2019 International Symposium on Micro-NanoMechatronics and Human Science (MHS)最新文献

{"title":"Study of a dura mater model using fiber materials","authors":"Shusaku Hayakawa, A. Ichikawa, Masaru Takeuchi, T. Fukuda","doi":"10.1109/MHS48134.2019.9249305","DOIUrl":"https://doi.org/10.1109/MHS48134.2019.9249305","url":null,"abstract":"In this study, we focused on fabricating dura mater model for brain surgeries training, especially for a transnasal pituitary surgery. In this paper, a dura mater model was developed by combining an elastic material and a fiber material to mimic actual dura mater. The fabricated dura mater model was compared with porcine dura mater and evaluated. The dura mater model can be used to improve surgical skills for suturing dura mater by installing into a surgical simulator.","PeriodicalId":264161,"journal":{"name":"2019 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129371949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soft bodies as input reservoir: role of softness from the viewpoint of reservoir computing","authors":"Katsuma Inoue, K. Nakajima, Y. Kuniyoshi","doi":"10.1109/MHS48134.2019.9249256","DOIUrl":"https://doi.org/10.1109/MHS48134.2019.9249256","url":null,"abstract":"Biological systems are composed of a large number of continuum elements and they effectively realize their flexible and smooth functionalities by capitalizing on the rich dynamics occurring in their soft bodies. In particular, the diverse spatiotemporal patterns of the continuum body have recently been demonstrated as highly useful in implementing a certain class of computation, implying that soft bodies can work as computational devices like nervous systems. However, unlike nervous systems whose activities are basically chaotic and spontaneous, soft bodies are passive and eventually stop their movements without undergoing external force. In addition, both nervous systems and soft bodies are tightly coupled in biological systems and seamlessly contribute to establishing the functionalities as a whole, making it difficult to clarify the specific roles of each element and the degrees of contribution. In this paper, we quantitatively investigate a general role of the soft bodies by introducing a new concept called input reservoir and examining the contribution of the passive elements to information processing. Input reservoir refers to a dynamical system that acts as a filter with a fading memory property whose output is projected onto a chaotic dynamical system and works as an interface between the external stimulus and the chaotic system. Soft bodies can be considered as one type of input reservoir in terms of function because soft bodies are placed between the environment and the chaotic nervous system. We show that the performance of a certain type of temporal task can be improved by installing an input reservoir and training the internal weights of the connected chaotic neural network using a reservoir computing method called innate training. Moreover, we demonstrate that complicated spatiotemporal patterns collected by sensing the soft body dynamics significantly contribute to increasing the computational capacity of the whole by projecting them onto a chaotic neural network and modifying the network weights by innate training. These results imply that soft continuum elements in biological systems have a significant effect in the system's information processing even when the soft elements are firmly joined with the nervous system.","PeriodicalId":264161,"journal":{"name":"2019 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","volume":"203 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124932561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femtosecond laser direct-writing technique using reduction of glyoxylic acid metal complexes","authors":"M. Mizoshiri, Junya Narushima, Tomoyuki Imakita, Hikaru Nakatani, Akira Uetsuki, T. Ohishi","doi":"10.1109/MHS48134.2019.9249356","DOIUrl":"https://doi.org/10.1109/MHS48134.2019.9249356","url":null,"abstract":"Metal and metal oxide materials were directly written using femtosecond laser pulse-pulse induced reduction of glyoxylic acid metal complexes. Absorption spectra of the glyoxylic acid metal complexes indicated that multiphoton absorption was caused by femtosecond laser pulses with the wavelength of 515 nm. Metal and metal oxide composite materials were precipitated by scanning the focal spot on the glyoxylic acid metal complexes films in air.","PeriodicalId":264161,"journal":{"name":"2019 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122597118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Transparent Soft Actuator toward Realizing Three-Dimensional Transparent Soft Actuator","authors":"Natsumi Koike, T. Hayakawa","doi":"10.1109/MHS48134.2019.9249333","DOIUrl":"https://doi.org/10.1109/MHS48134.2019.9249333","url":null,"abstract":"To realize three-dimensional transparent soft actuator, we show driving method of a dielectric elastomer actuator (DEA) in three-dimensional shape in this paper. We construct systems to apply pre-stretch to fabricated DEA with uniaxial direction by using weight and three-dimensional direction by using water pressure. Then, we evaluated the displacement of DEA with each system.","PeriodicalId":264161,"journal":{"name":"2019 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116867305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study for Motion-Planning Method Resident-tracking Robot based on Reinforcement Learning","authors":"Masashi