The journal of Kansai Medical University最新文献

{"title":"PAFおよびその関連物質の生物活性第1編PAF(血小板活性化因子)の血管透過性充進作用に及ぼす阻害物質の影響","authors":"山本 真理子","doi":"10.5361/JKMU1956.44.1_9","DOIUrl":"https://doi.org/10.5361/JKMU1956.44.1_9","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1992-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129452549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"頭蓋内腫瘍化学療法における抗腫瘍剤感受性試験としてのSubrenal Capsule Assay の基礎的実験ならびに臨床応用に関する研究","authors":"雅文 大内","doi":"10.5361/JKMU1956.44.1_17","DOIUrl":"https://doi.org/10.5361/JKMU1956.44.1_17","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1992-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130679356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"27th Kinki Neuropathology Conference","authors":"E. Tani, K. Kawamoto","doi":"10.5361/JKMU1956.43.1-2_101","DOIUrl":"https://doi.org/10.5361/JKMU1956.43.1-2_101","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115141789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Glucose, Medium-Chain Triglycerides and Long-Chain Triglycerides on Branched-Chain Amino and Keto Acid Metabolism in Septic Rats","authors":"Takaya Tanaka, T. Taniguchi, N. Takeyama, Y. Kitazawa","doi":"10.5361/JKMU1956.42.SUPPLEMENT_S15","DOIUrl":"https://doi.org/10.5361/JKMU1956.42.SUPPLEMENT_S15","url":null,"abstract":"The effects of administering medium-chain fatty acids (MCT), long-chain fatty acids (LCT), and glucose on plasma and skeletal muscle branched-chain amino acid (BCAA) and branchedchain alpha-keto acid (BCKA) metabolism were studied in septic rats and sham-operated controls. The plasma BCAA level decreased in the septic rats as compared with the controls, and the decrease was significant in MCTand LCT-treated animals. In contrast, the skeletal muscle BCAA concentration increased significantly in all septic rats, especially in those treated with LCT. The plasma and skeletal muscle BCKA concentrations increased in all groups, with the increases in the muscle being significant. In the septic animals, the plasma BCAA concentration was markedly reduced, but the skeletal muscle BCAA concentration increased significantly in MCTand LCT-treated groups in comparison with the glucose-treated group. There were no significant differences in the plasma BCKA concentration among the various treatments, but the muscle BCKA concentration was significantly higher in the LCT-treated than in the glucose-treated group. The ratios of the blood versus tissue concentrations of BCAA and BCKA suggested that they were released in large amounts from the tissues into the blood in septic animals, and this tendency was more notable with BCKA. However, these changes in the plasma and skeletal muscle BCAA and BCKA metabolism were the smallest in the glucose-treated animals, suggesting that glucose is more beneficial than LCT or MCT for BCAA and BCKA metabolism and for the prevention of protein breakdown in sepsis.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1990-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114366486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Management of 100 Primary Carcinomas of the Liver; Prognostic factors after hepatic resection for primary liver cancer","authors":"M. Yamamura, S. Uetsuji, Y. Okuda, K. Yamamichi, Y. Kise, H. Komada, M. Kwon, Yoshiaki Inada, T. Minoura, Takeo Yamada, M. Yamamoto","doi":"10.5361/JKMU1956.42.SUPPLEMENT_S55","DOIUrl":"https://doi.org/10.5361/JKMU1956.42.SUPPLEMENT_S55","url":null,"abstract":"Between January 1980 and December 1989, surgical treatment of primary liver cancer was performed in 100 cases including two reoperations. Of these 89 were male and 11 female ; their ages ranged from 5 months to 74 years. Pathological findings showed that 92 of the patients had hepatocellular carcinoma, 6 cholangiocellular carcinoma, and 2 hepatoblastoma ; in 85% of the cases these were associated with cirrhosis. Of the 100 patients, 52 underwent typical resection of the liver, 28 limited resection, and 20 no resection. Follow-up results in resected cases showed that the cumulative survival rates at 1, 3, and 5 years were 66. 6%, 46.7%, and 36. 7%, respectively. Non-resected patients died within 3 years. Various factors w ere evaluated by analysis in respect to cumulative survival, after exclusion of operative deaths, to clarify prognosis after hepatic resection. Factors affecting the outcome were gross tumor findings including tumor size. A better prognosis was associated with encapsulated nodular forms, a tumor size of less than 2cm, and no portal vein and hepatic serosal involvement in the resected specimen.