Bioorganic Chemistry最新文献_第6页

Exploring a novel thiazole derivatives hybrid with fluorinated-indenoquinoxaline as dual inhibitors targeting VEGFR2/AKT and apoptosis inducers against hepatocellular carcinoma with docking simulation.

IF 4.5 2区医学

Bioorganic Chemistry Pub Date : 2024-12-02 DOI: 10.1016/j.bioorg.2024.108023

Moustafa S Abusaif, Ahmed Ragab, Eman A Fayed, Yousry A Ammar, Ayah M H Gowifel, Soha Osama Hassanin, Ghada E Ahmed, Nirvana A Gohar

{"title":"Exploring a novel thiazole derivatives hybrid with fluorinated-indenoquinoxaline as dual inhibitors targeting VEGFR2/AKT and apoptosis inducers against hepatocellular carcinoma with docking simulation.","authors":"Moustafa S Abusaif, Ahmed Ragab, Eman A Fayed, Yousry A Ammar, Ayah M H Gowifel, Soha Osama Hassanin, Ghada E Ahmed, Nirvana A Gohar","doi":"10.1016/j.bioorg.2024.108023","DOIUrl":"https://doi.org/10.1016/j.bioorg.2024.108023","url":null,"abstract":"Hepatocellular carcinoma (HCC) ranks as the third most prevalent reason for cancer-related death on a global scale. Tyrosine kinase inhibitors (TKIs) continue to be the primary treatment option for advanced hepatocellular carcinoma. A series of fluoro-11H-indeno[1,2-b]quinoxaline derivatives as an HCC drug targeting the VEGFR2/AKT axis was designed and synthesized. The novel compounds were investigated against HepG-2 and HuH-7 liver tumor cell lines. Compound 5 was the most active derivative against HepG-2 and HuH-7 cell lines with IC50 = 0.75 ± 0.04 and 3.43 ± 0.16 μM, respectively, in contrast to Sorafenib which shows IC50 values of 5.23 ± 0.31 and 4.58 ± 0.21 μM, respectively. IC50 values on normal liver cells (THLE-2) show that all tests are more selective than Sorafenib, prompting further research. The most promising cytotoxic compound has virtually equal VEGFR2 inhibition efficacy to Sorafenib. The total VEGFR2 and p-VEGFR2 inhibitory effects were subsequently evaluated, showing 38.32 % and 77.64 % attenuation, respectively. Compound 5 also reduced total and phosphorylated AKT concentrations in HepG-2 cells by 55.29 % and 78.01 %, respectively. Furthermore, Compound 5 upregulated BAX and caspase-3 and downregulated Bcl-2 to promote apoptosis. Hybrid 5 stops HepG-2's cell cycle at the S phase 48.02 % higher than untreated. Docking experiments assessed AKT and VEGFR2 binding patterns.","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"154 ","pages":"108023"},"PeriodicalIF":4.5,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlorine containing tetrahydropyrimidines: Synthesis, characterization, anticancer activity and mechanism of action. 含氯四氢嘧啶：合成、表征、抗癌活性和作用机理。

IF 4.5 2区医学

Bioorganic Chemistry Pub Date : 2024-12-01 Epub Date: 2024-10-23 DOI: 10.1016/j.bioorg.2024.107907

Emilija Milović, Ivana Z Matić, Nina Petrović, Ivana Pašić, Tatjana Stanojković, Miloš R Petrović, Goran A Bogdanović, Ferda Ari, Nenad Janković

