Unraveling the mechanisms of ubiquitin-specific proteases in hepatocellular carcinoma: A focus on inhibitors.

IF 4.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic Chemistry Pub Date : 2025-09-29 DOI:10.1016/j.bioorg.2025.109049

Yaojiang Xu, Jiayuan Ye

引用次数: 0

Abstract

Due to heterogeneity and the development of drug resistance, Hepatocellular carcinoma (HCC) patients still benefit minimally from current treatment methods. In recent years, an increasing number of studies have reported the presence of abnormal ubiquitination modifications in HCC. Therefore, exploring the underlying regulatory mechanisms and developing effective interventions hold the promise of providing new treatment options for HCC patients. This article focuses on the deubiquitinating enzymes (DUB) that play a promoting role in the occurrence and development of HCC, emphasizing their mechanisms of action and related small molecule interventions, with the aim of providing new strategies for the treatment of HCC.

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揭示泛素特异性蛋白酶在肝细胞癌中的作用机制：对抑制剂的关注。

由于异质性和耐药性的发展，肝细胞癌（HCC）患者从目前的治疗方法中获益甚微。近年来，越来越多的研究报道了HCC中存在异常泛素化修饰。因此，探索潜在的调控机制和开发有效的干预措施有望为HCC患者提供新的治疗选择。本文重点介绍在HCC发生发展中起促进作用的去泛素化酶（deubiquitination enzyme， DUB），强调其作用机制及相关的小分子干预措施，以期为HCC的治疗提供新的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioorganic Chemistry 生物-生化与分子生物学

CiteScore

9.70

自引率

3.90%

发文量

679

审稿时长

31 days

期刊介绍： Bioorganic Chemistry publishes research that addresses biological questions at the molecular level, using organic chemistry and principles of physical organic chemistry. The scope of the journal covers a range of topics at the organic chemistry-biology interface, including: enzyme catalysis, biotransformation and enzyme inhibition; nucleic acids chemistry; medicinal chemistry; natural product chemistry, natural product synthesis and natural product biosynthesis; antimicrobial agents; lipid and peptide chemistry; biophysical chemistry; biological probes; bio-orthogonal chemistry and biomimetic chemistry. For manuscripts dealing with synthetic bioactive compounds, the Journal requires that the molecular target of the compounds described must be known, and must be demonstrated experimentally in the manuscript. For studies involving natural products, if the molecular target is unknown, some data beyond simple cell-based toxicity studies to provide insight into the mechanism of action is required. Studies supported by molecular docking are welcome, but must be supported by experimental data. The Journal does not consider manuscripts that are purely theoretical or computational in nature. The Journal publishes regular articles, short communications and reviews. Reviews are normally invited by Editors or Editorial Board members. Authors of unsolicited reviews should first contact an Editor or Editorial Board member to determine whether the proposed article is within the scope of the Journal.