Research and Review Insights最新文献

{"title":"Neuroinflammation as part of a possible neuro-regeneration in a patient with ASIA-A scale using combinatorial biologics: Bioquantine® and allogeneic mesenchymal stem cells","authors":"Joel I Osorio, Sergei Paylian, Ale Ismael Gonzalez Cazares, I. Pastor","doi":"10.15761/RRI.1000154","DOIUrl":"https://doi.org/10.15761/RRI.1000154","url":null,"abstract":"Received: June 12, 2019; Accepted: June 26, 2019; Published: June 28, 2019 A complete spinal cord injury (SCI) is the complete sensory and motor loss below the site of spinal cord injury following acute or chronic destruction, compression, or ischemia of the spinal cord. Initially, this may present as spinal shock, which is an acute physiological loss or depression of spinal cord function. It presents as a flaccid areflexic paralysis below the level of the injury with autonomic features (e.g., hypotension and bradycardia). After some days to weeks the spinal shock wears off and a complete spinal cord injury may remain. It presents with spastic paresis, hyperreflexia, and continued sensory loss. The differentiation and regeneration potential of stem cells has been well studied in both preclinical and clinical investigations. A traumatic spinal cord injury triggers a complex local inflammatory reaction capable of enhancing repair and exacerbating pathology (Figure 1).","PeriodicalId":267114,"journal":{"name":"Research and Review Insights","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116801390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on the mechanism of action of favipiravir and hydroxychloroquine in COVID-19","authors":"V. Pavlova, S. Hristova, K. Uzunova, T. Vekov","doi":"10.15761/rri.1000167","DOIUrl":"https://doi.org/10.15761/rri.1000167","url":null,"abstract":"","PeriodicalId":267114,"journal":{"name":"Research and Review Insights","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128824461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can standardized and evidence based plant immunomodulator (rice bran arabinoxylan concentrate) increase the effect of Gemcitabine in a synergistic manner? Case report of a patient with ductal pancreas carcinoma","authors":"T. Hajtó","doi":"10.15761/rri.1000161","DOIUrl":"https://doi.org/10.15761/rri.1000161","url":null,"abstract":"Background: Pancreatic ductal carcinoma is leading cause of cancer mortality. Gemcitabine with nab-Paclitaxel as a standard first line therapy is reporting improved clinical parameters but they are only transient. Immunological observations suggest that in background of this rapid resistance a tumor induced dysregulation of immune balance can also play a role. As it was shown the tumor-induced type-2 innate immune cells activate various inhibitory regulatory cells and growth factors which can diminish both the activity of immune effectors and the immune sensitivity of tumor cells. As it well known, the immune sensitivity related to the MHC class-I chain-related A / B (MICA and MICB) stress molecules on tumor cells which are the ligands of the most important killing activator receptor (NKG2D) on natural killer (NK) cells. Because of the discovery several years ago, that Gemcitabine can enhance the expression of MICA and MICB molecules on tumor cells, its combination with an evidence based immunomodulator has a growing clinical interest. Material and methods: In this case report a patient with metastatic and inoperable pancreas ductal adenocarcinoma is presented who was treated with gemcitabine (1678 mg) and nab-paclitaxel (210 mg) on 1.- 8. -15. days of months given eight cycles. This therapy was regularly combined with 45 mg / kg Biobran /MGN-3 given per oral three times a week which is a standardized rice bran arabinoxylan concentrate. Results : In a now 56 years old patient an inoperable ductal adenocarcinoma (39x46 mm) in caudal part of pancreas with multiplex liver metastases (10-30 mm) was established by CT and biopsy. He was in a nearly terminal stage (having 27 kg decrease in body weight and intensive pains). Three months after the start of the therapy a remission of pancreas tumor (25x38 mm) and in liver metastases average 3-10 mm decreases were established by CT. Seven months later in pancreas a complete remission was found and his liver metastases showed further 3-6 mm decreases. After 10 months these remissions were also established. The patient has not now any complaints and is able to work 100%. Conclusion : The combination of gemcitabine with evidence based and standardized immunomodulators (such as MGN-3) may open new strategies in the tumor therapy.","PeriodicalId":267114,"journal":{"name":"Research and Review Insights","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115464047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing effect of streptozotocin-induced insulin deficit on antitumor innate immune defense in rats","authors":"Hajto Tibor, Pecze László, Kuzma Monika, Hormay Edina, Ollmann Tamás, Jaksó Pál, Baranyai Lilla, Karádi Zoltán","doi":"10.15761/rri.1000170","DOIUrl":"https://doi.org/10.15761/rri.1000170","url":null,"abstract":"","PeriodicalId":267114,"journal":{"name":"Research and Review Insights","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116782558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health and covid19","authors":"C. Azevedo, E. Crosato, I. Henriques, Paulo S G Henriques","doi":"10.15761/RRI.1000157","DOIUrl":"https://doi.org/10.15761/RRI.1000157","url":null,"abstract":"Since December 2019, the newly discovered coronavirus (2019nCov) has caused an outbreak of pneumonia in Wuhan and throughout China. 