“DEVELOPMENT AND CHARACTERIZATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS) FOR BAUHINIA VARIEGATA LEAF EXTRACT”

Nidhi Chandrakar, Dr Pulak Das, Dr.Mohit Mishra, Dr.Durgeshwar Karley, Dr Akanksha Pandey
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Abstract

This study aimed to formulate and characterize a Self-Microemulsifying Drug Delivery System (SMEDDS) for Bauhinia variegata leaves, a traditional medicinal plant renowned for its anti-tumor properties, in order to enhance the solubility and bioavailability of its bioactive compounds. Bauhinia variegate leaves were collected locally (Amity university ).The successful formulation and characterization of the SMEDDS for Bauhinia variegata not only contribute to advancing drug delivery technologies for traditional medicines but also pave the way for further research into practical applications in the pharmaceutical and herbal medicine industries. This study provides valuable insights for the development of innovative and effective delivery systems for bioactive compounds derived from traditional medicinal plants. Developing a self-microemulsifying drug delivery system (SMEDDS) for an ethanol extract from Bauhinia Variegate leaves involves creating a formulation that can spontaneously form a stable microemulsion when introduced to aqueous media, such as the gastrointestinal fluids. The use of a ternary phase diagram can help optimize the proportions of the key components in the formulation. SMEDDS are described as isotropic mixtures of herbal or synthetic oils, solid or liquid surfactants, or instead, one or greater hydrophilic solvents and co-solvents/surfactants that have a completely unique ability of forming satisfactory oil-in-water (o/w) microemulsions upon mild agitation followed by way of dilution in aqueous media, including GI fluids
"紫荆叶提取物自微乳化给药系统(SMEDDS)的开发与表征"
紫荆叶是一种传统药用植物,因其抗肿瘤特性而闻名于世。本研究旨在为紫荆叶配制一种自微乳化给药系统(SMEDDS)并对其进行表征,以提高其生物活性化合物的可溶性和生物利用度。紫荆叶的 SMEDDS 的成功配制和表征不仅有助于推进传统药物的给药技术,还为进一步研究其在制药和草药行业的实际应用铺平了道路。这项研究为从传统药用植物中提取的生物活性化合物开发创新、有效的给药系统提供了宝贵的见解。为洋紫荆叶乙醇提取物开发一种自微乳化给药系统(SMEDDS)涉及到创建一种配方,当引入水介质(如胃肠液)时,它能自发形成稳定的微乳化液。使用三元相图有助于优化配方中关键成分的比例。SMEDDS 被描述为草本或合成油、固体或液体表面活性剂的各向同性混合物,或一种或多种亲水性溶剂和助溶剂/表面活性剂的各向同性混合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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