Journal Syifa Sciences and Clinical Research最新文献_第2页

Penetapan kadar Nipagin (Methyl Paraben) pada body lotion yang beredar di Kota Gorontalo secara Spektrofotometri UV-Vis 用紫外可见分光光度法测定戈伦塔洛市流通的沐浴露中尼泊金（苯甲酸甲酯）的含量

Journal Syifa Sciences and Clinical Research Pub Date : 2024-01-21 DOI: 10.37311/jsscr.v6i1.9077

Mohamad Adam Mustapa, Ariani H. Hutuba, Dizky Ramadani Putri Papeo, Wiwit Zuriati Uno

{"title":"Penetapan kadar Nipagin (Methyl Paraben) pada body lotion yang beredar di Kota Gorontalo secara Spektrofotometri UV-Vis","authors":"Mohamad Adam Mustapa, Ariani H. Hutuba, Dizky Ramadani Putri Papeo, Wiwit Zuriati Uno","doi":"10.37311/jsscr.v6i1.9077","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.9077","url":null,"abstract":"Body lotion is a skincare cosmetics products that usually contain preservatives as inhibitors of bacteria and fungi growth. According to the Food and Drug Supervisory Agency of Indonesian Republic, 2011: HK.03.1.23.08.11.07517, in which the preservative levels of nipagin (methyl paraben) in a body lotion must be 0.4%, Preservative level over 0.4% may result in skin irritation and allergic reactions. The purpose of this study was to determine the nipagin’s essence and levels in body lotions sold in Gorontalo City. Nipagin’s identification was carried out with a qualitative analysis using Thin Layer Chromatography and color change using 2% of deniges reactor and sodium nitrite, while the quantitative analysis was carried out with spectrophotometry UV-Vis at 258 nm wavelength that was previously extracted with 96% of ethanol solvent. The results of the qualitative study show that four (A, D, E, and F) out of six samples of body lotions: A, B, C, D, E, and F contained preservatives. Quantitatively, the levels of nipagin) on the four samples are sequentially shown as follows: by A:0.38%, D:0.04%, E:0.14%, F:0.14%. All in all, the samples are entirely eligible according to the Regulotions of the National Agency of Drug and Food of Indonesian Republic 2011: HK.03.1.23.08.11.07517.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"218 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140501285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standarisasi dan Analisis Kandungan Flavonoid Total Daun Pulai (Alstonia shcolaris L.) 普莱叶（Alstonia shcolaris L.）总黄酮含量的标准化和分析

Journal Syifa Sciences and Clinical Research Pub Date : 2024-01-21 DOI: 10.37311/jsscr.v6i1.15546

A. A. Andy Suryadi, Mahdalena Sy. Pakaya, Mohamad Adam Mustapa, A.Takdir Makkulawu, Faramita Hiola

{"title":"Standarisasi dan Analisis Kandungan Flavonoid Total Daun Pulai (Alstonia shcolaris L.)","authors":"A. A. Andy Suryadi, Mahdalena Sy. Pakaya, Mohamad Adam Mustapa, A.Takdir Makkulawu, Faramita Hiola","doi":"10.37311/jsscr.v6i1.15546","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.15546","url":null,"abstract":"The island plant (Alstonia scholaris) is one of the plants that is often used for traditional medicinePulai plant (Alstonia scholaris L.) is often used as a traditional medicine to treat fever, itch, malaria, and diarrhea. The secondary metabolite compounds obtained from this plant are flavonoid, tannin, and steroid. This study aims to determine the specific and non-specific parameters and the total flavonoid levels of Pulai's 70% ethanol extract. The standardization of medicine plant extract is needed as an effort to traditional medicine quality control. The standardization test result for specific parameter showed that the organoleptic extract was a dark green and thick extract, bitter, and had a distinctive smell, containing water soluble content (20.14% ±0.1649) and ethanol soluble content (9.495%±0.0928). The standardization for non-specific parameter showed water content (9.17%±0.02055), total ash content (1.76%±0.00547), acid insoluble ash content (2.82%±0.01257), and drying shrinkage (5.08%± 0.04636). Meanwhile, the analysis of flavonoid level of Pulai's 70% ethanol extract fraction was done at the wavelength of 438.36 nm and the absorbance value of 0.0011. The total flavonoid content was analyzed using quercetin standard linear equation of y=0.0643x + (-0.0232) with the correlational coefficient (R)- 0.9974, and the total flavonoid content of 3.77%.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"131 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140501273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Penapisan Fitokimia dan Efek Penyembuhan Luka Insisi Daun Jarak Merah (Jatropha gossypiifolia) pada Mencit (Mus musculus) 红蓖麻叶的植物化学成分筛选和对小鼠切口愈合的影响

