Intercontinental Journal of Internal Medicine最新文献

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The effect of anthropometric and metabolic parameters on the development of erosive reflux disease in patients with gastroesophageal reflux disease 胃食管反流病患者的人体测量和代谢参数对糜烂性反流病发展的影响
Intercontinental Journal of Internal Medicine Pub Date : 2023-05-29 DOI: 10.51271/icjim-0009
Şeyma Arısoy, B. Ergül, Özlem Gül, D. Oğuz, N. Dindar Badem
{"title":"The effect of anthropometric and metabolic parameters on the development of erosive reflux disease in patients with gastroesophageal reflux disease","authors":"Şeyma Arısoy, B. Ergül, Özlem Gül, D. Oğuz, N. Dindar Badem","doi":"10.51271/icjim-0009","DOIUrl":"https://doi.org/10.51271/icjim-0009","url":null,"abstract":"Aims: Gastroesophageal reflux disease (GERD) is a common health problem worldwide. Previous studies have reported that\u0000central obesity associated with visceral steatosis is an important problem in digestive system diseases, especially reflux-related diseases. This study aimed to examine the effect of body fat distribution on the development of erosive esophagitis.\u0000Methods: A total of 131 individuals, 105 patients and 26 healthy volunteers, were included in this study. The FSSG questionnaire was applied to all individuals. Patients with an FSSG questionnaire score of 10 or more underwent upper gastrointestinal tract endoscopy. Patients with esophagitis on endoscopy were included in the erosive esophagitis group, whereas patients without esophagitis were included in the non-erosive group. Serum biochemistry (fasting glucose, insulin, lipid panel, uric acid, TSH, AST, ALT) analyzes were performed. Waist circumference was measured. Body compositions were evaluated using the bioelectrical impedance method (Tanita).\u0000Results: Erosive esophagitis was found in 68 of 105 patients enrolled in the study, and non-erosive esophagitis in 37. There\u0000was no statistically significant difference in age, BMI, and waist circumference between the erosive, non-erosive and control\u0000groups. The visceral fat percentage was higher in the erosive esophagitis group than the other groups (p <0.001). At the end of the pairwise comparison of the groups, it was found that visceral fat value was higher in the erosive group than the non-erosive and control groups, while the visceral fat value was similar in the control and non-erosive groups. Except for the control group, when comparing the erosive and non-erosive groups, it was found that most of the patients in the erosive group were male, their FFM values and muscle mass were relatively high, and visceral fat values were significantly higher.\u0000Conclusion: An increase in visceral fat is a more important risk factor for the development of erosive esophagitis than obesity, waist circumference and increased BMI.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"253 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124178826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between thyroid function tests and bioelectrical impedance measurement parameters according to degree of obesity 肥胖程度下甲状腺功能测试与生物电阻抗测量参数的关系
Intercontinental Journal of Internal Medicine Pub Date : 2023-05-29 DOI: 10.51271/icjim-0008
VE Ürün, K. Üreten
{"title":"Relationship between thyroid function tests and bioelectrical impedance measurement parameters according to degree of obesity","authors":"VE Ürün, K. Üreten","doi":"10.51271/icjim-0008","DOIUrl":"https://doi.org/10.51271/icjim-0008","url":null,"abstract":"Aims: This study aimed to investigate the relationship between thyroid function tests and bioelectrical impedance measurement parameters showing body composition in groups of patients with varying degrees of obesity as determined by body mass index (BMI).\u0000Methods: A total of 120 people between the ages of 18 and 65 years were enrolled in the study, including 20 individuals with stage 1 obesity, 20 with Stage 2 obesity, 20 with Stage 3 obesity, and 40 with normal body weights. In the collection of data, a case report form prepared by the researcher for gathering information about the participants and the results of blood tests and bioelectrical impedance measurements made with a Tanita device were used. Blood samples were taken from the antecubital vein between 09:00 and 10:00 in the morning after at least 8 hours of fasting. HOMA-IR values were calculated by measuring fasting plasma glucose and insulin.