2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE)最新文献_第6页

The Relevance of Upstream and Downstream Regions of mRNA in the Prediction of Translation Initiation Site of the Protein mRNA上下游区域在预测蛋白质翻译起始位点中的相关性

2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2017-10-01 DOI: 10.1109/BIBE.2017.00-69

Wallison W. Guimarães, C. L. N. Pinto, C. Nobre, Luis E. Zárate

{"title":"The Relevance of Upstream and Downstream Regions of mRNA in the Prediction of Translation Initiation Site of the Protein","authors":"Wallison W. Guimarães, C. L. N. Pinto, C. Nobre, Luis E. Zárate","doi":"10.1109/BIBE.2017.00-69","DOIUrl":"https://doi.org/10.1109/BIBE.2017.00-69","url":null,"abstract":"The correct prediction of Protein Translation Initiation Site is a problem of considerable interest in the molecular biology. In the literature, some papers investigate conservative positions of the mRNA that favor an ideal context for begin of translation, as it is the case of the work of Kozak. The Kozak Consensus is known to reveal some important mRNA textit{upstream} region positions to recognize an early translation. This work investigated the real contribution of these conservative positions, besides analyzing sequences in the textit{downstream} region to be considered as non-initiators of translation. In this paper, we use the Support Vector Machine classifier and three different scenarios. The results indicate that the proposed methodology was efficient, guaranteeing a gain in the performance of the larger organisms. For the smaller organisms, the three scenarios investigated maintain the same behavior. However, due to the lack of consideration of the textit{upstream} region of the mRNA, the proposed methodology allows evaluating organisms not considered in other works, as is the case of the textit{Caenorhabditis elegans} organism.","PeriodicalId":262603,"journal":{"name":"2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121265424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Towards a Modular, Customizable Robotic System for Needle-Based Image-Guided Interventions: Preliminary Designs, Implementation, and Testing 面向基于针的图像引导干预的模块化，可定制的机器人系统:初步设计，实施和测试

2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2017-10-01 DOI: 10.1109/BIBE.2017.00-14

N. Navkar, Leonardo Barbosa, S. Balakrishnan, J. Abinahed, W. E. Ansari, Khalid Al-Rumaihi, A. Darweesh, A. Al-Ansari, N. Tsekos, M. Karkoub, Mohamed Gharib

{"title":"Towards a Modular, Customizable Robotic System for Needle-Based Image-Guided Interventions: Preliminary Designs, Implementation, and Testing","authors":"N. Navkar, Leonardo Barbosa, S. Balakrishnan, J. Abinahed, W. E. Ansari, Khalid Al-Rumaihi, A. Darweesh, A. Al-Ansari, N. Tsekos, M. Karkoub, Mohamed Gharib","doi":"10.1109/BIBE.2017.00-14","DOIUrl":"https://doi.org/10.1109/BIBE.2017.00-14","url":null,"abstract":"Needle–based image–guided interventions (NB-IGI) are well established practices that are rapidly expanding to a wider range of therapeutic and diagnostic interventions due to their impact on clinical outcomes. In parallel, a number of robotic manipulators are emerging to increase accuracy, decrease inter-operator variabilities, and reduce the duration of the procedure. Most current systems are application–specific, thereby are appropriate for a limited number of procedures and further exacerbating the already rising costs of healthcare. In order to expand clinical usage of robotic NB-IGI, and eventually reduce the burden on healthcare costs, this paper proposes a modular, customizable robotic systems concept. The concept includes simplified hardware and control techniques, and initial results demonstrate that accuracy is within clinically acceptable limits. Preliminary designs, implementations, and assessments of the proposed system demonstrate its potential and clinical value.","PeriodicalId":262603,"journal":{"name":"2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120958198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Assessment of Brachial-Ankle Pulse Wave Velocity and Stiffness Index: Hypertriglyceridemia Effects on Arterial Stiffness 臂踝脉搏波速度和僵硬指数的临床评估:高甘油三酯血症对动脉僵硬的影响

2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2017-10-01 DOI: 10.1109/BIBE.2017.00008

An Zhao, Yinbao Chong, Hangmei Zhong, Jieshi Ma, Huan Zhang, Z. Luo, Gaosen Li, Xiaomin Luo