Journal Syifa Sciences and Clinical Research Pub Date : 2024-01-21 DOI: 10.37311/jsscr.v6i1.20256

Hamsidar Hasan, Faramita Hiola, Mahdalena Sy. Pakaya, Juliyanti Akuba, Muhammad Andre Viswanathan Maaruf

{"title":"Penapisan Fitokimia dan Efek Penyembuhan Luka Insisi Daun Jarak Merah (Jatropha gossypiifolia) pada Mencit (Mus musculus)","authors":"Hamsidar Hasan, Faramita Hiola, Mahdalena Sy. Pakaya, Juliyanti Akuba, Muhammad Andre Viswanathan Maaruf","doi":"10.37311/jsscr.v6i1.20256","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.20256","url":null,"abstract":"Bellyache Bush (Jatropha gossypiifolia) is a plant registered as one of the plants withvarious medical properties due to its Flavonoids, Alkaloids, Tannins, and Terpenoids. Bellyache Bush plays a significant role in accelerating wound healing and cell regeneration. This research aims to determine the effectiveness of the ethyl acetate fraction from Bellyache Bush leaves (Jatropha gossypiifolia) on male mice (Mus musculus). Bellyache Bush leaves was extracted using a multistage maceration method using n-hexane and ethyl acetate as solvents. This effectiveness of incision wound healing was tested by divided the test animals into five experimental groups, and each consisting of 3 male mice. All mice were treated according to their respective experimental groups : Group 1 (negative control), Group 2 (positive control with 10% povidone iodine), Group 3 (5% Bellyache Bush extract), Group 4 (10% Bellyache Bush extract), Group 5 (15% Bellyache Bush extract), until the wounds healed or white scar tissue was observed. The results indicate that at a concentration of 15% the ethyl acetate fraction of Bellyache Bush extract was more effective compared to the positive control, povidine iodine.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"19 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140501398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Penyembuhan Luka Bakar Gel Enzim Bromelin Secara In Vivo 体内烧伤愈合的溴霉素凝胶

Journal Syifa Sciences and Clinical Research Pub Date : 2024-01-21 DOI: 10.37311/jsscr.v6i1.20384

N. Thomas, M. Taupik, Fika Nuzul Ramadhani, Ariani H. Hutuba, Dizky Ramadani Putri Papeo

{"title":"Penyembuhan Luka Bakar Gel Enzim Bromelin Secara In Vivo","authors":"N. Thomas, M. Taupik, Fika Nuzul Ramadhani, Ariani H. Hutuba, Dizky Ramadani Putri Papeo","doi":"10.37311/jsscr.v6i1.20384","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.20384","url":null,"abstract":"Bromelain is a proteolytic enzyme or natural protease found in tissues, including the stem, fruit, and leaves of pineapple (Ananas comosus var. comosus) and other plant species of the Bromeliaceae family. Bromelain is known as an efficient debdriding agent because it is beneficial in burn healing and tissue regeneration. This research aims to determine the effectiveness of bromelain enzyme for burns wounds in rabbits (Oryctolagus cuniculus). This research began with the optimization of carbopol 940 base preparations with variations in concentration, namely Formula 1 (F1) for 0,5%, Formula 2 (F2) for 1%, and Formula 3 (F3) for 1,5%. The evaluation of the gel formulation includes an organoleptic test, homogeneity test, pH test, viscosity test, adhesive force test, and spreadability test. The evaluation result indicates the base concentration in Formula 1 (F1) at 0,5% has met the requirements for a gel preparation. Formula 1 (F1) for 0,5, then combined with varying concentration of bromelain, namely Formula 1A (0,1%), Formula 1B (0,5%), and Formula 1C (1%). The gel formulation wa re-evaluated, including an organoleptic test, homogeneity test, pH test, viscosity test, adhesion test, spreadability test, irritation test, and in vivo test. In vivo effectiveness testing and irritation testing were conducted on five treatment groups, namely a positive control group (Bioplacenton®), Formula 1A (0,1%), Formula 1B (0,5%), Formula 1C (1%), and a group without treatment, then observed for 15 days. The observation data were processed using the One Way ANOVA test. Based on the results of the irritation test, Formula 1A (0,1%). Formula 1B (0,5%) and Formula 1C (1%) did not cause skin irritation. In the in vivo test, Formula 1C (1%) indicated the fastest recovery compared to other treatment groups, as evidenced by the decrease in wound diameter and visual observation, where the wound had started to close completely on day 15 of observation.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"110 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140501131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studi Penatalaksanaan dan Ketepatan Pengobatan Antihipertensi pada Wanita Hamil di RSUD Toto Kabila 关于托托-卡比拉医院孕妇抗高血压治疗的管理和准确性的研究