\u0000Results: No significant correlation was found between median BMI and TSH, fT3 and fT4 levels in the whole population.\u0000While a negative correlation was found between median TSH and BMI in the group with normal body weight (r=-0.430,\u0000p=0.006), a positive correlation was found in the Stage 1 obese group (r=0.553, p=0.011). This relationship was not significant in the Stage 2 and morbidly obese groups. There was no significant correlation between BMI and fT4 and fT3 in all groups. A positive correlation was found between fat percentage and TSH (r=0.391, p=0.014) and fT3 (r=0.333, p=0.038) levels in the group with normal body weight, while no correlation was found with T4 levels.\u0000Conclusion: No statistically significant differenceswere found in terms of thyroid functions in different obesity classes as\u0000determined by BMI. Elevations of thyroid-stimulating hormone in obese patients are thought to be a result of obesity, not the cause.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123137543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the effect of obesity on oxidative stress with thiol/disulphide balance 用硫醇/二硫平衡评价肥胖对氧化应激的影响
Intercontinental Journal of Internal Medicine Pub Date : 2023-02-25 DOI: 10.51271/icjim-0002
Kübra Öklü, A. Çi̇fci̇, Aşkın Gün Güneş, Ş. Durmaz Ceylan, Ö. Erel
{"title":"Evaluation of the effect of obesity on oxidative stress with thiol/disulphide balance","authors":"Kübra Öklü, A. Çi̇fci̇, Aşkın Gün Güneş, Ş. Durmaz Ceylan, Ö. Erel","doi":"10.51271/icjim-0002","DOIUrl":"https://doi.org/10.51271/icjim-0002","url":null,"abstract":"Aims: As the body mass index (BMI) increases, the percentage of body fat increases and oxidative stress increases accordingly. This change can be determined by looking at the thiol/disulphide balance which is a biochemical test. We aim to emphasize the importance of oxidative stress due to obesity. Thus, by protecting obese individuals from oxidative stress (with antioxidant support treatments, etc.), studies to minimize the impact of obesity can be opened the front. Methods: The study group of our study was selected from 18-55-year-old female obese or overweight female patients who applied to Kırıkkale University Medical Faculty Internal Medicine and Endocrinology (Obesity) Polyclinics for slimming. Acontrol group consisting of healthy and normal weighted women who were in the same age range and applied to our hospital for general control were included in the study. According to BMI; groups consisting of 45 women, normal weight (18,5-24,9 kg/m²), overweight (25-29,9 kg/m²), stage 1 (mild obese; 30-34,9 kg/m²), stage 2 (moderately obese; 35-39,9 kg/m²) and stage 3 (morbid obese; 40-49,9 kg/m²), were formed. Participants were premenopausal women with no additional disease. Demographic data and routine investigations were obtained from the hospital system. Blood samples were studied with thiol/disulphide balance measurement tests. Results: We analyzed the five groups that were graded as normal weight, overweight, obese (mild, moderate, morbid) and the positive correlation between BMI and BC and BFP was significant in all groups (r =0.936, p<0.001; r =0.857, p<0.001, respectively). In all groups, the levels of native thiol and total thiol were decreased as BMI increased. There is a relatively lower difference between the normal thiol and total thiol levels of the normal weight and overweight group; there was a significant decrease in these values when passing from overweight to any stage of obesity. Negative correlation between all groups with native thiol (r =-0.473, p<0.001), total thiol (r =-0.472, p<0.001) and SH/total SH values (r =-0.296, p<0.001) were significant. The positive correlation between SS/SH (r = 0.296, p<0.001) and SS/total SH (r =0.296, p<0.001) was significant in all groups. The positive correlation between disulphide and all groups (r =0.103, p=0.25) was not significant. Conclusion: Increased fat tissue inflammation in obesity is associated with oxidative stress. Thiol-containing organic compounds are antioxidants for defense against oxidative stress. Measures should be taken in the early period to reduce oxidative stress in the management of obesity.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130345348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective evaluation of platelet indices and RAS mutations in patients with colon cancer 结肠癌患者血小板指数和RAS突变的回顾性评价
