Science Archives最新文献

{"title":"Prevalence and association of pks+ Escherichia coli with colorectal cancer in Iraqi patients","authors":"Raghad Abdullah Hassan, Suhad Saad Mahmood, Basem Ahmed Askar","doi":"10.47587/sa.2023.4309","DOIUrl":"https://doi.org/10.47587/sa.2023.4309","url":null,"abstract":"Colorectal cancer (CRC) is a malignant tumor in the digestive system whose incidence and mortality are high-ranking among tumors worldwide. The present work aimed to investigate the role of colibactin-produced isolates of pks+ Escherichia coli in CRC disease. Among 159 specimens, which were subjected to different examinations, a total of 57.36% (n=88) of E. coli isolates were obtained, including 32.08% (n=51) of isolates from patients with CRC, including 21.4% (n=34) from fecal specimens and 10.7% (n=17) from tissue specimens as well as 23.3% (n=37) of isolates were obtained from healthy controls, including 16.4% (n=26) from fecal specimens and 6.92% (n=11) from tissue specimens. Genomic DNA was extracted from 57 selected E. coli isolates, which obtained 20 specimens (10 from CRC patients and 10 from controls) and 37 fecal specimens (21 from CRC patients and 16 from controls) for molecular detections of two genes ( uidA and pks ). All isolates of E. coli harbored uidA gene, while 11 (55.0%) of isolates were given positive for pks , including 8 (80.0%) from CRC patients and 3 (30.0%) from healthy controls. Immunofluorescence assay (IFA) was utilized to study the effect of pks + and pks - E. coli isolates on Normal human derived adipose tissue (NHF) cell line for determining the quantification of H2AX expression. The results indicated that there was significant variation in H2AX expression between pks + E. coli isolate-treated NHF and other groups. However, there was a non-significantly variation in H2AX expression between pks - E. coli isolate treated NHF and untreated NHF (as control) tissues. The results indicated that high effect of pks + E. coli on H2AX expression in NHF cell line.","PeriodicalId":273863,"journal":{"name":"Science Archives","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136257433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effect of Toxoplasma gonodii on some reproductive hormones in females","authors":"Zeyad Taha Hussein","doi":"10.47587/sa.2023.4310","DOIUrl":"https://doi.org/10.47587/sa.2023.4310","url":null,"abstract":"Toxoplasmosis is a common disease in worldwide. It is considered one of the common grounds between Humans and animals (zoonosis), which is caused by the Toxoplasma gondii parasite Between (30-60%) of the world's population, the most important cause of infection with the parasite is eating uncooked meat And unwashed vegetables that are contaminated as well by touching the feces of infected cats, as most of the infected people are With this type without symptoms or they do not show obvious symptoms, early pregnancies are severe, accompanied by infection leading to spontaneous abortion, hydrocephalus, and mental retardation, while transmission rates are high Highest During the third trimester, a third of all cases of ocular toxoplasmosis occur before birth It is possible that it occurs after birth, and that this disease is congenital, possessing a parasite Toxoplasma gondii is a characteristic that distinguishes it from other opportunistic parasites, as it parasitizes on many types of hosts .This makes it spread widely) and attack various organs, but mainly it attacks the nervous system Central and Reticuloendothelial System, For over 60 years. Pyrimethamine has been combined with Sulfadiazine, a classic drug, which has a synergistic effect on different steps in the synthesis of DNA in the toxoplasmosis parasite. The study was conducted from April 2022 to March 2023, where 160 creative women were collected from the new arrivals women between the ages of (20 and 40 years) and admissions to primary health care centers in government projects or referrals to private laboratories in Iraq, After it was determined that 25% of pregnant women infected with pathogens, while 75% of pregnant women were healthy from this parasite, and the percentage of parasite infection in the age group 20-30 years was 25%, while the percentage was 75% in age group was 30-40, the percentage of women infected with toxoplasmosis by place of residence was 37.5 in urban while 62.5 in village. The percentage of women infected with toxoplasmosis who keep cats and pets is 70% while 30% are without animals. The results of the current study showed that there were significant differences in the results of luteinizing hormone and follicle-stimulating hormone between women infected with Toxoplasma gondii and women in the control group.","PeriodicalId":273863,"journal":{"name":"Science Archives","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136257590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic structure study of clusters containing triiron metal atoms: QTAIM Approach","authors":"Shatha Raheem Helal Alhimidi","doi":"10.47587/sa.2023.4307","DOIUrl":"https://doi.org/10.47587/sa.2023.4307","url":null,"abstract":"The bridging Fe-S-Fe, bridging