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Diffuse optical tomography setup using a nanosecond laser 使用纳秒激光的漫射光学层析成像装置
European Conference on Biomedical Optics Pub Date : 2023-08-09 DOI: 10.1117/12.2670651
Meghdoot Mozumder, Jarkko J. Leskinen, T. Tarvainen
{"title":"Diffuse optical tomography setup using a nanosecond laser","authors":"Meghdoot Mozumder, Jarkko J. Leskinen, T. Tarvainen","doi":"10.1117/12.2670651","DOIUrl":"https://doi.org/10.1117/12.2670651","url":null,"abstract":"Time-domain diffuse optical tomography (TD-DOT) systems use pulsed lasers and measure time-varying temporal point spread function to estimate spatially varying optical parameters in biological tissues. Generally, the TD-DOT systems have been based on picosecond light sources and measurements were performed using photon counting methods or time-gated detectors. In this work, we demonstrate the feasibility of TD-DOT using a nanosecond laser source and measurements using a standard digital oscilloscope. For this, we constructed a prototype TD-DOT experimental system utilising a high-energy nanosecond Nd:YAG laser combined with a high-bandwidth oscilloscope. The system was used to image an optical phantom. The experiment verified that both absorbing and scattering objects can be simultaneously reconstructed with nanosecond TD-DOT.","PeriodicalId":278089,"journal":{"name":"European Conference on Biomedical Optics","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122891986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relation between fluence rate and mean photons pathlengths: an alternative option for Monte Carlo-based calculations of fluence 通量率与平均光子路径长度之间的关系:基于蒙特卡罗的通量计算的另一种选择
European Conference on Biomedical Optics Pub Date : 2023-08-09 DOI: 10.1117/12.2670936
F. Tommasi, A. Sassaroli, L. Fini, S. Cavalieri, Ernesto Pini, L. Pattelli, F. Martelli
{"title":"Relation between fluence rate and mean photons pathlengths: an alternative option for Monte Carlo-based calculations of fluence","authors":"F. Tommasi, A. Sassaroli, L. Fini, S. Cavalieri, Ernesto Pini, L. Pattelli, F. Martelli","doi":"10.1117/12.2670936","DOIUrl":"https://doi.org/10.1117/12.2670936","url":null,"abstract":"Usually, in biomedical optics, the average photon fluence rate, evaluated in a subvolume of a propagating medium, is obtained by Monte Carlo simulations by calculating the power deposited by photons absorbed in the subvolume. We propose an alternative method based on evaluating the average path length traveled by all photons injected within the subvolume. Application examples are given. This method also works for a zero absorption coefficient and for a nonconstant spatial distribution of the absorption coefficient within the subvolume. The proposed approach is a re-visitation of a well-known method applied to nuclear and radiation physics. The results obtained show that a potential advantage of the proposed method is that it can improve the convergence of Monte Carlo simulations. Indeed, when calculating the fluence in a region of interest with the proposed method, all photons passing through the region are considered. Whereas with the traditional approach, only absorbed\" photons are considered. In the latter case, this can produce a poorer Monte Carlo statistic for the same number of photons launched.","PeriodicalId":278089,"journal":{"name":"European Conference on Biomedical Optics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128654576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI classification for hepatitis B virus detection based on Mueller matrix imaging 基于Mueller矩阵成像的乙型肝炎病毒检测AI分类
European Conference on Biomedical Optics Pub Date : 2023-08-09 DOI: 10.1117/12.2671019
Van-Tung Nguyen, Quoc-Thinh Dinh, Q. Phan, T. Pham
{"title":"AI classification for hepatitis B virus detection based on Mueller matrix imaging","authors":"Van-Tung Nguyen, Quoc-Thinh Dinh, Q. Phan, T. Pham","doi":"10.1117/12.2671019","DOIUrl":"https://doi.org/10.1117/12.2671019","url":null,"abstract":"A novel method of artificial intelligence (AI) classification is proposed for hepatitis B virus (HBV) detection based on the Mueller matrix imaging system. The feasibility of the proposed technique is demonstrated by measuring the optical properties of non-infected and infected HBV blood samples. Furthermore, different AI classifier techniques namely Yolo5, Yolo5-Restnet101, Yolo5-EfficientnetB0, and Yolo5-MobilenetV2 have been employed to classify the HBV samples. The results show that the proposed method provides 99% accuracy for HBV classification. In general, the proposed technique provides reliable and simple devices for HBV diagnosis applications.","PeriodicalId":278089,"journal":{"name":"European Conference on Biomedical Optics","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121464254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time-domain diffuse correlation spectroscopy performance at different source-detector separation 不同源-探测器分离时的时域漫射相关光谱性能
European Conference on Biomedical Optics Pub Date : 2023-08-09 DOI: 10.1117/12.2670670
Neda Mogharari, Saeed Samaei, S. Wojtkiewicz, A. Liebert, M. Kacprzak
