Bioorganic Chemistry最新文献

{"title":"¹H NMR- and GC-MS-based metabolomics reveal the metabolic response of Pseudomonas granadensis to the presence of Staphylococcus epidermidis.","authors":"Maria Michela Salvatore, Umberto Galdiero, Martina Aversa, Anna Andolfi, Paulina Corral, Francesco Salvatore, Maria Rosaria Catania, Emanuela Roscetto, Marco Masi, Marina DellaGreca","doi":"10.1016/j.bioorg.2026.110418","DOIUrl":"10.1016/j.bioorg.2026.110418","url":null,"abstract":"<p><p>Soil hosts a myriad of highly competitive microorganisms that develop specialized metabolic strategies to survive and interact with competitors. In this study, we report that a soil strain of Pseudomonas granadensis isolated from the Campi Flegrei volcanic area (Southern Italy) inhibits the human pathogen Staphylococcus epidermidis through cell free supernatant (CFS) derived from mixed cultures. Interestingly, this inhibitory activity emerged only in CFSs obtained from mixed cultures of the two species. CFSs from P. granadensis monocultures showed no activity, indicating that the presence of S. epidermidis triggers a specific metabolic response by P. granadensis. To investigate this phenomenon, we applied an integrated metabolomics strategy combining ¹H NMR and GC-MS. This dual-platform approach revealed extensive metabolic reprogramming of P. granadensis when cultured in the presence of S. epidermidis. The metabolic shift included enhanced glucose consumption and increased production of lactic, acetic, succinic, fumaric, and gluconic acids, together with multiple fatty and dicarboxylic acids. These changes indicate activation of stress-related metabolic pathways, including increased flux through the Entner-Doudoroff pathway, induction of the glyoxylate shunt of the TCA cycle, and stimulation of fatty acid biosynthesis. Overall, this study highlights the value of metabolic profiling for exploring microbial strategies in competitive environments and provides insight into the ability of soil bacteria to generate antimicrobial metabolites in response to competitive pressure.</p>","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"181 ","pages":"110418"},"PeriodicalIF":5.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, structural characterization and antifungal activity of azo-based compounds bearing hydroxy and nitro terminal groups.","authors":"Nurul Asma Razali, Zuhair Jamain, Fauze Mahmud, Dayang Najwa Datu Borhan","doi":"10.1016/j.bioorg.2026.110421","DOIUrl":"10.1016/j.bioorg.2026.110421","url":null,"abstract":"<p><p>Azo compounds, known for their durability and chemical stability, are being studied for their antifungal potential. This study aims to synthesize and evaluate a new series of azo-based compounds with varying terminal groups to assess their bioactivity. Compounds 4(a-d), containing a nitro group, and compound 5(a-d), containing a hydroxy group, were synthesized via a multistep reaction sequence, with percentage yields ranging between 79.5 and 98.6%. Structural characterization of representative compounds 4a and 5a were confirmed by FTIR, NMR and CHN analyses. Compound 4a, displayed several characteristics band in the FTIR spectrum [1538 cm^-1 (N=N) and 1496 & 1348 cm^-1 (NO)], while compound 5a, [1516 cm^-1 (N=N) and 3390 cm^-1 (OH)]. In the ¹H NMR spectra, 4a showed resonances corresponding to amide (δ 9.82 ppm), while 5a displayed signals for amide (δ 10.28 ppm) and hydroxyl (δ 9.68 ppm). In the ¹³C NMR spectra, the main differences are attributable to the substituents: compound 4a had aromatic carbons shifted downfield near the nitro group, while compound 5a had a hydroxyl-substituted aromatic carbon. CHN elemental confirmed the purity of both compounds 4a and 5a, with minimal deviation from theoretical values of 0.14 and 0.13%, respectively. Derivatives 4a (LC₅₀: 315.6 ppm) and 5a (LC₅₀: 230.0 ppm) were selected for further antifungal evaluation after preliminary cytotoxicity screening. Antifungal screening used disk diffusion and microdilution methods to assess potency. Compound 4a showed better antifungal activity against Candida albicans, with an inhibition zone of 12 mm (1.0 M) and 12 mm (0.5 M), respectively, whereas compound 5a produces 12 mm and 10 mm at the same concentrations. The MIC testing showed that compound 4a achieved complete inhibition at 0.625 mM, with an IC₅₀ value of 0.2816 mM, while compound 5a did not reach complete inhibition and displayed a higher IC₅₀ value of 0.8110 mM.