Neuroinflammation as part of a possible neuro-regeneration in a patient with ASIA-A scale using combinatorial biologics: Bioquantine® and allogeneic mesenchymal stem cells

Abstract

Received: June 12, 2019; Accepted: June 26, 2019; Published: June 28, 2019 A complete spinal cord injury (SCI) is the complete sensory and motor loss below the site of spinal cord injury following acute or chronic destruction, compression, or ischemia of the spinal cord. Initially, this may present as spinal shock, which is an acute physiological loss or depression of spinal cord function. It presents as a flaccid areflexic paralysis below the level of the injury with autonomic features (e.g., hypotension and bradycardia). After some days to weeks the spinal shock wears off and a complete spinal cord injury may remain. It presents with spastic paresis, hyperreflexia, and continued sensory loss. The differentiation and regeneration potential of stem cells has been well studied in both preclinical and clinical investigations. A traumatic spinal cord injury triggers a complex local inflammatory reaction capable of enhancing repair and exacerbating pathology (Figure 1).