Fe-CO-Fe, and terminal Fe-CO bonds of mono-chalcogenide triiron carbonyl cluster [Fe 3 (CO) 7 (µ 3 -CO)(µ 3 -S)(µ-dppm)][dppm; diphosphine bis(diphenylphosphino)methane] were characterized utilizing the quantum theory of atoms in a molecule (QTAIM) topological analysis. To our knowledge, there are a few studies investigating Fe–Fe and Fe–S bonds using QTAIM topological analysis. Analysis of the Fe1-s1-Fe2-C3-Fe3 moiety, which is the core of the bridged cluster, showed that there is no bonding pathway between the bonding critical point and the Fe atoms. The parameters electron density ρ(r) and its Laplacian ∇ 2ρ(r) calculated for Fe-s and Fe-C showed a pronounced pure σ-bonding of this interaction.","PeriodicalId":273863,"journal":{"name":"Science Archives","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136257595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gas chromatography- mass spectrometry analysis of natural products in Pimpinella olivieri from North Iraq","authors":"Wijdan Saadi Aziz, Ali Hossen Altaef Al Tikriti, Zahraa B. Muhammed","doi":"10.47587/sa.2023.4308","DOIUrl":"https://doi.org/10.47587/sa.2023.4308","url":null,"abstract":"Wild plants possess many bioactive ingredients derived from by-metabolic process, which have a wide broad uses as medication and pharmaceutical importance. Therefore, the aim of the present study on a species of genus Pimpinella that belong to the family Apiaceae (Umbelliferae) developing northern Iraq Pimpinella olivieri , is the qualitative analysis of the methanolic extract of the plant to find out the active compounds in it by gas chromatographic technique equipped with mass spectroscopy. The results of the extract showed the presence of phenols, alkaloids, steroids, flavonoids, glycosides, fatty acids, terpenoids and carbohydrates. The results of GC-Mass analysis revealed presence of 20 biological compounds in the methanolic extract of the plant, such as sesquiterpenoid, lipophilic compounds. Bisbollene, Cis-13-octadecenoic acid, methyl ester (highest percentage of 72.05and 5.14) % at 15.1 and 24 minutes respectively of the detention time and the proportions of the rest of the terpenes in the plant extract were varied. The Benzene methanol was phenolic compound, 3,5-dimethyl, in ratio 12.96 at 13.3 minutes of detention time. While the two compounds (1,3,5,7-tetraethyl-1-methox cycl tetra siloxane and Cyclohexane, 1R-acetamido-2cis,4trans-bis(acetoxy)-3trans- azido) gave the lowest percentage of 0.13%.","PeriodicalId":273863,"journal":{"name":"Science Archives","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136257404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of some nutritional values and mineral elements in some oil extracts from medicinal plants","authors":"Nuha Ali Hadi al-Samarrai","doi":"10.47587/sa.2022.3308","DOIUrl":"https://doi.org/10.47587/sa.2022.3308","url":null,"abstract":"The study included evaluating the following bio-chemical evidence (Moisture, the percentage of the total Solid materials, the percentage of the extracted Oil, Acid Value, Iodine Value, Saponifing Value, Ester Value and Peroxide Value). The extracted oil of poupied had the higher ratio of the acid Value (27) whereas the ginger is recorded the lowest ratio of the acid Value (0.08). The extracted oil of the radish Seed is registered the highest (201.1) Concentration of the Saponifing Value whereas the extracted oil of the frozen fish (71.8) had Contained the lowest degree of the Saponifing Value. For the Ester value ,the free fat of sheep is given the higher(199.8) ratio whereas the extracted oil of frozen fish is indicated the lesser ratio(70.6) .For Iodine value the extracted oil of linseed is reached to highest (170.7) ratio while the butter is granted the lesser(31.7) ratio .As regard to the Peroxide value in the almond(21.4) oil while the lower value was in the free fat sheep (31.7). the study focused on assessing some of the mineral elements (Calcium, Potassium, Zinc, Iron and Magnesium). The sunflower oil had the highest concentration in Ca (2.1), K (9.0), Fe (0.9) and Mg (1.05) where the olive oil is registered the highest concentration in Zinc (0.3)","PeriodicalId":273863,"journal":{"name":"Science Archives","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123103419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel β-lactamase inhibitors and the pursuit of MBL inhibitors to combat antibiotic-resistant bacteria: a review","authors":"Ahmed A. Saleh, Ahmed A. J. Mahmood","doi":"10.47587/sa.2023.4304","DOIUrl":"https://doi.org/10.47587/sa.2023.4304","url":null,"abstract":"Bacterial resistance is spreading internationally and poses a serious threat to humans. β-lactam resistance has enhanced to an uncontrolled rate due to many reasons. The most significant form of resistance is destruction of the ß-lactam ring by a bacterial enzyme named ß-lactamase enzyme which is essential for antibacterial activity. There are currently six β-lactamases inhibitors that can be used clinically in conjugation with the antibiotic in order to protect them from enzymatic attacks. They bind the β-lactamase enzyme thus the β-lactam