Journal Syifa Sciences and Clinical Research最新文献_第7页

Uji Toksisitas Ekstrak Etanol Daun Ekor Kucing (Acalypha hispida Burm.f.) Dengan Metode Brine Shrimp Lethality Test (BSLT) 猫尾乙醇乙醇提取物毒性试验(学名Acalypha hispida Burm.f.)用盐水虾试验(BSLT)

Journal Syifa Sciences and Clinical Research Pub Date : 2021-08-30 DOI: 10.37311/JSSCR.V3I2.11398

Hadi Kurniawan, Meri Ropiqa

{"title":"Uji Toksisitas Ekstrak Etanol Daun Ekor Kucing (Acalypha hispida Burm.f.) Dengan Metode Brine Shrimp Lethality Test (BSLT)","authors":"Hadi Kurniawan, Meri Ropiqa","doi":"10.37311/JSSCR.V3I2.11398","DOIUrl":"https://doi.org/10.37311/JSSCR.V3I2.11398","url":null,"abstract":"Daun Ekor Kucing (Acalypha hispida Burm.f.) merupakan jenis tanaman hias yang telah dikenal masyarakat Indonesia untuk pengobatan, namun belum ada penelitian untuk meneliti toksisitas akut daun ekor kucing. Tanaman ini mengandung senyawa alkaloid dan flavonoid. Tujuan dari penelitian ini adalah untuk mengetahui potensi ketoksikan akut ekstrak etanol daun ekor kucing (A. hispida Burm.f.) terhadap larva Artemia salina Leach dengan metode Brine Shrimp Lethality Test (BSLT) yang ditunjukkan dengan nilai LC50. Penelitian eksperimental ini menggunakan 300 ekor larva udang (Artemia salina Leach) yang dibagi menjadi 5 kelompok kontrol negatif dan 5 kelompok seri konsentrasi ekstrak. Masing-masing kelompok terdiri dari 10 ekor larva dengan replikasi 3 kali untuk tiap kelompok perlakuan. Kelima kelompok perlakuan diberi suspensi sediaan uji ekstrak etanol daun ekor kucing dengan konsentrasi 100 ppm, 250 ppm, 500 ppm, 750 ppm, dan 1.000 ppm. Data kematian Artemia salina Leach dianalisis dengan analisis probit untuk mengetahui nilai LC50. Hasil penelitian ini menunjukkan harga LC50 dari ekstrak etanol daun ekor kucing adalah 220,005 ppm. Ekstrak etanol daun ekor kucing memiliki potensi toksisitas akut terhadap larva Artemia salina Leach menurut metode BSLT yang ditunjukkan dengan harga LC50 1.000 ppm.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122463962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Analisis Kadar Metabolit Sekunder, Histokimia, dan Aktivitas Antioksidan Akar Acalypha indica L. 分析次生代谢率、组织化学和抗氧化剂根活性。

Journal Syifa Sciences and Clinical Research Pub Date : 2021-08-25 DOI: 10.37311/JSSCR.V3I2.11376

Novia Agustina, Nurul Istiqomah

{"title":"Analisis Kadar Metabolit Sekunder, Histokimia, dan Aktivitas Antioksidan Akar Acalypha indica L.","authors":"Novia Agustina, Nurul Istiqomah","doi":"10.37311/JSSCR.V3I2.11376","DOIUrl":"https://doi.org/10.37311/JSSCR.V3I2.11376","url":null,"abstract":"Acalypha indica L. is a species of wild plant that has secondary metabolites are used as medicine, but the usage is not optimized yet. The objective of of this study was to determine secondary metabolites content, location and distribution of secondary metabolites, and also the capacity for antioxidant. Secondary metabolites content was determined included phenol, flavonoids, tannin of chloroform and methanol extracts from Acalypha indica L. root, using spectrophotometre. Histochemical test was done by making fresh sliced preparation which was reacted with reagent. Antioxidant activity was determined by using DPPH method. The result of this study showed that secondary metabolites content of chloroform extract, were phenol 9,89 ± 0,77 %GAE, flavonoids 5,87 ± 1,40 %QE, and tannin 3,33 ± 1,21 %GAE, while methanol extract were phenol 45,11 ± 4,86 %GAE, flavonoids 19,87 ± 0,61 %QE, and tannin 6,76 ± 0,31 %GAE. Histochemical test showed that phenol, flavonoids, tannin, and alkaloids were found in Acalypha indica L. root. Antioxidant activity showed the IC50 value was 161,81 ± 7,88 μg/mL for chloroform extract and 92,81 ± 4,33 μg/mL for methanol extract.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123717606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efektivitas Terapi Antibiotika Demam Tifoid Pada Pediatrik Di Rumah Sakit X Kota Kediri X城Kediri医院儿科伤寒抗生素治疗的有效性