Journal Syifa Sciences and Clinical Research Pub Date : 2024-01-19 DOI: 10.37311/jsscr.v6i1.23785

Madania Madania, W. Abdulkadir, E. Djuwarno, A. Suryadi, Sherina Sherina

{"title":"Studi Penatalaksanaan dan Ketepatan Pengobatan Antihipertensi pada Wanita Hamil di RSUD Toto Kabila","authors":"Madania Madania, W. Abdulkadir, E. Djuwarno, A. Suryadi, Sherina Sherina","doi":"10.37311/jsscr.v6i1.23785","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.23785","url":null,"abstract":"Hypertension is a condition that can affect pregnancy. High blood pressure during pregnancy can hinder fetal and uterine growth, lead to fetal death in the womb, and result in premature birth. These complications can be minimized with appropriate antihypertensive therapy. The objective of this study is to determine the incidence rate, management, and accuracy of antihypertensive treatment according to the reference standards of the 2016 Preeclampsia National Medical Service Guidelines (PNPK). This research was an observational descriptive study where the data obtained were secondary data collected retrospectively from medical records at Regional Public Hospital of Toto Kabila from September 2022 to May 2023. The sample was taken using a saturated sampling technique, so the sample in this study included all pregnant women diagnosed with preeclampsia. The results of the study obtained 65 patients, consisting of 36 severe preeclampsia patients and 29 mild preeclampsia patients. The study showed that hypertension in pregnant women was often found in the age group of 26-35 years, with 25 patients (39%), and in the third trimester of pregnancy, with 23 cases, while 2 experienced hypertension in the first trimester. 12 patients were diagnosed with severe preeclampsia and 13 patients with mild preeclampsia. The treatment of hypertension in pregnant women for mild preeclampsia included methyldopa (34%) and nifedipine (7%). For severe preeclampsia, single therapy included methyldopa (39%), amlodipine (8%), and combination therapy such as nifedipine + methyldopa (36%) and methyldopa + amlodipine (17%). The accuracy of antihypertensive drug use in pregnant women based on the 2016 Preeclampsia PNPK was 86%, including appropriate indications, correct drugs and correct doses.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"396 1-6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uji Efektivitas Ekstrak Daun Jambu Biji (Psidium guajava) dalam Menurunkan Kadar Gula Darah Mencit (Mus musculus) 番石榴叶提取物降低小鼠血糖水平的有效性试验

Journal Syifa Sciences and Clinical Research Pub Date : 2024-01-19 DOI: 10.37311/jsscr.v6i1.21376