{"title":"Chlorine containing tetrahydropyrimidines: Synthesis, characterization, anticancer activity and mechanism of action.","authors":"Emilija Milović, Ivana Z Matić, Nina Petrović, Ivana Pašić, Tatjana Stanojković, Miloš R Petrović, Goran A Bogdanović, Ferda Ari, Nenad Janković","doi":"10.1016/j.bioorg.2024.107907","DOIUrl":"10.1016/j.bioorg.2024.107907","url":null,"abstract":"The aim of the presented research was to explore anticancer potential of eleven newly synthesized tetrahydropyrimidine derivatives. The compounds were synthesized via Biginelli multicomponent one-pot reaction using different derivatives of vanillin, ethyl 4-chloroacetoacetate and (N-methyl)urea. The cytotoxic effects of the compounds were examined on three human malignant cell lines (HeLa, K562, and MCF7), and normal lung fibroblasts MRC-5. The mechanisms of anticancer activity were examined for two compounds 4a and 4b which showed the strongest and selective cytotoxicity against chronic myelogenous leukaemia K562 cells (IC50 = 1.76 ± 0.09, and 1.66 ± 0.05, respectively). The changes of matrix metalloproteinase 2 (MMP2), matrix metalloproteinase 9 (MMP9), and vascular endothelial growth factor A (VEGFA) were investigated in the K562 cell line, as well as oncomiRNA miR-10b, miR-23a described to have both features, depending on a specific type of malignancy, and miR-34a with mostly described as a tumour suppressor.","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"153 ","pages":"107907"},"PeriodicalIF":4.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular tweaking by generative cheminformatics and ligand-protein structures for rational drug discovery. 通过生成式化学信息学和配体-蛋白质结构进行分子调整，促进合理药物开发。

IF 4.5 2区医学

Bioorganic Chemistry Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1016/j.bioorg.2024.107920

Ashwini K Nangia

引用次数: 0

In vitro and in vivo studies of a decanuclear Ni(II) complex as a potential anti-breast cancer agent. 十核 Ni(II) 复合物作为潜在抗乳腺癌药物的体外和体内研究。

IF 4.5 2区医学

Bioorganic Chemistry Pub Date : 2024-12-01 Epub Date: 2024-11-10 DOI: 10.1016/j.bioorg.2024.107949

Haitao Zhu, Houcong Li, Yuxin Ji, Min Hou, Qingling Yang, Lili Liang, Wenge Li

{"title":"In vitro and in vivo studies of a decanuclear Ni(II) complex as a potential anti-breast cancer agent.","authors":"Haitao Zhu, Houcong Li, Yuxin Ji, Min Hou, Qingling Yang, Lili Liang, Wenge Li","doi":"10.1016/j.bioorg.2024.107949","DOIUrl":"10.1016/j.bioorg.2024.107949","url":null,"abstract":"A non-platinum-metal decanuclear complex [Ni10L4(CH3COO)8 (C2H5OH)8]·8(C2H5OH) (Ni10 complex) has been developed with a tri-dentate 2,3-dihydroxybenzaldehyde-2-aminophenol Schiff base ligand (H3L). Single crystal X-ray analysis reveals that the Ni10 complex displays a sandwich loaf-shaped decanuclear structure and its anticancer activity was evaluated. The cell cytotoxicity results indicating that the Ni10 complex is most effective to human breast cancer cells MDA-MB-231 and its mechanism were further investigated. Flow cytometry analysis showed that the Ni10 complex triggered cell cycle arrest and induced apoptosis of MDA-MB-231 cells. Western blot analysis of the changes of intracellular protein expression showed that Ni10 triggers MDA-MB-231 apoptosis through mitochondrial mediated apoptosis signaling pathways. In vivo experiments showed that the Ni10 complex significantly suppressed breast tumor growth with low toxicity against major organs in a nude mice model. The good treatment effect, low toxicity and pharmacological mechanisms of the decanuclear NiII complex may provide a clue for the research and development of non-platinum multinuclear based chemotherapeutic drugs.","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"153 ","pages":"107949"},"PeriodicalIF":4.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and evaluation of anticancer activity of new 4,5,6,7-tetrabromo-1H-benzimidazole derivatives. 4,5,6,7-四溴-1H-苯并咪唑新衍生物的合成及抗癌活性评价。

IF 4.5 2区医学

Bioorganic Chemistry Pub Date : 2024-12-01 Epub Date: 2024-10-10 DOI: 10.1016/j.bioorg.2024.107880

Edyta Łukowska-Chojnacka, Egor Fedorov, Anna Kowalkowska, Monika Wielechowska, Anna Sobiepanek, Mirosława Koronkiewicz, Patrycja Wińska

