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“DEVELOPMENT AND CHARACTERIZATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS) FOR BAUHINIA VARIEGATA LEAF EXTRACT” "紫荆叶提取物自微乳化给药系统（SMEDDS）的开发与表征"
NATURAL VOLATILES & ESSENTIAL OILS Pub Date : 2024-01-03 DOI: 10.53555/nveo.v8i5.5614
Nidhi Chandrakar, Dr Pulak Das, Dr.Mohit Mishra, Dr.Durgeshwar Karley, Dr Akanksha Pandey
{"title":"“DEVELOPMENT AND CHARACTERIZATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS) FOR BAUHINIA VARIEGATA LEAF EXTRACT”","authors":"Nidhi Chandrakar, Dr Pulak Das, Dr.Mohit Mishra, Dr.Durgeshwar Karley, Dr Akanksha Pandey","doi":"10.53555/nveo.v8i5.5614","DOIUrl":"https://doi.org/10.53555/nveo.v8i5.5614","url":null,"abstract":"This study aimed to formulate and characterize a Self-Microemulsifying Drug Delivery System (SMEDDS) for Bauhinia variegata leaves, a traditional medicinal plant renowned for its anti-tumor properties, in order to enhance the solubility and bioavailability of its bioactive compounds. Bauhinia variegate leaves were collected locally (Amity university ).The successful formulation and characterization of the SMEDDS for Bauhinia variegata not only contribute to advancing drug delivery technologies for traditional medicines but also pave the way for further research into practical applications in the pharmaceutical and herbal medicine industries. This study provides valuable insights for the development of innovative and effective delivery systems for bioactive compounds derived from traditional medicinal plants. Developing a self-microemulsifying drug delivery system (SMEDDS) for an ethanol extract from Bauhinia Variegate leaves involves creating a formulation that can spontaneously form a stable microemulsion when introduced to aqueous media, such as the gastrointestinal fluids. The use of a ternary phase diagram can help optimize the proportions of the key components in the formulation. SMEDDS are described as isotropic mixtures of herbal or synthetic oils, solid or liquid surfactants, or instead, one or greater hydrophilic solvents and co-solvents/surfactants that have a completely unique ability of forming satisfactory oil-in-water (o/w) microemulsions upon mild agitation followed by way of dilution in aqueous media, including GI fluids","PeriodicalId":269770,"journal":{"name":"NATURAL VOLATILES & ESSENTIAL OILS","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139389305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical constituents, antimicrobial and anti-inflammatory activities of Anaphalis triplinervis essential oil 三叶蛇麻精油的化学成分及抑菌抗炎活性
NATURAL VOLATILES & ESSENTIAL OILS Pub Date : 2023-08-23 DOI: 10.53555/nveo.v10i1.5388
Dr. Vinit Prakash, Harpreet Kaur, R. Bala
{"title":"Chemical constituents, antimicrobial and anti-inflammatory activities of Anaphalis triplinervis essential oil","authors":"Dr. Vinit Prakash, Harpreet Kaur, R. Bala","doi":"10.53555/nveo.v10i1.5388","DOIUrl":"https://doi.org/10.53555/nveo.v10i1.5388","url":null,"abstract":"The essential oil of Anaphalis triplinervis has been isolated through hydro-distillation and analysed by gas chromatography-mass spectroscopy (GC-MS). The in-vitro antimicrobial activity has been investigated by well-diffusion method against gram-positive and gram-negative bacteria as well as pathogenic fungus and in-vivo anti-inflammation activity has been evaluated by using complete Freund’s adjuvant (CFA) induced model into the left hind paw oedema. A total of nighteen components have been observed which constitute 93.2% of the total oil, observed major group components are fatty acids (40%), sesquiterpene hydrocarbons (29%), oxygenated sesquiterpenes (19.7%), fatty acids methyl esters (1.1%), diterpene (2.7%), monoterpene (0.8%) and phthalate contamination (0.6%). The main constituents of the oil are n-hexadecanoic acid (33.7%), cis-β - franesene (17.1%), phytone (7.1%), α - humulene (3.8%),elemol (3.6%), caryophyllen e oxide (3.4%), δ -cadinene (3.3 %) and β -caryophyllene (3%). This essential oil has shown effective antimicrobial activity against both Staphylococcus aureus and Escherichia coli bacteria as well as pathogenic fungus Aspergillus niger at 400 ppm concentrtion and also has shown the reduction in paw volume and haematological parameters in inflammatory rats at 200 mg/kg dose.","PeriodicalId":269770,"journal":{"name":"NATURAL VOLATILES & ESSENTIAL OILS","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114187328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Docking Approach On Potential Of 2,6-Diphenylpiperidin-4-Ol Derivatives To Inhibit Covid 19 Mainprotease 2,6-二苯哌啶-4-醇衍生物抑制新冠病毒主蛋白酶潜力的分子对接研究
NATURAL VOLATILES & ESSENTIAL OILS Pub Date : 2023-08-09 DOI: 10.53555/nveo.v10i1.4977