Widy Susanti Abdulkadir, Endah Nurrhohwinta Djuwarno, Sukmawati A. Damiti

{"title":"Uji Efektivitas Ekstrak Daun Jambu Biji (Psidium guajava) dalam Menurunkan Kadar Gula Darah Mencit (Mus musculus)","authors":"Widy Susanti Abdulkadir, Endah Nurrhohwinta Djuwarno, Sukmawati A. Damiti","doi":"10.37311/jsscr.v6i1.21376","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.21376","url":null,"abstract":"Diabetes mellitus is a disorder of blood sugar metabolism chronically characterized by high blood sugar levels resulting from impaired insulin secretion, insulin resistance, or both. Treatment of diabetes mellitus consists of four pillars: education, medical nutrition therapy (MNT), and physical and pharmacological therapies. One of the plants that can be used as a medicinal ingredient is guava leaves. Guava (Psidium guajava L.) leaves are a group of herbal plants with a chemical content that is good for health. Therefore, guava (Psidium guajava L.) leaves are plants that are efficacious as medicine. This plant contains secondary metabolites that act as antidiabetics. Thus, the research aimed to determine the effectiveness of ethanol extract of guava (Psidium guajava L.) leaves on the decrease in blood sugar levels in male mice. The research method employed was maceration, phytochemical screening, and antidiabetic testing with the pre-test and post-test control group design methods to determine if there was a decrease after administration of the extract. The findings indicated that the phytochemical screening test found that guava (Psidium guajava L.) contained secondary metabolites, including alkaloids, flavonoids, and tannins. In contrast, the antidiabetic test revealed that three extracts with concentrations of 50 mg, 100 mg. and 200 mg could decrease blood sugar levels by 15%, 21%, and 47%, respectively. From these findings, it can be concluded that antidiabetic compounds which play a role in the ellanol extrict of guava (Psidium guajava L.) leaves are alkaloids, flavonoids, and tannins.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profil Penggunaan Obat Antibiotik pada Penderita Infeksi Saluran Pernapasan Akut (ISPA) di Puskesmas Kabupaten Gorontalo 戈龙塔洛县医院急性呼吸道感染（ARI）患者使用抗生素药物的概况

Journal Syifa Sciences and Clinical Research Pub Date : 2024-01-19 DOI: 10.37311/jsscr.v6i1.21889

T. S. Tuloli, Juliyanti Akuba, E. Djuwarno, A.Takdir Makkulawu, Riska Ahmad

{"title":"Profil Penggunaan Obat Antibiotik pada Penderita Infeksi Saluran Pernapasan Akut (ISPA) di Puskesmas Kabupaten Gorontalo","authors":"T. S. Tuloli, Juliyanti Akuba, E. Djuwarno, A.Takdir Makkulawu, Riska Ahmad","doi":"10.37311/jsscr.v6i1.21889","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.21889","url":null,"abstract":"Acute respiratory infection (ARI) is a disease with a high prevalence. Most ARIs that occur are caused by viruses and do not require antibiotics. This study aims to determine whether or not Acute Respiratory Infection (ARI) patients at Gorontalo Regency Health Center treated with antibiotic and to determine the appropriate drugs, appropriate indication, appropriate patients, and appropriate dose in Acute Respiratory Infection (ARI) patients. This study is conducted retrospectively by taking data from the medical records of 300 ARI patients. Patient characteristics by sex are: male patients are 49% and females 51%. Most patients with ARI occurred at the age of 0-5 years are 155 cases (51.7%), 6-10 years are 47 cases (15.7%), 21-25 years are 39 cases (13%), 16-20 years are 31 cases (10.3%), and 11-15 years are 28 cases (9.3%). The research findings discover that the use of antibiotic drug in ARI patients comprises Amoxicillin for 51 cases (17%), Amoxicillin syrup for 13 cases (4,3%), Amoxicillin powder for 46 cases (15,3%), Cotrimoxazole for 2 cases (0,6%), Cefadroxil for 2 cases (0,6%), and Ciprofloxacin for 1 case (0,5%). In the meantime, those who are not treated with antibiotic drug are 185 cases (61,7%). Additionally, the use of drugs includes appropriate drugs for 86,7%, appropriate indications for 62,3%, appropriate doses for 72,3%, and appropriate patients for 100% which have been in accordance with clinical practice manual book in the primary health facility.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"73 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140503291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gambaran Penggunaan Obat Antipsikotik pada Pasien Skizofrenia di Puskesmas Kota Gorontalo 戈伦塔洛市医疗中心精神分裂症患者抗精神病药物使用概况

Journal Syifa Sciences and Clinical Research Pub Date : 2024-01-19 DOI: 10.37311/jsscr.v6i1.23849