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1990-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121426650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinical Study of Retrograde Amnesia Following Accidental Head Injuries","authors":"M. Saito, D. Ohya, Kizo Sakaguchi, T. Aoki, M. Wakeno","doi":"10.5361/JKMU1956.42.SUPPLEMENT_S69","DOIUrl":"https://doi.org/10.5361/JKMU1956.42.SUPPLEMENT_S69","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"165 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1990-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115546641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of L-Carnitine on Fatty Acid Metabolism in Regenerating Rat Liver","authors":"Takaya Tanaka, D. Takagi, N. Takeyama, Y. Kitazawa","doi":"10.5361/JKMU1956.42.SUPPLEMENT_S30","DOIUrl":"https://doi.org/10.5361/JKMU1956.42.SUPPLEMENT_S30","url":null,"abstract":"Serial changes in the intrahepatic fatty acid and energy metabolism during liver regeneration after partial hepatectomy were studied O. 5, 1, and 2 days after the operation, and the effects of preadministration of L-carnitine were examined. The acetoacetate/p-hydroxybutyrate ratio increased O. 5 and 1 day after hepatectomy, suggesting increased oxidation of mitochondria, but there were no changes in energy charge with both energy production and consumption being enhanced in the cells. In this period, marked decreases in acetyl CoA and total ketone bodies and a remarkable increase in citrate were observed, and the activity of mitochondria' carnitine palmitoyltransferase (CPT) increased, suggesting an increase in fatty acid oxidation. The level of free carnitine also reduced. When L-carnitine, a free carnitine, was preadministered before hepatectomy under such clinical process, the activity of CPT increased higher 1 day after hepatectomy and energy charge after 2 days. These results suggest that preadministration of L-carnitine promotes fatty acid oxidation, and, therefore, is effective for elevating energy matabolism in the regenerating liver.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1990-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115666492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"悪性脳腫瘍に対するInterferon(α,β,γ)の作用機序解明と抗腫瘍効果及び臨床例への応用","authors":"義博 沼","doi":"10.5361/JKMU1956.42.4_300","DOIUrl":"https://doi.org/10.5361/JKMU1956.42.4_300","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1990-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124364100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Acute Hemodialysis Performed immediately after Cardiac Arrest due to Uremia","authors":"K. Yamagami, Tohru Yamamoto, K. Katou, Y. Itoh, Takaya Tanaka","doi":"10.5361/JKMU1956.42.SUPPLEMENT_S50","DOIUrl":"https://doi.org/10.5361/JKMU1956.42.SUPPLEMENT_S50","url":null,"abstract":"We report a patient with uremia due to polycystic kidneys who developed cardiopulmonary arrest shortly after admission. The initial laboratory data revealed severe acidosis and hyperkalemia caused by terminal uremia. The patient was resuscitated after 20 minutes of cardiac massage with the administration of epinephrine and other inotropic agents. Subsequently, acute hemodialysis was performed even though a stable circulation could not be maintained by the constant infusion of dopamine. It is very important to take immediate steps to correct the severe acidosis and significant derangements of electrolytes which are present in cardiac emergencies due to uremia. Introduction The survival rate after cardiopulmonary arrest has improved greatly since the descripsion of cardiopulmonary resuscitation (CPR) techniques by Kouwenhovenl) in 1960. Cardiac resuscitation in a series of 552 patients at The Royal Victoria Hospital had a survival rate of 21%, but there was only one successful resuscitation among 32 patients with uremia2) . We report a patient with cardiopulmonary arrest due to terminal ueremia who was successfully resuscitated after undergoing acute hemodialysis. Case Report A 35-year-old man was admitted in an unconscious state with marked acetone breath. He suffered a cardiopulmonary arrest shortly after admission. Cardiac massage was commenced and he was intubated. Epinephrine (2mg) was given as an intravenouse bolus and a constant infusion of dopamine (15pg/kg per min) was begun. His pupils were about 6. 