Intercontinental Journal of Internal Medicine最新文献

{"title":"A rare food poisoning: clostridium botulinum","authors":"Yusuf Ziya Deniz, N. Nas","doi":"10.51271/icjim-0016","DOIUrl":"https://doi.org/10.51271/icjim-0016","url":null,"abstract":"Botulismus is a gram-positive anaerobic, spore-forming bacterium commonly found in soil. Exotaxins secreted by Clostridium \u0000bolulinum bacteria are heat-labile and irreversibly block the release of acetylcholine at the cholinergic ends of presynaptic and autonomic nerves at the neuromuscular junction after ingestion with food. The incubation period of botulismus is between 18-38 hours, and the first finding is blurred vision and diplopia symptoms due to the involvement of the eye muscles. The most important point in its treatment is early diagnosis and rapid administration of antitoxin. In this article, a case who was successfully treated in our intensive care unit with the diagnosis of botulismus poisoning is presented.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128312330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current approach to diabetic polyneuropathy: current diagnosis and treatment","authors":"Hilal Yaşar, A. Çi̇fci̇","doi":"10.51271/icjim-0014","DOIUrl":"https://doi.org/10.51271/icjim-0014","url":null,"abstract":"Diabetes mellitus and its associated neuropathy are among the leading problems affecting the quality of life negatively. Diabetic foot problems due to neuropathy cause very serious problems. Physicians may focus too much on blood sugar regulation and ignore examinations for other macro and microvascular complications of diabetes. Although it appears earlier in patients with impaired blood sugar regulation, neuropathic symptoms are seen in almost half of diabetic patients who generally exceed 10 years. With early diagnosis and treatment, the quality of life of patients increases significantly. We touched on this issue in order to raise awareness of neuropathy, which is so common.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125443246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A look at common gastrointestinal system diseases: current review","authors":"Yunus Tekin, B. Başgöz, Ihsan Solmaz","doi":"10.51271/icjim-0010","DOIUrl":"https://doi.org/10.51271/icjim-0010","url":null,"abstract":"The gastrointestinal system consists of the esophagus, stomach, small intestine, large intestine, and rectum. Although they\u0000are called accessory organs, the liver, pancreas, and gallbladder are also evaluated in this system with their vital features.\u0000Gastrointestinal system disorders (GISD) are observed quite frequently in society. Considering the morbidity and mortality\u0000they cause, effective treatment methods become crucial. Situations such as patients’ non-compliance with nutritional\u0000recommendations and the inadequacy of pharmacological and surgical methods at some points make different perspectives\u0000and treatment methods more valuable. From this point of view, we will try to examine the GISD that causes muscle loss and the physiotherapy modalities that can be applied to these patients in light of the current literature.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116326238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the clarithromycin-resistance of helicobacter pylori in first-line therapy with melting curve analysis","authors":"Kemalettin Yılmaz, A. Uygun, A. Kubar","doi":"10.51271/icjim-0007","DOIUrl":"https://doi.org/10.51271/icjim-0007","url":null,"abstract":"Aims: We aimed to determine the usefulness of melting curve analysis with the PCR technique in predicting the primary\u0000clarithromycin resistance of H. pylori before antibiotic use.\u0000Methods: 46 H. pylori positive clarithromycin based therapy naïve patients were included in the study. After proving H. pylori positivity with a real-time test, histopathological examination and rapid urease test, patients were treated with clarithromycinbased triple therapy for 14 days. Then patients were underwent a control endoscopy and tissue samples were taken 8 weeks after the initial endoscopy. The presence of H. pylori was investigated by using TaqMan-based real-time PCR and clarithromycin resistance was determined using two different molecular methods:melting curve analysis and DNA sequencing.\u0000Results: In total 18 patients (39.1%) were diagnosed as H. pylori positive on histopathological examination and 26 (56.5%) were diagnosed as H. pylori positive with TaqMan-based PCR, after triple therapy. According to results of melting curve analysis, primary resistance was found in 4 samples before treatment and secondary resistance was found in a different 4 samples after treatment. The DNA analysis showed that 9 patients had primary mutations in the pre-treatment group:4 patients had A2142CA2143G(T), 3 patients had T2182C, and 2 patients had both mutations, and also showed that 6 patients had mutations in the post-treatment group:4 patients had A2142C-A2143G, 2 patients had T2182C mutations.\u0000Conclusion: PCR based melting curve analysis may fail in determining clarithromycin resistance before eradication therapy.\u0000Hence, this method may also be used in combination with another molecular method such as DNA sequence analysis for\u0000improved detection of clarithromycin resistance.