Sugimoto, T. Yoshioka, K. Ishii, S. Nonaka, Mikio Deguchi, S. Tsuzuki, Masatsugu Hirano","doi":"10.1109/MHS48134.2019.9249075","DOIUrl":"https://doi.org/10.1109/MHS48134.2019.9249075","url":null,"abstract":"Among the advanced countries, especially in Japan, we are facing on the decreasing birthrate and aging population ahead of the world. In recent, population of single-living elder, and elderly people have been taking care by same-aged person, have been actualized. Unfortunately, the population of caregivers is decreasing according to year. In this situation, the Elderly Person Watching System has been focused on. Especially, Robotics, Internet of Things, and Artificial Intelligence technology have been having high affinity with this system. In this study, firstly, the person watching robot system will be developed. In detail, in this paper, the flexible-analyze system will be focused on. In the algorithm, a resident-tracking task and an energy-saving task are holding. The whole tasks are working based on Reinforcement Learning. Thus, the behavior algorithm of the person watching robot system will be developed. In detail, in this paper, the flexible-analyze system will be focused on. In the algorithm, a resident-tracking task and an energy-saving task are holding. From the verification experiment, the simulation results showed the proposed method has been acquired actions to switch the desired task.","PeriodicalId":264161,"journal":{"name":"2019 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115228976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assembly of Magnetic Fibers to form Perfusable Vascular Network with a three-dimensional tissue","authors":"Eunhye Kim, Masaru Takeuchi, Ryohei Sakurai, T. Kozuka, Takuto Nomura, Akiyuki Hasegawa, A. Ichikawa, T. Fukuda","doi":"10.1109/MHS48134.2019.9249250","DOIUrl":"https://doi.org/10.1109/MHS48134.2019.9249250","url":null,"abstract":"In this paper, we constructed 3D hepatic lobule-like structure in 3D cellular structure. Without perfusable channel networks, 3D cellular structure more than 200 µm cannot keep the cells in core of the structure in living condition. To construct mm-sized cellular structure, well-organized vascular network is required. For this, we proposed a method to construct hepatic lobule like vascular network. Two types of steel rods and alginate gel fiber embedding magnetic particles were utilized to make a shape of the hepatic tissue. It has a hexagonal structure and consists of several veins. To realize portal veins and a central vein, 0.4 mm and 0.2 mm of steel rods were used, respectively. In addition, sinusoids were replaced by 0.15 mm magnetic fibers. By using these materials, we construct 3D hepatic tissue with similar size of the real things. In addition, we perfused nutrients to the cells through channels. Finally, we constructed 3D perfusable vascular network that mimics hepatic lobule tissues.","PeriodicalId":264161,"journal":{"name":"2019 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","volume":"13 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123537225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Super Twisting Control of Passive Gait Training Exoskeleton Driven by Pneumatic Muscles","authors":"Mengshi Zhang, Jian Huang, Yu Cao, Hai-Tao Zhang","doi":"10.1109/MHS48134.2019.9249319","DOIUrl":"https://doi.org/10.1109/MHS48134.2019.9249319","url":null,"abstract":"Pneumatic Muscles (PMs) - driven exoskeleton has a promising prospect in the field of rehabilitation and assistance, because of the PMs intrinsic features of compliance and high force-to-weight ratio. However, the precise control of PMs-driven exoskeleton still remains a challenging problem due to the hysteresis, time-varying parameters of PMs and complexity of the mechanism. To solve this problem, this paper presents a super twisting controller (STC), essentially a second-order sliding mode control, to realize the human gait tracking control of lower limb exoskeleton. As a result, the disturbances and uncertainties of the system can be handled, and the chattering caused by the traditional sliding mode control (SMC) could be eliminated. The stability of the closed-loop system is ensured according to the Lyapunov theorem. In addition, we conduct experiments in real exoskeleton system and the results illustrate the validity of the super twisting algorithm. Pneumatic Muscles (PMs) - driven exoskeleton has a promising prospect in the field of rehabilitation and assistance, because of the PMs' intrinsic features of compliance and high force-to-weight ratio. However, the precise control of PMs-driven exoskeleton still remains a challenging problem due to the hysteresis, time-varying parameters of PMs and complexity of the mechanism. To solve this problem, this paper presents a super twisting controller (STC), essentially a second-order sliding mode control, to realize the human gait tracking control of lower limb exoskeleton. As a result, the disturbances and uncertainties of the system can be handled, and the chattering caused by the traditional sliding mode control (SMC) could be eliminated. The stability of the closed-loop system is ensured according to the Lyapunov theorem. In addition, we conduct experiments in real exoskeleton system and the results illustrate the validity of the super twisting algorithm..","PeriodicalId":264161,"journal":{"name":"2019 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124965238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of cooling and warming rates to cell viability