{"title":"Simultaneous measurement of ciliary beat frequency and wave disorder on respiratory epithelial cells","authors":"W. Yi, K.S. Park, C.H. Lee, C. Rhee","doi":"10.1109/IEMBS.2003.1279424","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1279424","url":null,"abstract":"Ciliary beat and its metachronism are fundamental to effective mucociliary transport. The beat frequencies (CBF) and metachronal wave directions of multiple cilia beating in culture media were measured simultaneously using digital microscopic images. The wave propagation directions of cilia were determined from a 2-dimensional correlation map by a principal axis method. The standard deviation of measured wave directions in a region of interest (ROI) was defined as a measure of metachronal wave disorder (MWD). Considerable variation was found in the beat frequencies and metachronal wave directions of cilia beating on epithelium. The pooled mean of MWDs was 23.4+/-8.79 /spl deg/ and the pooled mean of CBFs 10.1+/-1.89Hz on 120 cells in mucosae of the sphenoid sinus from 5 healthy subjects.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"517 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123101067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Doublet stimulation to reduce fatigue in electrically stimulated muscle during controlled leg lifts","authors":"G.R. Routh, W. Durfee","doi":"10.1109/IEMBS.2003.1279643","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1279643","url":null,"abstract":"Stimulation trains using doublets, two closely spaced stimulation pulses, are thought to reduce the rapid fatigue seen in electrically stimulated muscle. The purpose of this study was to determine if doublet trains could elicit more leg lifts than conventional singlet trains when using surface stimulation of human quadriceps muscle. Eighteen subjects had singlet and doublet stimulation trains applied to their quadriceps to produce closed-loop, leg lift trajectory cycles. Trials ran until the muscle fatigued. Data was collected from 23 legs. The mean/spl plusmn/standard deviation of the number of cycles resulting from singlets was 160/spl plusmn/105 while the number for doublets was 127/spl plusmn/114. A paired t-test showed this difference to be significant. It is thought that the conflicting reports of doublet performance seen in the literature is due to the different protocols used by each study.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122304794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nonlinear characteristics of visual evoked potential and their correlation with the visual responses on magnocellular and parvocellular pathways","authors":"Keiko Momose, S. Kasahara","doi":"10.1109/IEMBS.2003.1280383","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1280383","url":null,"abstract":"Purpose was to investigate the nonlinear characteristics of visual evoked potentials (VEPs), and their correlation with the visual responses on parvocellular and magnocellular pathways. The VEPs elicited by checkerboard pattern alternating based on pseudorandom binary sequence were measured, and their nonlinear parameters (binary kernels) were calculated. VEPs to checkerboard with 0.5, 1.0, 2.0 and 4.0 [c/d] were measured. First and second-order binary kernels were compared with steadystate VEPs (S-VEPs) to pattern reversal stimulation with a constant temporal frequency (4, 8, 12, 16, and 32 Hz). Positive peak latency at 150 ms of second-order first slice was correlated with S-VEP amplitude for 32 Hz (r = - 0.71). Amplitudes of second slice were well correlated with S-VEPs to 4, 8, 12, and 16 Hz stimuli (r = 0.62, 0.77, 0.61, and 0.72). These results support the previously reported observations that the first and second slice response functions reflect the response of the parvocellular and magnocellular pathways, respectively.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124718777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Qian, A. Montillo, Dimitris N. Metaxas, L. Axel
{"title":"Segmenting cardiac MRI tagging lines using Gabor filter banks","authors":"Z. Qian, A. Montillo, Dimitris N. Metaxas, L. Axel","doi":"10.1109/IEMBS.2003.1279834","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1279834","url":null,"abstract":"This paper describes a new method for the automated segmentation and extraction of cardiac MRI tagging lines. Our method is based on the novel use of a 2D Gabor filter bank. By convolving the tagged input image with our Gabor filters, the tagging lines are automatically enhanced and segmented out. We design the Gabor filter bank based on the input image's spatial and frequency characteristics. The final result is a combination of each filter's response in the Gabor filter bank. We demonstrate that compared to bandpass filter methods such as HARP, this method results in robust and accurate segmentation of the tagging lines.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125627307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Wu, A. Bowman, C. Chung, M. Karamanoglu, S. Kovacs
{"title":"Frequency-based analysis of diastolic function","authors":"Y. Wu, A. Bowman, C. Chung, M. Karamanoglu, S. Kovacs","doi":"10.1109/IEMBS.2003.1279522","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1279522","url":null,"abstract":"Quantitative determination of the filling (diastolic) function of the heart has been primarily correlative rather than causal and has been thwarted by the inability to define sensitive and specific non-invasive numerical indexes. In analogy to impedance, Z(/spl omega/)=V(/spl omega/)/I(/spl omega/) relating voltage V to current I in circuit theory, we introduce the concept of frequency-based analysis of diastolic function (DF) by analyzing the left ventricular (LV) filling pressure (P) to flow(Q) relation in terms of impedance as, Z(/spl omega/)=P(/spl omega/)/Q(/spl omega/). This allows abnormal DF to be viewed as a state of impedance mismatch between pressure and flow, relative to normal. Simultaneous pressure-flow data in 11 subjects was recorded during catheterization. Analysis of variance between groups (ANOVA) shows that the direct current (DC) component of impedance, Z/sub 0/ and the first harmonic coefficient, Z/sub 1/, differentiated between normal and abnormal DF groups (p<0.05). We conclude frequency-based analysis of DF differentiates between normal and abnormal DF states, elucidates the physiology of normal filling as a low-pass filter and has potential as a method for noninvasive DF quantitation.