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"394 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123523105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of hematological indices in patients with colon cancer","authors":"Kemalettin Yılmaz","doi":"10.51271/icjim-0011","DOIUrl":"https://doi.org/10.51271/icjim-0011","url":null,"abstract":"I read with interest the formerly published paper entitled “Retrospective evaluation of platelet indices and RAS mutations in patients with colon cancer” by Şanlıer et al. (1). In that published paper, the authors evaluated the hematological indices in colon cancer patients and their relationships between RAS mutations. It has been noticed that the authors evaluated neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), platelet to lymphocyte ratio (PLR) and red cell distribution width (RDW) as hematological indices in colon cancer cases. I would like to thank the authors for valuable contribution to the literature for especially topic on colon cancer.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116381622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of anthropometric and metabolic parameters on the development of erosive reflux disease in patients with gastroesophageal reflux disease","authors":"Şeyma Arısoy, B. Ergül, Özlem Gül, D. Oğuz, N. Dindar Badem","doi":"10.51271/icjim-0009","DOIUrl":"https://doi.org/10.51271/icjim-0009","url":null,"abstract":"Aims: Gastroesophageal reflux disease (GERD) is a common health problem worldwide. Previous studies have reported that\u0000central obesity associated with visceral steatosis is an important problem in digestive system diseases, especially reflux-related diseases. This study aimed to examine the effect of body fat distribution on the development of erosive esophagitis.\u0000Methods: A total of 131 individuals, 105 patients and 26 healthy volunteers, were included in this study. The FSSG questionnaire was applied to all individuals. Patients with an FSSG questionnaire score of 10 or more underwent upper gastrointestinal tract endoscopy. Patients with esophagitis on endoscopy were included in the erosive esophagitis group, whereas patients without esophagitis were included in the non-erosive group. Serum biochemistry (fasting glucose, insulin, lipid panel, uric acid, TSH, AST, ALT) analyzes were performed. Waist circumference was measured. Body compositions were evaluated using the bioelectrical impedance method (Tanita).\u0000Results: Erosive esophagitis was found in 68 of 105 patients enrolled in the study, and non-erosive esophagitis in 37. There\u0000was no statistically significant difference in age, BMI, and waist circumference between the erosive, non-erosive and control\u0000groups. The visceral fat percentage was higher in the erosive esophagitis group than the other groups (p <0.001). At the end of the pairwise comparison of the groups, it was found that visceral fat value was higher in the erosive group than the non-erosive and control groups, while the visceral fat value was similar in the control and non-erosive groups. Except for the control group, when comparing the erosive and non-erosive groups, it was found that most of the patients in the erosive group were male, their FFM values and muscle mass were relatively high, and visceral fat values were significantly higher.\u0000Conclusion: An increase in visceral fat is a more important risk factor for the development of erosive esophagitis than obesity, waist circumference and increased BMI.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"253 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124178826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between thyroid function tests and bioelectrical impedance measurement parameters according to degree of obesity","authors":"VE Ürün, K. Üreten","doi":"10.51271/icjim-0008","DOIUrl":"https://doi.org/10.51271/icjim-0008","url":null,"abstract":"Aims: This study aimed to investigate the relationship between thyroid function tests and bioelectrical impedance measurement parameters showing body composition in groups of patients with varying degrees of obesity as determined by body mass index (BMI).\u0000Methods: A total of 120 people between the ages of 18 and 65 years were enrolled in the study, including 20 individuals with stage 1 obesity, 20 with Stage 2 obesity, 20 with Stage 3 obesity, and 40 with normal body weights. In the collection of data, a case report form prepared by the researcher for gathering information about the participants and the results of blood tests and bioelectrical impedance measurements made with a Tanita device were used. Blood samples were taken from the antecubital vein between 09:00 and 10:00 in the morning after at least 8 hours of fasting. HOMA-IR values were calculated by measuring fasting plasma glucose and insulin.\u0000Results: No significant correlation was found between median BMI and TSH, fT3 and fT4 levels in the whole population.\u0000While a negative correlation was found between median TSH and BMI in the group with normal body weight (r=-0.430,\u0000p=0.006), a positive correlation was found in the Stage 1 obese group (r=0.553, p=0.011). This relationship was not significant in the Stage 2 and morbidly obese groups. There was no significant correlation between BMI and fT4 and fT3 in all groups. A positive correlation was found between fat percentage and TSH (r=0.391, p=0.014) and fT3 (r=0.333, p=0.038) levels in the group with normal body weight, while no correlation was found with T4 levels.\u0000Conclusion: No statistically significant differenceswere found in terms of thyroid functions in different obesity classes as\u0000determined by BMI. Elevations of thyroid-stimulating hormone in obese patients are thought to be a result of obesity, not the cause.