{"title":"Synthesis and evaluation of anticancer activity of new 4,5,6,7-tetrabromo-1H-benzimidazole derivatives.","authors":"Edyta Łukowska-Chojnacka, Egor Fedorov, Anna Kowalkowska, Monika Wielechowska, Anna Sobiepanek, Mirosława Koronkiewicz, Patrycja Wińska","doi":"10.1016/j.bioorg.2024.107880","DOIUrl":"10.1016/j.bioorg.2024.107880","url":null,"abstract":"An efficient method for the synthesis of new 4,5,6,7-tetrabromo-1H-benzimidazole derivatives has been developed. New ketones were obtained by N-alkylation of TBBi or 2-Me-TBBi with various phenacyl halides and then reduced to the corresponding alcohols. All compounds were obtained with satisfactory yields in the range of 40-91 %. The synthesized compounds appeared a weak CK2 and PIM-1 inhibitors but exhibit an interesting cytotoxic activity against cancer cell lines, i.e. MCF-7, PC-3, CCRF-CEM, K-562. 1-Phenyl-2-(4,5,6,7-tetrabromo-1H-benzimidazol-1-yl)ethanone 3aA exhibits the highest cytotoxic activity with IC50 value of 5.30 µM for MCF-7 and 6.80 µM for CCRF-CEM. Moreover, this compound shows the highest selectivity against both MCF-7 and CCRF-CEM with SI selectivity coefficients (against MRC-5 and Vero cells) equal 5.45 and 4.30 for MCF-7 and 4.25 and 3.35 for CCRF-CEM, respectively. Furthermore, it was shown that compound 3aA exhibits very good pro-apoptotic properties, through induction of the mitochondrial apoptotic pathway in CCRF-CEM cells. These results correlate with data showing the effect of 3aA on intracellular level of CK2α protein and CK2-mediated phosphorylation of Ser529 in NF-κBp65. Study of the effect of compound 3aA on mRNA levels of CK2α and CK2α' showed no significant differences in gene expression levels in control CCRF-CEM and cells treated with 3aA, indicating 3aA action at the protein level.","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"153 ","pages":"107880"},"PeriodicalIF":4.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery and optimization of novel 4-morpholinothieno[3,2-d]pyrimidine derivatives as potent BET inhibitors for cancer therapy. 发现和优化新型 4-吗啉基噻吩并[3,2-d]嘧啶衍生物，作为癌症治疗的强效 BET 抑制剂。

IF 4.5 2区医学

Bioorganic Chemistry Pub Date : 2024-12-01 Epub Date: 2024-11-02 DOI: 10.1016/j.bioorg.2024.107929

Kai Ran, Yong Li, Yi-Mei Zhang, Dian-Yong Tang, Zhong-Zhu Chen, Zhi-Gang Xu, Li Zhang, Bo-Chu Wang, Jiu-Hong Huang

{"title":"Discovery and optimization of novel 4-morpholinothieno[3,2-d]pyrimidine derivatives as potent BET inhibitors for cancer therapy.","authors":"Kai Ran, Yong Li, Yi-Mei Zhang, Dian-Yong Tang, Zhong-Zhu Chen, Zhi-Gang Xu, Li Zhang, Bo-Chu Wang, Jiu-Hong Huang","doi":"10.1016/j.bioorg.2024.107929","DOIUrl":"10.1016/j.bioorg.2024.107929","url":null,"abstract":"The identification of structurally novel and potently active BET inhibitors represents a significant advancement in the field of anticancer therapeutics. In the present investigation, leveraging the outcomes of previous screening endeavors, we successfully optimized and synthesized a novel series of bromodomain and extra-terminal (BET) inhibitors with a 4-morpholinothieno[3,2-d]pyrimidine structure. Among the synthesized compounds, compound 6c emerged as a promising candidate, exhibiting exceptional inhibitory activities against various BET isoform proteins, with IC50 values ranging from 3.3 to 42.0 nM. In cellular assays, compound 6c demonstrated robust antiproliferative effects in SU-DHL-4 cells, achieving an IC50 value of 8.6 ± 3.3 nM. Further mechanistic studies revealed that compound 6c effectively decreased the expression of c-Myc, a critical oncogenic driver regulated by the BET protein, and induced cell cycle arrest at the G1 phase, as well as cell apoptosis, in a dose-dependent manner. Moreover, in-silico prediction of the physiochemical and pharmacokinetic properties clarified that compound 6c has acceptable drug-like profiles. Taken these findings together, compound 6c represents a novel and potent BET inhibitor, thus positioning it as a promising candidate for subsequent pre-clinical evaluations in the realm of cancer therapy.","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"153 ","pages":"107929"},"PeriodicalIF":4.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical applications of small-molecule GABA_AR modulators for neurological disorders. 小分子 GABAAR 调节剂在神经系统疾病中的临床应用。