{"title":"Time-domain diffuse correlation spectroscopy performance at different source-detector separation","authors":"Neda Mogharari, Saeed Samaei, S. Wojtkiewicz, A. Liebert, M. Kacprzak","doi":"10.1117/12.2670670","DOIUrl":"https://doi.org/10.1117/12.2670670","url":null,"abstract":"Time domain diffuse correlation spectroscopy (td-DCS), has been proposed as a method that can increase the sensitivity of DCS for detecting blood flow index (BFI) in deep tissue. Several important parameters including the instrument response function (IRF), gate start time, gate width, and source-detector separation (SDS) must be taken into consideration. In our study, we characterized td-DCS system at three different SDS values and assessed each SDS's ability to detect dynamic changes of blood flow caused by moving red blood cells during cuff occlusion.","PeriodicalId":278089,"journal":{"name":"European Conference on Biomedical Optics","volume":"258 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116231062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CNN-assisted quantitative phase microscopy for biological cell imaging cnn辅助的生物细胞成像定量相显微镜
European Conference on Biomedical Optics Pub Date : 2023-08-09 DOI: 10.1117/12.2668352
I. Shevkunov, M. Kandhavelu, K. Egiazarian
{"title":"CNN-assisted quantitative phase microscopy for biological cell imaging","authors":"I. Shevkunov, M. Kandhavelu, K. Egiazarian","doi":"10.1117/12.2668352","DOIUrl":"https://doi.org/10.1117/12.2668352","url":null,"abstract":"Phase imaging is a solution for the reconstruction of phase information from intensity observations. To make phase imaging possible, sophisticated extra systems are embedded into the existing imaging systems. Contrary, we propose a phase problem solution by DCNN-based framework, which is simple in terms of an optical system. We propose to replace optical lenses with computational algorithms such as CNN phase reconstruction and wavefront propagation. The framework is tested in simulation and real-life experimental phase imaging. To have real experiments with objects close to real-life biological cells, we simulated experimental training datasets on a phase-only spatial light modulator, where phase objects are modeled with corresponding phase distribution to biological cells.","PeriodicalId":278089,"journal":{"name":"European Conference on Biomedical Optics","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116451682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital modeling of a heterogeneous and dynamic brain phantom: application to the choice of an RGB camera for intraoperative functional brain mapping studies 异质动态脑幻影的数字建模:RGB相机在术中脑功能测绘研究中的应用
European Conference on Biomedical Optics Pub Date : 2023-08-09 DOI: 10.1117/12.2670750
C. Caredda, L. Mahieu-Williame, R. Sablong, M. Sdika, F. Schneider, T. Picart, J. Guyotat, B. Montcel
{"title":"Digital modeling of a heterogeneous and dynamic brain phantom: application to the choice of an RGB camera for intraoperative functional brain mapping studies","authors":"C. Caredda, L. Mahieu-Williame, R. Sablong, M. Sdika, F. Schneider, T. Picart, J. Guyotat, B. Montcel","doi":"10.1117/12.2670750","DOIUrl":"https://doi.org/10.1117/12.2670750","url":null,"abstract":"RGB imaging is a non-invasive technique that is able to monitor hemodynamic brain responses following neuronal activation during neurosurgery. These cameras are often present in operating rooms, but a robust quantification is complicated to perform during neurosurgery. Liquid blood have been proposed, but it is not possible to model hemodynamic responses similar to those that occur in the brain. To overcome this issue, we propose a 3D brain model, including activated, non-activated grey matter and temporal hemodynamic fluctuations using Monte Carlo simulations. Several setups were modeled to evaluate their impact for identifying activated brain areas using statistical parametric mapping.","PeriodicalId":278089,"journal":{"name":"European Conference on Biomedical Optics","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126657991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fiber-conduit-based laser speckle contrast imaging device for point of care diagnostics 基于光纤导管的激光散斑对比成像装置，用于护理点诊断
European Conference on Biomedical Optics Pub Date : 2023-08-09 DOI: 10.1117/12.2686890
Ria Paul, Susweta Das, Soumyajit Sarkar, Mohammad Zaffar, H. Varma
{"title":"Fiber-conduit-based laser speckle contrast imaging device for point of care diagnostics","authors":"Ria Paul, Susweta Das, Soumyajit Sarkar, Mohammad Zaffar, H. Varma","doi":"10.1117/12.2686890","DOIUrl":"https://doi.org/10.1117/12.2686890","url":null,"abstract":"We present a laser speckle contrast imaging (LSCI) device equipped with an image conduit to image microvascular blood flow in remote tissues like ear, nose, throat (ENT) and cervical region. The system is validated using a tissue mimicking microfluidic flow phantom with different widths and flow speeds. The proposed system is being developed as a point of care testing (POCT) device best suited for at-home self-monitoring in resource-limited areas as it is non-invasive, portable, affordable and real time.","PeriodicalId":278089,"journal":{"name":"European Conference on Biomedical Optics","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126169655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fourier-space evaluation of tissue order in animal models of peritonitis 腹膜炎动物模型组织秩序的傅里叶空间评价
European Conference on Biomedical Optics Pub Date : 2023-08-09 DOI: 10.1117/12.2670914
J. Stergar, K. Lakota, M. Perše, N. Kojc, M. Milanič