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123137543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effect of obesity on oxidative stress with thiol/disulphide balance","authors":"Kübra Öklü, A. Çi̇fci̇, Aşkın Gün Güneş, Ş. Durmaz Ceylan, Ö. Erel","doi":"10.51271/icjim-0002","DOIUrl":"https://doi.org/10.51271/icjim-0002","url":null,"abstract":"Aims: As the body mass index (BMI) increases, the percentage of body fat increases and oxidative stress increases accordingly. This change can be determined by looking at the thiol/disulphide balance which is a biochemical test. We aim to emphasize the importance of oxidative stress due to obesity. Thus, by protecting obese individuals from oxidative stress (with antioxidant support treatments, etc.), studies to minimize the impact of obesity can be opened the front. Methods: The study group of our study was selected from 18-55-year-old female obese or overweight female patients who applied to Kırıkkale University Medical Faculty Internal Medicine and Endocrinology (Obesity) Polyclinics for slimming. Acontrol group consisting of healthy and normal weighted women who were in the same age range and applied to our hospital for general control were included in the study. According to BMI; groups consisting of 45 women, normal weight (18,5-24,9 kg/m²), overweight (25-29,9 kg/m²), stage 1 (mild obese; 30-34,9 kg/m²), stage 2 (moderately obese; 35-39,9 kg/m²) and stage 3 (morbid obese; 40-49,9 kg/m²), were formed. Participants were premenopausal women with no additional disease. Demographic data and routine investigations were obtained from the hospital system. Blood samples were studied with thiol/disulphide balance measurement tests. Results: We analyzed the five groups that were graded as normal weight, overweight, obese (mild, moderate, morbid) and the positive correlation between BMI and BC and BFP was significant in all groups (r =0.936, p<0.001; r =0.857, p<0.001, respectively). In all groups, the levels of native thiol and total thiol were decreased as BMI increased. There is a relatively lower difference between the normal thiol and total thiol levels of the normal weight and overweight group; there was a significant decrease in these values when passing from overweight to any stage of obesity. Negative correlation between all groups with native thiol (r =-0.473, p<0.001), total thiol (r =-0.472, p<0.001) and SH/total SH values (r =-0.296, p<0.001) were significant. The positive correlation between SS/SH (r = 0.296, p<0.001) and SS/total SH (r =0.296, p<0.001) was significant in all groups. The positive correlation between disulphide and all groups (r =0.103, p=0.25) was not significant. Conclusion: Increased fat tissue inflammation in obesity is associated with oxidative stress. Thiol-containing organic compounds are antioxidants for defense against oxidative stress. Measures should be taken in the early period to reduce oxidative stress in the management of obesity.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130345348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective evaluation of platelet indices and RAS mutations in patients with colon cancer","authors":"Merve Şanlıer, S. Yalçın","doi":"10.51271/icjim-0001","DOIUrl":"https://doi.org/10.51271/icjim-0001","url":null,"abstract":"Aims: Colon cancers are one of the most common cancer types in the world and cause significant mortality. The presence of RAS mutation is also associated with poor prognosis in colon cancers and plays an important role in the choice of treatment. Platelet indices, which have recently been evaluated with an easy-to-reach method, have been discussed as an inflammatory marker in many studies. In this study, it was aimed to investigate the relationship between platelet distribution width (PDW), colon cancer stage and the presence of RAS mutation. Methods: File records of 132 patients who were followed up with the diagnosis of colon cancer in Kırıkkale University Faculty of Medicine, Department of Internal Medicine and Medical Oncology Department between January 1, 2015 and January 1, 2021 were retrospectively analyzed. Patients with RAS mutations and who did not receive chemotherapy were included in the study. Patients with and without RAS mutation were divided into two groups and their platelet index (especially PDW) values were compared. PDW values were compared according to the stages of the patients. The correlation between stage and PDW was examined. Results: Of the 132 patients included in the study, 82 (62.1%) were male and 50 (37.9%) were female. Participants; 12 (9.1%) stage 1, 23 (17.4%) stage 2, 29 (22%) stage 3, 68 (51.5%) stage 4 colon cancer patients. There were no RAS mutations in 73 (55.3%)patients, and 59 (44.7%) patients had RAS mutations. There was no significant difference in PDW between the two groups with negative and positive RAS mutations (p=0.826). According to the stages; PDW values were significantly different between the four stages (X2=9.878, p=0.020). Conclusion: In the study, PDW increased as the stage increased, but there was no significant relationship between RAS mutation and PDW. This was attributed to the fact that as the stage increases, the level of inflammation may be associated with an increase. Larger studies on this subject are needed.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"210 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115759635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late diagnosed prolactinoma in men: a case report","authors":"Umut Karabulut, Ihsan Solmaz, Süleyman Özçaylak, Halit Eraslan, Sipan Polat, Abdullah Budak, F. Bingöl, M. S. Yıldırım","doi":"10.51271/icjim-0006","DOIUrl":"https://doi.org/10.51271/icjim-0006","url":null,"abstract":"Endocrinologic examinations encounter hyperprolactinemia, which is the release of prolactin hormone in excess of normal amounts, more frequently than any other pathological condition. In this case , we present a case of it is explained that a 42-year-old male patient can be diagnosed with prolactinoma by deepening the anamnesis without specifics symptoms. It is aimed to raise awareness on this issue.","PeriodicalId":271257,"journal":{"name":"Intercontinental Journal of Internal Medicine","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128349558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}