</p>","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"181 ","pages":"110421"},"PeriodicalIF":5.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel VHL ligand-based PROTACs targeting JNK1: design, synthesis, and biological evaluation with potent anti-EMT activity.","authors":"Shuhua Ren, Ye Zhang, Rui Hao, Jiale Yuan, Man Chi, Weiqi Cai, Wenjing Gu, Yi Huang, Yaxia Yuan, Xiabin Chen, Lei Ma","doi":"10.1016/j.bioorg.2026.110388","DOIUrl":"10.1016/j.bioorg.2026.110388","url":null,"abstract":"<p><p>Epithelial-mesenchymal transition (EMT) is essential for embryogenesis and tissue regeneration, yet its aberrant activation is closely associated with organ fibrosis and tumor metastasis. c-Jun N-terminal kinase 1 (JNK1) has been identified as a key mediator of transforming growth factor-β (TGF-β)-driven EMT, making it a promising therapeutic target. Herein, we describe the design, synthesis, and biological evaluation of a series of JNK1-targeting PROTACs that recruit either CRBN or VHL E3 ligases. Systematic structure-activity relationship optimization led to the discovery of compound YC2, which incorporates a newly developed VHL ligand modified with a 2,4-dimethyloxazole moiety, as a potent and selective degrader. YC2 induced efficient, concentration- and time-dependent degradation of JNK1 (DC₅₀ of 4.90 nM) via VHL-mediated ubiquitin-proteasome pathway engagement, while displaying strong selectivity over related kinases including JNK2, p38α, and ERK. Moreover, YC2 markedly attenuated TGF-β1-induced EMT, as evidenced by reduced fibronectin levels and restoration of E-cadherin expression, with efficacy comparable to nintedanib. Collectively, YC2 featuring a novel VHL ligand demonstrates excellent degradation potency and selectivity for JNK1, highlighting its potential as a valuable chemical probe for EMT-associated pathologies.</p>","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"181 ","pages":"110388"},"PeriodicalIF":5.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, thymidylate synthase docking, and biological evaluation of Pyrazolone- and Benzothiazole-functionalized Bis(acetamide) derivatives in Caco-2 and HDF cells.","authors":"Ihab Abbas Taher, Firyal Weli Askar, Fatin Fadhel Al-Kazzaz","doi":"10.1016/j.bioorg.2026.110393","DOIUrl":"10.1016/j.bioorg.2026.110393","url":null,"abstract":"<p><p>Three phenylene-linked bis(acetamide) compounds were synthesized and evaluated to determine how pyrazolone or benzothiazole terminal groups alter chemical radical-scavenging, cellular metabolic viability, and predicted accommodation within human thymidylate synthase (hTS). Spectroscopic characterization supported the proposed structures, while RP-HPLC indicated purities of 94.80% for R1, 96.72% for R2, and 90.16% for R3. Redocking of co-crystallized dUMP reproduced its experimental pose with an RMSD of 1.3 Å, supporting pose recovery by the docking setup. R2 and R3 produced AutoDock Vina scores of -9.2 and - 9.4 kcal/Mol, respectively, compared with -7.45 kcal/Mol for FdUMP; these values were interpreted as exploratory scoring outputs rather than evidence of hTS inhibition. In the cell-free DPPH assay, R3 showed the strongest response among the synthesized compounds, with an IC₅₀ of 28.95 μg/mL, whereas R1 and R2 gave 46.29 and 47.64 μg/mL, respectively, and ascorbic acid gave 19.79 μg/mL. In Caco-2 cells, R2 and R3 yielded comparable MTT-derived IC₅₀ values of 59.94 and 60.43 μg/mL, both lower than R1 at 148.7 μg/mL. Their corresponding HDF IC₅₀ values were 141.2, 109.5, and 161.7 μg/mL, giving HDF/Caco-2 indices of 2.36, 1.81, and 1.09. 