Cancer Screening and Prevention最新文献

Early Explosive Recurrence of Hepatocellular Carcinoma after Radical Resection: Risk Factors and Clinical Significance 肝细胞癌根治性切除术后的早期爆发性复发：风险因素和临床意义

Cancer Screening and Prevention Pub Date : 2023-12-19 DOI: 10.14218/csp.2023.00037

Kai Yan, Wei Dong, Xiaowei Li, Zhe Han, Si Li, Guoyi Wu, Haibin Zhang, Yong Fu

引用次数: 0

Overtreatment of Supposedly Radiogenic Cancer and Precancerous Lesions 过度治疗假定的放射性癌症和癌前病变

Cancer Screening and Prevention Pub Date : 2023-11-30 DOI: 10.14218/csp.2023.00013

Sergei V. Jargin

引用次数: 0

Prevention and Screening of Gastric Cancer by Helicobacter pylori Management: Synthesis of Existing Data 通过幽门螺旋杆菌管理预防和筛查胃癌：现有数据综述

Cancer Screening and Prevention Pub Date : 2023-11-24 DOI: 10.14218/csp.2023.00010

Xianzhu Zhou, Zhaoshen Li, Yiqi Du

引用次数: 0

Evaluation of miRNA-derived Extracellular Vesicles as Biomarkers in Ovarian Cancer Stem Cells mirna来源的细胞外囊泡作为卵巢癌干细胞生物标志物的评价

Cancer Screening and Prevention Pub Date : 2023-06-27 DOI: 10.14218/csp.2023.00016

Minoo Roostaie, A. Esmaily, Hamid Taghvaei Javanshir, M. Arabi, A. Tafti, A. Bereimipour, H. Mahmoodzadeh, F. Hadjilooei, Melikasadat Hosseininejad

{"title":"Evaluation of miRNA-derived Extracellular Vesicles as Biomarkers in Ovarian Cancer Stem Cells","authors":"Minoo Roostaie, A. Esmaily, Hamid Taghvaei Javanshir, M. Arabi, A. Tafti, A. Bereimipour, H. Mahmoodzadeh, F. Hadjilooei, Melikasadat Hosseininejad","doi":"10.14218/csp.2023.00016","DOIUrl":"https://doi.org/10.14218/csp.2023.00016","url":null,"abstract":"Background and objectives: Ovarian cancer (OvCa) is the most deadly gynecological cancer. This study aimed to determine which genes and miRNAs play an important role in OvCa. Methods: We accessed the Gene Expression Omnibus database and downloaded the mRNA microarray dataset. Through the use of GEO2R, we were able to collect data on differentially expressed genes (DEGs) and microRNAs (DEMs). By querying the Enrichr database, we were able to conduct functional and pathway enrichment analysis on DEGs. STRING was used to create a network of protein–protein interactions, and Cytoscape was used to display the networks. Gene Expression Profiling Interactive Analysis and The Cancer Genome Atlas were then used to conduct overall survival and clinical data analyses of hub genes. DEM target predictions were also made using miRnet. For extracellular vesicles confirmation, Exocarta and Vesiclepedia were used. Results: There were a total of 1,778 DEGs found, and most of them were enriched for terms associated with the cell cycle, mitosis, and the ovulation cycle. There were 141 nodes used in the creation of the protein–protein interaction network. There were 10 genes with a lot of connections between them. Patients with OvCa had a shorter overall survival if they had high expression of four of the 10 genes tested: ATF3 , ZEB1 , CSF1R , and HSPA8 . We found out that the protein–protein interaction network has a significant module. The cell cycle, extracellular matrix receptor, and cell invasion were among the enriched functions and pathways. In addition, we found a total of 20 DEMs. The hsa-let-7 family (hsa-let-15a-3p, hsa-let-18a-5p, and hsa-let-615-5p) may target ZEB1 because its expression is inversely correlated with that of ZEB1","PeriodicalId":273565,"journal":{"name":"Cancer Screening and Prevention","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125380658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Sedated Endoscopy on Colorectal Adenoma Detection Rate: A Multicenter Study 镇静内镜对结直肠腺瘤检出率的影响:一项多中心研究