M. Meenakumari, R. Girija
{"title":"Molecular Docking Approach On Potential Of 2,6-Diphenylpiperidin-4-Ol Derivatives To Inhibit Covid 19 Mainprotease","authors":"M. Meenakumari, R. Girija","doi":"10.53555/nveo.v10i1.4977","DOIUrl":"https://doi.org/10.53555/nveo.v10i1.4977","url":null,"abstract":": COVID-19 is a disease caused due to SARS-CoV-2, the deadliest global spread of recent years. The virus spreads among humans through any type of contact between each other, through the air, and also through contaminated surfaces. The Main Protease (M Pro ) of SARS-CoV-2 is one of the expected targets in the development of new drug molecules for the disease. Some drugs like \"chloroquine\" and \"remdesivir\" have been used for therapeutics of COVID-19, even though the effect of these compounds is still mysterious. In the present study, the ligand and structure-based study was applied to compute the interaction with 2,6-diphenylpiperidin-4-ol derivatives on COVID-19 main protease. 2,6-diphenylpiperidin-4-ol derivatives (M1-M7) were found to show a similar structure of some Antiviral drugs via Qikprop. In silico docking study was carried out by 2,6-diphenylpiperidin-4-ol derivatives using Schrodinger Maestro 12.4 on SARS-CoV-2 M Pro receptors with PDB ID of 5R84. The potential imperative energy were calculated and the interactivity of each ligand were analyzed. To further expound the binding sites of the inhibitors for 5R84 active sites of three docking programs such as, Glide Score, Extra Precision (XP) Energy, Glide Energy were used. The attribute of the actively binding sites were then set out by the conformations of docking results. In conclusion, the 2,6-diphenylpiperidin-4-ol derivative with the best binding energy was noted to have high potency against COVID-19 Mainprotease.","PeriodicalId":269770,"journal":{"name":"NATURAL VOLATILES & ESSENTIAL OILS","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127828523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive review on phytoconstituents, bioactivities, and clinical studies on Ficus carica L. (Moraceae) and its role in human health and disease management 桑科榕属植物成分、生物活性、临床研究及其在人类健康和疾病管理中的作用综述
NATURAL VOLATILES & ESSENTIAL OILS Pub Date : 2023-07-24 DOI: 10.53555/nveo.v10i1.4273
F. Alsenani, Muath A. Alsufyani, Majed Taib, W. Almalki, Faris Bdirah
{"title":"A comprehensive review on phytoconstituents, bioactivities, and clinical studies on Ficus carica L. (Moraceae) and its role in human health and disease management","authors":"F. Alsenani, Muath A. Alsufyani, Majed Taib, W. Almalki, Faris Bdirah","doi":"10.53555/nveo.v10i1.4273","DOIUrl":"https://doi.org/10.53555/nveo.v10i1.4273","url":null,"abstract":"","PeriodicalId":269770,"journal":{"name":"NATURAL VOLATILES & ESSENTIAL OILS","volume":" 33","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131978321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Automated Hard Exudates Detection Systems i n Diabetic Retinopathy 最新的糖尿病视网膜病变硬渗出物自动检测系统
NATURAL VOLATILES & ESSENTIAL OILS Pub Date : 2021-11-27 DOI: 10.53555/nveo.v8i5.2052
Kanchan S. Gorde, Dr. Ajay A. Gurjar
{"title":"Recent Automated Hard Exudates Detection Systems i n Diabetic Retinopathy","authors":"Kanchan S. Gorde, Dr. Ajay A. Gurjar","doi":"10.53555/nveo.v8i5.2052","DOIUrl":"https://doi.org/10.53555/nveo.v8i5.2052","url":null,"abstract":"","PeriodicalId":269770,"journal":{"name":"NATURAL VOLATILES & ESSENTIAL OILS","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125137527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytoremediaton: An Alternative Approach To Detoxify Heavy Metals With Arbuscular Mycorrhizal Fungi 植物修复:用丛枝菌根真菌解毒重金属的另一种方法
NATURAL VOLATILES & ESSENTIAL OILS Pub Date : 2021-04-16 DOI: 10.53555/nveo.v8i4.5557
Permod Kumar, Adesh Kmar, A. Rani, Harish Pal Bhati, Shipra Choudhary, Raj Singh, Neha Chaudhary
{"title":"Phytoremediaton: An Alternative Approach To Detoxify Heavy Metals With Arbuscular Mycorrhizal Fungi","authors":"Permod Kumar, Adesh Kmar, A. Rani, Harish Pal Bhati, Shipra Choudhary, Raj Singh, Neha Chaudhary","doi":"10.53555/nveo.v8i4.5557","DOIUrl":"https://doi.org/10.53555/nveo.v8i4.5557","url":null,"abstract":"","PeriodicalId":269770,"journal":{"name":"NATURAL VOLATILES & ESSENTIAL OILS","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128949541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Spectral Study, Electrochemistry And Reactivity Of Ruthenium(II)-B-Naphthyl-Azo-Imidazole (B-Nair)-Nitro-Nitroso-Terpyridine (TPY)-Complexes. 钌(II)- b -萘-偶氮咪唑(B-Nair)-硝基-亚硝基三吡啶(TPY)配合物的合成、光谱研究、电化学及反应性
NATURAL VOLATILES & ESSENTIAL OILS Pub Date : 2020-11-24 DOI: 10.53555/nveo.v7i4.5554
P. Byabartta