{"title":"Clinical Assessment of Brachial-Ankle Pulse Wave Velocity and Stiffness Index: Hypertriglyceridemia Effects on Arterial Stiffness","authors":"An Zhao, Yinbao Chong, Hangmei Zhong, Jieshi Ma, Huan Zhang, Z. Luo, Gaosen Li, Xiaomin Luo","doi":"10.1109/BIBE.2017.00008","DOIUrl":"https://doi.org/10.1109/BIBE.2017.00008","url":null,"abstract":"Objectives: Being the noninvasive measures of arterial stiffness, both brachial-ankle Pulse Wave Velocity (baPWV) and Stiffness Index (SI) had been used for more than ten years and broadly applied in clinical settings. However, the relationship of the two arterial stiffness measures detected at different sites but defined alike has not been fully investigated into the causes and circumstances. The aim of the present study is to assessment the relationship between baPWV and SI applied to evaluate hypertriglyceridemia (hyperTG) effects on arterial stiffness in clinical settings. Methods: A total of 61 (39 males and 22 females) subjects were subjected to biochemistry parameters measurements. Two kinds of parameters – baPWV and SI were used to evaluate the arterial stiffness. Here, in order to minimize the uncertainty in a comparative study of SI and baPWV, photoplethysmography (PPG) wave train was employed to accurately acquire the most representative pulses for calculation of SI value. Results: BaPWV was significantly correlated with SI (r = 0.60, p < 0.01). The arterial stiffness of hyperTG group has a significance difference compared to normal control group. Conclusion: Our findings suggest both SI and baPWV could be a reliable estimator of arterial stiffness. There exists a significance difference of arterial stiffness among hyperTG group and normal control group. And the use of statistical method could be beneficial in improving effectively the measurement of arterial stiffness.","PeriodicalId":262603,"journal":{"name":"2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"320 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123163733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracting the Co-occurrences of DNA Maximal Repeats in both Human and Viruses 提取人与病毒DNA最大重复序列的共现

2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2017-10-01 DOI: 10.1109/BIBE.2017.00-70

Jing-doo Wang, Yi-Chun Wang, Rouh-Mei Hu, J. Tsai

{"title":"Extracting the Co-occurrences of DNA Maximal Repeats in both Human and Viruses","authors":"Jing-doo Wang, Yi-Chun Wang, Rouh-Mei Hu, J. Tsai","doi":"10.1109/BIBE.2017.00-70","DOIUrl":"https://doi.org/10.1109/BIBE.2017.00-70","url":null,"abstract":"This paper aims to extract significant DNA sequences appearing in both the genomes of human and viruses. To extract the co-occurrences of DNA sequences as long as possible, this study adopts a scalable approach that is based on hadoop mapreduce programming model and can extract maximal repeats; meanwhile compute the class frequency distribution of these repeats. The genomes of human and all of 4,388 viruses available in NCBI are downloaded at 2017/1/14. To take the taxonomy of viruses into consideration for further observation, only the 2,712 viruses that had been named with genus are selected from those 4,388 viruses. In this study, the taxonomic level “genus” is as the units (classes) when comparing viruses and human for experiments. Experimental results show that the longest DNA sequence appearing in both human and viruses extracted in this study is 463 base pair (bp), and that sequence, consisting of tandem repeats as “(CTAACC)n”, appears in the 5th human chromosome and virus “Human herpesvirus 6B”. It may be attractive for virologists to have further research why there exists such a long DNA fragment existed in both human and that virus. Indeed, this study may provide a new direction for genomic sequences comparison across classesthat can provide clues to inspect the existence of the relationship between these DNA maximal repeats (genotypes) with biased class frequency distribution and the features of classes (phenotypes).","PeriodicalId":262603,"journal":{"name":"2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114237255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Image Enhancement of Routine Biopsies: A Case for Liver Tissue Detection 常规活检图像增强:肝组织检测一例

2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2017-10-01 DOI: 10.1109/BIBE.2017.00-49

N. Giannakeas, Maria Tsiplakidou, M. Tsipouras, P. Manousou, R. Forlano, A. Tzallas

引用次数: 1

Effect of Regional Cellular Uncoupling in presence of LQTS2 in a 2D Cardiac Tissue LQTS2对二维心脏组织局部细胞解偶联的影响

2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2017-10-01 DOI: 10.1109/BIBE.2017.00-24

P. Priya, M. Reddy

引用次数: 0

Predicting Heart Failure Patient Events by Exploiting Saliva and Breath Biomarkers Information 利用唾液和呼吸生物标志物信息预测心力衰竭患者事件

2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2017-10-01 DOI: 10.1109/BIBE.2017.00-40

E. Tripoliti, G. Karanasiou, F. Kalatzis, Y. Goletsis, A. Bechlioulis, S. Ghimenti, T. Lomonaco, F. Bellagambi, R. Fuoco, M. Marzilli, M. Scali, K. Naka, A. Errachid, D. Fotiadis

引用次数: 3

Investigating the Effects of Rare Variants in Concurrent Drug Usage: An Association Analysis Approach 研究罕见变异对并发用药的影响:一种关联分析方法

2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2017-10-01 DOI: 10.1109/BIBE.2017.00-83