Intercontinental Journal of Internal Medicine Pub Date : 2023-02-25 DOI: 10.51271/icjim-0001
Merve Şanlıer, S. Yalçın
{"title":"Retrospective evaluation of platelet indices and RAS mutations in patients with colon cancer","authors":"Merve Şanlıer, S. Yalçın","doi":"10.51271/icjim-0001","DOIUrl":"https://doi.org/10.51271/icjim-0001","url":null,"abstract":"Aims: Colon cancers are one of the most common cancer types in the world and cause significant mortality. The presence of RAS mutation is also associated with poor prognosis in colon cancers and plays an important role in the choice of treatment. Platelet indices, which have recently been evaluated with an easy-to-reach method, have been discussed as an inflammatory marker in many studies. In this study, it was aimed to investigate the relationship between platelet distribution width (PDW), colon cancer stage and the presence of RAS mutation. Methods: File records of 132 patients who were followed up with the diagnosis of colon cancer in Kırıkkale University Faculty of Medicine, Department of Internal Medicine and Medical Oncology Department between January 1, 2015 and January 1, 2021 were retrospectively analyzed. Patients with RAS mutations and who did not receive chemotherapy were included in the study. Patients with and without RAS mutation were divided into two groups and their platelet index (especially PDW) values were compared. PDW values were compared according to the stages of the patients. The correlation between stage and PDW was examined. Results: Of the 132 patients included in the study, 82 (62.1%) were male and 50 (37.9%) were female. Participants; 12 (9.1%) stage 1, 23 (17.4%) stage 2, 29 (22%) stage 3, 68 (51.5%) stage 4 colon cancer patients. There were no RAS mutations in 73 (55.3%)patients, and 59 (44.7%) patients had RAS mutations. There was no significant difference in PDW between the two groups with negative and positive RAS mutations (p=0.826). According to the stages; PDW values were significantly different between the four stages (X2=9.878, p=0.020). Conclusion: In the study, PDW increased as the stage increased, but there was no significant relationship between RAS mutation and PDW. This was attributed to the fact that as the stage increases, the level of inflammation may be associated with an increase. Larger studies on this subject are needed.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"210 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115759635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Late diagnosed prolactinoma in men: a case report 男性晚期诊断催乳素瘤1例
Intercontinental Journal of Internal Medicine Pub Date : 2023-01-01 DOI: 10.51271/icjim-0006
Umut Karabulut, Ihsan Solmaz, Süleyman Özçaylak, Halit Eraslan, Sipan Polat, Abdullah Budak, F. Bingöl, M. S. Yıldırım
{"title":"Late diagnosed prolactinoma in men: a case report","authors":"Umut Karabulut, Ihsan Solmaz, Süleyman Özçaylak, Halit Eraslan, Sipan Polat, Abdullah Budak, F. Bingöl, M. S. Yıldırım","doi":"10.51271/icjim-0006","DOIUrl":"https://doi.org/10.51271/icjim-0006","url":null,"abstract":"Endocrinologic examinations encounter hyperprolactinemia, which is the release of prolactin hormone in excess of normal amounts, more frequently than any other pathological condition. In this case , we present a case of it is explained that a 42-year-old male patient can be diagnosed with prolactinoma by deepening the anamnesis without specifics symptoms. It is aimed to raise awareness on this issue.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128349558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of helicobacter pylori eradication on the oxidative stress index 幽门螺杆菌根除对氧化应激指标的影响
Intercontinental Journal of Internal Medicine Pub Date : 2023-01-01 DOI: 10.51271/icjim-0003
M. Polat, Y. Nazlıgül
