{"title":"Practical method for photon fluency evaluation of digital X-ray image system","authors":"J. Albuquerque, E. Costa, F. Bóscolo","doi":"10.1109/IEMBS.2003.1280786","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1280786","url":null,"abstract":"Quantum detective efficiency (DQE) is referred in literature as the most robust object-independent parameter for characterization of radiation detectors efficiency. DQE evaluation is particularly important in digital X-ray detectors, where the efficiency loss implies in image quality degradation and increase of patient exposed radiation dose. However, DQE cannot be evaluated directly. Its evaluation is derived of four other measurements: the modulation transfer function (MTF), the noise power spectrum (NFS), the gamma factor (/spl gamma/) and the photon fluency (/spl Phi/). The photon fluency has a not easy experimental evaluation, being calculated by the integral of the X-ray radiation emission spectrum, using spectrophotometers or X-ray tube mathematical modeling. These approaches may lead to errors. In this study, photon fluency was extrapolated from the measurements of absorbed dose and of half value layer, using monochromatic radiation. Assuming this restriction, the photon fluency can be evaluated using only a conventional dosimeter. Therefore, this technique is compatible with the investments allocated for regular services of preventive maintenance and image quality control. As an evaluation of the viability in using this methodology in clinical environment, a DQE evaluation routine was implemented for the Digora (Soredex, Helsink, Finland) dental digital X-ray system with very good results that agreed with those obtained with conventional techniques.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129349295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Automatic segmentation of scanning electron microscopy images for molecular aggregation profiling","authors":"F. Ourique, V. Licks, R. Jordan, M. Pattichis","doi":"10.1109/IEMBS.2003.1279860","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1279860","url":null,"abstract":"Scanning electron microscopy (SEM) imaging has made it possible to obtain accurate inferences about functional intra-cellular events by the indirect observation of cell surface receptors' aggregation. Such observations are made with the use of colloidal gold particles that bind to the surface of specific ligands that cross-link to the desired receptors. Since the reliability of statistical inference methods about intra-cellular activities based on the observation of the receptors depend on the quality of the data set in hand, we propose in this paper a method to automatically segment gold labels in SEM images. This method includes an automatic thresholding operation aiming at simultaneously minimizing probabilities of false alarm and missed detection errors. Morphological filtering is used to deal with the partial superposition cases of structures of interest and additional median filtering is used for noise reduction purposes. We validate the method against a set of manually processed images of rat basophilic leukemia cells and we present results for the automatic estimation of aggregation density.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124586698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design of a turbulence-enhanced deaggregation system for dry powder formulations","authors":"N. Teh, F. Sarvar, P. Conway","doi":"10.1109/IEMBS.2003.1281008","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1281008","url":null,"abstract":"This paper reports on the engineering design, manufacture and experimental analysis of a combined impaction and deaggregation delivery system for patient inspiration-driven pulmonary dry powder formulations. A modular technology platform has been designed and analysed with computational fluid dynamics analysis to investigate and optimise configurations of the device. The device was then manufactured in a modular form using rapid prototyping techniques to allow a range of impaction and deaggregation options to be investigated by experimental verification. Experimental investigation included twin stage impinger trials to assess fine particle fraction and fine particle dose capabilities and instrumentation of the device to determine fluid flow and flow resistance at a specified pressure drop of 4 kPa, allowing further optimisation of the device to patient inspiration capabilities.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"389 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124761392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biomimetic hand prosthesis with easily programmable microprocessor and high torque motor","authors":"R. Okuno, M. Fujikawa, M. Yoshida, K. Akazawa","doi":"10.1109/IEMBS.2003.1279709","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1279709","url":null,"abstract":"The purpose of this study was to develop the biomimetic hand prosthesis with an easily programmable microprocessor and a high torque DC. Firstly, we developed the digital servo system with the microprocessor and peripheral circuits. Secondly, the control program that calculated the finger angle from external force and the estimated contraction torque of flexor and extensor muscles and control the rotation angle of DC motor was developed with C language. Finally, we conducted the myoelectric control experiments with a normal subject. It was shown that he could control the finger angle and compliance of the finger movements and grasp a soft object easily.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126671066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Mitsis, S. Courellis, A. S. French, V. Marmarelis
{"title":"Principal dynamic mode analysis of a spider mechanoreceptor action potentials","authors":"G. Mitsis, S. Courellis, A. S. French, V. Marmarelis","doi":"10.1109/IEMBS.2003.1280139","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1280139","url":null,"abstract":"The nonlinear dynamics of a spider mechanoreceptor are examined using the principal dynamic mode (PDM) methodology. The cuticilar sense organ of an adult Cupiennius Salei spider was stimulated with a pseudorandom Gaussian process spectrally bound at 400 Hz and the resulting action potentials were recorded. Data analysis reveals three PDMs that describe the system dynamics, based on the second order Volterra kernel, which is estimated from the recorded input/output datasets. The first PDM exhibits high-pass behavior, illustrating the importance of the speed of the slit displacement to the mechanoreceptor, while the other two PDMs exhibit bandpass behavior. The probability of firing an action potential is represented by a static multiple-input nonlinearity that receives the values of the convolution of each mode with the pseudorandom input as its inputs. The probability of firing function exhibits asymmetric behavior with respect to its arguments, suggesting directional dependence of the mechanoreceptor response on the PDM outputs. Trigger regions for a probability threshold value of 0.1 are also presented.