5-fluorouracil showed an index of 3.16. Comparisons between Caco-2 and HDF fitted logIC₅₀ values were significant for R2 and R3 but not R1, and no compound reached the stringent SI threshold of 10. Thus, DPPH reactivity and cellular response followed different trends, and the modest differential sensitivity, limited compound series, and suboptimal purity of R3 support cautious interpretation and further mechanistic validation using adequately purified compound batches.</p>","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"181 ","pages":"110393"},"PeriodicalIF":5.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-driven discovery and optimization of natural LSD1 inhibitors for the treatment of Alzheimer's disease.","authors":"Zhonghua Li, Tiancheng Sun, Mengyu Han, Bingyu Xiao, Sijia Liu, Jiaxin Zhang, JinLian Ma, Huifen Ma, Jige Yang, Zhenqiang Zhang","doi":"10.1016/j.bioorg.2026.110396","DOIUrl":"10.1016/j.bioorg.2026.110396","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with limited effective disease-modifying treatments. Lysine-specific demethylase 1 (LSD1) has emerged as a promising target for AD therapy. However, current LSD1 inhibitors for AD still suffer from poor brain permeability, off-target toxicity, and chemical-scaffold scarcity. Herein, we developed a multimodal deep learning model (PLM-CAFT-DTA) for drug-target affinity (DTA) prediction. This model integrates ChemBERTa, ESM-2, graph attention, and cross-attention fusion to achieve high prediction precision. Using this model combined with virtual screening and molecular simulation, we identified silybin as a hit compound from a library of over 70,000 natural products. After rational modification, compound S3 was obtained with significantly improved LSD1 inhibition (IC₅₀ = 2.30 μM), approximately 7-fold more potent than the silybin. In vitro assays showed that S3 exhibited favorable neuroprotective and antioxidant activities. In APP/PS1 mice, S3 upregulated hippocampal H3K9me2, suppressed neuroinflammation and Aβ deposition, and improved cognitive function. By addressing unmet demands for AI-assisted anti-AD lead discovery, this study provides a generalized DTA tool for early-stage drug development, and identifies S3 as a novel LSD1 inhibitor with potent anti-AD efficacy.</p>","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"181 ","pages":"110396"},"PeriodicalIF":5.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Discovery of novel H₃R antagonists with potent antiseizure activity and favorable pharmacokinetics via scaffold-hopping from pitolisant to rigid 4-phenylindoles\" [Bioorg. Chem. 181 (2026) 110309].","authors":"Ying Zheng, Guowen He, Mingxia Song, Jiuhong Kang, Jianglong Wu, Yingna Zhu, Ruokun Wu, Ping Liu, Xianqing Deng","doi":"10.1016/j.bioorg.2026.110364","DOIUrl":"10.1016/j.bioorg.2026.110364","url":null,"abstract":"","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":" ","pages":"110364"},"PeriodicalIF":5.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scutellarin as a specific GEN1 inhibitor synergizes with olaparib to induce synthetic lethality in human tumor cells.","authors":"Binbin Zhan, Yichen Zhong, Xuening Chen, Yijun Dai, Liyang Du, Zhonghui Lin, Zuoan Li","doi":"10.1016/j.bioorg.2026.110414","DOIUrl":"10.1016/j.bioorg.2026.110414","url":null,"abstract":"<p><p>The synthetic lethal interaction between poly(ADP-ribose) polymerase (PARP) inhibition and homologous recombination (HR)-deficiency, particularly in BRCA1/2-mutant tumors, has emerged as an effective strategy for cancer therapy. GEN1, a structure-selective endonuclease that resolves Holliday junctions (HJs) during HR, represents an attractive antitumor target. However, effective