{"title":"Synthesis, Spectral Study, Electrochemistry And Reactivity Of Ruthenium(II)-B-Naphthyl-Azo-Imidazole (B-Nair)-Nitro-Nitroso-Terpyridine (TPY)-Complexes.","authors":"P. Byabartta","doi":"10.53555/nveo.v7i4.5554","DOIUrl":"https://doi.org/10.53555/nveo.v7i4.5554","url":null,"abstract":"","PeriodicalId":269770,"journal":{"name":"NATURAL VOLATILES & ESSENTIAL OILS","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126899157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of S and N fertilization on yield of Wheat Grain S和N施肥对小麦籽粒产量的影响
NATURAL VOLATILES & ESSENTIAL OILS Pub Date : 1900-01-01 DOI: 10.52783/nveo.5474
Vikas Nautiyal
{"title":"Effect of S and N fertilization on yield of Wheat Grain","authors":"Vikas Nautiyal","doi":"10.52783/nveo.5474","DOIUrl":"https://doi.org/10.52783/nveo.5474","url":null,"abstract":"The research set out to assess the impact of N and S fertilizer on spring wheat production and quality from a technical standpoint. In 2015–2017, researchers in India carried out a field study. Fertilization using sulphur (S) as well as nitrogen (N) was tested. The addition of S considerably raised the concentration of gluten (3.2%), cysteine (6.0%), and methionine (16.5%). The levels of nitrogen, sulfur, total protein, gluten, cysteine, and methionine were all positively affected by nitrogen applications of 80 kg/ha and sulfur applications of 50 kg/ha. The amount of S in grain was shown to positively correlate with harvest success (r = 0.73). Grain yield was also shown to have significant correlations with all quality variables except nitrogen and starch content.","PeriodicalId":269770,"journal":{"name":"NATURAL VOLATILES & ESSENTIAL OILS","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123567104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of liquid formulation of Silver nanoparticles against selected fungal disease 抗选定真菌疾病的纳米银液体制剂的研制
NATURAL VOLATILES & ESSENTIAL OILS Pub Date : 1900-01-01 DOI: 10.52783/nveo.5473
Vikas Nautiyal
{"title":"Development of liquid formulation of Silver nanoparticles against selected fungal disease","authors":"Vikas Nautiyal","doi":"10.52783/nveo.5473","DOIUrl":"https://doi.org/10.52783/nveo.5473","url":null,"abstract":"The high protein yields, manageability, and low toxicity of the residues are all positives for the biogenic production of silver nanoparticles employing fungi as reducing and stabilizing agents. Additionally, the biomolecules generated from the fungus are coated onto the nanoparticles during this production process, which may increase stability and perhaps impart biological activity. AgNPs' biogenesis and recent instances of their use in plant disease control. AgNPs have shown promise as NPs for suppressing pathogen growth and managing plant diseases.","PeriodicalId":269770,"journal":{"name":"NATURAL VOLATILES & ESSENTIAL OILS","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114884900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological and therapeutic potential of various Indian medicinal plants: An Empirical Investigation of Ayurveda Experts 各种印度药用植物的药理学和治疗潜力:阿育吠陀专家的实证调查
NATURAL VOLATILES & ESSENTIAL OILS Pub Date : 1900-01-01 DOI: 10.52783/nveo.5459
Shatakshi Lal
{"title":"Pharmacological and therapeutic potential of various Indian medicinal plants: An Empirical Investigation of Ayurveda Experts","authors":"Shatakshi Lal","doi":"10.52783/nveo.5459","DOIUrl":"https://doi.org/10.52783/nveo.5459","url":null,"abstract":"India has a long history of using traditional medical techniques to treat a variety of illnesses and disorders. Ayurveda is one such system, which relies on herbal treatments obtained from plants and other natural sources. Many medicinal plants with pharmacological and therapeutic potential have been recognized by ayurvedic practitioners; these plants are still commonly employed in contemporary medicine. Neem, turmeric, ashwagandha, amla, and guduchi are a few of the medicinal herbs that are most frequently utilized in India. Neem is used to treat fever, gastrointestinal issues, and skin infections because of its antibacterial, antiviral, and antifungal qualities. On the other side, turmeric has anti-inflammatory and antioxidant effects and is used to treat cancer, arthritis, and stomach ulcers. These and other Indian medicinal herbs have a large range of pharmacological and therapeutic possibilities, and ongoing research is providing new light on their potential applications in contemporary medicine.","PeriodicalId":269770,"journal":{"name":"NATURAL VOLATILES & ESSENTIAL OILS","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128243280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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