Cancer Screening and Prevention Pub Date : 2023-06-26 DOI: 10.14218/csp.2023.00012

Jiawei Zhou, Zhen Li, Rui Ji, Pei-zhu Wang, Ai-jun Zhang, Kangkang Wu, Cheng-Xia Liu, Qiong Niu, Y. Chu, Xiu-Feng Su, X. Zuo, Yan-Qing Li

{"title":"Influence of Sedated Endoscopy on Colorectal Adenoma Detection Rate: A Multicenter Study","authors":"Jiawei Zhou, Zhen Li, Rui Ji, Pei-zhu Wang, Ai-jun Zhang, Kangkang Wu, Cheng-Xia Liu, Qiong Niu, Y. Chu, Xiu-Feng Su, X. Zuo, Yan-Qing Li","doi":"10.14218/csp.2023.00012","DOIUrl":"https://doi.org/10.14218/csp.2023.00012","url":null,"abstract":"Background and objectives: Studies on the effect of sedated endoscopy on adenoma detection rate (ADR) and advanced adenoma detection rate (AADR) remain scarce. The present study aims to determine whether sedation can help improve ADR and AADR. Methods: Colonoscopies conducted in four endoscopy centers from January 2012 to July 2019 were included to create a propensity score-matched cohort, and compare the endoscopic factors. Results: The colonoscopies of 216,400 cases were included. The ADR (32.24% vs. 31.63%, p < 0.05), AADR (5.59% vs. 5.39%, p < 0.05), and polyp (20.61% vs. 20.21%, p < 0.05) increased in the sedated endoscopy group, especially for flat adenomas (44.80% vs. 43.95%, p < 0.05) and adenomas of 0–5 mm (66.99% vs. 66.24%, p < 0.05). However, there was no significant difference, in terms of lesion site. Furthermore, the number of biopsies per colonoscopy was significantly higher in the sedated group (0.79 ± 0.93 vs. 0.56 ± 0.80, p < 0.001). Moreover, there was a significant increase in electronic (0.92% vs. 0.83%, p < 0.05) and chemical staining (0.57% vs. 0.45%, p < 0.001) in the sedated group. Conclusions: The ADR, AADR and polyp detection rate increased for sedated colonoscopy, especially for flat adenomas and adenomas of 0–5 mm. In addition, the frequency of staining, image enhancement techniques, and number of biopsies per colonoscopy increased in sedated colonoscopy.","PeriodicalId":273565,"journal":{"name":"Cancer Screening and Prevention","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130144839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early screening of Pancreatic Cancer: A Bibliometric Study Over the Past Two Decades 胰腺癌的早期筛查:过去二十年的文献计量学研究

Cancer Screening and Prevention Pub Date : 2023-06-25 DOI: 10.14218/csp.2023.00022

Guo-Xiu Ma, Yuan-Chen Wang, Yan Liu, Xiaotong Mao, Shenghan Mao, Si-huai Xiong, Zhao-Shen Li, Li-Yuan Hou, Wen‐Bin Zou