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"455 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131017504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ferromagnetic ultrasound microbubbles contrast agent","authors":"K. Soetanto, H. Watarai","doi":"10.1109/IEMBS.2003.1279473","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1279473","url":null,"abstract":"Microbubbles have attracted attention as ultrasonic contrast agents because their ultrasonic scattering property is excellent in comparison with other ultrasonic contrast agents. In the development of ultrasound contrast agent, the main difficulties accounted are the making of small microbubbles less than 10 /spl mu/m and the elongation of the lifetime of microbubbles. A new ultrasonic contrast agent, which is microbubbles typed coating by surfactant, has been developed. The contrast images produced by different-sized microbubbles contrast agents are studied quantitatively. Furthermore, a ferromagnetic ultrasound contrast agent was also studied for its potential as a Drug Delivery System (DDS). In this paper, a new ultrasonic contrast agent for the Drug Delivery System will be discussed. Ferromagnetic materials are placed on the surfaces of the surfactant microbubbles developed in our laboratory for the above purpose. Multivalent ions such as calcium ions are used to put the ferromagnetic materials on the surfaces of the microbubbles. It is confirmed that the developed magnetic microbubbles could be lead by a permanent magnet. The performance of the magnetic microbubbles is evaluated by measuring the time dependence of the attenuation constant as one of their acoustic properties.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130743540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transdermal drug delivery: a comparative analysis of skin impedance models and parameters","authors":"A. Coston, J.K.-J. Li","doi":"10.1109/IEMBS.2003.1280545","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1280545","url":null,"abstract":"Variability in skin impedance can significantly influence the effectiveness of transdermal drug delivery. In order to optimize drug delivery, skin impedance frequency response must be considered. Several electrical models for skin impedance and a comparative analysis of different model parameters are presented in an attempt to identify critical parameters for an efficient drug delivery through iontophoresis. It was concluded that skin resistance and capacitance, as well as the mode of stimulation are important considerations in optimal transdermal drug delivery.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"107 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131899785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interlimb differences in trajectory and positional control mechanisms","authors":"R. Sainburg, S. Schaefer, L. B. Bagesteiro","doi":"10.1109/IEMBS.2003.1279601","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1279601","url":null,"abstract":"Previous findings suggest that movement trajectory and final position are specified and controlled differentially by the dominant and nondominant limb/hemisphere systems. In the current studies, we examine interlimb differences in trajectory planning and feedback mediated positional control mechanisms. The first study examines load compensation responses, whereas, the second study examines control of movements made to a range of distances. In the first study, the nondominant arm showed substantially better response to load compensation, whereas, the dominant arm over-compensated the effects of the load, producing a large and systematic overshoot of final position. In the second study, dominant arm movement amplitude was well predicted by peak acceleration, reflecting pre-planning of movement distance. However, nondominant arm peak accelerations did not predict movement distance well. Instead, the duration of acceleration varied systematically with peak velocity and movement amplitude. These findings suggest that the nondominant and dominant controllers specify and control movement distance through distinct mechanisms, the former utilizing a pulse-height strategy, and the latter using a pulse-width strategy. Taken together, these findings support the hypothesis that the dominant arm system is specialized for feedforward control of trajectory, and the nondominant system, for feedback mediated control of final limb posture.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"158 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124426439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A simulation study of motor unit electrical and mechanical relations for the first dorsal interosseous muscle in man","authors":"P. Zhou, W. Rymer","doi":"10.1109/IEMBS.2003.1279632","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1279632","url":null,"abstract":"Two different relations between motor unit electrical and mechanical properties were used to simulate isometric force and surface EMG signals of the first dorsal interosseous (FDI) muscle in man: 1) motor unit action potential (MUAP) amplitude was linearly proportional to the square root of twitch force; 2) MUAP amplitude was linearly proportional to twitch force. The EMG amplitude-force relations that emerged from simulations indicated that the experimentally observed linear EMG amplitude-force relation was most likely due to the linear electrical and mechanical relation at motor unit level. When MUAP amplitude was proportional to the square root of twitch force, the amplitude of the simulated surface EMG increased slower than force, which was unlike that observed experimentally. The simulation results also suggested that estimating the number of MUAP's in the surface EMG may be a more physiologically meaningful surface EMG processing approach than the prevailing surface EMG amplitude measurements.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114489132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A system for automatic adjustment of the inspired oxygen in mechanically ventilated premature infants","authors":"N. Claure, O. Ozdamar, E. Bancalari","doi":"10.1109/IEMBS.2003.1279713","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1279713","url":null,"abstract":"Episodes of hypoxemia are often observed in ventilated preterm infants. Assistance with a transient increase in the fraction of inspired oxygen (FiO/sub 2/) is difficult and time consuming for the intensive care personnel. In order to reduce the morbidities associated with hypoxemia and oxygen toxicity, a system for closed loop control of FiO/sub 2/ (cFiO/sub 2/) was developed to respond to frequent and severe hypoxemic episodes and minimize oxygen exposure. The cFiO/sub 2/ system is based on a hybrid algorithm of rule based and differential feedback control. It automatically adjusts FiO/sub 2/ depending on the occurrence of the severity, duration, rate of change of the ensuing/resolving hypoxemia, and on the basal FiO/sub 2/ required to maintain oxygenation. In a clinical study, cFiO/sub 2/ was compared to a dedicated trained nurse managing the FiO/sub 2/ in a group of ventilated preterm infants and it was effective in limiting the duration and seventy of hypoxemia. Close loop FiO/sub 2/ control could improve the respiratory, ophthalmic and neurological outcome and facilitate the care of premature neonates.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"34 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116378610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}