Journal Syifa Sciences and Clinical Research Pub Date : 2021-08-03 DOI: 10.37311/jsscr.v3i2.11688

Feny Oktaviana, Puput Noviana

{"title":"Efektivitas Terapi Antibiotika Demam Tifoid Pada Pediatrik Di Rumah Sakit X Kota Kediri","authors":"Feny Oktaviana, Puput Noviana","doi":"10.37311/jsscr.v3i2.11688","DOIUrl":"https://doi.org/10.37311/jsscr.v3i2.11688","url":null,"abstract":"Typhoid fever has the highest incidence in children. Treatment for typhoid fever uses antibiotics. Increasing bacterial resistance to antibiotics is a global problem. This study was conducted to determine the differences in the effectiveness of antibiotics in the treatment of typhoid fever on the heat-free time and the length of treatment for pediatric patients in the inpatient ward of the X Hospital, Kediri City. This research is a descriptive analysis research. A retrospective study was conducted using medical records in 2017. Data were collected by purposive sampling. Data were taken on pediatric patients with typhoid fever aged 5-11 years. The statistical test used to analyze the effectiveness of therapy in pediatric patients with typhoid fever was performed using the Kruskal-Wallis test. The sample used in this study were 38 pediatric patients. The antibiotics used were ciprofloxacin 52.63%, ceftriaxone 28.95%, cefuroxim 10.53%, and penicillin 7.89%. The results of the analysis of differences in the effectiveness of antibiotics against heat-free time obtained a sig value 0.05 (0.947) and a sig value 0.05 (0.329) for the length of treatment. There was no significant difference in heat-free time and length of treatment between ceftriaxone, cefuroxim, ciprofloxacin and penicillin.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125207319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Uji Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Notika (Arcboldiodendron calosericeum Kobuski) Terhadap Kadar Kolesterol Total Tikus (Rattus norvegicus) Jantan Galur Wistar 对雄蛙的总胆固醇(学名arcboldiodenceum caloceum Kobuski)的抗高脂活性测试

Journal Syifa Sciences and Clinical Research Pub Date : 2019-11-13 DOI: 10.37311/JSSCR.V2I1.2704

N. Nuralifah, W. Wahyuni, P. Parawansah, Ulan Dwi Shintia

引用次数: 4

Pemberian Jus Mentimun (Cucumis Sativus Linn) Pada Penderita Hipertensi Wanita Usia Produktif 给有生产力的女性高血压患者黄瓜汁(Cucumis Sativus Linn)

Journal Syifa Sciences and Clinical Research Pub Date : 2019-09-19 DOI: 10.37311/JSSCR.V1I2.2663

Z. Ahmad, Siti Surya Indah Nurdin

{"title":"Pemberian Jus Mentimun (Cucumis Sativus Linn) Pada Penderita Hipertensi Wanita Usia Produktif","authors":"Z. Ahmad, Siti Surya Indah Nurdin","doi":"10.37311/JSSCR.V1I2.2663","DOIUrl":"https://doi.org/10.37311/JSSCR.V1I2.2663","url":null,"abstract":"Hypertension is one of the public health problems that cause mortality and inability to reach life expectancy. The aim of the research is to assess the effect of juice cucumber (Cucumis sativus Linn) on blood pressure of hypertension patients. The research used a quasi experiment design with Non-Randomized Control Group Pre-test Post-test Design. The populations include pre-hypertension and hypertension grade I patients of women childbearing age in the working area of Telaga Biru Health Centre of Gorontalo Regency. The samples were 42 pre-hypertension and hypertension grade I patients. They were divided into two groups, a group given cucumber juice without seeds and another group given cucumber juice with seeds. The data were analyzed using Paired-samples t Test and Independent-samples t Test. The result of the study indicate that giving cucumber juice without seeds decrease of systolic blood pressure by 18,524 mmHg (p = 0,000) and decrease diastolic blood pressure by 8,905 mmHg (p = 0,000). Giving cucumber juice with seeds could decrease systolic blood pressure by 15,952 mmHg (p = 0,000) and diastolic blood pressure by 7,571 mmHg (p = 0,000). There was no difference between giving cucumber juice without seeds and giving cucumber juice with seeds in the decrease of systolic blood pressure (p = 0,257) and the decrease of diastolic blood pressure (p = 0,414). This shows that giving cucumber juice can decrease blood pressure.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116717149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Uji Aktivitas Analgetik Ekstrak Etanol Daun Inggu (Ruta angustifolia [l.] Pers) Pada Tikus Putih Jantan 草药乙醇提取物试验试验新闻界)关于一只雄性白老鼠

