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Journal of Clinical Case Studies Reviews & Reports最新文献

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Retrospective Review of 374 Samples, Circulating DNA; as a Biomarker Assay to Support Clinical Management in Solid Tumors Treated With Multi Targeted Epigenetic Therapy (MTET) 374份循环DNA样本的回顾性分析作为支持实体肿瘤多靶向表观遗传治疗(MTET)临床管理的生物标志物分析
Journal of Clinical Case Studies Reviews & Reports Pub Date : 2019-12-31 DOI: 10.35248/0974-8369.20.12.462
M. Nezami, C. Klowsowski, Hager Sj
{"title":"Retrospective Review of 374 Samples, Circulating DNA; as a Biomarker Assay to Support Clinical Management in Solid Tumors Treated With Multi Targeted Epigenetic Therapy (MTET)","authors":"M. Nezami, C. Klowsowski, Hager Sj","doi":"10.35248/0974-8369.20.12.462","DOIUrl":"https://doi.org/10.35248/0974-8369.20.12.462","url":null,"abstract":"Here in this abstract we retrospectively review preliminary findings on 374 samples of circulating DNAextracted from 173 patients treated by multitargeted epigenetic therapy (MTET), which is a combination of natural histone deacetylase inhibitors and DNMT methyl transferase inhibitors. This therapy could dynamically interrupt the expression of altered genes, in a variety of solid tumor types, both in invitro and invivo models. We hypothesize that serial monitoring of the circulating DNA provides a feasible option for therapeutic decisions making based on presence of the driver genes in these cases. We also were able to track the antineoplastic response in these group of patients by monitoring their tumor circulating DNA mutated allele fractions and propose a direct correlation with interim epigenetic therapy effectiveness.","PeriodicalId":274729,"journal":{"name":"Journal of Clinical Case Studies Reviews & Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131184464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metaplastic Carcinoma of the Breast, Spindle Cell Type: A Case Report 乳腺梭形细胞型化生癌1例报告
Journal of Clinical Case Studies Reviews & Reports Pub Date : 2019-12-31 DOI: 10.47363/jccsr/2019(1)103
Angelie Grace V Alvarez
{"title":"Metaplastic Carcinoma of the Breast, Spindle Cell Type: A Case Report","authors":"Angelie Grace V Alvarez","doi":"10.47363/jccsr/2019(1)103","DOIUrl":"https://doi.org/10.47363/jccsr/2019(1)103","url":null,"abstract":"Metaplastic breast carcinoma accounts for less than 1% of all breast malignancies. This subtype is the most aggressive triple negative breast cancer and remains therapeutically challenging to treat, highly unresponsive to chemotherapy. Here we present a case of a 54 year old female presenting as a non-tender, left breast mass. Core needle biopsy reports atypical cells present, suggestive of malignancy: considerations are Malignant Phyllodes tumor and Invasive Ductal Carcinoma. Subsequently she underwent a modified radical mastectomy (MRM). Microscopic examination revealed spindle cell neoplasm without epithelial component. On immunohistochemically examination, the tumor cells were positive for Cytokeratin and Smooth Muscle Actin and negative for S-100, ER (Estrogen receptors), PR (progesterone receptors) and Her2/Neu.","PeriodicalId":274729,"journal":{"name":"Journal of Clinical Case Studies Reviews & Reports","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122825031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-operatively Managed Proximal Humerus Fracture 非手术治疗肱骨近端骨折
Journal of Clinical Case Studies Reviews & Reports Pub Date : 2019-12-31 DOI: 10.47363/jccsr/2019(1)101
S. Hosseininejad
{"title":"Non-operatively Managed Proximal Humerus Fracture","authors":"S. Hosseininejad","doi":"10.47363/jccsr/2019(1)101","DOIUrl":"https://doi.org/10.47363/jccsr/2019(1)101","url":null,"abstract":"","PeriodicalId":274729,"journal":{"name":"Journal of Clinical Case Studies Reviews & Reports","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116944287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gallbladder Perforation: An Uncommon Complication of Acute Cholecystitis 胆囊穿孔:急性胆囊炎的罕见并发症
Journal of Clinical Case Studies Reviews & Reports Pub Date : 2019-12-31 DOI: 10.47363/jccsr/2019(1)108
M. R. Mohammed