small-molecule GEN1 inhibitors have yet to be reported. Here, we established a fluorescence resonance energy transfer (FRET)-based high-throughput screening platform and identified the natural flavonoid scutellarin (SCU) as a specific inhibitor of human GEN1. SCU selectively inhibited GEN1 endonuclease activity against both 5'-flap and HJ DNA substrates, with no effect on other tested structure-selective endonucleases, such as SLX1-SLX4 and MUS81-EME1. Mechanistic studies showed that SCU does not disrupt GEN1-DNA binding but instead binds to the catalytic center of GEN1, thereby inhibiting its endonuclease activity. In HCT116 cells, SCU acted in synergy with the PARP inhibitor olaparib to markedly impair DNA double-strand break (DSB) repair, increase γH2AX accumulation, induce G2/M cell cycle arrest, and suppress cell migration. Notably, the SCU/olaparib combination produced robust synthetic lethality in both HCT116 and HeLa cells, resulting in substantial inhibition of cell viability and colony formation. Our study identifies SCU as a novel selective GEN1 inhibitor, and suggests a new therapeutic strategy that combines GEN1 inhibitors with PARP inhibitors for cancer treatment.</p>","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"181 ","pages":"110414"},"PeriodicalIF":5.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological inhibition of LSD1 suppresses the CD155/TIGIT immune checkpoint axis and enhances NK cell-mediated cytotoxicity in colorectal cancer.","authors":"Xing-Jie Dai, Jiang-Wan Wu, Jin-Man Zhu, Jing-Ying Hu, Hong-Min Liu, Hui-Min Liu, Yi-Chao Zheng","doi":"10.1016/j.bioorg.2026.110366","DOIUrl":"10.1016/j.bioorg.2026.110366","url":null,"abstract":"<p><p>Colorectal cancer (CRC) remains poorly responsive to immune checkpoint blockade in a substantial proportion of patients, highlighting the need to identify druggable mechanisms that regulate tumor immune evasion. CD155, a ligand of the inhibitory receptor TIGIT, is highly expressed in CRC and contributes to impaired natural killer (NK) cell-mediated antitumor immunity. Lysine-specific demethylase 1 (LSD1/KDM1A) is a pharmacologically targetable epigenetic enzyme with emerging roles in tumor immunogenicity, but whether LSD1 inhibition modulates the CD155/TIGIT immune checkpoint axis in CRC remains unclear. In this study, we found that LSD1 and CD155 were highly expressed in CRC tissues and showed a significant positive correlation. Genetic depletion of LSD1 reduced CD155 expression at both the mRNA and protein levels in CRC cells. Importantly, pharmacological inhibition of LSD1 with two small-molecule inhibitors, CC-90011 and ORY-1001, markedly decreased CD155 expression and membrane abundance in multiple CRC cell lines. Mechanistically, LSD1 depletion or inhibition increased H3K4me2 enrichment at the CD155 promoter, suggesting that LSD1 activity is required for maintaining CD155 transcription in CRC cells. Functionally, LSD1 inhibition decreased CD155 expression and cell-surface abundance, resulting in reduced CD155/TIGIT interaction and enhanced NK cell-mediated cytotoxicity, accompanied by increased secretion of IFN-γ and TNF-α. In a CT26 syngeneic tumor model, LSD1 knockdown suppressed tumor growth and decreased CD155 expression in vivo. Collectively, these findings reveal that pharmacological inhibition of LSD1 attenuates CRC immune escape, at least in part, by epigenetically suppressing the CD155/TIGIT axis. This study provides a rationale for exploiting LSD1 inhibitors as immunomodulatory agents to enhance antitumor immunity in CRC.</p>","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"181 ","pages":"110366"},"PeriodicalIF":5.