5mm in diameter and nonreactive to light. The patient had a history of mild renal dysfunction and hypertension of 10 years duration but he had never taken any medication for these problems. Initial laboratory investigation revealed the following data : pH, 7. 014 ; PaCO2, 8. 7 torr ; and Pa02, 151. 1 torr (on an Fi02 of O. 2, since oxygen was given in the ambulance before arrival). The following initial data were also obtained; sodium, 144mEq/1; potassium, 7. 6mEq/1 ; chloride, 111mEq/1; creatinine, 35. 4mg/d1; BUN, 312mg/dl; glucose, 210mg/di; s-amylase, 1339U/1; Hct, 17. 6%; WBC, 9, 600/mm3; platelets, 11, 700/mm3 ; and CRP 15. 8mg/dt. The data indicated severe renal insufficiency and anemia. He was next given 250s1 of 7% sodium bicarbonate. A chest X-ray showed opacity 1n the left lung field, and blood-streaked of the sputum was observed. Over the same part of the chest, moist rales were heard on auscultation. After 20 minutes of CPR he was resuscitated. Following the insertion of a dual lumen subclavian catheter, acute hemodialysis was performed using a 0. 8m2 membrane surface hemofilter. The flow was set at 70n€/min initially, and a continuous dopamine infusion was given at a rate that changed, depending on the blood pressure. Despite fluctuations in blood pressure, hemodialysis was continued for 3 hours (Fig. 1) . During dialysis, ECG monitoring revealed ventricular premature beats, but these did not become a serious problem. Transfusion","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1990-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115775572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Plasma Amino Acids during Oral Glucose Tolerance Test in Liver Cirrhosis with impaired Glucose Tolerance","authors":"Y. Hijikata, S. Fujinami, Y. Shiozaki, Y. Sameshima","doi":"10.5361/JKMU1956.42.SUPPLEMENT_S1","DOIUrl":"https://doi.org/10.5361/JKMU1956.42.SUPPLEMENT_S1","url":null,"abstract":"Changes in plasma amino acids, insulin, C-peptide, , glucose and glucagon levels were investigated during 100g oral glucose tolerance test (OGTT) in patients with liver cirrhosis (LC) , LC with impaired glucose tolerance (IGT) and delayed hypersecretion of insulin during OGTT (LC-IGT-1) , LC with IGT and low response of insulin secretion during OGTT (LCIGT-2) , LC with hepatocellular carcinoma (LC-HCC) , chronic active hepatitis (CAH) , chronic persistent hepatitis (CPH) , untreated diabetes mellitus without hepatic diseases (DM) and healthy controls. The decrease ratio (DR) of plasma amino acids was defined as the decrease at 3 hrs after glucose loading/initial concentration. Among the liver diseases examined, except LC-HCC, significant relationships and differences of amino acids and the above hormones in liver diseases were as follows ; Tyr (i) and Phe (i) correlated negatively with cholinesterase activity (Ole) and cholesterol concentration (Cho (i) ), and correlated positively with indocyanine green retention rate (ICG) and sum of plasma glucose (IPG) (i means value before loading, I means sum of five sampling points during OGTT) . Ser (i) correlated negatively with Che (i) , Cho (i) and albumin (Alb) (i) and positively with ICG, and was higher in LC and LC-IGT-1 compared to the controls. Cit (i) had a positive correlation with £PG, PG (i) and ICG, a negative correlation with Che (0 and was significantly higher in LC-IGT-2, LC-IGT-1 and LC in this order than that of the control. Cit DR showed a positive correlation with Che (i) and Alb (i) and a negative correlation with ICG and /PG. Trp DR had a negative correlation with ICG, EPG and PG (i) , and was lower in liver diseases accompanying LC. Despite lower Orn (i) in DM, it was higher in LC-IGT-1 than in LC. In LC-HCC, Glu DR was higher than in LC and Gly DR was higher than in control. Ala and Trp tend to increase at 1 hr after loading in LC with IGT, but they decreased in the control and DM. The higher level of Ser (i) and Tyr (i), and the lower level of Glu (i) , Ile +Leu +Val/Phe + Tyr (BCAA/AAA) (i) and Trp DR might imply the shift to LC from chronic hepatitis.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1990-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133799077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}