IF 4.5 2区医学

Bioorganic Chemistry Pub Date : 2024-12-01 Epub Date: 2024-11-22 DOI: 10.1016/j.bioorg.2024.107983

Guangyong Chen, Meiling Xu, Zhuo Chen, Fuwei Yang

{"title":"Clinical applications of small-molecule GABAAR modulators for neurological disorders.","authors":"Guangyong Chen, Meiling Xu, Zhuo Chen, Fuwei Yang","doi":"10.1016/j.bioorg.2024.107983","DOIUrl":"10.1016/j.bioorg.2024.107983","url":null,"abstract":"Gamma-aminobutyric acid type A receptor (GABAAR) modulators are crucial in treating neurological and psychiatric disorders, including epilepsy, anxiety, insomnia, and depression. This review examines the synthetic approaches and clinical applications of representative small-molecule GABAAR modulators. Benzodiazepines, such as Diazepam, are well-known positive allosteric modulators (PAMs) that enhance GABAAR function, providing therapeutic effects but also associated with side effects like sedation and dependence. Non-benzodiazepine modulators, including Z-drugs like Zolpidem and Zaleplon, offer improved selectivity for the α1 subunit of GABAAR, reducing some of these side effects. Neurosteroids such as allopregnanolone and its synthetic analogs, including Brexanolone, have emerged as potent GABAAR modulators with applications in conditions like postpartum depression and refractory epilepsy. Advances in molecular biology and pharmacology have facilitated the development of isoform-specific modulators, potentially reducing off-target effects and enhancing therapeutic profiles. Additionally, combining GABAAR modulators with other therapeutic agents has shown promise in enhancing efficacy and minimizing side effects. This review highlights the design strategies, pharmacodynamics, clinical efficacy, and safety profiles of these compounds, emphasizing the opportunities for developing novel GABAAR modulators with improved therapeutic outcomes.","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"153 ","pages":"107983"},"PeriodicalIF":4.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tyrosine modifications of insulin-degrading enzyme enable favorable control of substrate specificity for both Alzheimer's disease and type-2 diabetes mellitus. 对胰岛素降解酶进行酪氨酸修饰，有利于控制阿尔茨海默病和 2 型糖尿病的底物特异性。

IF 4.5 2区医学

Bioorganic Chemistry Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1016/j.bioorg.2024.107916