in cryoprotectant-free cryopreservation","authors":"Hiroki Watanabe, Hideyo Takizawa, Y. Akiyama","doi":"10.1109/MHS48134.2019.9249324","DOIUrl":"https://doi.org/10.1109/MHS48134.2019.9249324","url":null,"abstract":"Cryopreservation is widely used to maintain backups of cells as it enables the semipermanent storage of cells. In general, cell structures are damaged or destroyed by ice crystals during freezing method. Therefore, all conventional cryopreservation methods use at least one cryoprotectant agent (CPA) to suppress generation and growth of ice crystals, moreover, vitrify water inside and outside the cells. On the other hand, CPAs should be ideally avoided due to their cytotoxicity and potential side effects. We previously reported a novel cryopreservation method without a CPA by ultrarapid cooling. In this method, cells were ejected as tiny droplets by inkjet cell printing. The droplets were deposited on the liquid nitrogen (LN) cooled substrate and were vitrified, that enables cell cryopreservation. Remarkably, the cryopreserved cell viabilities were dependent on substrate and droplet size. We had 85.8 % cell viability when the cells were contained in 40 pL droplets and deposited on glass substrate 5 μm in thickness cooled by LN. Moreover, the cell viabilities were lower as the droplets size became larger or substrates became thicker. We found that the cell viabilities were influenced by both of cooling and warming rates in CPA-free cryopreservation.","PeriodicalId":264161,"journal":{"name":"2019 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123820509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenocyte Response to Interleukin-1 Beta Depends on Substrate Stiffness: Implication to the Etiology of Tendon Inflammation","authors":"Eijiro Maeda, Kaname Kuroyanagi, Yoriko Ando, Takeo Matsumoto","doi":"10.1109/MHS48134.2019.9249298","DOIUrl":"https://doi.org/10.1109/MHS48134.2019.9249298","url":null,"abstract":"Early responses to tendon overloading involve functional changes of tenocytes from anabolic (producing matrix protein) to catabolic (breaking down matrix proteins) state. These changes are thought to be induced by a combination of changes in extracellular mechanical environment as well as extrinsic inflammatory stimulation such as interleukin-1 β (IL-1 β), which stimulates tenocyte catabolism. However, detailed mechanisms are still largely unknown. We have focused on cellular tension as a possible regulator of tenocyte catabolism and inflammatory responses. The present study was performed to investigate if tenocyte response to IL-1 β stimulation can be regulated by cellular tension. Tenocytes isolated from rabbit Achilles tendons were seeded onto one of the following substrates: glass or PDMS-made micropillar substrate (3 µm diameter, 6 µm spacing in a hexagonal lattice with a pillar height of 2, 4 or 8 µm). Substrate stiffness was the highest in glass and the lowest in 8 µm-height micropillars. Following a 24-h incubation, IL-1β was administrated at 0 pM (control), 1 pM, 10 pM or 100 pM. IL-1β culture was performed for 3 days. Cell shapes and mRNA expression of matrix metalloproteinase-1 (MMP-1) in each condition was assessed. It was demonstrated that cell shape was remarkably influenced by both substrate stiffness and the concentration of IL-1 β. Cell area was significantly decreased with lowering substrate stiffness and increasing IL-1β concentration. The expression of MMP-1 mRNA was also influenced by both the substrate stiffness and ILl β concentration. These findings suggest that cellular tension, which is thought to reflect the substrate stiffness, is a key mechanical factor in the regulation of tenocyte functions, in particular their responses to inflammatory stimulation.","PeriodicalId":264161,"journal":{"name":"2019 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116554874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future medical applications of single cell analysis","authors":"Y. Mineharu","doi":"10.1109/mhs48134.2019.9249251","DOIUrl":"https://doi.org/10.1109/mhs48134.2019.9249251","url":null,"abstract":"Single cell analysis has made rapid progression in parallel with the development of micro/nano technologies in recent years. For further development, analysis of cell-cell contacts and interaction of cells with cell-free DNA/RNA inside and outside extracellular vesicles (EV) would be essential. In fact, several reports showed that cancer cells gain malignant phenotype via cell-free RNA from EV. Integration of organoid may improve the accuracy of the analysis. Time control would also be important because circadian rhythm has impact on most of human diseases especially for sleep disturbance, dementia and cancer. Such a sequential, time-controlled complex network analysis should be performed by automatic system and artificial intelligence (AI), where microfluidics has potential to realize it. The advanced single cell analysis in combination with omics data will change diagnosis and treatment of growing and challenging diseases such as cancer, cerebral and cardiovascular disease, neuropsychiatric diseases such as Alzheimer disease and depression. For clinical application, simple preparation, reproducibility and low cost is required but irreplaceability would be primarily important in this field.","PeriodicalId":264161,"journal":{"name":"2019 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","volume":"24 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133470152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}