{"title":"The impact of helicobacter pylori eradication on the oxidative stress index","authors":"M. Polat, Y. Nazlıgül","doi":"10.51271/icjim-0003","DOIUrl":"https://doi.org/10.51271/icjim-0003","url":null,"abstract":"Aims: Oxidative stress index is a parameter that is found by the ratio of total antioxidant status and total oxidant status. The oxidative stress index is a parameter that is found by the ratio of total antioxidant status and total oxidant status. Methods: A total of 100 patients with H. pylori-positive and who were given eradication treatment were included in the study; a total of 46 men 29 of whom with H. pylori eradication and 17 without; a total of 54 women 28 of whom with eradication and 26 without. Results: No significant difference in terms of oxidative stress index levels were found between the eradicated and non-eradicated groups. TAS levels were found to be 2,5± 0.4 in the non-eradicated group and 2.5 ± 0.3 in the eradicated group (p>0.05). Conclusion: In our study, no significant difference was found in antioxidant and oxidative stress levels between H. pylori positive and negative groups after eradication treatment was given to the patients infected with H. pylori.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"203 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115817441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity: etiology and the problems it causes 肥胖:病因及其引起的问题
Intercontinental Journal of Internal Medicine Pub Date : 2023-01-01 DOI: 10.51271/icjim-0005
A. Çi̇fci̇, Kübra Öklü
{"title":"Obesity: etiology and the problems it causes","authors":"A. Çi̇fci̇, Kübra Öklü","doi":"10.51271/icjim-0005","DOIUrl":"https://doi.org/10.51271/icjim-0005","url":null,"abstract":"Obesity is one of the biggest health problems today and its prevalence is increasing. It develops with excessive fat accumulation in the body secondary to high energy intake in obesity. It is a chronic disease in which the interaction of genetic, endocrine, metabolic, behavioral, psychological and sociocultural factors plays a role. In addition to endocrine (type 2 diabetes mellitus and insulin resistance, metabolic syndrome, etc.), cardiovascular (hypertension, hyperlipidemia, etc.) and cerebrovascular diseases, diseases such as cholecystitis, sleep apnea, osteoarthritis, hyperuricemia and gout, endometrial, breast, gallbladder cancers in women are associated with diseases such as colon, rectum, prostate cancer in men. These diseases both reduce the quality of life and lead to financial losses in individuals and national economies. Today, preventive health policies aim to reduce morbidity, mortality and economic burden by treating obesity without causing chronic diseases.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121743850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new hope in the management of hematologic malignancy: immunotherapy 恶性血液病治疗的新希望:免疫治疗
Intercontinental Journal of Internal Medicine Pub Date : 2023-01-01 DOI: 10.51271/icjim-0004
B. Başgöz, Ihsan Solmaz, Jehat Kılıç
{"title":"A new hope in the management of hematologic malignancy: immunotherapy","authors":"B. Başgöz, Ihsan Solmaz, Jehat Kılıç","doi":"10.51271/icjim-0004","DOIUrl":"https://doi.org/10.51271/icjim-0004","url":null,"abstract":"In recent years, Hodgkin's and Non-Hodgkin's lymphoma incidence is increasing all over the world. In the United States, lymphomas are the fourth most common malignancies among all. Lymphoid malignancies have a broad spectrum from mild indolent types, such as chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL), follicular lymphoma(FL), marginal zone lymphoma, and cutaneous T-cell lymphoma to aggressive types such as diffuse large B cell lymphoma (DLBCL), mantle cell lymphoma, Burkitt's lymphoma, peripheral T-cell lymphoma. With better response rates to chemotherapy, longer disease-free survival and overall survival rates, lymphomas have satisfactory treatment results rather than solid organ tumors for oncologists. Throughout history, conventional chemotherapy agents, radiotherapy and their combinations have been used for the treatment of lymphoma. Especially, in the early stages of Hodgkin's lymphoma, a rate of 85-90% complete remission and high rate long-term remission can be achieved. However, despite this high response rate, 15-30% of patients are resistant to treatment. With current therapiesresponse rate and persistent long-term remission rate in Non-Hodgkin's lymphomas are around 50%. Therefore, new therapeutic approaches such as immunotherapy and the using of cytotoxic properties of T cells against tumor has been developed and used in recent years for the treatment of refractory lymphoma.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"264 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133748722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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