Rebekah K. Loving, Michael Peterson

{"title":"Investigating the Effects of Rare Variants in Concurrent Drug Usage: An Association Analysis Approach","authors":"Rebekah K. Loving, Michael Peterson","doi":"10.1109/BIBE.2017.00-83","DOIUrl":"https://doi.org/10.1109/BIBE.2017.00-83","url":null,"abstract":"The influence of rare variants in the concurrent drug usage on the outcome of interest has not been analyzed in-depth. The standard method of analysis has only encompassed testing of the significance of common variants in concurrent drug usage, comorbidities, and genetic markers. This study proposes the application of state of the art association analysis tools: Combined Multivariate Collapsing (CMC), Kernel-Based Adaptive Clustering (K-BAC), and Weighted Sum Statistics (WSS) algorithms, for testing association of patient drug usage description data to drug treatment outcome. We demonstrate the usefulness of this novel approach in detecting significant rare descriptive data sequences with an analysis of a pharmacology dataset, featuring patients treated with Warfarin. This manuscript presents an examination of the association of comorbidities and concurrent drug usage with reaching stable dosage levels of Warfarin. Statistically significant results will reveal important, undocumented associations between concurrent drug usage and a patientâ€™s ability to reach stable dosage levels of Warfarin. We consider rare variants in self-governed medical decisions, which lead to significant difference in dosage stability outcomes. Significant results are found both in rare variants of concurrent drug usage which provide higher probability of either reaching or not reaching stable dosage levels of Warfarin.","PeriodicalId":262603,"journal":{"name":"2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125742102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Implementation of Medical Image Reconstruction Algorithm for Photoacoustic Imaging Using k-wave Toolkit 利用k波工具箱实现光声成像医学图像重建算法

2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2017-10-01 DOI: 10.1109/BIBE.2017.000-3

Enkhbat Batbayar, Ju Yeon Lee, W. Ham, E. Tumenjargal, Chulgyu Song, Seungkuk Roh

{"title":"Implementation of Medical Image Reconstruction Algorithm for Photoacoustic Imaging Using k-wave Toolkit","authors":"Enkhbat Batbayar, Ju Yeon Lee, W. Ham, E. Tumenjargal, Chulgyu Song, Seungkuk Roh","doi":"10.1109/BIBE.2017.000-3","DOIUrl":"https://doi.org/10.1109/BIBE.2017.000-3","url":null,"abstract":"This paper describes the implementation of a proposed image reconstruction algorithm for stereo photo-acoustic medical imaging system. The main goal of this algorithm is to evaluate the existence possibility of acoustic source within a search area by using the geometric information which is the distance between each sensor element of ultrasound probe and corresponding searching point. We briefly describe the proposed algorithm in this paper which was comprehensively and clearly explained in our previous paper cite{ref40}. We also discussed an algorithm that is calculated the arc length of searching area corresponding to an element of acoustic detector. In this paper, some experimental results are presented which utilized the proposed algorithm with and without calculating arc length. We also compared the image quality of the proposed algorithm with and without calculating arc length and conventional k-wave algorithm in which FFT should be used. Apart from implementing the proposed algorithm with k-wave toolbox, we also implemented the hardware and software aspects of an ultrasound system that is explained in hardware implementation section of this paper. The simulation results proved the effectiveness of the proposed reconstruction algorithm with arc length calculation.","PeriodicalId":262603,"journal":{"name":"2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127449743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Identification of ADHD Cognitive Pattern Disturbances Using EEG and Wavelets Analysis 利用脑电图和小波分析识别ADHD认知模式障碍

2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2017-10-01 DOI: 10.1109/BIBE.2017.00-62

R. Gabriel, M. Spindola, A. Mesquita, Angelo Zerbetto Neto

{"title":"Identification of ADHD Cognitive Pattern Disturbances Using EEG and Wavelets Analysis","authors":"R. Gabriel, M. Spindola, A. Mesquita, Angelo Zerbetto Neto","doi":"10.1109/BIBE.2017.00-62","DOIUrl":"https://doi.org/10.1109/BIBE.2017.00-62","url":null,"abstract":"Recurrent investigations about human cognitive patterns evidenced by electrical brain signals have been performed with the use of non-invasive electroencephalographic instrumentation (EEG). In this context, this work proposes a methodology which is characterized by using EEG technique in the investigation of brain signal patterns in learners with Attention Deficit Hiperactivity Disorder - ADHD, evoked during the course of a typical activity called \"Oddball Paradigm\". Therefore, was applied the methodology that consisted in the selection of a group of children previously diagnosed with ADHD and a control group. During the work environments are also presented that have been implemented for the acquisition, preprocessing and visualization of brain electrical biossignals as well as environments for visual stimulation of Oddball Paradigm. With software support it was made using of mathematical modeling of Wavelet Transform to the decomposition of EEG signals. It was also applied the data classification method, using the Support Vector Machine (SVM) technique to establish patterns indicative of ADHD and normality based on the energy and power information extracted from the application of Morlet Wavelet Transform to the EEG records. It was obtained as a result of the applied methodology, the construction a model capable of classifying ADHD individuals and control group with 94.74% of accuracy.","PeriodicalId":262603,"journal":{"name":"2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132797179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4