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The journal of Kansai Medical University最新文献

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Lack of in vitro effects of interferon on drug-metabolizing activity in the human liver 缺乏干扰素对人肝脏药物代谢活性的体外影响
The journal of Kansai Medical University Pub Date : 1995-06-20 DOI: 10.5361/JKMU1956.47.1-2_72
H. Okuno, S. Fukushima, T. Hirota, M. Takasu, Y. Shiozaki, Kyoichi Inoue
{"title":"Lack of in vitro effects of interferon on drug-metabolizing activity in the human liver","authors":"H. Okuno, S. Fukushima, T. Hirota, M. Takasu, Y. Shiozaki, Kyoichi Inoue","doi":"10.5361/JKMU1956.47.1-2_72","DOIUrl":"https://doi.org/10.5361/JKMU1956.47.1-2_72","url":null,"abstract":"The in vitro effects of interferon (IFN) on drug—metabolizing activity in the human liver were investigated. The activities of 7-methoxycoumarin (7-MC) O-demethylase and 7-ethoxycoumarin (7-EC) Odeethylase in liver microsomes were measured in the absence and presence of IFN-a 2a. The peak blood concentration reached during clinical IFN-a 2a treatment has been reported to be 101 to 103 IU/ml. At a high concentration (106 IU/ml), IFN-a 2a inhibited the activities of both enzymes, to 75.6% and 72.4% of the control activity, respectively, but few effects were observed at concentrations of 101 to 105 IU/ml. These results indicate that the depression of drug metabolism during IFN treatment is not due to the direct inhibition of drug—metabolizing enzymes by IFN molecules, but that other factor(s) are needed for IFN to exhibit this action.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125133292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma platelet-activating factor acetylhydrolase 活性に対するホルモン調節 对Plasma platelet-activating factor acetylhydrolase活性的激素调节
The journal of Kansai Medical University Pub Date : 1995-06-20 DOI: 10.5361/JKMU1956.47.1-2_20
藤上 文隆
{"title":"Plasma platelet-activating factor acetylhydrolase 活性に対するホルモン調節","authors":"藤上 文隆","doi":"10.5361/JKMU1956.47.1-2_20","DOIUrl":"https://doi.org/10.5361/JKMU1956.47.1-2_20","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115443849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The Gonial Angle Stripper: Clinical Application for Mandibular Angle Osteotomy 角剥离器在下颌角截骨术中的临床应用
The journal of Kansai Medical University Pub Date : 1994-06-20 DOI: 10.5361/JKMU1956.46.1-2_45
S. Kyutoku, Y. Ogawa
{"title":"The Gonial Angle Stripper: Clinical Application for Mandibular Angle Osteotomy","authors":"S. Kyutoku, Y. Ogawa","doi":"10.5361/JKMU1956.46.1-2_45","DOIUrl":"https://doi.org/10.5361/JKMU1956.46.1-2_45","url":null,"abstract":"INTRODUCTION A prominent, gonialangle, so called benign masseteric hypertrophy16, ), is rather common and considered to be unattractive feature79) in the Orient. A face with this kind of deformity can only be corrected surgically10-13)Though most of the procedures are performed intraorally, exposure of the operation site is often not large enough for osteoplasty to proceed safely. Since the definite indication of the site of osteotomy is needed, especially in a narrower operative field, a special instrument was deviced to perform safe and accurate mandibular angle osteotomy.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1994-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115569890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polarized sorting of the viral glycoproteins of Herpes Simplex Virus Type I in murine embryonic neurons in culture: A confocal laser scanning microscopic study 培养小鼠胚胎神经元中单纯疱疹病毒I型病毒糖蛋白的极化分选:共聚焦激光扫描显微镜研究
The journal of Kansai Medical University Pub Date : 1994-06-20 DOI: 10.5361/JKMU1956.46.1-2_25
I. Hashimoto, Tominori Kimura, A. Ohyama
{"title":"Polarized sorting of the viral glycoproteins of Herpes Simplex Virus Type I in murine embryonic neurons in culture: A confocal laser scanning microscopic study","authors":"I. Hashimoto, Tominori Kimura, A. Ohyama","doi":"10.5361/JKMU1956.46.1-2_25","DOIUrl":"https://doi.org/10.5361/JKMU1956.46.1-2_25","url":null,"abstract":"gestation were employed to study the polarized sorting of infected Herpes simplex virus type I (HSV-1) envelope glycoproteins. Following trypsinization the cortical neurons were successfully maintained at low density on polylysine-coated coverslips or culture dishes in a glucose-enriched medium. The intracellular distribution of viral glycoproteins was monitored by laser scanning confocal immunofluorescence microscopy. In mature, fully