Uji Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Notika (Arcboldiodendron calosericeum Kobuski) Terhadap Kadar Kolesterol Total Tikus (Rattus norvegicus) Jantan Galur Wistar

Journal Syifa Sciences and Clinical Research Pub Date : 2019-11-13 DOI:10.37311/JSSCR.V2I1.2704

N. Nuralifah, W. Wahyuni, P. Parawansah, Ulan Dwi Shintia

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引用次数: 4

Abstract

Hyperlipidemia is an increase of lipid due to excessive fat consumption, that the intake and alteration of lipid is not balanced. Notika are plants that contain secondary metabolites in the form of flavonoids, tannins, saponins and triterpenoids which are antioxidant compounds that are thought to have the effect of reducing blood lipids. This study aims to determine the effect of ethanol extract of leaves of Notika on decreasing total cholesterol levels in rats induced by egg and propylthiouracil (PTU). This research was experimental in 6 groups, namely 4 groups given ethanol extract of leaves of Notika at a dose of 50 mg/kgBB, 100 mg/kgBB, 200 mg/kgBB, and 300 mg/kgBB, one group was given Na CMC 0.5% as a negative control, and one group was given simvastatin 10 mg as a positive control. The results showed that the ethanol extract of the leaves of Notika significantly reduced the total cholesterol level of rats with a significant value 0.05 and 300 mg/kgBB is an effective dose to reduce total cholesterol level.

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对雄蛙的总胆固醇(学名arcboldiodenceum caloceum Kobuski)的抗高脂活性测试

高脂血症是由于脂肪摄入过多而引起的脂质增高，即脂质摄入与改变不平衡。Notika是一种含有类黄酮、单宁、皂苷和三萜等次生代谢物的植物，它们是抗氧化化合物，被认为具有降低血脂的作用。本研究旨在探讨野藿香叶乙醇提取物对降低鸡蛋和丙硫脲嘧啶(PTU)诱导大鼠总胆固醇水平的影响。本研究分6组进行实验，4组分别给予50 mg/kgBB、100 mg/kgBB、200 mg/kgBB、300 mg/kgBB, 1组给予0.5%钠CMC作为阴性对照，1组给予辛伐他汀10 mg作为阳性对照。结果表明，野藿香叶乙醇提取物显著降低大鼠总胆固醇水平，显著值为0.05,300 mg/kgBB是降低总胆固醇水平的有效剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal Syifa Sciences and Clinical Research

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