Journal Syifa Sciences and Clinical Research Pub Date : 2019-09-12 DOI: 10.3731/JSSCR.V1I2.2662

Yane Dila Keswara, S. Handayani

{"title":"Uji Aktivitas Analgetik Ekstrak Etanol Daun Inggu (Ruta angustifolia [l.] Pers) Pada Tikus Putih Jantan","authors":"Yane Dila Keswara, S. Handayani","doi":"10.3731/JSSCR.V1I2.2662","DOIUrl":"https://doi.org/10.3731/JSSCR.V1I2.2662","url":null,"abstract":"Pain is an uncomfortable feeling caused by strong or destructive stimulation, if unchecked can affect daily routine. This study aims to determine the analgesic effect and dosage of the leaf extract ethanol, as well as to determine the effectiveness of the leaf extract ethanol as a narcotic analgesic by the Tail Flick method or as a non-narcotic analgesic by the Paw Pressure Test Randall Selitto method. Extraction was done by maceration of leaf powder with a solvent 96% ethanol. 25 male Wistar white rats were divided into 5 groups, positive group mefenamic acid 9 mg /200 g BW for the Paw Pressure Test Randall Selitto Method and tramadol 0.9 mg /200 g BW for the Tail Flick Method, negative control CMC Na 0,5%, ethanol extract leaves inggu leaves a dose of 10 mg /200 g BW, 20 mg /200 g BW and 40 mg /200 g BW. The data obtained were analyzed by ANOVA test, then LSD test was used to determine differences between groups. The results showed extract dosage of 10 mg /200 g BW, 20 mg /200 g BW, 40 mg /200 g BW had analgesic effect. Extract dosage of 20 mg /200 g BW and 40 mg /200 g BW in the Randall selitto Paw Pressure Test method is equivalent to mefenamic acid, extract dose 10 mg /200 g BW, 20 mg /200 g BW, and 40 mg /200 g BW the Tail Flick method is equivalent to Tramadol. Ethanol leaf extract is more effective as a narcotic analgesic by the Tail Flick method.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124536066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hubungan Antara Peran Pengawas Menelan Obat (PMO) dengan Keberhasilan Pengobatan Tuberkulosis Paru Kategori I 监管者服用药物(PMO)与成功治疗I型肺结核病的关系

Journal Syifa Sciences and Clinical Research Pub Date : 2019-09-12 DOI: 10.3731/JSSCR.V1I2.2664

Selly Septi Fandinata, R. Darmawan

{"title":"Hubungan Antara Peran Pengawas Menelan Obat (PMO) dengan Keberhasilan Pengobatan Tuberkulosis Paru Kategori I","authors":"Selly Septi Fandinata, R. Darmawan","doi":"10.3731/JSSCR.V1I2.2664","DOIUrl":"https://doi.org/10.3731/JSSCR.V1I2.2664","url":null,"abstract":"TB is an infectious disease caused by Gercobacterium tuberculosis that attacks the lungs and can cause disturbances in the respiratory tract. The DOTS Program can help the achievement of successful treatment targets. The role and motivation of PMO and family are essential for the successful treatment of lung TB patients. This type of study is an analytical observational research with prospective data collection in March – May 2019, which is recorded as medical data of patients diagnosed with lung TB category I in September – November 2018 at Rubaru Puskesmas Sumenep Regency. The purpose of this research is to know the role of PMO relationship with the successful treatment of lung TB category I. With the number of samples of this research 40 patients. The results of this study using Pearson correlation statistics indicate that the value significance 0.013 < 0.05, this means a significant link between the PMO role with the success of patient treatment. The value of the correlation coefficient R obtained from 0388, the relationship between PMO role and the success of patient treatment in direct, this means that the greater the role of PMO then the higher the success of treatment, the smaller the PMO role then the lower the Successful treatment. In addition, the table also gained that the relationship between the PMO role and the successful treatment of the patient is weak due to the correlation coefficient of R < 0.4.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114861716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Formulasi Self-Nanoemulsifiying Drug Delivery System (SNEDDS) Asam Mefenamat menggunakan VCO dengan Kombinasi Surfaktan Tween dan Span

Journal Syifa Sciences and Clinical Research Pub Date : 2019-09-06 DOI: 10.37311/JSSCR.V1I2.2660