polarized neurons the HSV-1 glycoprotein moved from the perinuclear Golgilike region to the dendritic domains, whereas in underdeveloped immature neurons and glia cells no polarized distribution of the viral glycoproteins was observed. Since the HSV-1 glycoproteins are sorted to the basolateral plasma membrane of MDCK cells in a polarized manner', it is suggested that a common mechanism for polarized protein sorting could be shared between neurons and epithelial cells. Implications of the polarized sorting of the viral glycoproteins are also discussed on the basis for the pathogenesis of HSV-1 encephalitis.","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1994-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134502267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3, 3', 5'-Triiodothyronine Inhibits Angiotensin II-Induced Calcium Mobilization and Formation of Inositol 1, 4, 5-Trisphosphate in Vascular Smooth Muscle Cells 3,3 '， 5'-三碘甲状腺原氨酸抑制血管紧张素ii诱导的钙动员和血管平滑肌细胞中肌醇1,4,5 -三磷酸的形成
The journal of Kansai Medical University Pub Date : 1994-06-20 DOI: 10.5361/JKMU1956.46.1-2_4
H. Masaki, M. Nishikawa, M. Urakami, M. Inada
{"title":"3, 3', 5'-Triiodothyronine Inhibits Angiotensin II-Induced Calcium Mobilization and Formation of Inositol 1, 4, 5-Trisphosphate in Vascular Smooth Muscle Cells","authors":"H. Masaki, M. Nishikawa, M. Urakami, M. Inada","doi":"10.5361/JKMU1956.46.1-2_4","DOIUrl":"https://doi.org/10.5361/JKMU1956.46.1-2_4","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1994-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130889241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
気管支喘息患者における喀癖中血小板活性化因子(platelet-activating factor) の検討 支气管哮喘患者咯癖中血小板活化因子(platelet-activating factor)的研究
The journal of Kansai Medical University Pub Date : 1993-03-20 DOI: 10.5361/JKMU1956.45.1_1
一郎 池田
{"title":"気管支喘息患者における喀癖中血小板活性化因子(platelet-activating factor) の検討","authors":"一郎 池田","doi":"10.5361/JKMU1956.45.1_1","DOIUrl":"https://doi.org/10.5361/JKMU1956.45.1_1","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126618220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
血小板機能阻害剤,特にca2+調節に関与する薬剤の血小板リン脂質代謝と細胞内Ca2+動態に及ぼす影響についての検討 探讨血小板功能抑制剂，特别是调节ca2+的药物对血小板磷脂代谢和细胞内ca2+动态的影响
The journal of Kansai Medical University Pub Date : 1992-12-20 DOI: 10.5361/JKMU1956.44.4_229
親穂 北田
{"title":"血小板機能阻害剤,特にca2+調節に関与する薬剤の血小板リン脂質代謝と細胞内Ca2+動態に及ぼす影響についての検討","authors":"親穂 北田","doi":"10.5361/JKMU1956.44.4_229","DOIUrl":"https://doi.org/10.5361/JKMU1956.44.4_229","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"79 16","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1992-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120818734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
34th Kinki Neuropathology Conference 第34届Kinki神经病理学会议
The journal of Kansai Medical University Pub Date : 1992-12-20 DOI: 10.5361/JKMU1956.44.4_346
Y. Nakashima, K. Kawamoto
{"title":"34th Kinki Neuropathology Conference","authors":"Y. Nakashima, K. Kawamoto","doi":"10.5361/JKMU1956.44.4_346","DOIUrl":"https://doi.org/10.5361/JKMU1956.44.4_346","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"161 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1992-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122765560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
肝,腎,肝・腎障害における分岐鎖アミノ酸,分岐鎖ケト酸のエネルギー動態に関する研究 关于分支链氨基酸、分支链酮酸在肝、肾、肝·肾损害中的能量动态的研究
The journal of Kansai Medical University Pub Date : 1992-06-20 DOI: 10.5361/JKMU1956.44.2_83
一哉 安達
{"title":"肝,腎,肝・腎障害における分岐鎖アミノ酸,分岐鎖ケト酸のエネルギー動態に関する研究","authors":"一哉 安達","doi":"10.5361/JKMU1956.44.2_83","DOIUrl":"https://doi.org/10.5361/JKMU1956.44.2_83","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1992-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129247254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
第1編 1-アセチル-2-O-ヘキサデシル-ラセミック-グリセロ-3-ボスホコリンの生物活性 第1篇1-乙酰-2-O-六羟色胺-拉西米克-甘油-3-玻色胆碱的生物活性
The journal of Kansai Medical University Pub Date : 1992-03-20 DOI: 10.5361/JKMU1956.44.1_1
山本 真理子
{"title":"第1編 1-アセチル-2-O-ヘキサデシル-ラセミック-グリセロ-3-ボスホコリンの生物活性","authors":"山本 真理子","doi":"10.5361/JKMU1956.44.1_1","DOIUrl":"https://doi.org/10.5361/JKMU1956.44.1_1","url":null,"abstract":"","PeriodicalId":281939,"journal":{"name":"The journal of Kansai Medical University","volume":"2010 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1992-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127339269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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