{"title":"Fourier-space evaluation of tissue order in animal models of peritonitis","authors":"J. Stergar, K. Lakota, M. Perše, N. Kojc, M. Milanič","doi":"10.1117/12.2670914","DOIUrl":"https://doi.org/10.1117/12.2670914","url":null,"abstract":"In this contribution we show a novel application of Fourier space analysis to determine overall order of tissue architecture in samples of murine abdominal walls from an animal study of induced peritonitis. Such metrices present a necessary steppingstone in the development of digital histology, facilitating both longitudinal as well as large screening studies through introduction of quantitative and rapidly computable biomarkers. The samples were collected from a study including three different experimental groups receiving different intraperitoneal injections; a control group, which received a phosphate-buffered saline solution, a pure model group, receiving chlorhexidine gluconate to induce peritonitis, and a treated model group, which was additionally administered resolvin D1. We present an approach for analysis of hematoxylin and eosin stained histological slices from this study. First, hyperspectral microscopy images of the slides are acquired, and Beer-Lambert law is used to calculate relative volume fraction maps of both stains. Following this decomposition, a Fourier space representation of the eosin cellular image is calculated. Differences between healthy and diseased subjects, which are attributed to necrosis and edema, are then quantified in the Fourier space through the ellipticity of spatial frequency distribution. The proposed metric is shown to significantly discriminate between the healthy and diseased subject (p=0.02) and is additionally strongly linearly correlated to scattering parameter b on macroscopic scale observed in our previous analysis employing macroscopic imaging of whole abdominal walls (linear correlation coefficient of -0.9).","PeriodicalId":278089,"journal":{"name":"European Conference on Biomedical Optics","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126184248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testing novel miniature NIR spectrometers for wearable broadband NIRS devices 测试用于可穿戴宽带近红外设备的新型微型近红外光谱仪
European Conference on Biomedical Optics Pub Date : 2023-08-09 DOI: 10.1117/12.2668162
Musa Talati, F. Lange, I. Tachtsidis
{"title":"Testing novel miniature NIR spectrometers for wearable broadband NIRS devices","authors":"Musa Talati, F. Lange, I. Tachtsidis","doi":"10.1117/12.2668162","DOIUrl":"https://doi.org/10.1117/12.2668162","url":null,"abstract":"The feasibility of new-generation miniature spectrometers for use in portable broadband NIRS (bNIRS) devices was explored in this investigation. The study outlines tests of varying integration time between 1000 ms, 500 ms and 250 ms and source-detector separations between 2 cm, 3cm and 4 cm, and their effect on the received signal through MEDPHOT tissue-mimicking phantoms, A2, B2, B3 and D7, using the Oceans Optics HL-2000-HP tungsten halogen lamp as a broadband light source. The spectra and SNR were then compared to two gold-standard bNIRS systems. It is found that two of the spectrometers give respectable SNR values for the detection range of 600 - 1000 nm in all regimes except when saturated or using phantom D7. It is demonstrated that these two devices can appropriately be used for source-detector separations of 3 cm and 4 cm at 500 ms and 1000 ms integration times, to determine absorption changes in tissue and thus chromophore concentrations. To use them for 2 cm separations, an additional attenuation component will be required.","PeriodicalId":278089,"journal":{"name":"European Conference on Biomedical Optics","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133902830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short and long-term photostability of 3D printed fluorescent phantoms for near-infrared diffuse optical imaging 用于近红外漫射光学成像的3D打印荧光幻影的短期和长期光稳定性
European Conference on Biomedical Optics Pub Date : 2023-08-09 DOI: 10.1117/12.2670658
Sandra Schädel-Ebner, O. Hirsch, T. Gladytz, D. Gutkelch, K. Licha, J. Berger, D. Grosenick
{"title":"Short and long-term photostability of 3D printed fluorescent phantoms for near-infrared diffuse optical imaging","authors":"Sandra Schädel-Ebner, O. Hirsch, T. Gladytz, D. Gutkelch, K. Licha, J. Berger, D. Grosenick","doi":"10.1117/12.2670658","DOIUrl":"https://doi.org/10.1117/12.2670658","url":null,"abstract":"We have successfully printed an anatomically shaped hand model with properties similar to in vivo investigations with a fluorescence hand imager using indocyanine green (ICG). By adding the fluorescent dye Lumogen IR 765, titanium dioxide powder and black ink to a 3D printing methacrylate photopolymer we realized phantoms with physiologically relevant absorption and reduced scattering coefficients as well as fluorescence properties similar to the widely applied contrast agent ICG. The phantoms show an excellent long-term photostability making them well suited for device performance monitoring and comparison. In contrast, fluorescence of phantoms printed with ICG continuously decreases over time.","PeriodicalId":278089,"journal":{"name":"European Conference on Biomedical Optics","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133250881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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