Herlina Jusuf, Madania Madania, Fika Nuzul Ramadhani, Dizky Ramadani putri Papeo, Maryam Kalasi

{"title":"Gambaran Penggunaan Obat Antipsikotik pada Pasien Skizofrenia di Puskesmas Kota Gorontalo","authors":"Herlina Jusuf, Madania Madania, Fika Nuzul Ramadhani, Dizky Ramadani putri Papeo, Maryam Kalasi","doi":"10.37311/jsscr.v6i1.23849","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.23849","url":null,"abstract":"Schizophrenia is one of the most common forms of psychotic mental disorder, with the main symptoms being the absence of self-understanding (insight) and the inability to assess reality (reality testing ability is disturbed). This study aimed to determine the description of the antipsychotic drug's usage, including the drug classes, types, doses, and medication rules in schizophrenia patients at the Kota Selatan Public Health Center, Gorontalo City. This observational study used secondary data and was conducted retrospectively. Further, data obtained from the medical records of 25 schizophrenia patients were analyzed univariately. The results disclosed that schizophrenia was more experienced by men (60%), more prevalent in the age range of 36-45 years (52%), and unmarried (48%)The most widely used antipsychotic drugs were atypical groups (72%). The most widely used type of drug was Risperidone 2 mg with a rule of use of 2 x 1 (39%) and 1 x 1 (9%). Clozapine, 25 mg. with a rule of 2 x 1 was 14%, and 1 x 1 was 9%. Meanwhile, the had 28% consisting typical group only of chlorpromazine 25 mg with tule of use of 1x 1 (12%), haloperidol with a dose of 1.5 mg with a rule of use of 2 sikzonoate 25 mg/ml with 1 x 1 was 5%.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"389 1-3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Purification of 3×Myc PKG-Puro-Poly A Gene for Bacterial Transformation 纯化用于细菌转化的 3×Myc PKG-Puro-Poly A 基因

Journal Syifa Sciences and Clinical Research Pub Date : 2024-01-14 DOI: 10.37311/jsscr.v5i3.24069

Khairil Pahmi, M. Sidratullah

引用次数: 0

Uji Toksisitas Ekstrak Etanol Kulit Terong Ungu (Solanum melongena L.) Menggunakan Metode Brine Shrimp Lethality Test (BSLT) 茄子皮乙醇萃取毒性试验。使用Brine Shrimp方法试验(BSLT)

Journal Syifa Sciences and Clinical Research Pub Date : 2023-06-12 DOI: 10.37311/jsscr.v4i1.13630

Nur Rahma Dwi Cahya, W. Abdulkadir, Hamsidar Hasan

{"title":"Uji Toksisitas Ekstrak Etanol Kulit Terong Ungu (Solanum melongena L.) Menggunakan Metode Brine Shrimp Lethality Test (BSLT)","authors":"Nur Rahma Dwi Cahya, W. Abdulkadir, Hamsidar Hasan","doi":"10.37311/jsscr.v4i1.13630","DOIUrl":"https://doi.org/10.37311/jsscr.v4i1.13630","url":null,"abstract":"Purple eggplant skin (Solanum melongena L.) is one of the herbal plants that contain compounds such as flavonoids, alkaloids, saponnins, tannins, and terpenoids that are beneficial for health. This research is a laboratory experimental study that aims to determine the level of acute toxicity (LC50) of the ethanol extract of purple eggplant skin (Solanum melongena L.) using the Brine Shrimp Lethality Test (BSLT) method. Purple eggplant peel extraction was carried out using 70% ethanol as solvent. This test was conducted using 10 Artemia salina Leach larvae with 3 replications at 6 concentration variants, which are 500 ppm, 250 ppm, 125 ppm, 50 ppm, 25 ppm, and 12.5 ppm, along with negative controls. The larval mortality rate was observed after 24 hours of adding extract. The result of probit analysis showed that the LC50 value of the ethanol extract of purple eggplant skin (Solanum melongena L.) was 100.8 ppm. Moreover, the results of LC50 1000 ppm indicated that the ethanol extract of purple eggplant skin (Solanum melongena L.) was considered toxic and potential to be an anticancer agent.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114682684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0