{"title":"Gallbladder Perforation: An Uncommon Complication of Acute Cholecystitis","authors":"M. R. Mohammed","doi":"10.47363/jccsr/2019(1)108","DOIUrl":"https://doi.org/10.47363/jccsr/2019(1)108","url":null,"abstract":"Acute Cholecystitis is a common condition that may present with unusual complications like gallbladder perforation. Such an uncommon complication usually presents a challenge to surgeons to diagnose and provide the necessary management on as early as possible. The mortality rates are directly related to early surgical intervention. Therefore, it is crucial to keep in mind such a complication and know when to further investigate such patients. In this report we will describe a case of acute perforated cholecystitis which was almost missed due to the unspecific clinical presentation.","PeriodicalId":274729,"journal":{"name":"Journal of Clinical Case Studies Reviews & Reports","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124584778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social Acupuncture a Case Study 社会针灸:个案研究
Journal of Clinical Case Studies Reviews & Reports Pub Date : 2019-12-31 DOI: 10.47363/jccsr/2019(1)106
V. Stambolović
{"title":"Social Acupuncture a Case Study","authors":"V. Stambolović","doi":"10.47363/jccsr/2019(1)106","DOIUrl":"https://doi.org/10.47363/jccsr/2019(1)106","url":null,"abstract":"","PeriodicalId":274729,"journal":{"name":"Journal of Clinical Case Studies Reviews & Reports","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133675209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is Zero-Balance Ultrafiltration an Effective Clinical Method for SIRS Prevention During Extracorporeal Circulation in Adults Heart Diseases Correction? 零平衡超滤是预防成人心脏病体外循环过程中SIRS的有效临床方法吗?
Journal of Clinical Case Studies Reviews & Reports Pub Date : 2019-12-31 DOI: 10.47363/jccsr/2019(1)104
E. Vârlan
{"title":"Is Zero-Balance Ultrafiltration an Effective Clinical Method for SIRS Prevention During Extracorporeal Circulation in Adults Heart Diseases Correction?","authors":"E. Vârlan","doi":"10.47363/jccsr/2019(1)104","DOIUrl":"https://doi.org/10.47363/jccsr/2019(1)104","url":null,"abstract":"Background: Ultrafiltration, which is currently considered as a standard method to remove the excess water administered during cardiopulmonary bypass (CPB), aims to minimize the adverse effects of hemodilution, such as tissue edema and blood transfusion. Three ultrafiltration techniques can be used before, during and after CPB procedure, including conventional ultrafiltration (CUF), zero-balance ultrafiltration (Z-BUF), and modified ultrafiltration (MUF) at the end of CPB. The aim of study: The present research attempts to revise the efficiency of Z-BUF ultrafiltration method, laboratory results, and clinical impacts. Material and methods: 94 adults (54 men and 40 women) with acquired heart diseases undergoing a single cardiac surgical procedure in condition of cardiopulmonary bypass (clamp aortic 89, 9± 38, 8 min. and pump 135,14 ± 45,17 min.) were divided into 3 groups. 1st group (no ultrafiltration) - 34 patients with classic cardiac surgery, 2nd with the use of zero-balance ultrafiltration (ZBUF) group - 37 patients with classic cardiac surgery, and 3rd group ZBUF with mini invasive cardiac surgery - 23 patients.","PeriodicalId":274729,"journal":{"name":"Journal of Clinical Case Studies Reviews & Reports","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126109693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Bilateral Otitis Externa was the First Manifestation of Newly Diagnosed Diabetes Mellitus, Case Report 重度双侧外耳炎是新诊断糖尿病的首发表现
Journal of Clinical Case Studies Reviews & Reports Pub Date : 2019-12-31 DOI: 10.47363/jccsr/2019(1)107
Eyad Zein Aldean
{"title":"Severe Bilateral Otitis Externa was the First Manifestation of Newly Diagnosed Diabetes Mellitus, Case Report","authors":"Eyad Zein Aldean","doi":"10.47363/jccsr/2019(1)107","DOIUrl":"https://doi.org/10.47363/jccsr/2019(1)107","url":null,"abstract":"","PeriodicalId":274729,"journal":{"name":"Journal of Clinical Case Studies Reviews & Reports","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121605535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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