{"title":"Early screening of Pancreatic Cancer: A Bibliometric Study Over the Past Two Decades","authors":"Guo-Xiu Ma, Yuan-Chen Wang, Yan Liu, Xiaotong Mao, Shenghan Mao, Si-huai Xiong, Zhao-Shen Li, Li-Yuan Hou, Wen‐Bin Zou","doi":"10.14218/csp.2023.00022","DOIUrl":"https://doi.org/10.14218/csp.2023.00022","url":null,"abstract":"Background and objectives: Pancreatic cancer (PC) is a highly malignant tumor of the digestive system with a poor prognosis. The early diagnosis and accurate screening of PC in high-risk populations are warranted to improve the prognosis of patients. The present study aimed to evaluate the global research characteristics, hotspots, and future trends of the early screening of PC. Methods: A comprehensive search of studies on early screening of PC in the Web of Science core database was performed between 1 January 2003 and 28 December 2022. The information, which included the study population, authorship, journal, contributing institution, country of origin, and keywords, were collected. The Excel, VOSviewer, and Citespace software were used for the bibliometric analytical processing and visualization. Results: A total of 581 publications were included and analyzed after the screening. For the past 20 years, the annual number of publications exhibited a fluctuating rising trend. The United States contributed more than 40% of the publications. Ralph H. Hruban was the most cited scholar. Pancreas ( n = 35), World Journal of Gastroenterology ( n = 24), and Pancreatology ( n = 18) were the top three journals with the highest number of publications. Keywords related to liquid biopsies, such as “extracellular vesicle”, “dna”, and “circulating tumor cell”, continued to burst until 2022. Conclusions: Over the past two decades, this area has been gradually gaining attention, with the number of publications rising annually. Liquid biopsy will be the future research trend. These present findings will provide the latest insight into the state of PC early screening, identifying new perspectives for further research.","PeriodicalId":273565,"journal":{"name":"Cancer Screening and Prevention","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133164674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Heightened Importance of EZH2 in Cancer Immunotherapy EZH2在肿瘤免疫治疗中的重要性

Cancer Screening and Prevention Pub Date : 2023-06-20 DOI: 10.14218/csp.2023.00006

Xiaodong Lin, Wen-Kai Zhou, Chengzhong Lin, W. Cao

引用次数: 0

The Potential Use of Phenethyl Isothiocyanate for Cancer Prevention 异硫氰酸苯乙酯预防癌症的潜在用途

Cancer Screening and Prevention Pub Date : 2023-06-14 DOI: 10.14218/csp.2023.00005

Tsu-Hsiang Kuo

引用次数: 0

Diet and Supplements in Cancer Prevention 饮食和补充剂在癌症预防中的作用

Cancer Screening and Prevention Pub Date : 2023-06-14 DOI: 10.14218/csp.2023.00001

Anandu Chandra Khanashyam, P. Thorakkattu, Karthik Sajith Babu, K. Shah, M. Rajput, Siriwan Nirmal, N. Nirmal

引用次数: 0

Possibilities for the Early Diagnosis of Head and Neck Squamous Cell Carcinoma 头颈部鳞状细胞癌早期诊断的可能性

Cancer Screening and Prevention Pub Date : 2023-05-11 DOI: 10.14218/csp.2023.00002

Juliette Juster, C. Page

{"title":"Possibilities for the Early Diagnosis of Head and Neck Squamous Cell Carcinoma","authors":"Juliette Juster, C. Page","doi":"10.14218/csp.2023.00002","DOIUrl":"https://doi.org/10.14218/csp.2023.00002","url":null,"abstract":"Head and neck cancers (including cancers of the oral cavity, oropharynx, hypopharynx, and larynx) are the sixth most common type of cancer worldwide. Almost all of these cancers are squamous cell carcinomas that develop from the mucosal lining. Due to the lack of specificity of the symptoms and inadequate screening methods, less than half of these tumors are currently discovered, albeit at an early stage. These cancers, therefore, constitute a real public health problem. Smoking, alcohol consumption, certain HPV infections, and chronic betel nut consumption are the main risk factors for developing squamous cell carcinoma of the upper aerodigestive tract. Early diagnosis depends on performing a complete and systematic physical examination of the oral cavity, pharynx, and larynx with a nasofibroscope in populations at risk. However, there are no strict criteria, in terms of alcohol and tobacco consumption, to trigger a physical examination by an ENT specialist, and there are no indications concerning the frequency with which such “screening” should be performed in at-risk populations. Even if such “screening strategies” are used in the absence of an alternative, different approaches are used in practice, depending on the medical system and country, and their efficacy and ideal modes of implementation remain unknown.","PeriodicalId":273565,"journal":{"name":"Cancer Screening and Prevention","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126470709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0