compared with untreated controls, the mammary gland exhibited significantly predominant terminal ducts (TD) with an accompanying decrease in alveolar buds (AB) in nearly normal-sized parenchyma at the termination of subchronic treatment with CB. It also exhibited a marked predominance of lobules (Lob) and AB with fewer TD in larger parenchyma 3 and 6 days after the termination. Immunohistochemically, there were fewer bromodeobxyuridine (BrdU) -labeled glandular cells in terminal end buds (TEB) and TD at termination, and more in ducts and AB 3 days after termnation, compared with untreated controls. Therefore, the development of the mammary glands is retarded in rats with low serum PRL levels, and a rebound increase in PRL levels accelerated the development.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"529 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1988-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114404213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Cardiac Reserve in Hyperthyroid Patients with or without Beta-Adrenoreceptor-Blockade by Handgrip Exercise","authors":"Y. Nakagawa","doi":"10.5361/JKMU1956.40.SUPPLEMENT_S42","DOIUrl":"https://doi.org/10.5361/JKMU1956.40.SUPPLEMENT_S42","url":null,"abstract":"To evaluate latent left ventricular dysfunction in patients with Graves' disease, hemodynamic response to isometric exercise were examined in 93 patients and 18 controls by impedance cardiography. All patients were treated with anti-thyroid drugs and 64 patients were stll clinically thyrotxic with elevated triiodothyronine (T3) in serum. The remaining 29 patients were clinically free of thyrotoxicosis with normal serum T3. Thirty three of 93 patients received beta-bloccker. The distinct elevation of cardiac index (CI) , associated with elevation of cardiac work index (CWI) and total peripheral resistance index (TPRI) , was observed during the exercise in control group. Values for CWI and TPRI were apparently elevated in all patients studied, and the magnitude of the alterations in CWI and TPRI before and during the exercise was almost the same as that observed in control group. However, the CI values were almost unchanged before and during the exercise in hyperthyroid patients without beta-blockade, suggesting the impaired cardiac reserve in hyperthyroidism. Moreover, it was noteworthy that CI values before and during the exercise were also unchanged even in euthyroid patients without beta-blockade. This result supports the contention that a biochemical euthroid state may be achieved many weeks before normalization of contractile response to exercise. There was a significant correlation between serum T3 and CI at rest in 60 patients without beta-blockade, but this correlation was lost in 33 patients, who received beta-blocker. The beta-blocker induced reduction of the resting CI was evident in hyperthyroid patients, and this reduction of CI values was also observed in these patients with beta-blocker during exercise, showing negative inotropic effects of the beta-adrenoreceptor blocking drugs. Thus, beta-blocker may be beneficial in lowering heart rate in severe hyperthyroidism, but the beta-blockade should be avoided in euthyroid patients, who showed the delayed recovery of left ventricular function after antithyroid treatment.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1988-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127103993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Exchangeable Long Biliary Endoprosthesis for Percutaneous Transhepatic Internal Drainage","authors":"S. Sawada, T. Oshima, Tsutomu Kato, Yoshimasa Tanaka, Hironobu Nakamura","doi":"10.5361/JKMU1956.40.SUPPLEMENT_S27","DOIUrl":"https://doi.org/10.5361/JKMU1956.40.SUPPLEMENT_S27","url":null,"abstract":"A newly devised long biliary stent which can be removed by only a small skin incision was applied to the patients who have obstructive jaundice. This long stent showed many advantages compared to the conventional short stent. A survival period as well as complications were also","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1988-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123681183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}