Yusuke Hatakawa, Yuki Takeuchi, Seon Hwa Lee, Tomoyuki Oe

{"title":"Tyrosine modifications of insulin-degrading enzyme enable favorable control of substrate specificity for both Alzheimer's disease and type-2 diabetes mellitus.","authors":"Yusuke Hatakawa, Yuki Takeuchi, Seon Hwa Lee, Tomoyuki Oe","doi":"10.1016/j.bioorg.2024.107916","DOIUrl":"10.1016/j.bioorg.2024.107916","url":null,"abstract":"Insulin-degrading enzyme (IDE) cleaves amyloid beta (Aβ), insulin, and other bioactive peptides. Because Aβ and insulin are closely related to Alzheimer's disease (AD) and type-2 diabetes mellitus (T2DM), respectively, IDE is a candidate drug target for treating both AD and T2DM. However, the activity of IDE has opposing effects, including decreasing AD risk by degrading Aβ and increasing T2DM risk by degrading insulin. The opposed substrate specificity is associated with the exo- and active sites containing Tyr314 and Tyr831 residues, the plausible modification targets for controlling substrate specificity. In this study, we used a tyrosine-specific modification regent, Cookson reagent (4-phenyl-1,2,4-triazoline-3,5-dione, PTAD), for IDE and examined the degradation activities on Aβ40 and insulin. Fifteen tyrosine residues, including Tyr314 and Tyr831, were modified by PTAD. After incubation with PTAD-modified IDE for 3 days, insulin remained intact, whereas Aβ40 was completely degraded. This favorable change of substrate specificity was also observed in the mixture of Aβ40 and insulin, suggesting that tyrosine modification of IDE might be a therapeutic strategy for AD and T2DM.","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"153 ","pages":"107916"},"PeriodicalIF":4.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5H-benzo[c]fluorene derivative exhibits antiproliferative activity via microtubule destabilization. 5H-苯并[c]芴衍生物通过破坏微管稳定而表现出抗增殖活性。

IF 4.5 2区医学

Bioorganic Chemistry Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1016/j.bioorg.2024.107891

Eram Fatima, Yashveer Gautam, Barsha Thapa, Ranjana Das, Amrita Singh, Laxmikant Trivedi, Palak Singh, Kavita Singh, Divya Bhatt, Prema G Vasudev, Atul Gupta, Debabrata Chanda, Dnyaneshwar U Bawankule, Karuna Shanker, Feroz Khan, Arvind S Negi

{"title":"5H-benzo[c]fluorene derivative exhibits antiproliferative activity via microtubule destabilization.","authors":"Eram Fatima, Yashveer Gautam, Barsha Thapa, Ranjana Das, Amrita Singh, Laxmikant Trivedi, Palak Singh, Kavita Singh, Divya Bhatt, Prema G Vasudev, Atul Gupta, Debabrata Chanda, Dnyaneshwar U Bawankule, Karuna Shanker, Feroz Khan, Arvind S Negi","doi":"10.1016/j.bioorg.2024.107891","DOIUrl":"10.1016/j.bioorg.2024.107891","url":null,"abstract":"Present study aimed at a single component cyclization of 2-benzylidene-1-tetralones for the preparation of 5H-benzo[c]fluorenes and their antiproliferative activity. This ring closure reaction underwent via reductive cyclization in the presence of a sodium borohydride-aluminium chloride system. Ten diverse 5H-benzo[c]fluorene derivatives were prepared and evaluated for antiproliferative activity against three human cancer cell lines by SRB assay. Four of these benzofluorenes exhibited significant antiproliferative effect with an IC50 < 10.75 µM. The best representative compound 21, exhibited IC50 against K562 leukemic cells at 3.27 µM in SRB assay and 7.68 µM in Soft agar colony assay. It exhibited a microtubule destabilization effect in tubulin kinetics and inhibited 82.9 % microtubule polymer mass at 10 µM concentration in Protein Sedimentation assay (Microtubule). Compound 21 exerted G0/G1 phase arrest in cell division cycle analysis in K562 cells. It also induced apoptosis in K562 cells via activation of Caspase cascade pathway. Furthermore, compound 21 also possessed anti-inflammatory activity by inhibiting TNF-α and IL-6 moderately. It exhibited significant in vivo efficacy and reduced K562 tumour in xenograft mice by 47 % at an 80 mg/kg oral dose. Further, it was found to be safe and well tolerable up to 1000 mg/kg in Swiss albino mice. Compound 21 needs to be optimized for better in vivo efficacy in rodent models for further development.","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"153 ","pages":"107891"},"PeriodicalIF":4.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the role of natural and synthetic products as DNA topoisomerase inhibitors in hepatocellular carcinoma. 揭示天然和合成产品作为 DNA 拓扑异构酶抑制剂在肝癌中的作用。

IF 4.5 2区医学

Bioorganic Chemistry Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI: 10.1016/j.bioorg.2024.107860

Qing Ren, Guoming Chen, Qi Wan, Liangman Xiao, Zhitong Zhang, Yibin Feng

引用次数: 0