2019-nCov enters host cells through human cell receptor ACE2, the same with SARS-CoV, but with higher binding affinity. The rapidly increasing number of cases and evidence of human-tohuman transmission suggested that the virus was more contagious than SARS-CoV and MERS-CoV. By mid-February 2020, a large number of infections of medical staff have been reported, and the specific reasons for protection failure needs to be further investigated. This new infectious agent is more likely to affect older males and causes severe respiratory diseases indicating that a new person-to-person transmission infectious agent has caused this emergent viral pneumonia outbreak. Although clinics such as stomatology have been closed during the epidemic, a large number of emergency patients still go to the dental clinics and hospitals for treatment. We have summarized the possible transmission routes of 2019-nCov in stomatology, such as the airborne spread, contact spread, and contaminated surface spread. We also reviewed several detailed practical strategies to block virus transmission to provide a reference for preventing the transmission of 2019-nCov during dental diagnosis and treatment, including patient evaluation, hand hygiene, personal protective measures for the dental professionals, mouthrinse before dental procedures, rubber dam isolation, anti-retraction handpiece, disinfection of the clinic settings, and management of medical waste [1].","PeriodicalId":267114,"journal":{"name":"Research and Review Insights","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130829838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal cardiomyopathy: A review and pooled analysis of pathophysiology, diagnosis and clinical management","authors":"Aref Albakri","doi":"10.15761/rri.1000151","DOIUrl":"https://doi.org/10.15761/rri.1000151","url":null,"abstract":"The incidence of invasive fungal disease has dramatically increased over the past few decades corresponding to the rising number of immunocompromised patients – mostly those with Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency syndrome (AIDS) and cancer. The major risk factors for severe cardiac fungal disease are prolonged administration of antibiotics, corticosteroids and cytotoxic agents, invasive medical procedures, and transplant recipients. Invasive fungal infection often affects multiple organs and cardiac involvement frequently occurs in disseminated disease. Ante mortem diagnosis of fungal cardiomyopathy (FCM) is difficult because clinical findings of myocardial involvement are often absent or ambiguous and blood cultures are often negative. Although an uncommon cause of infectious cardiomyopathy (CM), FCM is potentially fatal and thus early diagnosis of the primary infecting fungal pathogen, organs involved and the status of the host immune system is important to guide clinical management. Thus, this paper reviews the major fungal pathogens responsible for CM, clinical setting in which they occur, pathophysiology, diagnosis and management as well as highlights the burden of cardiac fungal infection and the need for additional research to refine current strategies or develop more effective diagnostic and therapeutic strategies. *Correspondence to: Aref Albakri, St-Marien hospital Bonn Venusberg, Department of Internal Medicine, Bonn, Germany, E-mail: arefalbakri@yahoo. com","PeriodicalId":267114,"journal":{"name":"Research and Review Insights","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133960108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inactivated vaccines: a promising old tool against Covid-19","authors":"Enrique Iglesias","doi":"10.15761/rri.1000160","DOIUrl":"https://doi.org/10.15761/rri.1000160","url":null,"abstract":"","PeriodicalId":267114,"journal":{"name":"Research and Review Insights","volume":"282 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134215137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dispossessed of Egypt part V: the scheme of genetic trumpization for the supremacy of the elite versus the world’s majority plagued with poverty and diseases","authors":"J. Wassili, Cyril Baradaeus","doi":"10.15761/rri.1000169","DOIUrl":"https://doi.org/10.15761/rri.1000169","url":null,"abstract":"","PeriodicalId":267114,"journal":{"name":"Research and Review Insights","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122526779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying the impact of COVID-19 isolation practices on persons experiencing homelessness with concurrent disorders","authors":"M. Young, Rana Van Tuyl","doi":"10.15761/rri.1000168","DOIUrl":"https://doi.org/10.15761/rri.1000168","url":null,"abstract":"","PeriodicalId":267114,"journal":{"name":"Research and Review Insights","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131622021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The health effects of electronic cigarette use: An overview","authors":"Evangelia Gkoulitou, Chrysoula Vakaki, E. Pepelassi","doi":"10.15761/RRI.1000158","DOIUrl":"https://doi.org/10.15761/RRI.1000158","url":null,"abstract":"E-cigarettes were first introduced as smoking cessation aids and then expanded among non-smokers. E-cigarettes are relatively new and their impact on health has not been sufficiently explored, particularly in the long-term. The aim of this study was to review the effect of e-cigarettes on general and oral health. E-cigarette use is considered significantly less harmful than smoking though it is not deprived of health risks, which might vary depending on e-liquid and e-vapor content, manufacturing and storage conditions and prolonged use. Flavorings, propylene glycol, glycerin, aldehydes, heavy metal traces and nicotine are some of their hazardous compounds. E-cigarettes affect several cellular activities, such as inflammatory and apoptotic response, cellular metabolism and proliferation, commensal microbe proliferation and virulence. They have cytotoxic, genotoxic, and carcinogenic properties. Chronic use affects mostly the respiratory and cardiovascular systems and possibly the central nervous system. They increase heart rate, blood pressure, arterial stiffness and risks of presenting heart diseases that pave the way for cardiac arrhythmias. Periodontal tissues presented less inflammation with e-cigarettes than smoking. Periimplant tissues presented higher proinflammatory cytokine levels with e-cigarettes than never-smoking. Oral mucosal lesions were in total similarly prevalent for e-cigarette users and former smokers, though nicotine stomatitis, hairy tongue and angular cheilitis were more frequent with e-cigarettes. C. albicans carriage was higher with e-cigarettes than never-smoking. Switching from smoking to e-cigarettes may reduce oral and throat symptomatology, though several oral health consequences might be associated with e-cigarettes. Evidence supports that chronic e-cigarette use may affect health negatively. Taking into consideration that e-cigarettes might help quit smoking, health professionals should inform patients that smokers selecting e-cigarettes as smoking cessation aid should soon discontinue them since prolonged use entails health risks. Moreover, health professionals","PeriodicalId":267114,"journal":{"name":"Research and Review Insights","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115735178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}