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of 3-[(5-nitro-2-heteroaryl)methylene]-2-indolinone derivatives as highly potent antileishmanial agents and their bioactivation by NTR1 and 2.","authors":"Seyyed Hasan Shariatmadari, Marta Lopes Lima, Rachel Milne, Susan Wyllie, Latifeh Navidpour","doi":"10.1016/j.bioorg.2026.110391","DOIUrl":"10.1016/j.bioorg.2026.110391","url":null,"abstract":"<p><p>A novel series of 2-indolinone derivatives bearing a nitroheteroarylmethylene moiety, including nitroimidazole, nitrofuran, and nitrothiophene at their 3-position, were synthesized as potential antileishmanial agents. The in vitro antileishmanial activity and cytotoxicity of these analogues were assessed using L.donovani axenic amastigotes and L6 cell lines, respectively. All compounds except 16k and 18c exhibited promising activity, with IC₅₀ values in the submicromolar range; however, only the nitroimidazole analogues achieved notable selectivity indices (SI). 5-Chloro-3-[(1-methyl-5-nitro-1H-imidazol-2-yl)methylene]-2-indolinone (16c) was the most potent compound, demonstrating impressive antileishmanial activity with an IC₅₀ value of 2.5 nM and an SI of 1760, relative to the reference drug miltefosine (IC₅₀ = 1252.3 nM). Further studies on the nitroimidazole analogues against intracellular amastigotes of L.donovani revealed promising activity for most compounds, with IC₅₀ values ranging from 1.5 to 29.5 μM and high SIs (5.8-42.9), relative to miltefosine (IC₅₀ = 3.9 μM, SI = 34.2). Subsequently, the bioactivation of the compounds by nitroreductases (NTR1 and NTR2) was studied. They were predominantly bioactivated by NTR1, producing DNA-damaging active amine metabolites. Owing to their high antileishmanial activity and selectivity indices, these compounds merit further investigation as potent agents against leishmaniasis, a critical health issue among the tropical diseases.</p>","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"181 ","pages":"110391"},"PeriodicalIF":5.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural cyclic depsipeptides and their analogs as potential antimicrobial candidates: mechanistic insight.","authors":"Gautam Kumar, Kritika Engle","doi":"10.1016/j.bioorg.2026.110343","DOIUrl":"10.1016/j.bioorg.2026.110343","url":null,"abstract":"<p><p>Microorganisms such as bacteria, viruses, fungi, and parasites cause serious infections in humans. The misuse of antimicrobial treatments in humans, animals, and agriculture has led to the development of resistant pathogens that can survive and multiply even in the presence of antibiotics. The rise of antibiotic-resistant pathogens has caused significant loss of life and impacted social and economic conditions. Antimicrobial peptides exert antibacterial activity through multiple modes of action. Cyclic peptides are known for greater stability and bioavailability than linear peptides. Among them, cyclic depsipeptides represent a distinct subclass characterized by the presence of an ester bond in addition to peptide bonds. Because of the distinct molecular structure of cyclic depsipeptides, particularly their amino acid components, they demonstrate robust antimicrobial efficacy. Cyclic depsipeptides demonstrate antimicrobial efficacy by targeting various components of the cell wall, including lipid II, menaquinone, lipopolysaccharides, and the DNA polymerase β sliding clamp, as well as by inhibiting biofilm formation and quorum sensing. Additionally, it demonstrated a lower likelihood of resistance development, emphasizing its ability to fight multidrug-resistant pathogens. Given these promising findings, cyclic depsipeptides offer a promising molecular framework for addressing a range of human infections, particularly in an era of increasing antibiotic resistance. This review summarises the recently identified cyclic depsipeptide-based antimicrobial candidates for the treatment of bacterial, fungal, and parasitic infections.</p>","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"181 ","pages":"110343"},"PeriodicalIF":5.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148704925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}