antibiotic catches the transpeptidase (PBP) which has the responsibility of peptidoglycan synthesis and disables it thus causing cell wall lysis. However, in order to tackle the fast escalating ß-lactam resistance, additional research is needed in order to create novel drugs with broad-spectrum. Herein we represent the recently published works of the β-lactamases inhibitors. Until nowadays there are no clinically approved MBL inhibitors, Efforts should be put to discover and evaluate novel MBLi to impede the spread of pathogenic-resistant bacteria and minimize their global health impact. The scientists realize this fact and emphasize their effort toward MBL inhibitors.","PeriodicalId":273863,"journal":{"name":"Science Archives","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125974866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital education accelerates at Diyala University in the presence of the COVID-19 pandemic","authors":"Hussam Najmuddin Abdul Shammari","doi":"10.47587/sa.2021.2209","DOIUrl":"https://doi.org/10.47587/sa.2021.2209","url":null,"abstract":"","PeriodicalId":273863,"journal":{"name":"Science Archives","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125533073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health effects of nitrate concentrations in the groundwater of Al-Manara village, north-east of Mosul city, Iraq","authors":"Badeea M. Ali Al-Bhar, Abdulazeez Y. T. Al-Saffawi","doi":"10.47587/sa.2021.2319","DOIUrl":"https://doi.org/10.47587/sa.2021.2319","url":null,"abstract":"The current study included estimating the concentration of nitrate ions to estimate human health risks (HHR) for groundwater for ten wells in Al-Manara village of Al-Hamdaniya District within Nineveh Governorate. The results indicated that the nitrate levels ranged between (10.8 to 19.1) ppm, thus 100% of the studied samples were within the international standard limits allowed for drinking, which reflected in the CDI and HQ values that fluctuated between (0.8691 to 0.2980) mg/kg. day and (0.5432 to 0.1862) consecutively, which are within the Safe limits for public health when this water is used for drinking by the local population","PeriodicalId":273863,"journal":{"name":"Science Archives","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127036687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effect of Hibiscus sabdariffa linn on some physiological variables in male white mice exposed to oxidative stress","authors":"Raghad Hazem Alabbasy","doi":"10.47587/sa.2022.3210","DOIUrl":"https://doi.org/10.47587/sa.2022.3210","url":null,"abstract":"This study was carried out to investigate the therapeutic effect of the water extract of the Hibiscus sabdariffa lin and its effect as an antioxidant on some physiological variables in male white mice exposed to oxidative stress induced by ethanol. Twenty adult white male mice aged 2-3 months were used with weights ranging from 20-30 g, divided into four groups of 5 rats per group. The groups were as follows: control group (G1), second group (G2) was given 5% of ethanol and the third group (G3) was given ethanol and water extract for Hibiscus sabdariffa lin at a concentration of 10%, and (G4) group was given ethanol and water extract of Hibiscus sabdariffa lin at a concentration of 20.","PeriodicalId":273863,"journal":{"name":"Science Archives","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129937744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endorphin: function and mechanism of action","authors":"Ansam Ali, Hanan Shihab Ahmed, A. S. Jawad, M. Mustafa","doi":"10.47587/sa.2021.2102","DOIUrl":"https://doi.org/10.47587/sa.2021.2102","url":null,"abstract":"Endorphins are chemicals naturally produced by the nervous system to manage pain or stress. They are often called “feel-good” chemicals because they act as a pain reliever and happiness booster. The exact mechanism of endorphins can be perceived through development in the peripheral nervous system (PNS) and the CNS through two distinct features. The illusion of pain relief in the PNS is produced by beta-endorphins that bind to opioid receptors. In the CNS, mu-opioid receptors are more abundant in descending pain control circuits including the amygdala, mesencephalic reticular formation, periaqueductal gray matter (PAG), and rostral ventral medulla. As for the Endorphins functions, they are found in high concentrations in certain regions of the brain that help in the transmission of pain sensations, breathing, motor activity, secretion of pituitary hormones, and mood. The relationship between the secretion of endorphins and the stimulating adrenal cortex hormone came through behavioral studies that indicated that stress increases the concentrations of endorphins in the blood and brain. With parallel changes in the pain threshold. Histochemical studies suggest that opiates have important relationships with cells that contain noradrenaline and cells that contain dopamine.","PeriodicalId":273863,"journal":{"name":"Science Archives","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128732783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}