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126812215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A linear cochlear model with active bi-directional coupling","authors":"Bo Wen, K. Boahen","doi":"10.1109/IEMBS.2003.1280129","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1280129","url":null,"abstract":"We present a linear active cochlear model that includes the outer hair cell (OHC) forces, which are delivered onto upstream and downstream basilar membrane (BM) segments through Deiters' cells (DCs) and their phalangeal processes (PhPs). Due to the longitudinal tilt of the OHC towards the base and the oblique orientation of the PhP towards the apex, each BM segment receives both feed-forward and feed-backward OHC forces. Transverse BM fibers are actively coupled longitudinally through these bi-directional OHC forces, included in a cochlear model for the first time. We present simulation results that demonstrate large amplification and sharp tuning, and we analyze the underlying mechanism.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126882763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Derived electrocardiograms on the posterior leads from 12-lead system: method and evaluation","authors":"D. Wei","doi":"10.1109/IEMBS.2003.1279513","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1279513","url":null,"abstract":"Correct interpretation of electrocardiogram (ECG) is important for treatment of patients with acute myocardial infarction (AMI). A large number of posterior AMI manifests ST elevation in posterior leads V7-V9 that are beyond the standard 12-lead ECG. In this paper, we propose a method where ECGs on posterior leads V7- V9 are derived from the standard 12-lead ECG. The posterior ECGs are calculated by a linear combination of eight measured ECG signals based on information redundancy in the 12-lead ECG system. One part of a 15-lead ECG database is used to derive a transfer matrix based on the least squares method, which represents the inherent relation among body surface ECG potentials. The other part of the database is used to evaluation the derived posterior ECG by comparing the derived ECGs with measured ones. A quantitative evaluation is performed with an automatic ECG interpretation program. The results show the accuracy of derived posterior ECGs is sufficiently good to provide useful information in diagnosis of posterior AMI.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126892120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Nessler, D. Reinkensmeyer, W. Timoszyk, K. Nelson, C. Acosta, R. Roy, V. Edgerton, R.D. de Le
{"title":"The use of a robotic body weight support mechanism to improve outcome assessment in the spinal cord injured rodent","authors":"J. Nessler, D. Reinkensmeyer, W. Timoszyk, K. Nelson, C. Acosta, R. Roy, V. Edgerton, R.D. de Le","doi":"10.1109/IEMBS.2003.1279684","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1279684","url":null,"abstract":"This paper describes the use of a robotic device to assess rodent locomotor ability following spinal cord injury by quantifying the amount of external body weight support required by the animal to step on a treadmill. Precisely controlled, upward forces were delivered to the rat torso through the use of a specially designed counterbalance system. The system utilized an electric motor to alter spring tension in a specific kinematic configuration, which enabled support to be changed rapidly (within a step) in order to adapt to the animal's specific needs, or to challenge the animal's capability. Spinal cord transected rats were trained to step while the amount of external body weight support was progressively decreased during several minutes of locomotion on a treadmill, i.e. the rats increasingly supported more of their own body weight. Each animal failed to step at a consistent amount of weight assistance (test-retest reliability=0.92). During three months of daily training, the rats demonstrated an improvement in their ability to support body weight (p=0.04). The system's unique ability to precisely quantify body weight support allows for a continuous measurement of what was previously a binary assessment, i.e. the animal can support body weight or it cannot, and augments the information derived from current outcome measurement techniques.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129172074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Canizares, N. Gómez, R. Gonzalez, M. Rivero, J. Folgueras, G. Meissimilly
{"title":"A new method for electrocardiogram study","authors":"M. Canizares, N. Gómez, R. Gonzalez, M. Rivero, J. Folgueras, G. Meissimilly","doi":"10.1109/IEMBS.2003.1280459","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1280459","url":null,"abstract":"A new method for the identification of electrocardiogram (ECG) waves and the study of atrial activity is discussed. It was designed to improve the performance of an automatic ECG interpretation program. The P wave detector uses an 80 ms bidirectional energy collector; it is computed for TQ intervals only. The QRS complex detector is based on the Function of Spatial Velocity; it was modified to improve the QRS frontiers identification. The T-wave offset was defined as the minimum difference between the ECG signal and the isoelectric line, this process was made after T-wave peak was reached. Five-hundred ECGs were recorded with two digital electrocardiographs; patients were chosen randomly at a Cardiology Service. Two cardiologists studied each ECG using a software with graphic tools, they identified and measured each wave or signal interval; their criteria were used as a golden rule for event identification. The sensitivity values were 97.12 % for P wave detection; 99.38 % for T-wave offset identification and 100 % for QRS complex detection. The algorithms developed are simple and satisfactory to be implemented in low speed processor platforms because the use only integer arithmetic with low execution time requirements.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129233201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Kahya, E. Bayatli, M. Yeginer, K. Ciftci, G. Kilinc
{"title":"Comparison of different feature sets for respiratory sound classifiers","authors":"Y. Kahya, E. Bayatli, M. Yeginer, K. Ciftci, G. Kilinc","doi":"10.1109/IEMBS.2003.1280513","DOIUrl":"https://doi.org/10.1109/IEMBS.2003.1280513","url":null,"abstract":"In this study, a comparison is made between the performances of k-NN classifiers with different feature sets derived from respiratory sound data acquired from four different fixed locations on the posterior chest area. The two class recognition problem between healthy and pathological subjects is addressed. Each subject is represented by a single respiration cycle divided into sixty segments from which three different feature sets consisting of 6th order AR model coefficients, percentile frequency parameters and principle components, respectively, are extracted. Performances of k-NN classifiers for these feature sets for four different microphone locations are considered in segment-wise and subject-wise results.","PeriodicalId":258551,"journal":{"name":"Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123346285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}