Muhamad Handoyo Sahumena, S. Suryani, Neni Rahmadani

{"title":"Formulasi Self-Nanoemulsifiying Drug Delivery System (SNEDDS) Asam Mefenamat menggunakan VCO dengan Kombinasi Surfaktan Tween dan Span","authors":"Muhamad Handoyo Sahumena, S. Suryani, Neni Rahmadani","doi":"10.37311/JSSCR.V1I2.2660","DOIUrl":"https://doi.org/10.37311/JSSCR.V1I2.2660","url":null,"abstract":"Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) which has analgesic, anti-inflammatory and antipyretic effects. Mefenamic acid works by inhibiting prostaglandin synthesis as an inflammatory mediator. Mefenamic acid has low drug solubility and a long process of dissolution in the body which greatly affects the speed of absorption and bioavailability of the drug. In this study, mefenamic acid nanoemulsion formulation was carried out through a Self-Nanoemulsifying Drug Delivery System (SNEDDS) delivery system. SNEDDS is a drug delivery method through isotropic oil extraction, surfactants, cosurfactans and drug that form oil in water (m/a) emulsions which when in contact with the water phase in the digestive tract wiil from a nanoemulsion that occurs spontaneously so that the drug dissolves with a particle size small so as to increase the effective surface area for absorption. The purpose of the study was to determine the ratio of surfactant and cosurfactant composition to the optimum formula of SNEDDS of mefenamic acid with VCO as an oil phase. The SNEDDS formula was obtained by mixing the surfactants tween 80 and span 80, cosurfactant PEG 400 and VCO as the oil phase using the characterization of determining the optimum formula, namely emulsion formation, transmittance and emulsification time. The composition of the optimum formula of SNEDDS of mefenamic acid is 1 mL VCO; 1 mL PEG 400; 6 mL tween 80; 1 mL span 80. Optimum formula showed clear emulsion results, with transmittance values of 89,04% and emulsification time under 1 minute. In this study produced the optimum formula SNEDDS the met the criteria based on droplet size parameters of 153,5 nm, potential zeta value of 8,2 mV and showed good stability.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115428090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Hubungan Dukungan Keluarga dengan Kepatuhan Pengobatan Pasien Rawat Jalan Skizofrenia di RSUD Banyumas 家庭支持关系与班尤马斯县精神分裂症门诊病人的药物依赖性关系

Journal Syifa Sciences and Clinical Research Pub Date : 2019-09-05 DOI: 10.37311/JSSCR.V1I2.2661

Alfu Wa Ichda, Laksmi Maharani, M. W. Suryoputri

引用次数: 2

IDENTIFIKASI ISOLAT KULIT BATANG WARU (Hibiscus tiliaceus L.) MENGGUNAKAN SPEKTROSKOPI INFRAMERAH

Journal Syifa Sciences and Clinical Research Pub Date : 2019-03-01 DOI: 10.37311/jsscr.v1i1.2199

Muhammad Taupik, M.Sc, Muhammad Adam Mustapa

{"title":"IDENTIFIKASI ISOLAT KULIT BATANG WARU (Hibiscus tiliaceus L.) MENGGUNAKAN SPEKTROSKOPI INFRAMERAH","authors":"Muhammad Taupik, M.Sc, Muhammad Adam Mustapa","doi":"10.37311/jsscr.v1i1.2199","DOIUrl":"https://doi.org/10.37311/jsscr.v1i1.2199","url":null,"abstract":"Waru (Hibiscustiliaceus L.) bark is a plant that is believed and used by community as a traditional medicine in treatment, especiallytotreat fever. This study aims to analyze the level of a secondary metabolite compound in the bark of waru (Hibiscustiliaceus L.) plant calculated using UV-Vis spectrophotometry and infrared methods. The method used to identify the flavonoid content is Thin Layer Chromatography (TLC) using eluent n-hexane and ethyl acetate at the best comparison (7:3). The result obtained from this study is waru bark extract containing flavonoid compound which is shown from the Rf value of the waru bark methanol extract of 0.82, which the value is close to the Rf value of quarcetine 0.83. Analysis of the flavonoid content of waru bark methanol extract has carried out on The Spectrophotometric UV-Vis at a wavelength of 382 nm and the total flavonoid content obtained is of 10 mg of waru bark methanol extract containing135.2166g/mL flavonoid compound with percentage of 13.521% and on the Spetroscopy Infrared, based on the obtained peak shows the existence of functional groups of OH, CH aliphatic, C=C aromatic and C-O indicates that this isolat is a flavonoid compound.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"329 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133678734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0